Protectin DX (BioDeep_00000629702)

   


代谢物信息卡片


10S,17S-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid

化学式: C22H32O4 (360.2300472)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC/C=C\C/C=C\C[C@H](O)/C=C/C=C\C=C\[C@@H](O)C/C=C\CC)(=O)O
InChI: InChI=1S/C22H32O4/c1-2-3-10-15-20(23)17-12-8-9-13-18-21(24)16-11-6-4-5-7-14-19-22(25)26/h3,5-13,17-18,20-21,23-24H,2,4,14-16,19H2,1H3,(H,25,26)/b7-5-,9-8-,10-3-,11-6-,17-12+,18-13+/t20-,21-/m0/s1

描述信息

同义名列表

6 个代谢物同义名

10S,17S-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoic acid; 10S,17S-DiHDoHE; 10S,17S-diHDHA; Protectin DX; FA 22:6;O2; PDX



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

50 个相关的代谢反应过程信息。

Reactome(50)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xin Hu, Ye-An Zhang, Ben Chen, Zi Jin, Mei-Lin Lin, Ming Li, Hong-Xia Mei, Jia-Chao Lu, Yu-Qiang Gong, Sheng-Wei Jin, Sheng-Xing Zheng. Protectin DX promotes the inflammatory resolution via activating COX-2/L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome. International immunopharmacology. 2022 Jan; 102(?):108348. doi: 10.1016/j.intimp.2021.108348. [PMID: 34920958]
  • Poorani Rengachar, Sailaja Polavarapu, Undurti N Das. Insights in diabetes: Molecular mechanisms-Protectin DX, an anti-inflammatory and a stimulator of inflammation resolution metabolite of docosahexaenoic acid, protects against the development of streptozotocin-induced type 1 and type 2 diabetes mellitus in male Swiss albino mice. Frontiers in endocrinology. 2022; 13(?):1053879. doi: 10.3389/fendo.2022.1053879. [PMID: 36778598]
  • Laís R Perazza, Patricia L Mitchell, Farah Lizotte, Benjamin A H Jensen, Philippe St-Pierre, Jocelyn Trottier, Olivier Barbier, Patrick Mathieu, Pedro M Geraldes, André Marette. Fish oil replacement prevents, while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 05; 35(5):e21559. doi: 10.1096/fj.202100073r. [PMID: 33835594]
  • Haifa Xia, Yangyang Ge, Fuquan Wang, Yu Ming, Zhouyang Wu, Jingxu Wang, Shujun Sun, Shiqian Huang, Ming Chen, Weimin Xiao, Shanglong Yao. Protectin DX ameliorates inflammation in sepsis-induced acute lung injury through mediating PPARγ/NF-κB pathway. Immunologic research. 2020 10; 68(5):280-288. doi: 10.1007/s12026-020-09151-7. [PMID: 32845434]
  • Yang Ye, Hua-Wei Zhang, Hong-Xia Mei, Hao-Ran Xu, Shu-Yang Xiang, Qian Yang, Sheng-Xing Zheng, Fang Gao Smith, Sheng-Wei Jin, Qian Wang. PDX regulates inflammatory cell infiltration via resident macrophage in LPS-induced lung injury. Journal of cellular and molecular medicine. 2020 09; 24(18):10604-10614. doi: 10.1111/jcmm.15679. [PMID: 32735065]
  • Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska. Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092026. [PMID: 32349225]
  • Tae Woo Jung, Sung Ho Ahn, Jong Wook Shin, Hyoung-Chun Kim, Eon Sub Park, A M Abd El-Aty, Ahmet Hacımüftüoğlu, Ki Hak Song, Ji Hoon Jeong. Protectin DX ameliorates palmitate-induced hepatic insulin resistance through AMPK/SIRT1-mediated modulation of fetuin-A and SeP expression. Clinical and experimental pharmacology & physiology. 2019 10; 46(10):898-909. doi: 10.1111/1440-1681.13131. [PMID: 31246318]
  • Tae Woo Jung, Yoon Hee Chung, Hyoung-Chun Kim, A M Abd El-Aty, Ji Hoon Jeong. Protectin DX attenuates LPS-induced inflammation and insulin resistance in adipocytes via AMPK-mediated suppression of the NF-κB pathway. American journal of physiology. Endocrinology and metabolism. 2018 10; 315(4):E543-E551. doi: 10.1152/ajpendo.00408.2017. [PMID: 29584445]
  • Tae Woo Jung, Eun Jung Kyung, Hyoung-Chun Kim, Yong Kyu Shin, Sung Hoon Lee, Eon Sub Park, Ahmet Hacımüftüoğlu, A M Abd El-Aty, Ji Hoon Jeong. Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression. The Journal of pharmacology and experimental therapeutics. 2018 06; 365(3):485-493. doi: 10.1124/jpet.117.246686. [PMID: 29572342]
  • Wen Tan, Lin Chen, Ya-Xin Wang, Li-Sha Hu, Wei Xiong, You Shang, Shang-Long Yao. Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury. Chinese medical journal. 2018 May; 131(10):1167-1173. doi: 10.4103/0366-6999.227618. [PMID: 29553051]
  • Xiao-Jun Zhuo, Yu Hao, Fei Cao, Song-Fan Yan, Hui Li, Qian Wang, Bi-Huan Cheng, Bin-Yu Ying, Fang Gao Smith, Sheng-Wei Jin. Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury. Experimental & molecular medicine. 2018 04; 50(4):1-13. doi: 10.1038/s12276-018-0075-4. [PMID: 29700291]
  • Rasagna Kosaraju, William Guesdon, Miranda J Crouch, Heather L Teague, E Madison Sullivan, Erik A Karlsson, Stacey Schultz-Cherry, Kymberly Gowdy, Lance C Bridges, Lauren R Reese, P Darrell Neufer, Michael Armstrong, Nichole Reisdorph, J Justin Milner, Melinda Beck, Saame Raza Shaikh. B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection. Journal of immunology (Baltimore, Md. : 1950). 2017 06; 198(12):4738-4752. doi: 10.4049/jimmunol.1601031. [PMID: 28500069]
  • Haifa Xia, Lin Chen, Hong Liu, Zhipeng Sun, Wen Yang, Yiyi Yang, Shunan Cui, Shengnan Li, Yaxin Wang, Limin Song, Amro Fayez Abdelgawad, You Shang, Shanglong Yao. Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype. Scientific reports. 2017 03; 7(1):99. doi: 10.1038/s41598-017-00103-0. [PMID: 28273909]
  • Kathy Stein, Melissa Stoffels, Mariola Lysson, Bianca Schneiker, Oliver Dewald, Gerhard Krönke, Jörg C Kalff, Sven Wehner. A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation. Journal of leukocyte biology. 2016 Feb; 99(2):231-9. doi: 10.1189/jlb.3hi0515-189r. [PMID: 26292977]
  • M Lagarde, C Calzada, M Guichardant, E Véricel. Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. Prostaglandins, leukotrienes, and essential fatty acids. 2013 Jan; 88(1):49-52. doi: 10.1016/j.plefa.2012.04.001. [PMID: 22520055]