PIP 37:4 (BioDeep_00000633285)
代谢物信息卡片
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1-myo-inositol-5-phosphate)
化学式: C46H82O16P2 (952.5078)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)OP(=O)(O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
InChI: InChI=1S/C46H82O16P2/c1-3-5-7-9-11-13-15-17-19-20-21-23-25-27-29-31-33-35-40(48)60-38(36-58-39(47)34-32-30-28-26-24-22-18-16-14-12-10-8-6-4-2)37-59-64(56,57)62-46-43(51)41(49)42(50)45(44(46)52)61-63(53,54)55/h11,13,17,19,21,23,27,29,38,41-46,49-52H,3-10,12,14-16,18,20,22,24-26,28,30-37H2,1-2H3,(H,56,57)(H2,53,54,55)/b13-11-,19-17-,23-21-,29-27-/t38-,41+,42+,43-,44-,45-,46+/m1/s1
描述信息
同义名列表
15 个代谢物同义名
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1-myo-inositol-5-phosphate); PIP[5](17:0/20:4(5Z,8Z,11Z,14Z)); Phosphatidylinositol-5-phosphate; PIP[5](17:0/20:4); PIP(17:0_20:4); PIP(37:4); PIP 37:4; 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1-myo-inositol-4-phosphate); Phosphatidylinositol-4-phosphate; PIP[4](17:0/20:4(5Z,8Z,11Z,14Z)); PIP[4](17:0/20:4); 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1-myo-inositol-3-phosphate); PIP[3](17:0/20:4(5Z,8Z,11Z,14Z)); Phosphatidylinositol-3-phosphate; PIP[3](17:0/20:4)
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:187480
- ChEBI: CHEBI:187168
- ChEBI: CHEBI:187127
- PubChem: 9776843
- PubChem: 9547150
- PubChem: 9776841
- LipidMAPS: LMGP07010004
- LipidMAPS: LMGP07010003
- LipidMAPS: LMGP07010002
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jason C Casler, Clare S Harper, Antoineen J White, Heidi L Anderson, Laura L Lackner. Mitochondria-ER-PM contacts regulate mitochondrial division and PI(4)P distribution.
The Journal of cell biology.
2024 Sep; 223(9):. doi:
10.1083/jcb.202308144. [PMID: 38781029] - Styliani Panagiotou, Kia Wee Tan, Phuoc My Nguyen, Andreas Müller, Affiong Ika Oqua, Alejandra Tomas, Anna Wendt, Lena Eliasson, Anders Tengholm, Michele Solimena, Olof Idevall-Hagren. OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion.
Cell reports.
2024 Apr; 43(4):113992. doi:
10.1016/j.celrep.2024.113992. [PMID: 38536815] - Moe Muramoto, Nanaru Mineoka, Kayoko Fukuda, Sayuri Kuriyama, Tatsunori Masatani, Akikazu Fujita. Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy.
Biochimica et biophysica acta. Biomembranes.
2024 Apr; 1866(4):184308. doi:
10.1016/j.bbamem.2024.184308. [PMID: 38437942] - Lianggong Ding, Florian Huwyler, Fen Long, Wu Yang, Jonas Binz, Kendra Wernlé, Matthias Pfister, Manuel Klug, Miroslav Balaz, Barbara Ukropcova, Jozef Ukropec, Chunyan Wu, Tongtong Wang, Min Gao, Pierre-Alain Clavien, Philipp Dutkowski, Mark W Tibbitt, Christian Wolfrum. Glucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL.
Nature cell biology.
2024 Apr; 26(4):552-566. doi:
10.1038/s41556-024-01386-y. [PMID: 38561547] - Mariko Kato, Machiko Watari, Tomohiko Tsuge, Sheng Zhong, Hongya Gu, Li-Jia Qu, Takashi Fujiwara, Takashi Aoyama. Redundant function of the Arabidopsis phosphatidylinositol 4-phosphate 5-kinase genes PIP5K4-6 is essential for pollen germination.
The Plant journal : for cell and molecular biology.
2024 Jan; 117(1):212-225. doi:
10.1111/tpj.16490. [PMID: 37828913] - Andrea Eisenreichova, Jana Humpolickova, Bartosz Różycki, Evzen Boura, Alena Koukalova. Effects of biophysical membrane properties on recognition of phosphatidylserine, or phosphatidylinositol 4-phosphate by lipid biosensors LactC2, or P4M.
Biochimie.
2023 Dec; 215(?):42-49. doi:
10.1016/j.biochi.2023.09.003. [PMID: 37683994] - Aya Mizuike, Shota Sakai, Kaoru Katoh, Toshiyuki Yamaji, Kentaro Hanada. The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi.
The Journal of cell biology.
2023 07; 222(7):. doi:
10.1083/jcb.202111069. [PMID: 37195633] - Rodrigo Enrique Gomez, Julie Castets, Josselin Lupette, Clément Chambaud, Jérôme Joubès, Amélie Bernard. Phosphatidylinositol-4-phosphate joins the dance of plant autophagosome formation.
Autophagy.
2023 05; 19(5):1609-1610. doi:
10.1080/15548627.2022.2132042. [PMID: 36215405] - Ruyue He, Furong Liu, Hui Wang, Shuai Huang, Kai Xu, Conggang Zhang, Yinghui Liu, Haijia Yu. ORP9 and ORP10 form a heterocomplex to transfer phosphatidylinositol 4-phosphate at ER-TGN contact sites.
Cellular and molecular life sciences : CMLS.
2023 Feb; 80(3):77. doi:
10.1007/s00018-023-04728-5. [PMID: 36853333] - Jay Xiaojun Tan, Toren Finkel. A phosphoinositide signalling pathway mediates rapid lysosomal repair.
Nature.
2022 09; 609(7928):815-821. doi:
10.1038/s41586-022-05164-4. [PMID: 36071159] - Vedrana Marković, Yvon Jaillais. Phosphatidylinositol 4-phosphate: a key determinant of plasma membrane identity and function in plants.
The New phytologist.
2022 08; 235(3):867-874. doi:
10.1111/nph.18258. [PMID: 35586972] - Wenbin Zhong, Weize Lin, Yingjie Yang, Dan Chen, Xiuye Cao, Mengyang Xu, Guoping Pan, Huanzhao Chen, Jie Zheng, Xiaoqin Feng, Li Hua Yang, Chaofeng Lai, Vesa M Olkkonen, Jun Xu, Shuzhong Cui, Daoguang Yan. An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis.
Nature communications.
2022 07; 13(1):4390. doi:
10.1038/s41467-022-32104-7. [PMID: 35906240] - Rodrigo Enrique Gomez, Clément Chambaud, Josselin Lupette, Julie Castets, Stéphanie Pascal, Lysiane Brocard, Lise Noack, Yvon Jaillais, Jérôme Joubès, Amélie Bernard. Phosphatidylinositol-4-phosphate controls autophagosome formation in Arabidopsis thaliana.
Nature communications.
2022 07; 13(1):4385. doi:
10.1038/s41467-022-32109-2. [PMID: 35902598] - James B Konopka. Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans.
mBio.
2022 06; 13(3):e0036622. doi:
10.1128/mbio.00366-22. [PMID: 35467420] - Machiko Watari, Mariko Kato, Romain Blanc-Mathieu, Tomohiko Tsuge, Hiroyuki Ogata, Takashi Aoyama. Functional Differentiation among the Arabidopsis Phosphatidylinositol 4-Phosphate 5-Kinase Genes PIP5K1, PIP5K2 and PIP5K3.
Plant & cell physiology.
2022 May; 63(5):635-648. doi:
10.1093/pcp/pcac025. [PMID: 35348769] - Anastasiia Starodubtseva, Tetiana Kalachova, Katarzyna Retzer, Adriana Jelínková, Petre Dobrev, Jozef Lacek, Romana Pospíchalová, Jindřiška Angelini, Anne Guivarc'h, Stéphanie Pateyron, Ludivine Soubigou-Taconnat, Lenka Burketová, Eric Ruelland. An Arabidopsis mutant deficient in phosphatidylinositol-4-phosphate kinases ß1 and ß2 displays altered auxin-related responses in roots.
Scientific reports.
2022 04; 12(1):6947. doi:
10.1038/s41598-022-10458-8. [PMID: 35484296] - Toshihiko Sugiki, Young-Ho Lee, Nesreen Alsanousi, Kaito Murata, Izuru Kawamura, Toshimichi Fujiwara, Kentaro Hanada, Chojiro Kojima. A hybrid strategy combining solution NMR spectroscopy and isothermal titration calorimetry to characterize protein-nanodisc interaction.
Analytical biochemistry.
2022 02; 639(?):114521. doi:
10.1016/j.ab.2021.114521. [PMID: 34906540] - Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu. PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission.
The Journal of cell biology.
2022 01; 221(1):. doi:
10.1083/jcb.202103141. [PMID: 34817532] - Chen Braun, Xiaorong Xu Parks, Haani Qudsi, Coeli M B Lopes. Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression.
Communications biology.
2021 12; 4(1):1392. doi:
10.1038/s42003-021-02909-1. [PMID: 34907346] - Yongqing Yang, Xiuli Han, Liang Ma, Yujiao Wu, Xiao Liu, Haiqi Fu, Guoyong Liu, Xiaoguang Lei, Yan Guo. Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H+-ATPase and Na+/H+ antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
Molecular plant.
2021 12; 14(12):2000-2014. doi:
10.1016/j.molp.2021.07.020. [PMID: 34339895] - Kay Oliver Schink, Kia Wee Tan, Hélène Spangenberg, Domenica Martorana, Marte Sneeggen, Virginie Stévenin, Jost Enninga, Coen Campsteijn, Camilla Raiborg, Harald Stenmark. The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes.
Nature communications.
2021 11; 12(1):6577. doi:
10.1038/s41467-021-26775-x. [PMID: 34772942] - Xu Chen, Yuhong Zhang, Xiang Ren, Qi Su, Yan Liu, Xing Dang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Yaya Wang, Zhantao Bai, Edward T H Yeh, Hongmei Wu, Yitao Qi. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
The Journal of biological chemistry.
2021 10; 297(4):101183. doi:
10.1016/j.jbc.2021.101183. [PMID: 34509475] - Ying Yang, Daniel J Klionsky. An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation.
Autophagy.
2021 10; 17(10):2663-2664. doi:
10.1080/15548627.2021.1959240. [PMID: 34369843] - Hema Adhikari, Walaa E Kattan, Shivesh Kumar, Pei Zhou, John F Hancock, Christopher M Counter. Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Nature communications.
2021 09; 12(1):5248. doi:
10.1038/s41467-021-25523-5. [PMID: 34504076] - Maxime Boutry, Peter K Kim. ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division.
Nature communications.
2021 09; 12(1):5354. doi:
10.1038/s41467-021-25621-4. [PMID: 34504082] - Andrew King On Wong, Barry Paul Young, Christopher J R Loewen. Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.
The Journal of cell biology.
2021 09; 220(9):. doi:
10.1083/jcb.201910161. [PMID: 34259806] - Noemi Ruiz-Lopez, Jessica Pérez-Sancho, Alicia Esteban Del Valle, Richard P Haslam, Steffen Vanneste, Rafael Catalá, Carlos Perea-Resa, Daniël Van Damme, Selene García-Hernández, Armando Albert, José Vallarino, Jinxing Lin, Jiří Friml, Alberto P Macho, Julio Salinas, Abel Rosado, Johnathan A Napier, Vitor Amorim-Silva, Miguel A Botella. Synaptotagmins at the endoplasmic reticulum-plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress.
The Plant cell.
2021 08; 33(7):2431-2453. doi:
10.1093/plcell/koab122. [PMID: 33944955] - Hongjun Zhang, Jiao Zhou, Peng Xiao, Yong Lin, Xin Gong, Shiyan Liu, Qingjia Xu, Minjin Wang, Haiyan Ren, Mengji Lu, Yuan Wang, Jing Zhu, Zhiping Xie, Huihui Li, Kefeng Lu. PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes.
Autophagy.
2021 08; 17(8):1907-1917. doi:
10.1080/15548627.2020.1796321. [PMID: 32693712] - Kai Liu, Lingjia Kong, Daniel B Graham, Kimberly L Carey, Ramnik J Xavier. SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance.
Cell reports.
2021 07; 36(4):109434. doi:
10.1016/j.celrep.2021.109434. [PMID: 34320354] - Lizhen Song, Yanning Wang, Zhiai Guo, Sin M Lam, Guanghou Shui, Youfa Cheng. NCP2/RHD4/SAC7, SAC6 and SAC8 phosphoinositide phosphatases are required for PtdIns4P and PtdIns(4,5)P2 homeostasis and Arabidopsis development.
The New phytologist.
2021 07; 231(2):713-725. doi:
10.1111/nph.17402. [PMID: 33876422] - Alex G Batrouni, Jeremy M Baskin. The chemistry and biology of phosphatidylinositol 4-phosphate at the plasma membrane.
Bioorganic & medicinal chemistry.
2021 06; 40(?):116190. doi:
10.1016/j.bmc.2021.116190. [PMID: 33965837] - Mouhannad Malek, Anna M Wawrzyniak, Peter Koch, Christian Lüchtenborg, Manuel Hessenberger, Timo Sachsenheimer, Wonyul Jang, Britta Brügger, Volker Haucke. Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites.
Nature communications.
2021 05; 12(1):2673. doi:
10.1038/s41467-021-22882-x. [PMID: 33976123] - Ryo Kuroda, Mariko Kato, Tomohiko Tsuge, Takashi Aoyama. Arabidopsis phosphatidylinositol 4-phosphate 5-kinase genes PIP5K7, PIP5K8, and PIP5K9 are redundantly involved in root growth adaptation to osmotic stress.
The Plant journal : for cell and molecular biology.
2021 05; 106(4):913-927. doi:
10.1111/tpj.15207. [PMID: 33606325] - Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X Edward Zhou, Xi Cheng, Icaro A Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H Eric Xu. Structural insights into the lipid and ligand regulation of serotonin receptors.
Nature.
2021 04; 592(7854):469-473. doi:
10.1038/s41586-021-03376-8. [PMID: 33762731] - Souade Ikhlef, Nicolas-Frédéric Lipp, Maud Magdeleine, Guillaume Drin. Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes.
Journal of visualized experiments : JoVE.
2021 03; ?(169):. doi:
10.3791/62177. [PMID: 33779604] - Jongyun Myeong, Cheon-Gyu Park, Byung-Chang Suh, Bertil Hille. Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains.
Proceedings of the National Academy of Sciences of the United States of America.
2021 03; 118(9):. doi:
10.1073/pnas.2025343118. [PMID: 33619111] - A Sun, O Simsek Papur, E Dirkx, L Wong, T Sips, S Wang, A Strzelecka, M Nabben, J F C Glatz, D Neumann, J J F P Luiken. Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes.
Cellular and molecular life sciences : CMLS.
2021 Mar; 78(6):2839-2856. doi:
10.1007/s00018-020-03669-7. [PMID: 33090289] - Zhike Feng, Jun-Ichi Inaba, Peter D Nagy. The retromer is co-opted to deliver lipid enzymes for the biogenesis of lipid-enriched tombusviral replication organelles.
Proceedings of the National Academy of Sciences of the United States of America.
2021 01; 118(1):. doi:
10.1073/pnas.2016066118. [PMID: 33376201] - Yuichi Wakana, Kaito Hayashi, Takumi Nemoto, Chiaki Watanabe, Masato Taoka, Jessica Angulo-Capel, Maria F Garcia-Parajo, Hidetoshi Kumata, Tomonari Umemura, Hiroki Inoue, Kohei Arasaki, Felix Campelo, Mitsuo Tagaya. The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.
The Journal of cell biology.
2021 01; 220(1):. doi:
10.1083/jcb.202002150. [PMID: 33156328] - Rebecca Cabral-Dias, Yasmin Awadeh, Roberto J Botelho, Costin N Antonescu. Detection of Plasma Membrane Phosphoinositide Dynamics Using Genetically Encoded Fluorescent Protein Probes.
Methods in molecular biology (Clifton, N.J.).
2021; 2251(?):73-89. doi:
10.1007/978-1-0716-1142-5_5. [PMID: 33481232] - Etienne Pays. The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection.
The FEBS journal.
2021 01; 288(2):360-381. doi:
10.1111/febs.15444. [PMID: 32530132] - Cathal Wilson, Rossella Venditti, Maria Antonietta De Matteis. Deregulation of phosphatidylinositol-4-phosphate in the development of amyotrophic lateral sclerosis 8.
Advances in biological regulation.
2021 01; 79(?):100779. doi:
10.1016/j.jbior.2020.100779. [PMID: 33461946] - Junsen Tong, Lingchen Tan, Young Jun Im. Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
PloS one.
2021; 16(4):e0248781. doi:
10.1371/journal.pone.0248781. [PMID: 33857182] - Chloe E Snider, Alaina H Willet, HannahSofia T Brown, Jun-Song Chen, Joshua M Evers, Kathleen L Gould. Fission yeast Opy1 is an endogenous PI(4,5)P2 sensor that binds to the phosphatidylinositol 4-phosphate 5-kinase Its3.
Journal of cell science.
2020 12; 133(23):. doi:
10.1242/jcs.247973. [PMID: 33172987] - Jian Li, David G Lambright, Victor W Hsu. Coordination of Grp1 recruitment mechanisms by its phosphorylation.
Molecular biology of the cell.
2020 12; 31(25):2816-2825. doi:
10.1091/mbc.e20-03-0173. [PMID: 33026967] - Lorena Benedetti, Jonathan S Marvin, Hanieh Falahati, Andres Guillén-Samander, Loren L Looger, Pietro De Camilli. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells.
eLife.
2020 11; 9(?):. doi:
10.7554/elife.63230. [PMID: 33174843] - Hossam Gewaid, Haruyo Aoyagi, Minetaro Arita, Koichi Watashi, Ryosuke Suzuki, Shota Sakai, Keigo Kumagai, Toshiyuki Yamaji, Masayoshi Fukasawa, Fumihiro Kato, Takayuki Hishiki, Ayako Mimata, Yuriko Sakamaki, Shizuko Ichinose, Kentaro Hanada, Masamichi Muramatsu, Takaji Wakita, Hideki Aizaki. Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in Hepatitis C Virus RNA Replication Factories.
Journal of virology.
2020 11; 94(23):. doi:
10.1128/jvi.01080-20. [PMID: 32938759] - Etienne Pays. The Mechanism of Kidney Disease Due to APOL1 Risk Variants.
Journal of the American Society of Nephrology : JASN.
2020 11; 31(11):2502-2505. doi:
10.1681/asn.2020070954. [PMID: 32943491] - Xue Dong, Zhiming Wang, Sheng Ye, Rongguang Zhang. The crystal structure of ORP3 reveals the conservative PI4P binding pattern.
Biochemical and biophysical research communications.
2020 09; 529(4):1005-1010. doi:
10.1016/j.bbrc.2020.06.090. [PMID: 32819557] - Patricia Bilodeau, Daniel Jacobsen, Denise Law-Vinh, Jonathan M Lee. Phosphatidylinositol 4-kinase III beta regulates cell shape, migration, and focal adhesion number.
Molecular biology of the cell.
2020 08; 31(17):1904-1916. doi:
10.1091/mbc.e19-11-0600. [PMID: 32583740] - Wei Dong, Juan Lu, Xuejing Zhang, Yan Wu, Kaela Lettieri, Gerald R Hammond, Yang Hong. A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.
The Journal of cell biology.
2020 07; 219(7):. doi:
10.1083/jcb.201903031. [PMID: 32580209] - Zsuzsanna Sasvari, Wenwu Lin, Jun-Ichi Inaba, Kai Xu, Nikolay Kovalev, Peter D Nagy. Co-opted Cellular Sac1 Lipid Phosphatase and PI(4)P Phosphoinositide Are Key Host Factors during the Biogenesis of the Tombusvirus Replication Compartment.
Journal of virology.
2020 06; 94(12):. doi:
10.1128/jvi.01979-19. [PMID: 32269127] - Nigel W Griffiths, Lauren M Del Bel, Ronit Wilk, Julie A Brill. Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1.
Molecular biology of the cell.
2020 05; 31(11):1183-1199. doi:
10.1091/mbc.e20-02-0161. [PMID: 32186963] - Veronika Fáberová, Ilona Kalasová, Alžběta Krausová, Pavel Hozák. Super-Resolution Localisation of Nuclear PI(4)P and Identification of Its Interacting Proteome.
Cells.
2020 05; 9(5):. doi:
10.3390/cells9051191. [PMID: 32403279] - Sophie Uzureau, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H Graversen, Fabrice Homblé, Pepe Ekulu Mfutu, Fanny Oliveira Arcolino, Ana Raquel Ramos, Rita M La Rovere, Tomas Luyten, Marjorie Vermeersch, Patricia Tebabi, Marc Dieu, Bart Cuypers, Stijn Deborggraeve, Marion Rabant, Christophe Legendre, Søren K Moestrup, Elena Levtchenko, Geert Bultynck, Christophe Erneux, David Pérez-Morga, Etienne Pays. APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
Cell reports.
2020 03; 30(11):3821-3836.e13. doi:
10.1016/j.celrep.2020.02.064. [PMID: 32187552] - Gergő Gulyás, Mira Sohn, Yeun Ju Kim, Péter Várnai, Tamas Balla. ORP3 phosphorylation regulates phosphatidylinositol 4-phosphate and Ca2+ dynamics at plasma membrane-ER contact sites.
Journal of cell science.
2020 03; 133(6):. doi:
10.1242/jcs.237388. [PMID: 32041906] - Deike J Omnus, Angela Cadou, Ffion B Thomas, Jakob M Bader, Nathaniel Soh, Gary H C Chung, Andrew N Vaughan, Christopher J Stefan. A heat-sensitive Osh protein controls PI4P polarity.
BMC biology.
2020 03; 18(1):28. doi:
10.1186/s12915-020-0758-x. [PMID: 32169085] - James P Zewe, April M Miller, Sahana Sangappa, Rachel C Wills, Brady D Goulden, Gerald R V Hammond. Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane.
The Journal of cell biology.
2020 03; 219(3):. doi:
10.1083/jcb.201906127. [PMID: 32211893] - Tao Guo, Hua-Chang Chen, Zi-Qi Lu, Min Diao, Ke Chen, Nai-Qian Dong, Jun-Xiang Shan, Wang-Wei Ye, Shanjin Huang, Hong-Xuan Lin. A SAC Phosphoinositide Phosphatase Controls Rice Development via Hydrolyzing PI4P and PI(4,5)P2.
Plant physiology.
2020 03; 182(3):1346-1358. doi:
10.1104/pp.19.01131. [PMID: 31882455] - John J H Shin, Peter Liu, Leslie J Chan, Azmat Ullah, Jingxi Pan, Christoph H Borchers, John E Burke, Christopher Stefan, Gertien J Smits, Christopher J R Loewen. pH Biosensing by PI4P Regulates Cargo Sorting at the TGN.
Developmental cell.
2020 02; 52(4):461-476.e4. doi:
10.1016/j.devcel.2019.12.010. [PMID: 31928972] - Chunguang Ren, Qianying Yuan, Xiaoying Jian, Paul A Randazzo, Wenwen Tang, Dianqing Wu. Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization.
Journal of immunology (Baltimore, Md. : 1950).
2020 02; 204(4):1012-1021. doi:
10.4049/jimmunol.1901080. [PMID: 31924649] - Joëlle Bigay, Bruno Mesmin, Bruno Antonny. [A lipid exchange market : vectorial cholesterol transport by the protein OSBP].
Medecine sciences : M/S.
2020 Feb; 36(2):130-136. doi:
10.1051/medsci/2020009. [PMID: 32129748] - Sabrina Chumpen Ramirez, Micaela R Astrada, Jose L Daniotti. PtdIns4P-mediated electrostatic forces influence S-acylation of peripheral proteins at the Golgi complex.
Bioscience reports.
2020 01; 40(1):. doi:
10.1042/bsr20192911. [PMID: 31854448] - Lizbeth de la Cruz, Alexis Traynor-Kaplan, Oscar Vivas, Bertil Hille, Jill B Jensen. Plasma membrane processes are differentially regulated by type I phosphatidylinositol phosphate 5-kinases and RASSF4.
Journal of cell science.
2020 01; 133(2):. doi:
10.1242/jcs.233254. [PMID: 31831523] - Ximing Du, Linkang Zhou, Yvette Celine Aw, Hoi Yin Mak, Yanqing Xu, James Rae, Wenmin Wang, Armella Zadoorian, Sarah E Hancock, Brenna Osborne, Xiang Chen, Jia-Wei Wu, Nigel Turner, Robert G Parton, Peng Li, Hongyuan Yang. ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets.
The Journal of cell biology.
2020 01; 219(1):. doi:
10.1083/jcb.201905162. [PMID: 31653673] - Mehdi Doumane, Marie-Cécile Caillaud. Assessing Extrinsic Membrane Protein Dependency to PI4P Using a Plasma Membrane to Endosome Relocalization Transient Assay in Nicotiana benthamiana.
Methods in molecular biology (Clifton, N.J.).
2020; 2177(?):95-108. doi:
10.1007/978-1-0716-0767-1_9. [PMID: 32632808] - Sonia Rodríguez-Fdez, Carmen Citterio, L Francisco Lorenzo-Martín, Jesús Baltanás-Copado, Clara Llorente-González, Senena Corbalán-García, Miguel Vicente-Manzanares, Xosé R Bustelo. Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output.
Cells.
2019 12; 8(12):. doi:
10.3390/cells8121649. [PMID: 31888228] - Hongliang Wang, Andrew W Tai. Nir2 Is an Effector of VAPs Necessary for Efficient Hepatitis C Virus Replication and Phosphatidylinositol 4-Phosphate Enrichment at the Viral Replication Organelle.
Journal of virology.
2019 11; 93(22):. doi:
10.1128/jvi.00742-19. [PMID: 31484747] - Avishek Ghosh, Sanjeev Sharma, Dhananjay Shinde, Visvanathan Ramya, Padinjat Raghu. A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues.
Bioscience reports.
2019 10; 39(10):. doi:
10.1042/bsr20192502. [PMID: 31652444] - Lin Bai, Amanda Kovach, Qinglong You, Hao-Chi Hsu, Gongpu Zhao, Huilin Li. Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p.
Nature communications.
2019 09; 10(1):4142. doi:
10.1038/s41467-019-12191-9. [PMID: 31515475] - Nicolas-Frédéric Lipp, Romain Gautier, Maud Magdeleine, Maxime Renard, Véronique Albanèse, Alenka Čopič, Guillaume Drin. An electrostatic switching mechanism to control the lipid transfer activity of Osh6p.
Nature communications.
2019 09; 10(1):3926. doi:
10.1038/s41467-019-11780-y. [PMID: 31477717] - Yuna Kurokawa, Rikako Konishi, Akane Yoshida, Kanna Tomioku, Taiki Futagami, Hisanori Tamaki, Kenji Tanabe, Akikazu Fujita. Essential and distinct roles of phosphatidylinositol 4-kinases, Pik1p and Stt4p, in yeast autophagy.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 09; 1864(9):1214-1225. doi:
10.1016/j.bbalip.2019.05.004. [PMID: 31125705] - Carlos Rubilar-Hernández, Claudio Osorio-Navarro, Francisca Cabello, Lorena Norambuena. PI4KIIIβ Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole.
Plant physiology.
2019 09; 181(1):112-126. doi:
10.1104/pp.19.00695. [PMID: 31285293] - Mark G Waugh. The Great Escape: how phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer).
The Biochemical journal.
2019 08; 476(16):2321-2346. doi:
10.1042/bcj20180622. [PMID: 31462439] - Taylor E Miller, Karen M Henkels, Mary Huddleston, Richard Salisbury, Saber M Hussain, Atsuo T Sasaki, Kwang-Jin Cho. Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria.
Journal of cell science.
2019 08; 132(16):. doi:
10.1242/jcs.231886. [PMID: 31331963] - Scott D Hansen, William Y C Huang, Young Kwang Lee, Peter Bieling, Sune M Christensen, Jay T Groves. Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction.
Proceedings of the National Academy of Sciences of the United States of America.
2019 07; 116(30):15013-15022. doi:
10.1073/pnas.1901744116. [PMID: 31278151] - Divyanshu Mahajan, Hieng Chiong Tie, Bing Chen, Lei Lu. Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking.
Nature communications.
2019 07; 10(1):3218. doi:
10.1038/s41467-019-11056-5. [PMID: 31324769] - Milena Timcenko, Joseph A Lyons, Dovile Januliene, Jakob J Ulstrup, Thibaud Dieudonné, Cédric Montigny, Miriam-Rose Ash, Jesper Lykkegaard Karlsen, Thomas Boesen, Werner Kühlbrandt, Guillaume Lenoir, Arne Moeller, Poul Nissen. Structure and autoregulation of a P4-ATPase lipid flippase.
Nature.
2019 07; 571(7765):366-370. doi:
10.1038/s41586-019-1344-7. [PMID: 31243363] - Alessandro Poli, Antonio Enrico Zaurito, Shidqiyyah Abdul-Hamid, Roberta Fiume, Irene Faenza, Nullin Divecha. Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage.
International journal of molecular sciences.
2019 Apr; 20(9):. doi:
10.3390/ijms20092080. [PMID: 31035587] - Chunguang Ren, Qianying Yuan, Martha Braun, Xia Zhang, Björn Petri, Jiasheng Zhang, Dongjoo Kim, Julia Guez-Haddad, Wenzhi Xue, Weijun Pan, Rong Fan, Paul Kubes, Zhaoxia Sun, Yarden Opatowsky, Franck Polleux, Erdem Karatekin, Wenwen Tang, Dianqing Wu. Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment.
Developmental cell.
2019 04; 49(2):206-219.e7. doi:
10.1016/j.devcel.2019.02.023. [PMID: 30930167] - Danny Mollerup Sørensen, Henrik Waldal Holen, Jesper Torbøl Pedersen, Helle Juel Martens, Daniele Silvestro, Lyubomir Dimitrov Stanchev, Sara Rute Costa, Thomas Günther Pomorski, Rosa Laura López-Marqués, Michael Palmgren. The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis.
Molecular biology of the cell.
2019 04; 30(9):1069-1084. doi:
10.1091/mbc.e18-06-0365. [PMID: 30785834] - Suthankamon Khrongyut, Atsara Rawangwong, Atthapon Pidsaya, Hiroyuki Sakagami, Hisatake Kondo, Wiphawi Hipkaeo. Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) α, β, γ in the three major salivary glands in situ of mice and their response to β-adrenoceptor stimulation.
Journal of anatomy.
2019 04; 234(4):502-514. doi:
10.1111/joa.12944. [PMID: 30734271] - Sergio Botero, Rachel Chiaroni-Clarke, Sanford M Simon. Escherichia coli as a platform for the study of phosphoinositide biology.
Science advances.
2019 03; 5(3):eaat4872. doi:
10.1126/sciadv.aat4872. [PMID: 30944849] - Ramya S Kuna, Seth J Field. GOLPH3: a Golgi phosphatidylinositol(4)phosphate effector that directs vesicle trafficking and drives cancer.
Journal of lipid research.
2019 02; 60(2):269-275. doi:
10.1194/jlr.r088328. [PMID: 30266835] - Diego Sbrissa, Louie Semaan, Barani Govindarajan, Yanfeng Li, Nicholas J Caruthers, Paul M Stemmer, Michael L Cher, Seema Sethi, Ulka Vaishampayan, Assia Shisheva, Sreenivasa R Chinni. A novel cross-talk between CXCR4 and PI4KIIIα in prostate cancer cells.
Oncogene.
2019 01; 38(3):332-344. doi:
10.1038/s41388-018-0448-0. [PMID: 30111818] - Nicolas-Frédéric Lipp, Guillaume Drin. In Vitro Strategy to Measure Sterol/Phosphatidylinositol-4-Phosphate Exchange Between Membranes.
Methods in molecular biology (Clifton, N.J.).
2019; 1949(?):269-292. doi:
10.1007/978-1-4939-9136-5_19. [PMID: 30790262] - Mira Sohn, Daniel J Toth, Tamas Balla. Monitoring Non-vesicular Transport of Phosphatidylserine and Phosphatidylinositol 4-Phosphate in Intact Cells by BRET Analysis.
Methods in molecular biology (Clifton, N.J.).
2019; 1949(?):13-22. doi:
10.1007/978-1-4939-9136-5_2. [PMID: 30790245] - Jung Mi Lim, Sujin Park, Mi-Sook Lee, Tamas Balla, Dongmin Kang, Sue Goo Rhee. Accumulation of PtdIns(4)P at the Golgi mediated by reversible oxidation of the PtdIns(4)P phosphatase Sac1 by H2O2.
Free radical biology & medicine.
2019 01; 130(?):426-435. doi:
10.1016/j.freeradbiomed.2018.11.008. [PMID: 30448513] - Stephen Weber, Bernhard Steiner, Amanda Welin, Hubert Hilbi. Legionella-Containing Vacuoles Capture PtdIns(4)P-Rich Vesicles Derived from the Golgi Apparatus.
mBio.
2018 12; 9(6):. doi:
10.1128/mbio.02420-18. [PMID: 30538188] - Parthajit Mukherjee, Hasam Madarati, Neale D Ridgway, Jeffrey Atkinson. Lipid and membrane recognition by the oxysterol binding protein and its phosphomimetic mutant using dual polarization interferometry.
Biochimica et biophysica acta. Biomembranes.
2018 11; 1860(11):2356-2365. doi:
10.1016/j.bbamem.2018.05.022. [PMID: 29879417] - Qianqian Zhang, Ringo van Wijk, Xavier Zarza, Muhammad Shahbaz, Max van Hooren, Aisha Guardia, Denise Scuffi, Carlos García-Mata, Wim Van den Ende, Susanne Hoffmann-Benning, Michel A Haring, Ana M Laxalt, Teun Munnik. Knock-Down of Arabidopsis PLC5 Reduces Primary Root Growth and Secondary Root Formation While Overexpression Improves Drought Tolerance and Causes Stunted Root Hair Growth.
Plant & cell physiology.
2018 Oct; 59(10):2004-2019. doi:
10.1093/pcp/pcy120. [PMID: 30107538] - Jaime Arellanes-Robledo, Karina Reyes-Gordillo, Joseph Ibrahim, Leslie Leckey, Ruchi Shah, M Raj Lakshman. Ethanol targets nucleoredoxin/dishevelled interactions and stimulates phosphatidylinositol 4-phosphate production in vivo and in vitro.
Biochemical pharmacology.
2018 10; 156(?):135-146. doi:
10.1016/j.bcp.2018.08.021. [PMID: 30125555] - Shinya Mochizuki, Harukata Miki, Ruyun Zhou, Yukiharu Kido, Wataru Nishimura, Motoshi Kikuchi, Yasuko Noda. Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons.
Experimental cell research.
2018 09; 370(2):601-612. doi:
10.1016/j.yexcr.2018.07.025. [PMID: 30028970] - Rafael Gil de Rubio, Richard F Ransom, Sundeep Malik, David I Yule, Arun Anantharam, Alan V Smrcka. Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.
Science signaling.
2018 09; 11(547):. doi:
10.1126/scisignal.aan1210. [PMID: 30206135] - Ximing Du, Nigel Turner, Hongyuan Yang. The role of oxysterol-binding protein and its related proteins in cancer.
Seminars in cell & developmental biology.
2018 09; 81(?):149-153. doi:
10.1016/j.semcdb.2017.07.017. [PMID: 28733164] - Sruthi S Balakrishnan, Urbashi Basu, Dhananjay Shinde, Rajan Thakur, Manish Jaiswal, Padinjat Raghu. Regulation of PI4P levels by PI4KIIIα during G-protein-coupled PLC signaling in Drosophila photoreceptors.
Journal of cell science.
2018 08; 131(15):. doi:
10.1242/jcs.217257. [PMID: 29980590] - Luis-Carlos Tábara, Juan-Jesús Vicente, Joanna Biazik, Eeva-Liisa Eskelinen, Olivier Vincent, Ricardo Escalante. Vacuole membrane protein 1 marks endoplasmic reticulum subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution.
Traffic (Copenhagen, Denmark).
2018 08; 19(8):624-638. doi:
10.1111/tra.12581. [PMID: 29761602] - Antonietta Pietrangelo, Neale D Ridgway. Golgi localization of oxysterol binding protein-related protein 4L (ORP4L) is regulated by ligand binding.
Journal of cell science.
2018 07; 131(14):. doi:
10.1242/jcs.215335. [PMID: 29930082] - Yong-Nan Liu, Xiao-Xiao Lu, Ang Ren, Liang Shi, Jing Zhu, Ai-Liang Jiang, Han-Shou Yu, Ming-Wen Zhao. Conversion of phosphatidylinositol (PI) to PI4-phosphate (PI4P) and then to PI(4,5)P2 is essential for the cytosolic Ca2+ concentration under heat stress in Ganoderma lucidum.
Environmental microbiology.
2018 07; 20(7):2456-2468. doi:
10.1111/1462-2920.14254. [PMID: 29697195]
