Glucosyl ceramide (BioDeep_00000634856)

   


代谢物信息卡片


N-(11Z-eicosenoyl)-1beta-glucosyl-4E,14Z-sphingadienine

化学式: C44H81NO8 (751.5961866)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: [C@](CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)([H])(NC(CCCCCCCCC/C=C\CCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCC/C=C\CCC
InChI: InChI=1S/C44H81NO8/c1-3-5-7-9-11-13-15-17-18-19-20-22-24-26-28-30-32-34-40(48)45-37(36-52-44-43(51)42(50)41(49)39(35-46)53-44)38(47)33-31-29-27-25-23-21-16-14-12-10-8-6-4-2/h8,10,17-18,31,33,37-39,41-44,46-47,49-51H,3-7,9,11-16,19-30,32,34-36H2,1-2H3,(H,45,48)/b10-8-,18-17-,33-31+/t37-,38+,39+,41+,42-,43+,44+/m0/s1



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Jose A Villalobos, Rebecca E Cahoon, Edgar B Cahoon, Ian S Wallace. Glucosylceramides impact cellulose deposition and cellulose synthase complex motility in Arabidopsis. Glycobiology. 2024 Apr; 34(6):. doi: 10.1093/glycob/cwae035. [PMID: 38690785]
  • Natsuki Kita, Asuka Hamamoto, Siddabasave Gowda B Gowda, Hiroyuki Takatsu, Kazuhisa Nakayama, Makoto Arita, Shu-Ping Hui, Hye-Won Shin. Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis. Journal of lipid research. 2024 03; 65(3):100508. doi: 10.1016/j.jlr.2024.100508. [PMID: 38280458]
  • Yadira X Perez-Paramo, Dawn Dufield, Rathna Veeramachaneni, Emily Parkhurst, Christopher Harp, Akshaya Ramesh, Ryan C Winger, Anne H Cross, Jeffrey M Gelfand, Amit Bar-Or, W Rodney Mathews, Veronica G Anania. Development of an LC-MS/MS method to measure sphingolipids in CSF from patients with multiple sclerosis. Molecular pharmacology. 2024 Jan; ?(?):. doi: 10.1124/molpharm.123.000779. [PMID: 38182433]
  • Subroto Chatterjee, Rebecca Yuan, Spriha Thapa, Resham Talwar. Central Role of β-1,4-GalT-V in Cancer Signaling, Inflammation, and Other Disease-Centric Pathways. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010483. [PMID: 38203654]
  • Mirinthorn Jutanom, Shunji Kato, Shinji Yamashita, Masako Toda, Mikio Kinoshita, Kiyotaka Nakagawa. Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models. Scientific reports. 2023 12; 13(1):22537. doi: 10.1038/s41598-023-49521-3. [PMID: 38110468]
  • Ying Liu, Carine Fillebeen, Anik Forest, Amy Botta, Thibault V Varin, André Marette, Yan Burelle, Christine Des Rosiers, Kostas Pantopoulos, Gary Sweeney. Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 12; 37(12):e23257. doi: 10.1096/fj.202301043r. [PMID: 37902616]
  • Anna E Eberwein, Swarat S Kulkarni, Emma Rushton, Kendal Broadie. Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C. Disease models & mechanisms. 2023 10; 16(10):. doi: 10.1242/dmm.050206. [PMID: 37815467]
  • Alessandro Terrinoni, Gabriele Sala, Ernesto Bruno, Consuelo Pitolli, Marilena Minieri, Massimo Pieri, Alessandra Gambacurta, Elena Campione, Riccardo Belardi, Sergio Bernardini. Partial Loss of Function ABCA12 Mutations Generate Reduced Deposition of Glucosyl-Ceramide, Leading to Patchy Ichthyosis and Erythrodermia Resembling Erythrokeratodermia Variabilis et Progressiva (EKVP). International journal of molecular sciences. 2023 Sep; 24(18):. doi: 10.3390/ijms241813962. [PMID: 37762265]
  • Rémi Planes, Elmostafa Bahraoui. HIV and SIV Envelope Glycoproteins Interact with Glycolipids and Lipids. International journal of molecular sciences. 2023 Jul; 24(14):. doi: 10.3390/ijms241411730. [PMID: 37511488]
  • Mark A Xatse, Andre F C Vieira, Chloe Byrne, Carissa Perez Olsen. Targeted lipidomics reveals a novel role for glucosylceramides in glucose response. Journal of lipid research. 2023 07; 64(7):100394. doi: 10.1016/j.jlr.2023.100394. [PMID: 37245562]
  • Justyna Spiewak, Ivan Doykov, Apostolos Papandreou, Jenny Hällqvist, Philippa Mills, Peter T Clayton, Paul Gissen, Kevin Mills, Wendy E Heywood. New Perspectives in Dried Blood Spot Biomarkers for Lysosomal Storage Diseases. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210177. [PMID: 37373322]
  • Zhiqiang Li, Mulin He, Guangzhi Chen, Tade Souaiaia, Tilla S Worgall, Xian-Cheng Jiang. Effect of Total SMS (Sphingomyelin Synthase) Activity on LDL (Low-Density Lipoprotein) Catabolism in Mice. Arteriosclerosis, thrombosis, and vascular biology. 2023 Apr; ?(?):. doi: 10.1161/atvbaha.123.319031. [PMID: 37128925]
  • Carrie Hayes Sutter, Shafquat Azim, Anyou Wang, Jyoti Bhuju, Amelia S Simpson, Aayushi Uberoi, Elizabeth A Grice, Thomas R Sutter. Ligand-activation of the aryl hydrocarbon receptor up-regulates epidermal UDP-glucose ceramide glucosyltransferase and glucosylceramides. The Journal of investigative dermatology. 2023 Mar; ?(?):. doi: 10.1016/j.jid.2023.03.1662. [PMID: 37004877]
  • Tian Xia, Xin Wu, Eunjin Hong, Kyle Jung, Chih-Jen Lai, Mi-Jeong Kwak, Hogyu Seo, Stephanie Kim, Zhongyi Jiang, Inho Cha, Jae U Jung. Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion. PLoS pathogens. 2023 Mar; 19(3):e1011232. doi: 10.1371/journal.ppat.1011232. [PMID: 36920967]
  • M Judith Peterschmitt, Meredith C Foster, Allena J Ji, Marianne B Zajdel, Gerald F Cox. Plasma glucosylsphingosine correlations with baseline disease burden and response to eliglustat in two clinical trials of previously untreated adults with Gaucher disease type 1. Molecular genetics and metabolism. 2023 Jan; 138(3):107527. doi: 10.1016/j.ymgme.2023.107527. [PMID: 36739645]
  • Jin-Ichi Inokuchi, Shinji Go, Yoshio Hirabayashi. Synthesis of O-Linked Glycoconjugates in the Nervous System. Advances in neurobiology. 2023; 29(?):95-116. doi: 10.1007/978-3-031-12390-0_4. [PMID: 36255673]
  • Makoto Yazawa, Tomoyoshi Kubota, Yuta Kaneko, Yusuke Otsuka, Yui Onuki, Hiroki Nanakubo, Masaki Sato, Yasuhiro Hongo, Mika Mochizuki, Kyoko Usui, Chisa Kaneko, Hiroko Miyamoto, Ryuta Suto, Takamichi Waki, Moe Kasahara, Ayumi Ohashi, Emi Yumoto, Hisakazu Yamane, Jinichiro Koga. A new method for the preparation of a purified glucosylceramide and ceramide from shiitake mushroom. Bioscience, biotechnology, and biochemistry. 2022 Nov; 86(12):1680-1687. doi: 10.1093/bbb/zbac157. [PMID: 36138494]
  • Jacquelyn D Lajiness, Nansalmaa Amarsaikhan, Kiet Tat, Angar Tsoggerel, Joan M Cook-Mills. β-Glucosylceramides and Tocopherols Regulate Development and Function of Dendritic Cells. Journal of immunology (Baltimore, Md. : 1950). 2022 11; 209(10):1837-1850. doi: 10.4049/jimmunol.2101188. [PMID: 36426950]
  • Rika Kojima, Mark Zurbruegg, Tianyi Li, Wojciech Paslawski, Xiaoqun Zhang, Per Svenningsson. Prosaposin Reduces α-Synuclein in Cells and Saposin C Dislodges it from Glucosylceramide-enriched Lipid Membranes. Journal of molecular neuroscience : MN. 2022 Nov; 72(11):2313-2325. doi: 10.1007/s12031-022-02066-y. [PMID: 36152140]
  • Lisa Peters, Wolfgang M Kuebler, Szandor Simmons. Sphingolipids in Atherosclerosis: Chimeras in Structure and Function. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911948. [PMID: 36233252]
  • Ahmed Othman, Yhiya Amen, Maki Nagata, Kuniyoshi Shimizu. Undescribed glucosylceramide, flavonol triglycoside, and oleanane saponin from the halophyte Agathophora alopecuroides: Promising candidates for stimulating ceramide synthesis. Phytochemistry. 2022 Oct; 202(?):113320. doi: 10.1016/j.phytochem.2022.113320. [PMID: 35843358]
  • Danielle Te Vruchte, Andrea Sturchio, David A Priestman, Panagiota Tsitsi, Ellen Hertz, Mattias Andréasson, Ioanna Markaki, Kerri-Lee Wallom, Frances Platt, Per Svenningsson. Glycosphingolipid Changes in Plasma in Parkinson's Disease Independent of Glucosylceramide Levels. Movement disorders : official journal of the Movement Disorder Society. 2022 10; 37(10):2129-2134. doi: 10.1002/mds.29163. [PMID: 35876461]
  • Kohei Yuyama, Yasuyuki Igarashi. Linking glycosphingolipids to Alzheimer's amyloid-ß: extracellular vesicles and functional plant materials. Glycoconjugate journal. 2022 10; 39(5):613-618. doi: 10.1007/s10719-022-10066-8. [PMID: 35920997]
  • Kenchi Miyasaka, Yoshiaki Manse, Akari Yoneda, Shogo Takeda, Norihito Shimizu, Wakana Yamada, Toshio Morikawa, Hiroshi Shimoda. Anti-melanogenic effects of glucosylceramides and elasticamide derived from rice oil by-products in melanoma cells, melanocytes, and human skin. Journal of food biochemistry. 2022 10; 46(10):e14353. doi: 10.1111/jfbc.14353. [PMID: 35986572]
  • Narito Asanuma. Effect of Dietary Ceramide and Glucosylceramide on the Alleviation of Experimental Inflammatory Bowel Disease in Mice. Journal of oleo science. 2022 Sep; 71(9):1397-1402. doi: 10.5650/jos.ess22169. [PMID: 35965094]
  • Giulia Lunghi, Emma Veronica Carsana, Nicoletta Loberto, Laura Cioccarelli, Simona Prioni, Laura Mauri, Rosaria Bassi, Stefano Duga, Letizia Straniero, Rosanna Asselta, Giulia Soldà, Alessio Di Fonzo, Emanuele Frattini, Manuela Magni, Nara Liessi, Andrea Armirotti, Elena Ferrari, Maura Samarani, Massimo Aureli. β-Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration. Cells. 2022 07; 11(15):. doi: 10.3390/cells11152343. [PMID: 35954187]
  • Atul Sharma, Arun Chauhan, Pooja Chauhan, Dustin L Evans, Randolph E Szlabick, Mary O Aaland, Bibhuti B Mishra, Jyotika Sharma. Glycolipid Metabolite β-Glucosylceramide Is a Neutrophil Extracellular Trap-Inducing Ligand of Mincle Released during Bacterial Infection and Inflammation. Journal of immunology (Baltimore, Md. : 1950). 2022 07; 209(2):391-400. doi: 10.4049/jimmunol.2100855. [PMID: 35768151]
  • Zhidong Qiu, Xuehong Wang, Zebin Yang, Sicong Liao, Wei Dong, Tian Sun, Huixian Wu, Qinqin Zhang, Zhixiong Pan, Sin Man Lam, Guanghou Shui, Junfei Jin. GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway. Cell death & disease. 2022 May; 13(5):508. doi: 10.1038/s41419-022-04968-6. [PMID: 35637196]
  • Lindsey T Lelieveld, Sophie Gerhardt, Saskia Maas, Kimberley C Zwiers, Claire de Wit, Ernst H Beijk, Maria J Ferraz, Marta Artola, Annemarie H Meijer, Christian Tudorache, Daniela Salvatori, Rolf G Boot, Johannes M F G Aerts. Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. Journal of lipid research. 2022 05; 63(5):100199. doi: 10.1016/j.jlr.2022.100199. [PMID: 35315333]
  • Mariko Komuro, Masaki Nagane, Rikito Endo, Takashi Nakamura, Takayoshi Miyamoto, Chiaki Niwa, Tomoki Fukuyama, Hideyoshi Harashima, Naoyuki Aihara, Junichi Kamiie, Rimina Suzuki, Tadashi Yamashita. Glucosylceramide in T cells regulates the pathology of inflammatory bowel disease. Biochemical and biophysical research communications. 2022 04; 599(?):24-30. doi: 10.1016/j.bbrc.2022.02.004. [PMID: 35168060]
  • Katsuyuki Mukai, Megumi Takeuchi, Masao Ohnishi, Masatake Kudoh, Hiroyuki Imai. Characterization of Ceramides and Glucosylceramides of the Satsuma Mandarin(Citrus unshiu) Fruit. Journal of oleo science. 2022 Apr; 71(4):535-540. doi: 10.5650/jos.ess21376. [PMID: 35283415]
  • Yuta Tanaka, Masaki Seto, Keiko Kakegawa, Kazuaki Takami, Fumiaki Kikuchi, Takeshi Yamamoto, Minoru Nakamura, Masaki Daini, Masataka Murakami, Tomohiro Ohashi, Takahito Kasahara, Junsi Wang, Zenichi Ikeda, Yasufumi Wada, Florian Puenner, Takahiro Fujii, Masakazu Inazuka, Sho Sato, Tomohiko Suzaki, Jeong-Ho Oak, Yuichi Takai, Hiroshi Kohara, Kouya Kimoto, Hideyuki Oki, Satoshi Mikami, Minoru Sasaki, Yuta Tanaka. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. Journal of medicinal chemistry. 2022 03; 65(5):4270-4290. doi: 10.1021/acs.jmedchem.1c02078. [PMID: 35188773]
  • Ivan Milenkovic, Shani Blumenreich, Anthony H Futerman. GBA mutations, glucosylceramide and Parkinson's disease. Current opinion in neurobiology. 2022 02; 72(?):148-154. doi: 10.1016/j.conb.2021.11.004. [PMID: 34883387]
  • M Judith Peterschmitt, Hidemoto Saiki, Taku Hatano, Thomas Gasser, Stuart H Isaacson, Sebastiaan J M Gaemers, Pascal Minini, Stéphane Saubadu, Jyoti Sharma, Samantha Walbillic, Roy N Alcalay, Gary Cutter, Nobutaka Hattori, Günter U Höglinger, Kenneth Marek, Anthony H V Schapira, Clemens R Scherzer, Tanya Simuni, Nir Giladi, Sergio Pablo Sardi, Tanya Z Fischer. Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson's Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial. Journal of Parkinson's disease. 2022; 12(2):557-570. doi: 10.3233/jpd-212714. [PMID: 34897099]
  • Lingling Zhang, Yanqiu Li, Ying Wang, Yugang Qiu, Hanchuan Mou, Yuanyao Deng, Jiyuan Yao, Zhiqing Xia, Wenzhe Zhang, Di Zhu, Zeyu Qiu, Zhongjie Lu, Jirong Wang, Zhouxin Yang, GenXiang Mao, Dan Chen, Leimin Sun, Leiming Liu, Zhenyu Ju. mTORC2 Facilitates Liver Regeneration Through Sphingolipid-Induced PPAR-α-Fatty Acid Oxidation. Cellular and molecular gastroenterology and hepatology. 2022; 14(6):1311-1331. doi: 10.1016/j.jcmgh.2022.07.011. [PMID: 35931382]
  • Raquel Roman Faedo, Gabriel da Silva, Rodrigo Moreira da Silva, Tatiane Resende Ushida, Ricardo Roberto da Silva, Riccardo Lacchini, Leandro Luongo Matos, Luiz Paulo Kowalski, Noberto Peporine Lopes, Andréia Machado Leopoldino. Sphingolipids signature in plasma and tissue as diagnostic and prognostic tools in oral squamous cell carcinoma. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022 01; 1867(1):159057. doi: 10.1016/j.bbalip.2021.159057. [PMID: 34655810]
  • Neelay Mehendale, Roop Mallik, Siddhesh S Kamat. Mapping Sphingolipid Metabolism Pathways during Phagosomal Maturation. ACS chemical biology. 2021 12; 16(12):2757-2765. doi: 10.1021/acschembio.1c00393. [PMID: 34647453]
  • Haruka Shimizu, Masaki Kuse, Ken-Ichiro Minato, Masashi Mizuno. Anti-allergic property of 4,8-sphingadienine stereoisomers in vivo and in vitro model. Biochemical and biophysical research communications. 2021 11; 577(?):32-37. doi: 10.1016/j.bbrc.2021.08.071. [PMID: 34500233]
  • V Rondelli, A Koutsioubas, J Pršić, E Deboever, J M Crowet, L Lins, M Deleu. Sitosterol and glucosylceramide cooperative transversal and lateral uneven distribution in plant membranes. Scientific reports. 2021 11; 11(1):21618. doi: 10.1038/s41598-021-00696-7. [PMID: 34732753]
  • Jinichiro Koga, Makoto Yazawa, Koji Miyamoto, Emi Yumoto, Tomoyoshi Kubota, Tomoko Sakazawa, Syun Hashimoto, Masaki Sato, Hisakazu Yamane. Sphingadienine-1-phosphate levels are regulated by a novel glycoside hydrolase family 1 glucocerebrosidase widely distributed in seed plants. The Journal of biological chemistry. 2021 11; 297(5):101236. doi: 10.1016/j.jbc.2021.101236. [PMID: 34563538]
  • Catherine Viel, Jennifer Clarke, Can Kayatekin, Amy M Richards, Ming Sum R Chiang, Hyejung Park, Bing Wang, Lamya S Shihabuddin, S Pablo Sardi. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model. Scientific reports. 2021 10; 11(1):20945. doi: 10.1038/s41598-021-00404-5. [PMID: 34686711]
  • Shinji Yamashita, Michiru Soga, Ephantus Nguma, Mikio Kinoshita, Teruo Miyazawa. Protective Mechanism of Rice-Derived Lipids and Glucosylceramide in an In Vitro Intestinal Tract Model. Journal of agricultural and food chemistry. 2021 Sep; 69(35):10206-10214. doi: 10.1021/acs.jafc.1c04562. [PMID: 34455784]
  • Kazushi Ohta, Shinobu Hiraki, Masakatsu Miyanabe, Tatsuro Ueki, Kazuhiko Aida, Yuki Manabe, Tatsuya Sugawara. Appearance of Intact Molecules of Dietary Ceramides Prepared from Soy Sauce Lees and Rice Glucosylceramides in Mouse Plasma. Journal of agricultural and food chemistry. 2021 Aug; 69(32):9188-9198. doi: 10.1021/acs.jafc.0c07259. [PMID: 33507082]
  • Jin-Yue Yang, Tian-Tian Zhang, Zhe Dong, Hao-Hao Shi, Jie Xu, Xiang-Zhao Mao, Yu-Ming Wang, Chang-Hu Xue. Dietary Supplementation with Exogenous Sea-Cucumber-Derived Ceramides and Glucosylceramides Alleviates Insulin Resistance in High-Fructose-Diet-Fed Rats by Upregulating the IRS/PI3K/Akt Signaling Pathway. Journal of agricultural and food chemistry. 2021 Aug; 69(32):9178-9187. doi: 10.1021/acs.jafc.0c06831. [PMID: 33560835]
  • Maksim Steshin, Toshiki Ishikawa. Liquid chromatography-tandem mass spectrometry with a new separation mode for rapid profiling of the Z/E isomers of plant glucosylceramides. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jul; 1178(?):122807. doi: 10.1016/j.jchromb.2021.122807. [PMID: 34147952]
  • Martijn J C van der Lienden, Jan Aten, André R A Marques, Ingeborg S E Waas, Per W B Larsen, Nike Claessen, Nicole N van der Wel, Roelof Ottenhoff, Marco van Eijk, Johannes M F G Aerts. GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice. International journal of molecular sciences. 2021 Mar; 22(5):. doi: 10.3390/ijms22052532. [PMID: 33802460]
  • Emi Yumoto, Masaki Sato, Tomoyoshi Kubota, Hirofumi Enomoto, Koji Miyamoto, Hisakazu Yamane, Jinichiro Koga. Direct LC-ESI-MS/MS analysis of plant glucosylceramide and ceramide species with 8E and 8Z isomers of the long chain base. Bioscience, biotechnology, and biochemistry. 2021 Feb; 85(2):205-210. doi: 10.1093/bbb/zbaa032. [PMID: 33604626]
  • Shinji Yamashita, Chisato Higaki, Asuka Kanai, Nobuhiro Kikuchi, Daisuke Suzuki, Mikio Kinoshita, Teruo Miyazawa. Sphingolipid Properties in Sake Rice Cultivars and Changes During Polishing and Brewing. Journal of oleo science. 2021 Feb; 70(2):203-212. doi: 10.5650/jos.ess20234. [PMID: 33456006]
  • Admassu Assen Adem, Anteneh Belete, Alena Soboleva, Andrej Frolov, Efrem N Tessema, Tsige Gebre-Mariam, Reinhard H H Neubert. Structural characterization of plant glucosylceramides and the corresponding ceramides by UHPLC-LTQ-Orbitrap mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2021 Jan; 192(?):113677. doi: 10.1016/j.jpba.2020.113677. [PMID: 33099117]
  • M Judith Peterschmitt, Nigel P S Crawford, Sebastiaan J M Gaemers, Allena J Ji, Jyoti Sharma, Theresa T Pham. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers. Clinical pharmacology in drug development. 2021 01; 10(1):86-98. doi: 10.1002/cpdd.865. [PMID: 32851809]
  • Ana E Ventura, Tânia C B Santos, Joaquim T Marquês, Rodrigo F M de Almeida, Liana C Silva. Biophysical Analysis of Lipid Domains by Fluorescence Microscopy. Methods in molecular biology (Clifton, N.J.). 2021; 2187(?):223-245. doi: 10.1007/978-1-0716-0814-2_13. [PMID: 32770510]
  • Philip W Wertz. Lipid Metabolic Events Underlying the Formation of the Corneocyte Lipid Envelope. Skin pharmacology and physiology. 2021; 34(1):38-50. doi: 10.1159/000513261. [PMID: 33567435]
  • Yoshiki Niimi, Yasuaki Mizutani, Hisako Akiyama, Hirohisa Watanabe, Ryoichi Shiroki, Yoshio Hirabayashi, Kiyotaka Hoshinaga, Tatsuro Mutoh. Cerebrospinal Fluid Profiles in Parkinson's Disease: No Accumulation of Glucosylceramide, but Significant Downregulation of Active Complement C5 Fragment. Journal of Parkinson's disease. 2021; 11(1):221-232. doi: 10.3233/jpd-202310. [PMID: 33216044]
  • Takuya Honda, Kaisei Motoyoshi, Junya Kasahara, Kazuyuki Yamagata, Hiromasa Takahashi, Hiroyuki Nakamura, Toshihiko Murayama. Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2021 01; 1866(1):158817. doi: 10.1016/j.bbalip.2020.158817. [PMID: 32980536]
  • Jian Gan, Su Jun Zheng, Xiao Rong Mao, Jun Feng Li. The role of glucosylceramide and glucosylceramide synthase in liver disease: from bench to bedside - Review. Acta biochimica Polonica. 2020 Dec; 68(1):33-39. doi: 10.18388/abp.2020_5478. [PMID: 33355876]
  • Tawfik Khoury, Yuval Ishay, Devorah Rotnemer-Golinkin, Lidya Zolotarovya, David Arkadir, Ari Zimran, Yaron Ilan. A synergistic effect of Ambroxol and Beta-Glucosylceramide in alleviating immune-mediated hepatitis: A novel immunomodulatory non-immunosuppressive formulation for treatment of immune-mediated disorders. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Dec; 132(?):110890. doi: 10.1016/j.biopha.2020.110890. [PMID: 33080465]
  • Motohide Murate, Nario Tomishige, Toshihide Kobayashi. Wrapping axons in mammals and Drosophila: Different lipids, same principle. Biochimie. 2020 Nov; 178(?):39-48. doi: 10.1016/j.biochi.2020.08.002. [PMID: 32800899]
  • J A Davis, R B Pares, M Palmgren, R L López-Marqués, J F Harper. A potential pathway for flippase-facilitated glucosylceramide catabolism in plants. Plant signaling & behavior. 2020 10; 15(10):1783486. doi: 10.1080/15592324.2020.1783486. [PMID: 32857675]
  • Katharina Klatt-Schreiner, Lucie Valek, Jun-Suk Kang, Alexander Khlebtovsky, Sandra Trautmann, Lisa Hahnefeld, Yannick Schreiber, Robert Gurke, Dominique Thomas, Annett Wilken-Schmitz, Sabine Wicker, Georg Auburger, Gerd Geisslinger, Jörn Lötsch, Waltraud Pfeilschifter, Ruth Djaldetti, Irmgard Tegeder. High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2020 10; 35(10):1822-1833. doi: 10.1002/mds.28186. [PMID: 32652698]
  • Nicoletta Loberto, Giulia Mancini, Rosaria Bassi, Emma Veronica Carsana, Anna Tamanini, Nicoletta Pedemonte, Maria Cristina Dechecchi, Sandro Sonnino, Massimo Aureli. Sphingolipids and plasma membrane hydrolases in human primary bronchial cells during differentiation and their altered patterns in cystic fibrosis. Glycoconjugate journal. 2020 10; 37(5):623-633. doi: 10.1007/s10719-020-09935-x. [PMID: 32666337]
  • Lin Ma, Bertram Y Fong, Alastair K H MacGibbon, Gillian Norris. Qualitative and Quantitative Study of Glycosphingolipids in Human Milk and Bovine Milk Using High Performance Liquid Chromatography-Data-Dependent Acquisition-Mass Spectrometry. Molecules (Basel, Switzerland). 2020 Sep; 25(17):. doi: 10.3390/molecules25174024. [PMID: 32899251]
  • Hiroshi Deguchi, Meenal Shukla, Mohammed Hayat, Ali Torkamani, Darlene J Elias, John H Griffin. Novel exomic rare variants associated with venous thrombosis. British journal of haematology. 2020 09; 190(5):783-786. doi: 10.1111/bjh.16613. [PMID: 32232851]
  • Shaun Martin, Stefanie Smolders, Chris Van den Haute, Bavo Heeman, Sarah van Veen, David Crosiers, Igor Beletchi, Aline Verstraeten, Helena Gossye, Géraldine Gelders, Philippe Pals, Norin Nabil Hamouda, Sebastiaan Engelborghs, Jean-Jacques Martin, Jan Eggermont, Peter Paul De Deyn, Patrick Cras, Veerle Baekelandt, Peter Vangheluwe, Christine Van Broeckhoven. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta neuropathologica. 2020 06; 139(6):1001-1024. doi: 10.1007/s00401-020-02145-7. [PMID: 32172343]
  • Virginia Sara Grancieri do Amaral, Stephanie Alexia Cristina Silva Santos, Paula Cavalcante de Andrade, Jenifer Nowatzki, Nilton Silva Júnior, Luciano Neves de Medeiros, Lycia Brito Gitirana, Pedro Geraldo Pascutti, Vitor H Almeida, Robson Q Monteiro, Eleonora Kurtenbach. Pisum sativum Defensin 1 Eradicates Mouse Metastatic Lung Nodules from B16F10 Melanoma Cells. International journal of molecular sciences. 2020 Apr; 21(8):. doi: 10.3390/ijms21082662. [PMID: 32290394]
  • Seigo Usuki, Yoshiaki Yasutake, Noriko Tamura, Tomohiro Tamura, Kunikazu Tanji, Takashi Saitoh, Yuta Murai, Daisuke Mikami, Kohei Yuyama, Kenji Monde, Katsuyuki Mukai, Yasuyuki Igarashi. Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain. Cells. 2020 02; 9(2):. doi: 10.3390/cells9020517. [PMID: 32102436]
  • Sally Chiu, Patty Siri-Tarino, Nathalie Bergeron, Jung H Suh, Ronald M Krauss. A Randomized Study of the Effect of Replacing Sugar-Sweetened Soda by Reduced Fat Milk on Cardiometabolic Health in Male Adolescent Soda Drinkers. Nutrients. 2020 Feb; 12(2):. doi: 10.3390/nu12020405. [PMID: 32033078]
  • Guang-Yi Dai, Jian Yin, Kai-En Li, Ding-Kang Chen, Zhe Liu, Fang-Cheng Bi, Chan Rong, Nan Yao. The Arabidopsis AtGCD3 protein is a glucosylceramidase that preferentially hydrolyzes long-acyl-chain glucosylceramides. The Journal of biological chemistry. 2020 01; 295(3):717-728. doi: 10.1074/jbc.ra119.011274. [PMID: 31819005]
  • Shinji Yamashita, Takuya Seino, Miho Inobe, Mirinthorn Jutanom, Satoshi Matsumoto, Mikio Kinoshita. Polar Lipid Fraction from Golden Oyster Mushrooms (Pleurotus citrinopileatus) Suppresses Colon Injuries from Inflammatory Stresses in vivo and in vitro. Journal of oleo science. 2020; 69(7):751-757. doi: 10.5650/jos.ess20050. [PMID: 32612025]
  • Hyun-Jun Jang, Seyoung Lim, Jung-Min Kim, Sora Yoon, Chae Young Lee, Hyeon-Jeong Hwang, Jeong Woo Shin, Kyeong Jin Shin, Hye Yun Kim, Kwang Il Park, Dougu Nam, Ja Yil Lee, Kyungmoo Yea, Yoshio Hirabayashi, Yu Jin Lee, Young Chan Chae, Pann-Ghill Suh, Jang Hyun Choi. Glucosylceramide synthase regulates adipo-osteogenic differentiation through synergistic activation of PPARγ with GlcCer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 01; 34(1):1270-1287. doi: 10.1096/fj.201901437r. [PMID: 31914593]
  • Mariana C Bernardino, Michel Leon C O Couto, Maite F S Vaslin, Eliana Barreto-Bergter. Antiviral activity of glucosylceramides isolated from Fusarium oxysporum against Tobacco mosaic virus infection. PloS one. 2020; 15(11):e0242887. doi: 10.1371/journal.pone.0242887. [PMID: 33237955]
  • Shinji Yamashita, Mariko Hata, Nobuhiro Kikuchi, Mikio Kinoshita, Teruo Miyazawa. Effects of Dietary Ethanol Extracts from Sake Rice and Sake Lees on Intestinal Impairment in Mice. Journal of oleo science. 2020; 69(8):929-939. doi: 10.5650/jos.ess20069. [PMID: 32759551]
  • Kohei Yuyama, Kaori Takahashi, Seigo Usuki, Daisuke Mikami, Hui Sun, Hisatoshi Hanamatsu, Junichi Furukawa, Katsuyuki Mukai, Yasuyuki Igarashi. Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-β pathologies in a mouse model of Alzheimer's disease. Scientific reports. 2019 11; 9(1):16827. doi: 10.1038/s41598-019-53394-w. [PMID: 31727994]
  • Mamoru Murakami, Yasuhiro Nishi, Kea Harada, Tomohiro Masuzaki, Yoko Minemoto, Takahiro Yanagisawa, Takaharu Shimizu, Akito Tsuboi, Taizo Hamada, Masahiro Nishimura. Impact of Oral Intake of Glucosylceramide Extracted from Pineapple on Xerostomia: A Double-Blind Randomized Cross-Over Trial. Nutrients. 2019 Aug; 11(9):. doi: 10.3390/nu11092020. [PMID: 31466334]
  • Xiao-Hong Liu, Shuang Liang, Yun-Yun Wei, Xue-Ming Zhu, Lin Li, Ping-Ping Liu, Qing-Xia Zheng, Hui-Na Zhou, Yong Zhang, Li-Juan Mao, Caroline Mota Fernandes, Maurizio Del Poeta, Naweed I Naqvi, Fu-Cheng Lin. Metabolomics Analysis Identifies Sphingolipids as Key Signaling Moieties in Appressorium Morphogenesis and Function in Magnaporthe oryzae. mBio. 2019 08; 10(4):. doi: 10.1128/mbio.01467-19. [PMID: 31431550]
  • Maryam Rakhshandehroo, Robert J van Eijkeren, Tanit L Gabriel, Colin de Haar, Sanne M W Gijzel, Nicole Hamers, Maria J Ferraz, Johannes M F G Aerts, Henk S Schipper, Marco van Eijk, Marianne Boes, Eric Kalkhoven. Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2019 08; 1864(8):1157-1167. doi: 10.1016/j.bbalip.2019.04.016. [PMID: 31051284]
  • Simon Wheeler, Per Haberkant, Meenakshi Bhardwaj, Paige Tongue, Maria J Ferraz, David Halter, Hein Sprong, Ralf Schmid, Johannes M F G Aerts, Nikol Sullo, Dan J Sillence. Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease. Neurobiology of disease. 2019 07; 127(?):242-252. doi: 10.1016/j.nbd.2019.03.005. [PMID: 30872158]
  • Xihua Yue, Yi Qian, Bopil Gim, Intaek Lee. Acyl-CoA-Binding Domain-Containing 3 (ACBD3; PAP7; GCP60): A Multi-Functional Membrane Domain Organizer. International journal of molecular sciences. 2019 Apr; 20(8):. doi: 10.3390/ijms20082028. [PMID: 31022988]
  • Virginia Sara Grancieri Amaral, Caroline Mota Fernandes, Mário R Felício, Aline Sol Valle, Paula G Quintana, Caroline Correa Almeida, Eliana Barreto-Bergter, Sónia Gonçalves, Nuno C Santos, Eleonora Kurtenbach. Psd2 pea defensin shows a preference for mimetic membrane rafts enriched with glucosylceramide and ergosterol. Biochimica et biophysica acta. Biomembranes. 2019 04; 1861(4):713-728. doi: 10.1016/j.bbamem.2018.12.020. [PMID: 30639288]
  • Letícia S Martins, Daniela A Nomura, Evandro L Duarte, Karin A Riske, M Teresa Lamy, Julio H K Rozenfeld. Structural characterization of cationic DODAB bilayers containing C24:1 β-glucosylceramide. Biochimica et biophysica acta. Biomembranes. 2019 03; 1861(3):643-650. doi: 10.1016/j.bbamem.2018.12.018. [PMID: 30611744]
  • Bartholomew P Roland, Tomoki Naito, Jordan T Best, Cayetana Arnaiz-Yépez, Hiroyuki Takatsu, Roger J Yu, Hye-Won Shin, Todd R Graham. Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs. The Journal of biological chemistry. 2019 02; 294(6):1794-1806. doi: 10.1074/jbc.ra118.005876. [PMID: 30530492]
  • Shinji Yamashita, Nobuhiro Kikuchi, Mikio Kinoshita, Teruo Miyazawa. Chemical Properties and Nutritional Value of Plant-Origin Glucosylceramide. Journal of nutritional science and vitaminology. 2019; 65(Supplement):S153-S157. doi: 10.3177/jnsv.65.s153. [PMID: 31619618]
  • Shinji Yamashita, Masahiro Yamamoto, Kenta Hirakawa, Nobuhiro Kikuchi, Mikio Kinoshita, Teruo Miyazawa. Extraction of Lipophilic Fraction from Polished Rice Improves Its Ameliorative Effect on Intestinal Impairment. Journal of oleo science. 2019; 68(5):463-470. doi: 10.5650/jos.ess19013. [PMID: 31061265]
  • Misho Kawata, Masato Suzuki, Shoko Akutsu, Natsuki Kawahara, Ami Tsukamoto, Shohei Nobukawa, Ryohei Isozaki, Seika Yuyama, Narito Asanuma. Augmentation of dietary glucosylceramide hydrolysis by the novel bacterium Glucerabacter canisensis NATH-2371T. Bioscience, biotechnology, and biochemistry. 2018 Dec; 82(12):2191-2197. doi: 10.1080/09168451.2018.1505484. [PMID: 30146946]
  • Michael D Rugen, Mathieu M J L Vernet, Laila Hantouti, Amalia Soenens, Vasilios M E Andriotis, Martin Rejzek, Paul Brett, Richard J B H N van den Berg, Johannes M F G Aerts, Hermen S Overkleeft, Robert A Field. A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals. Scientific reports. 2018 11; 8(1):16421. doi: 10.1038/s41598-018-34749-1. [PMID: 30401902]
  • Mark M Mitsnefes, Jessica Fitzpatrick, Stephen M Sozio, Bernard G Jaar, Michelle M Estrella, Jose M Monroy-Trujillo, Wujuan Zhang, Kenneth Setchell, Rulan S Parekh. Plasma glucosylceramides and cardiovascular risk in incident hemodialysis patients. Journal of clinical lipidology. 2018 Nov; 12(6):1513-1522.e4. doi: 10.1016/j.jacl.2018.07.011. [PMID: 30143433]
  • Anna Malekkou, Maura Samarani, Anthi Drousiotou, Christina Votsi, Sandro Sonnino, Marios Pantzaris, Elena Chiricozzi, Eleni Zamba-Papanicolaou, Massimo Aureli, Nicoletta Loberto, Kyproula Christodoulou. Biochemical Characterization of the GBA2 c.1780G>C Missense Mutation in Lymphoblastoid Cells from Patients with Spastic Ataxia. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103099. [PMID: 30308956]
  • Jayesh Sheth, Dhairya Pancholi, Mehul Mistri, Payal Nath, Chitra Ankleshwaria, Riddhi Bhavsar, Ratna Puri, Shubha Phadke, Frenny Sheth. Biochemical and molecular characterization of adult patients with type I Gaucher disease and carrier frequency analysis of Leu444Pro - a common Gaucher disease mutation in India. BMC medical genetics. 2018 10; 19(1):178. doi: 10.1186/s12881-018-0687-5. [PMID: 30285649]
  • Edouard Mobarak, Liliana Håversen, Moutusi Manna, Mikael Rutberg, Malin Levin, Rosie Perkins, Tomasz Rog, Ilpo Vattulainen, Jan Borén. Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico. Scientific reports. 2018 09; 8(1):13600. doi: 10.1038/s41598-018-31926-0. [PMID: 30206272]
  • Penelope J Hallett, Mylene Huebecker, Oeystein R Brekk, Elizabeth B Moloney, Emily M Rocha, David A Priestman, Frances M Platt, Ole Isacson. Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain. Neurobiology of aging. 2018 07; 67(?):189-200. doi: 10.1016/j.neurobiolaging.2018.02.028. [PMID: 29735433]
  • Manoj K Pandey, Gregory A Grabowski, Jörg Köhl. An unexpected player in Gaucher disease: The multiple roles of complement in disease development. Seminars in immunology. 2018 06; 37(?):30-42. doi: 10.1016/j.smim.2018.02.006. [PMID: 29478824]
  • Yohei Ishibashi, Makoto Ito, Yoshio Hirabayashi. Regulation of glucosylceramide synthesis by Golgi-localized phosphoinositide. Biochemical and biophysical research communications. 2018 05; 499(4):1011-1018. doi: 10.1016/j.bbrc.2018.04.039. [PMID: 29627573]
  • Misho Kawata, Ami Tsukamoto, Ryohei Isozaki, Shohei Nobukawa, Natsuki Kawahara, Shoko Akutsu, Masato Suzuki, Narito Asanuma. Glucerabacter canisensis gen. nov., sp. nov., isolated from dog feces and its effect on the hydrolysis of plant glucosylceramide in the intestine of dogs. Archives of microbiology. 2018 Apr; 200(3):505-515. doi: 10.1007/s00203-017-1463-1. [PMID: 29204666]
  • Pierre Le Pogam, Mickael Doué, Yann Le Page, Denis Habauzit, Maxim Zhadobov, Ronan Sauleau, Yves Le Dréan, David Rondeau. Untargeted Metabolomics Reveal Lipid Alterations upon 2-Deoxyglucose Treatment in Human HaCaT Keratinocytes. Journal of proteome research. 2018 03; 17(3):1146-1157. doi: 10.1021/acs.jproteome.7b00805. [PMID: 29430917]
  • James A Shayman. Targeting Glucosylceramide Synthesis in the Treatment of Rare and Common Renal Disease. Seminars in nephrology. 2018 03; 38(2):183-192. doi: 10.1016/j.semnephrol.2018.01.007. [PMID: 29602400]
  • Mathias Reisberg, Norbert Arnold, Andrea Porzel, Reinhard H H Neubert, Birgit Dräger. Malusides, novel glucosylceramides isolated from apple pomace (Malus domestica). Zeitschrift fur Naturforschung. C, Journal of biosciences. 2018 Jan; 73(1-2):33-39. doi: 10.1515/znc-2017-0059. [PMID: 28937966]
  • Seigo Usuki, Noriko Tamura, Kohei Yuyama, Tomohiro Tamura, Katsuyuki Mukai, Yasuyuki Igarashi. Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway. Journal of oleo science. 2018 Jan; 67(1):77-86. doi: 10.5650/jos.ess17141. [PMID: 29238028]
  • Anders P E Backman, Josefin Halin, Henrik Nurmi, Anna Möuts, Matti A Kjellberg, Peter Mattjus. Glucosylceramide acyl chain length is sensed by the glycolipid transfer protein. PloS one. 2018; 13(12):e0209230. doi: 10.1371/journal.pone.0209230. [PMID: 30550553]
  • Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Katsuyuki Mukai, Yasuyuki Igarashi. Characterization of Konjac Ceramide (kCer) Binding to Sema3A Receptor Nrp1. Journal of oleo science. 2018 Jan; 67(1):87-94. doi: 10.5650/jos.ess17142. [PMID: 29238029]
  • Philip Wertz. Epidermal Lamellar Granules. Skin pharmacology and physiology. 2018; 31(5):262-268. doi: 10.1159/000491757. [PMID: 30110701]