Span 60 (BioDeep_00000630130)
代谢物信息卡片
2-(3,4-dihydroxyoxolan-2-yl)-2-hydroxyethyl octadecanoate
化学式: C24H46O6 (430.3294216)
中文名称: 司班60
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCC(=O)OCC(C1C(C(CO1)O)O)O
InChI: InChI=1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:183394
- ChEBI: CHEBI:181141
- KEGGdrug: D05897
- PubChem: 16218600
- PubChem: 3793749
- PubChem: 23725022
- ChEMBL: CHEMBL3186117
- LipidMAPS: LMFA07011020
- CAS: 1338-41-6
- CAS: 5093-91-4
- CAS: 96094-21-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marianne Joseph Naguib, Ibrahim Elsayed, Mahmoud Hassan Teaima. Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride.
International journal of nanomedicine.
2021; 16(?):2917-2931. doi:
10.2147/ijn.s299326. [PMID: 33911861] - Marianne Joseph Naguib, Amira Moustafa Kamel, Ahmed Thabet Negmeldin, Ahmed Hassen Elshafeey, Ibrahim Elsayed. Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency.
Drug delivery.
2020 Dec; 27(1):996-1009. doi:
10.1080/10717544.2020.1787557. [PMID: 32611266] - Aline de Cristo Soares Alves, Vladimir Lavayen, Fabrício Figueiró, Danieli Rosane Dallemole, Amanda de Fraga Dias, Rodrigo Cé, Ana Maria Oliveira Battastini, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann. Chitosan-Coated Lipid-Core Nanocapsules Functionalized with Gold-III and Bevacizumab Induced In Vitro Cytotoxicity against C6 Cell Line and In Vivo Potent Antiangiogenic Activity.
Pharmaceutical research.
2020 May; 37(6):91. doi:
10.1007/s11095-020-02804-0. [PMID: 32385723] - Hadi Zare-Zardini, Ashraf Alemi, Asghar Taheri-Kafrani, Seyed Ahmad Hosseini, Hossein Soltaninejad, Amir Ali Hamidieh, Mojtaba Haghi Karamallah, Majid Farrokhifar, Mohammad Farrokhifar. Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study.
Drug design, development and therapy.
2020; 14(?):3315-3324. doi:
10.2147/dddt.s261027. [PMID: 32884236] - Mai Shaaban, Maha Nasr, Abeer Attia Tawfik, Maha Fadel, Omaima Sammour. Novel bergamot oil nanospanlastics combined with PUVB therapy as a clinically translatable approach for vitiligo treatment.
Drug delivery and translational research.
2019 12; 9(6):1106-1116. doi:
10.1007/s13346-019-00653-y. [PMID: 31187447] - Kamila Ramponi Rodrigues de Godoi, Rodrigo Corrêa Basso, Chiu Chih Ming, Vanessa Martins da Silva, Rosiane Lopes da Cunha, Daniel Barrera-Arellano, Ana Paula Badan Ribeiro. Physicochemical and rheological properties of soybean organogels: Interactions between different structuring agents.
Food research international (Ottawa, Ont.).
2019 10; 124(?):108475. doi:
10.1016/j.foodres.2019.05.023. [PMID: 31466657] - Shikang Meng, Lin Sun, Lun Wang, Zibei Lin, Zeyu Liu, Long Xi, Zhenping Wang, Ying Zheng. Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.
Colloids and surfaces. B, Biointerfaces.
2019 Oct; 182(?):110352. doi:
10.1016/j.colsurfb.2019.110352. [PMID: 31306831] - Silvana Sandri, Cristina Bichels Hebeda, Rodrigo Azevedo Loiola, Selma Calgaroto, Mayara Klimuk Uchiyama, Koiti Araki, Luiza Abrahão Frank, Karina Paese, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Sandra Helena Poliselli Farsky. Direct effects of poly(ε-caprolactone) lipid-core nanocapsules on human immune cells.
Nanomedicine (London, England).
2019 06; 14(11):1429-1442. doi:
10.2217/nnm-2018-0484. [PMID: 31169450] - Mariana Domingues Bianchin, Sílvia Maria Borowicz, Gabriella da Rosa Monte Machado, Bruna Pippi, Sílvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Alexandre Meneghello Fuentefria, Irene Clemes Külkamp-Guerreiro. Lipid core nanoparticles as a broad strategy to reverse fluconazole resistance in multiple Candida species.
Colloids and surfaces. B, Biointerfaces.
2019 Mar; 175(?):523-529. doi:
10.1016/j.colsurfb.2018.12.011. [PMID: 30579053] - Araceli Martín-Illana, Raúl Cazorla-Luna, Fernando Notario-Pérez, Luis Miguel Bedoya, Roberto Ruiz-Caro, María Dolores Veiga. Freeze-dried bioadhesive vaginal bigels for controlled release of Tenofovir.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Jan; 127(?):38-51. doi:
10.1016/j.ejps.2018.10.013. [PMID: 30343152] - Marcella Aparecida Stahl, Monise Helen Masuchi Buscato, Renato Grimaldi, Lisandro Pavie Cardoso, Ana Paula Badan Ribeiro. Structuration of lipid bases with fully hydrogenated crambe oil and sorbitan monostearate for obtaining zero-trans/low sat fats.
Food research international (Ottawa, Ont.).
2018 05; 107(?):61-72. doi:
10.1016/j.foodres.2018.02.012. [PMID: 29580526] - Kapilkumar Vithani, Adrian Hawley, Vincent Jannin, Colin Pouton, Ben J Boyd. Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion.
The AAPS journal.
2017 05; 19(3):754-764. doi:
10.1208/s12248-016-0036-6. [PMID: 28116678] - Saeid Moghassemi, Afra Hadjizadeh, Kobra Omidfar. Formulation and Characterization of Bovine Serum Albumin-Loaded Niosome.
AAPS PharmSciTech.
2017 01; 18(1):27-33. doi:
10.1208/s12249-016-0487-1. [PMID: 26817764] - Yoochan Myung, Seongyeol Yeom, Sanghwa Han. A niosomal bilayer of sorbitan monostearate in complex with flavones: a molecular dynamics simulation study.
Journal of liposome research.
2016 Dec; 26(4):336-44. doi:
10.3109/08982104.2016.1144204. [PMID: 26982006] - S Barbut, J Wood, A Marangoni. Quality effects of using organogels in breakfast sausage.
Meat science.
2016 Dec; 122(?):84-89. doi:
10.1016/j.meatsci.2016.07.022. [PMID: 27501232] - S Barbut, J Wood, A Marangoni. Potential use of organogels to replace animal fat in comminuted meat products.
Meat science.
2016 Dec; 122(?):155-162. doi:
10.1016/j.meatsci.2016.08.003. [PMID: 27552678] - Vivek M Ghate, Shaila A Lewis, Prabhakara Prabhu, Akhilesh Dubey, Nilkumar Patel. Nanostructured lipid carriers for the topical delivery of tretinoin.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2016 Nov; 108(?):253-261. doi:
10.1016/j.ejpb.2016.07.026. [PMID: 27519827] - S Barbut, J Wood, A G Marangoni. Effects of Organogel Hardness and Formulation on Acceptance of Frankfurters.
Journal of food science.
2016 Sep; 81(9):C2183-8. doi:
10.1111/1750-3841.13409. [PMID: 27514694] - Ayat Allam, Gihan Fetih. Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate.
Drug design, development and therapy.
2016; 10(?):2421-33. doi:
10.2147/dddt.s113775. [PMID: 27536063] - Karine Coradini, Rossana B Friedrich, Francisco N Fonseca, Marina S Vencato, Diego F Andrade, Cláudia M Oliveira, Ana Paula Battistel, Silvia S Guterres, Maria Izabel U M da Rocha, Adriana R Pohlmann, Ruy C R Beck. A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Oct; 78(?):163-70. doi:
10.1016/j.ejps.2015.07.012. [PMID: 26206297] - Rossana B Friedrich, Birthe Kann, Karine Coradini, Herman L Offerhaus, Ruy C R Beck, Maike Windbergs. Skin penetration behavior of lipid-core nanocapsules for simultaneous delivery of resveratrol and curcumin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Oct; 78(?):204-13. doi:
10.1016/j.ejps.2015.07.018. [PMID: 26215463] - Fernanda S Poletto, Catiúscia P De Oliveira, Heberton Wender, Dorothée Regent, Bruna Donida, Sérgio R Teixeira, Sílvia S Guterres, Bartira Rossi-Bergmann, Adriana R Pohlmann. How Sorbitan Monostearate Can Increase Drug-Loading Capacity of Lipid-Core Polymeric Nanocapsules.
Journal of nanoscience and nanotechnology.
2015 Jan; 15(1):827-37. doi:
10.1166/jnn.2015.9182. [PMID: 26328447] - Javier O Morales, Gero M Joks, Alf Lamprecht, Alistair C Ross, Jason T McConville. A design of experiments to optimize a new manufacturing process for high activity protein-containing submicron particles.
Drug development and industrial pharmacy.
2013 Nov; 39(11):1793-801. doi:
10.3109/03639045.2012.737332. [PMID: 23298292] - Tongyuan Lin, Qingying Fang, Daiyin Peng, Xia Huang, Tingting Zhu, Qing Luo, Kai Zhou, Weidong Chen. PEGylated non-ionic surfactant vesicles as drug delivery systems for Gambogenic acid.
Drug delivery.
2013 Sep; 20(7):277-84. doi:
10.3109/10717544.2013.836618. [PMID: 24044645] - Valéria Weiss-Angeli, Fernanda S Poletto, Samuel L de Marco, Miriam Salvador, Nádya P da Silveira, Sílvia S Guterres, Adriana R Pohlmann. Sustained antioxidant activity of quercetin-loaded lipid-core nanocapsules.
Journal of nanoscience and nanotechnology.
2012 Mar; 12(3):2874-80. doi:
10.1166/jnn.2012.5770. [PMID: 22755137] - Basavaraj K Nanjwade, Didhija J Patel, Ritesh A Udhani, Fakirappa V Manvi. Functions of lipids for enhancement of oral bioavailability of poorly water-soluble drugs.
Scientia pharmaceutica.
2011 Oct; 79(4):705-27. doi:
10.3797/scipharm.1105-09. [PMID: 22145101] - Aline Ferreira Ourique, Ana Melero, Cristiane de Bona da Silva, Ulrich F Schaefer, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres, Claus-Michael Lehr, Karl-Heinz Kostka, Ruy Carlos Ruver Beck. Improved photostability and reduced skin permeation of tretinoin: development of a semisolid nanomedicine.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Sep; 79(1):95-101. doi:
10.1016/j.ejpb.2011.03.008. [PMID: 21402157] - A Pardakhty, E Moazeni, J Varshosaz, V Hajhashemi, A Rouholamini Najafabadi. Pharmacokinetic study of niosome-loaded insulin in diabetic rats.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2011; 19(6):404-11. doi:
NULL. [PMID: 23008685] - Zhanwen Xing, Hengte Ke, Jinrui Wang, Bo Zhao, Xiuli Yue, Zhifei Dai, Jibin Liu. Novel ultrasound contrast agent based on microbubbles generated from surfactant mixtures of Span 60 and polyoxyethylene 40 stearate.
Acta biomaterialia.
2010 Sep; 6(9):3542-9. doi:
10.1016/j.actbio.2010.03.007. [PMID: 20226284] - Aranya Manosroi, Penpan Khanrin, Rolf G Werner, Friedrich Götz, Worapaka Manosroi, Jiradej Manosroi. Entrapment enhancement of peptide drugs in niosomes.
Journal of microencapsulation.
2010 May; 27(3):272-80. doi:
10.3109/02652040903131293. [PMID: 20113169] - Eliézer Jäger, Cristina G Venturini, Fernanda S Poletto, Letícia M Colomé, João P U Pohlmann, Andressa Bernardi, Ana M O Battastini, Silvia S Guterres, Adriana R Pohlmann. Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area.
Journal of biomedical nanotechnology.
2009 Feb; 5(1):130-40. doi:
10.1166/jbn.2009.1004. [PMID: 20055116] - M S Ahshawat, S Saraf, S Saraf. Preparation and characterization of herbal creams for improvement of skin viscoelastic properties.
International journal of cosmetic science.
2008 Jun; 30(3):183-93. doi:
10.1111/j.1468-2494.2008.00442.x. [PMID: 18452435] - A Manosroi, K Thathang, R G Werner, R Schubert, J Manosroi. Stability of luciferase plasmid entrapped in cationic bilayer vesicles.
International journal of pharmaceutics.
2008 May; 356(1-2):291-9. doi:
10.1016/j.ijpharm.2008.01.001. [PMID: 18281170] - I F Almeida, A R Fernandes, L Fernandes, M R Pena Ferreira, P C Costa, M F Bahia. Moisturizing effect of oleogel/hydrogel mixtures.
Pharmaceutical development and technology.
2008; 13(6):487-94. doi:
10.1080/10837450802282447. [PMID: 18720247] - Ismail A Attia, Sanaa A El-Gizawy, Medhat A Fouda, Ahmed M Donia. Influence of a niosomal formulation on the oral bioavailability of acyclovir in rabbits.
AAPS PharmSciTech.
2007 Dec; 8(4):E106. doi:
10.1208/pt0804106. [PMID: 18181527] - Prasun Bandyopadhyay, Madrid Johnson. Fatty alcohols or fatty acids as niosomal hybrid carrier: effect on vesicle size, encapsulation efficiency and in vitro dye release.
Colloids and surfaces. B, Biointerfaces.
2007 Jul; 58(1):68-71. doi:
10.1016/j.colsurfb.2007.01.014. [PMID: 17339104] - Isabel F Almeida, M Fernanda Bahia. Evaluation of the physical stability of two oleogels.
International journal of pharmaceutics.
2006 Dec; 327(1-2):73-7. doi:
10.1016/j.ijpharm.2006.07.036. [PMID: 16996708] - Jun-chan Li, Xian-yi Sha, Li-jun Zhang, Xiao-ling Fang. [9-nitrocamptothecin nanostructured lipid carrier system: in vitro releasing characteristics, uptake by cells, and tissue distribution in vivo].
Yao xue xue bao = Acta pharmaceutica Sinica.
2005 Nov; 40(11):970-5. doi:
NULL. [PMID: 16499078] - Behrooz Nasseri. Effect of cholesterol and temperature on the elastic properties of niosomal membranes.
International journal of pharmaceutics.
2005 Aug; 300(1-2):95-101. doi:
10.1016/j.ijpharm.2005.05.009. [PMID: 16006080] - Behrooz Nasseri, Alexander T Florence. A vesicular shuttle: transport of a vesicle within a flexible microtube.
Journal of controlled release : official journal of the Controlled Release Society.
2003 Oct; 92(3):233-40. doi:
10.1016/s0168-3659(03)00298-0. [PMID: 14568404] - W J Lin, L I Huang. Influence of pluronics on protein-loaded poly(epsilon-caprolactone) microparticles.
Journal of microencapsulation.
2001 Mar; 18(2):191-7. doi:
10.1080/02652040010000370. [PMID: 11253936] - S Murdan, G Gregoriadis, A T Florence. Sorbitan monostearate/polysorbate 20 organogels containing niosomes: a delivery vehicle for antigens?.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
1999 Jul; 8(3):177-86. doi:
10.1016/s0928-0987(99)00014-7. [PMID: 10379040] - S Murdan, G Gregoriadis, A T Florence. Novel sorbitan monostearate organogels.
Journal of pharmaceutical sciences.
1999 Jun; 88(6):608-14. doi:
10.1021/js980342r. [PMID: 10350496] - S Murdan, B van den Bergh, G Gregoriadis, A T Florence. Water-in-sorbitan monostearate organogels (water-in-oil gels).
Journal of pharmaceutical sciences.
1999 Jun; 88(6):615-9. doi:
10.1021/js980343j. [PMID: 10350497] - F Forsberg, Y Wu, I R Makin, W Wang, M A Wheatley. Quantitative acoustic characterization of a new surfactant-based ultrasound contrast agent.
Ultrasound in medicine & biology.
1997; 23(8):1201-8. doi:
10.1016/s0301-5629(97)00078-1. [PMID: 9372569] - S Nakhare, S P Vyas. Preparation and characterization of multiple emulsion based systems for controlled diclofenac sodium release.
Journal of microencapsulation.
1996 May; 13(3):281-92. doi:
10.3109/02652049609026016. [PMID: 8860684] - I F Uchegbu, J A Double, J A Turton, A T Florence. Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse.
Pharmaceutical research.
1995 Jul; 12(7):1019-24. doi:
10.1023/a:1016210515134. [PMID: 7494796] - K S Chandraprakash, N Udupa, P Umadevi, G K Pillai. Effect of macrophage activation on plasma disposition of niosomal 3H-methotrexate in sarcoma-180 bearing mice.
Journal of drug targeting.
1993; 1(2):143-5. doi:
10.3109/10611869308996070. [PMID: 8069552] - M Tsujimoto, K Inoue, S Nojima. C-Reactive protein induced agglutination of lipid suspensions prepared in the presence and absence of phosphatidylcholine.
Journal of biochemistry.
1980 May; 87(5):1531-7. doi:
10.1093/oxfordjournals.jbchem.a132894. [PMID: 7190145]