Uzarigenin (BioDeep_00000637379)
代谢物信息卡片
3beta,14beta-dihydroxy-5-alpha-card-20(22)-enolide
化学式: C23H34O4 (374.24569640000004)
中文名称: 乌沙甙元
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C[C@H](O)C[C@]2([H])CC[C@@]3([H])[C@@]4(O)CC[C@H](C5=CC(=O)OC5)[C@@]4(C)CC[C@]3([H])[C@@]12C
InChI: InChI=1S/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16-,17+,18-,19+,21-,22+,23-/m0/s1
描述信息
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 92760
- ChEMBL: CHEMBL109863
- LipidMAPS: LMST01120057
- MeSH: Digitoxigenin
- CAS: 466-09-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoqin Zhong, Wei Feng, Lianjie Liu, Qingping Liu, Qiang Xu, Minying Liu, Xiaobao Liu, Shudi Xu, Minzhen Deng, Changsong Lin. Periplogenin inhibits pathologic synovial proliferation and infiltration in rheumatoid arthritis by regulating the JAK2/3-STAT3 pathway.
International immunopharmacology.
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10.1016/j.intimp.2024.111487. [PMID: 38183911] - Yang Li, Xinchi Feng, Feng Qiu. Determination of Two Wound Healing Components in Streptocaulon juventas (Lour.) Merr.: Periplogenin and Digitoxigenin.
Chemistry & biodiversity.
2024 Jan; 21(1):e202301585. doi:
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Journal of natural medicines.
2023 Jan; 77(1):180-187. doi:
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Biomedical chromatography : BMC.
2022 Mar; 36(3):e5283. doi:
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Journal of cellular biochemistry.
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Molecular pharmacology.
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Anti-cancer agents in medicinal chemistry.
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Journal of natural products.
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Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):450-459. doi:
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PLoS pathogens.
2019 08; 15(8):e1007963. doi:
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Cellular and molecular biology (Noisy-le-Grand, France).
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Dec; 51(?):162-170. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Nov; 107(?):464-474. doi:
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Biomedical chromatography : BMC.
2018 Oct; 32(10):e4302. doi:
10.1002/bmc.4302. [PMID: 29809276] - Naira Fernanda Zanchett Schneider, Lara Persich, Sayonarah C Rocha, Ana Carolina Pacheco Ramos, Vanessa Faria Cortes, Izabella Thaís Silva, Jennifer Munkert, Rodrigo M Pádua, Wolfgang Kreis, Alex G Taranto, Leandro A Barbosa, Fernão C Braga, Cláudia M O Simões. Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):684-696. doi:
10.1016/j.biopha.2017.10.128. [PMID: 29101813] - Elke Nolte, Sven Wach, Izabella Thais Silva, Sabine Lukat, Arif B Ekici, Jennifer Munkert, Frieder Müller-Uri, Wolfgang Kreis, Cláudia Maria Oliveira Simões, Julio Vera, Bernd Wullich, Helge Taubert, Xin Lai. A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines.
Oncotarget.
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Biochemical pharmacology.
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Zeitschrift fur Naturforschung. C, Journal of biosciences.
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Biophysical journal.
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