Protectin D1 (BioDeep_00000629701)

   


代谢物信息卡片


10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid

化学式: C22H32O4 (360.23)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: C(CC/C=C\C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)C/C=C\CC)(=O)O
InChI: InChI=1S/C22H32O4/c1-2-3-10-15-20(23)17-12-8-9-13-18-21(24)16-11-6-4-5-7-14-19-22(25)26/h3,5-13,17-18,20-21,23-24H,2,4,14-16,19H2,1H3,(H,25,26)/b7-5-,9-8+,10-3-,11-6-,17-12-,18-13+/t20-,21+/m0/s1

描述信息

A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1

同义名列表

6 个代谢物同义名

Protectin D1; 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid; Neuroprotectin D1; FA 22:6;O2; NPD1; PD1



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

86 个相关的代谢反应过程信息。

Reactome(86)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li. Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M. Free radical biology & medicine. 2024 Jan; 210(?):42-53. doi: 10.1016/j.freeradbiomed.2023.11.011. [PMID: 37984750]
  • Madigan M Reid, Marie-Audrey I Kautzmann, Gethein Andrew, Andre Obenaus, Pranab K Mukherjee, Larissa Khoutorova, Jeff X Ji, Cassia R Roque, Reinaldo B Oria, Bola F Habeb, Ludmila Belayev, Nicolas G Bazan. NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes. Cellular and molecular neurobiology. 2023 Jun; ?(?):. doi: 10.1007/s10571-023-01363-3. [PMID: 37270727]
  • Luca Navarini, Marta Vomero, Damiano Currado, Onorina Berardicurti, Alice Biaggi, Annalisa Marino, Pietro Bearzi, Erika Corberi, Amelia Rigon, Luisa Arcarese, Alessandro Leuti, Marina Fava, Marta Fogolari, Alessia Mattei, Piero Ruscitti, Ilenia Di Cola, Federica Sambuco, Francesco Travaglino, Silvia Angeletti, Francesco Ursini, Erminia Mariani, Paola Cipriani, Felice Eugenio Agrò, Annamaria Iagnocco, Raffaele Antonelli Incalzi, Mauro Maccarrone, Roberto Giacomelli. The specialized pro-resolving lipid mediator Protectin D1 affects macrophages differentiation and activity in Adult-onset Still's disease and COVID-19, two hyperinflammatory diseases sharing similar transcriptomic profiles. Frontiers in immunology. 2023; 14(?):1148268. doi: 10.3389/fimmu.2023.1148268. [PMID: 37153620]
  • Ifeanyi Iwuchukwu, Doan Nguyen, Alireza Shirazian, Aram Asatryan, Bokkyoo Jun, Nicolas G Bazan. Neuroprotectin D1, a lipid anti-inflammatory mediator, in patients with intracerebral hemorrhage. Biochimie. 2022 Apr; 195(?):16-18. doi: 10.1016/j.biochi.2021.12.017. [PMID: 34990771]
  • Inês Ferreira, Filipa Falcato, Narcisa Bandarra, Amélia P Rauter. Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation. Molecules (Basel, Switzerland). 2022 Mar; 27(5):. doi: 10.3390/molecules27051677. [PMID: 35268778]
  • Apostolos Mikroulis, Marco Ledri, Gabriele Ruffolo, Eleonora Palma, Günther Sperk, Jesmond Dalli, Annamaria Vezzani, Merab Kokaia. Lipid mediator n-3 docosapentaenoic acid-derived protectin D1 enhances synaptic inhibition of hippocampal principal neurons by interaction with a G-protein-coupled receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 03; 36(3):e22203. doi: 10.1096/fj.202101815r. [PMID: 35188290]
  • Bohan Wang, Jingchao Wei, Qi Huangfu, Fei Gao, Lanxin Qin, Jiao Zhong, Jiaming Wen, Zhangqun Ye, Xiaoqi Yang, Haoran Liu. Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones. Oxidative medicine and cellular longevity. 2022; 2022(?):4345037. doi: 10.1155/2022/4345037. [PMID: 35251472]
  • Zhiyang Wu, Guotao Lu, Luyao Zhang, Lu Ke, Chenchen Yuan, Nan Ma, Xianqiang Yu, Xi Guo, Wei Zhao, Yingjie Wang, Sanyuan Hu, Dawei Wu, Weiqin Li. Protectin D1 decreases pancreatitis severity in mice by inhibiting neutrophil extracellular trap formation. International immunopharmacology. 2021 May; 94(?):107486. doi: 10.1016/j.intimp.2021.107486. [PMID: 33639566]
  • Evangelos Andreakos, Maria Papadaki, Charles N Serhan. Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19. Allergy. 2021 03; 76(3):626-628. doi: 10.1111/all.14595. [PMID: 32956495]
  • Kazuo Yamagata. Dietary docosahexaenoic acid inhibits neurodegeneration and prevents stroke. Journal of neuroscience research. 2021 02; 99(2):561-572. doi: 10.1002/jnr.24728. [PMID: 32964457]
  • Hylde Zirpoli, Sergey A Sosunov, Zoya V Niatsetskaya, Korapat Mayurasakorn, Denny Joseph Manual Kollareth, Charles N Serhan, Vadim S Ten, Richard J Deckelbaum. NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury. Experimental neurology. 2021 01; 335(?):113495. doi: 10.1016/j.expneurol.2020.113495. [PMID: 33038416]
  • Fabian Schulte, Abdul Aziz Asbeutah, Peter N Benotti, G Craig Wood, Christopher Still, Bruce R Bistrian, Markus Hardt, Francine K Welty. The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery. Scientific reports. 2020 11; 10(1):20128. doi: 10.1038/s41598-020-75353-6. [PMID: 33208757]
  • William W Christie, John L Harwood. Oxidation of polyunsaturated fatty acids to produce lipid mediators. Essays in biochemistry. 2020 09; 64(3):401-421. doi: 10.1042/ebc20190082. [PMID: 32618335]
  • Lirlândia P Sousa, Vanessa Pinho, Mauro M Teixeira. Harnessing inflammation resolving-based therapeutic agents to treat pulmonary viral infections: What can the future offer to COVID-19?. British journal of pharmacology. 2020 09; 177(17):3898-3904. doi: 10.1111/bph.15164. [PMID: 32557557]
  • Keishi Miyazawa, Hisanori Fukunaga, Yasuko Tatewaki, Yumi Takano, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki. Alzheimer's Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?. International journal of molecular sciences. 2020 Aug; 21(16):. doi: 10.3390/ijms21165783. [PMID: 32806612]
  • Yiu Yiu Lee, Jean-Marie Galano, Ho Hang Leung, Laurence Balas, Camille Oger, Thierry Durand, Jetty Chung-Yung Lee. Nonenzymatic oxygenated metabolite of docosahexaenoic acid, 4(RS)-4-F4t -neuroprostane, acts as a bioactive lipid molecule in neuronal cells. FEBS letters. 2020 06; 594(11):1797-1808. doi: 10.1002/1873-3468.13774. [PMID: 32215916]
  • Patrick Waindok, Elisabeth Janecek-Erfurth, Dimitri Lindenwald, Esther Wilk, Klaus Schughart, Robert Geffers, Laurence Balas, Thierry Durand, Katharina Maria Rund, Nils Helge Schebb, Christina Strube. Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis. PLoS neglected tropical diseases. 2019 09; 13(9):e0007706. doi: 10.1371/journal.pntd.0007706. [PMID: 31557153]
  • Yoshihisa Makino, Takuya Miyahara, Jun Nitta, Kazuhiro Miyahara, Akihiko Seo, Masaru Kimura, Masamitsu Suhara, Atsushi Akai, Daisuke Akagi, Kota Yamamoto, Katsuyuki Hoshina. Proresolving Lipid Mediators Resolvin D1 and Protectin D1 Isomer Attenuate Neointimal Hyperplasia in the Rat Carotid Artery Balloon Injury Model. The Journal of surgical research. 2019 01; 233(?):104-110. doi: 10.1016/j.jss.2018.07.049. [PMID: 30502235]
  • Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani. n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis. Brain : a journal of neurology. 2018 11; 141(11):3130-3143. doi: 10.1093/brain/awy247. [PMID: 30307467]
  • Alexander V Sorokin, Paul C Norris, Justin T English, Amit K Dey, Abhishek Chaturvedi, Yvonne Baumer, Joanna Silverman, Martin P Playford, Charles N Serhan, Nehal N Mehta. Identification of proresolving and inflammatory lipid mediators in human psoriasis. Journal of clinical lipidology. 2018 Jul; 12(4):1047-1060. doi: 10.1016/j.jacl.2018.03.091. [PMID: 29730187]
  • Lynn Calvin Shaw, Sergio Li Calzi, Nan Li, Leni Moldovan, Nilanjana Sengupta-Caballero, Judith Lindsey Quigley, Mircea Ivan, Bokkyoo Jun, Nicolas G Bazan, Michael Edwin Boulton, Julia Busik, Josef Neu, Maria B Grant. Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity. Investigative ophthalmology & visual science. 2018 02; 59(2):858-869. doi: 10.1167/iovs.17-23034. [PMID: 29490339]
  • Francisca Echeverría, Rodrigo Valenzuela, María Catalina Hernandez-Rodas, Alfonso Valenzuela. Docosahexaenoic acid (DHA), a fundamental fatty acid for the brain: New dietary sources. Prostaglandins, leukotrienes, and essential fatty acids. 2017 Sep; 124(?):1-10. doi: 10.1016/j.plefa.2017.08.001. [PMID: 28870371]
  • Huixia Ren, Zhen Yang, Chuanming Luo, Haitao Zeng, Peng Li, Jing X Kang, Jian-Bo Wan, Chengwei He, Huanxing Su. Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury. Molecular neurobiology. 2017 07; 54(5):3317-3326. doi: 10.1007/s12035-016-9931-1. [PMID: 27167127]
  • Ludmila Belayev, Pranab K Mukherjee, Veronica Balaszczuk, Jorgelina M Calandria, Andre Obenaus, Larissa Khoutorova, Sung-Ha Hong, Nicolas G Bazan. Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke. Cell death and differentiation. 2017 06; 24(6):1091-1099. doi: 10.1038/cdd.2017.55. [PMID: 28430183]
  • Thomas Gobbetti, Jesmond Dalli, Romain A Colas, Donata Federici Canova, Marius Aursnes, Delphine Bonnet, Laurent Alric, Nathalie Vergnolle, Celine Deraison, Trond V Hansen, Charles N Serhan, Mauro Perretti. Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proceedings of the National Academy of Sciences of the United States of America. 2017 04; 114(15):3963-3968. doi: 10.1073/pnas.1617290114. [PMID: 28356517]
  • Justin T English, Paul C Norris, Robin R Hodges, Darlene A Dartt, Charles N Serhan. Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics. Prostaglandins, leukotrienes, and essential fatty acids. 2017 02; 117(?):17-27. doi: 10.1016/j.plefa.2017.01.004. [PMID: 28237084]
  • Shalini Muralikumar, Umashankar Vetrivel, Angayarkanni Narayanasamy, Undurti N Das. Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. Lipids in health and disease. 2017 Jan; 16(1):17. doi: 10.1186/s12944-016-0404-3. [PMID: 28109294]
  • Jun Ren, Shanshan Meng, Bingdi Yan, Jinyan Yu, Jing Liu. Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation. Molecular medicine reports. 2016 Apr; 13(4):3627-38. doi: 10.3892/mmr.2016.4980. [PMID: 26955849]
  • Nicolas G Bazan. Molecular Principles for Decoding Homeostasis Disruptions in the Retinal Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases. Advances in experimental medicine and biology. 2016; 854(?):385-91. doi: 10.1007/978-3-319-17121-0_51. [PMID: 26427436]
  • Marius Aursnes, Jørn E Tungen, Romain A Colas, Iliyan Vlasakov, Jesmond Dalli, Charles N Serhan, Trond V Hansen. Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages. Journal of natural products. 2015 Dec; 78(12):2924-31. doi: 10.1021/acs.jnatprod.5b00574. [PMID: 26580578]
  • J M Calandria, A Asatryan, V Balaszczuk, E J Knott, B K Jun, P K Mukherjee, L Belayev, N G Bazan. NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. Cell death and differentiation. 2015 Aug; 22(8):1363-77. doi: 10.1038/cdd.2014.233. [PMID: 25633199]
  • Yumiko Imai. Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection. Biochimica et biophysica acta. 2015 Apr; 1851(4):496-502. doi: 10.1016/j.bbalip.2015.01.006. [PMID: 25617737]
  • Y Kanan, W C Gordon, P K Mukherjee, N G Bazan, M R Al-Ubaidi. Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. Cellular and molecular neurobiology. 2015 Mar; 35(2):197-204. doi: 10.1007/s10571-014-0111-4. [PMID: 25212825]
  • Alberto E Musto, Chelsey P Walker, Nicos A Petasis, Nicolas G Bazan. Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. PloS one. 2015; 10(1):e0116543. doi: 10.1371/journal.pone.0116543. [PMID: 25617763]
  • Jørn E Tungen, Marius Aursnes, Anders Vik, Sesquile Ramon, Romain A Colas, Jesmond Dalli, Charles N Serhan, Trond V Hansen. Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. Journal of natural products. 2014 Oct; 77(10):2241-7. doi: 10.1021/np500498j. [PMID: 25247845]
  • Marius Aursnes, Jørn E Tungen, Anders Vik, Romain Colas, Chien-Yee C Cheng, Jesmond Dalli, Charles N Serhan, Trond V Hansen. Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions. Journal of natural products. 2014 Apr; 77(4):910-6. doi: 10.1021/np4009865. [PMID: 24576195]
  • Gandrath Dayaker, Thierry Durand, Laurence Balas. A versatile and stereocontrolled total synthesis of dihydroxylated docosatrienes containing a conjugated E,E,Z-triene. Chemistry (Weinheim an der Bergstrasse, Germany). 2014 Mar; 20(10):2879-87. doi: 10.1002/chem.201304526. [PMID: 24520010]
  • Clark D Russell, Jürgen Schwarze. The role of pro-resolution lipid mediators in infectious disease. Immunology. 2014 Feb; 141(2):166-73. doi: 10.1111/imm.12206. [PMID: 24400794]
  • M Aursnes, J E Tungen, A Vik, J Dalli, T V Hansen. Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. Organic & biomolecular chemistry. 2014 Jan; 12(3):432-7. doi: 10.1039/c3ob41902a. [PMID: 24253202]
  • Naveen K Rajasagi, Pradeep B J Reddy, Sachin Mulik, Per Gjorstrup, Barry T Rouse. Neuroprotectin D1 reduces the severity of herpes simplex virus-induced corneal immunopathology. Investigative ophthalmology & visual science. 2013 Sep; 54(9):6269-79. doi: 10.1167/iovs.13-12152. [PMID: 23942967]
  • Angelika Neuhofer, Maximilian Zeyda, Daniel Mascher, Bianca K Itariu, Incoronata Murano, Lukas Leitner, Eva E Hochbrugger, Peter Fraisl, Saverio Cinti, Charles N Serhan, Thomas M Stulnig. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes. 2013 Jun; 62(6):1945-56. doi: 10.2337/db12-0828. [PMID: 23349501]
  • Ourania Koltsida, Sergey Karamnov, Katerina Pyrillou, Thad Vickery, Aikaterini-Dimitra Chairakaki, Constantin Tamvakopoulos, Paschalis Sideras, Charles N Serhan, Evangelos Andreakos. Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. EMBO molecular medicine. 2013 May; 5(5):762-75. doi: 10.1002/emmm.201201891. [PMID: 23584892]
  • Masayuki Morita, Keiji Kuba, Akihiko Ichikawa, Mizuho Nakayama, Jun Katahira, Ryo Iwamoto, Tokiko Watanebe, Saori Sakabe, Tomo Daidoji, Shota Nakamura, Ayumi Kadowaki, Takayo Ohto, Hiroki Nakanishi, Ryo Taguchi, Takaaki Nakaya, Makoto Murakami, Yoshihiro Yoneda, Hiroyuki Arai, Yoshihiro Kawaoka, Josef M Penninger, Makoto Arita, Yumiko Imai. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell. 2013 Mar; 153(1):112-25. doi: 10.1016/j.cell.2013.02.027. [PMID: 23477864]
  • Jun Miyata, Koichi Fukunaga, Ryo Iwamoto, Yosuke Isobe, Kyoko Niimi, Rina Takamiya, Takahisa Takihara, Katsuyoshi Tomomatsu, Yusuke Suzuki, Tsuyoshi Oguma, Koichi Sayama, Hiroyuki Arai, Tomoko Betsuyaku, Makoto Arita, Koichiro Asano. Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. The Journal of allergy and clinical immunology. 2013 Feb; 131(2):353-60.e1. doi: 10.1016/j.jaci.2012.07.048. [PMID: 23006546]
  • Nicolas G Bazan. Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. Molecular neurobiology. 2012 Aug; 46(1):221-6. doi: 10.1007/s12035-012-8322-5. [PMID: 22956271]
  • Sesquile Ramon, Fei Gao, Charles N Serhan, Richard P Phipps. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. Journal of immunology (Baltimore, Md. : 1950). 2012 Jul; 189(2):1036-42. doi: 10.4049/jimmunol.1103483. [PMID: 22711890]
  • Nicolas G Bazan, Tiffany N Eady, Larissa Khoutorova, Kristal D Atkins, Song Hong, Yan Lu, Changde Zhang, Bokkyoo Jun, Andre Obenaus, Gabrielle Fredman, Min Zhu, Jeremy W Winkler, Nicos A Petasis, Charles N Serhan, Ludmila Belayev. Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Experimental neurology. 2012 Jul; 236(1):122-30. doi: 10.1016/j.expneurol.2012.04.007. [PMID: 22542947]
  • Karsten H Weylandt, Cheng-Ying Chiu, Beate Gomolka, Simon F Waechter, Bertram Wiedenmann. Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. Prostaglandins & other lipid mediators. 2012 Mar; 97(3-4):73-82. doi: 10.1016/j.prostaglandins.2012.01.005. [PMID: 22326554]
  • Chul-Kyu Park, Ning Lü, Zhen-Zhong Xu, Tong Liu, Charles N Serhan, Ru-Rong Ji. Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Oct; 31(42):15072-85. doi: 10.1523/jneurosci.2443-11.2011. [PMID: 22016541]
  • P Flachs, R Rühl, M Hensler, P Janovska, P Zouhar, V Kus, Z Macek Jilkova, E Papp, O Kuda, M Svobodova, M Rossmeisl, G Tsenov, V Mohamed-Ali, J Kopecky. Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids. Diabetologia. 2011 Oct; 54(10):2626-38. doi: 10.1007/s00125-011-2233-2. [PMID: 21779874]
  • Sueleyman Bilal, Oliver Haworth, Lijun Wu, Karsten H Weylandt, Bruce D Levy, Jing X Kang. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. Biochimica et biophysica acta. 2011 Sep; 1812(9):1164-9. doi: 10.1016/j.bbadis.2011.05.002. [PMID: 21616147]
  • Alberto E Musto, Per Gjorstrup, Nicolas G Bazan. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia. 2011 Sep; 52(9):1601-8. doi: 10.1111/j.1528-1167.2011.03081.x. [PMID: 21569016]
  • David T Stark, Nicolas G Bazan. Neuroprotectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models. Molecular neurobiology. 2011 Apr; 43(2):131-8. doi: 10.1007/s12035-011-8174-4. [PMID: 21431475]
  • Tomohiro Yamada, Yukako Tani, Hiroki Nakanishi, Ryo Taguchi, Makoto Arita, Hiroyuki Arai. Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011 Feb; 25(2):561-8. doi: 10.1096/fj.10-170027. [PMID: 20959515]
  • Yuhai Zhao, Frederic Calon, Carl Julien, Jeremy W Winkler, Nicos A Petasis, Walter J Lukiw, Nicolas G Bazan. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. PloS one. 2011 Jan; 6(1):e15816. doi: 10.1371/journal.pone.0015816. [PMID: 21246057]
  • Natalie A Halapin, Nicolas G Bazan. NPD1 induction of retinal pigment epithelial cell survival involves PI3K/Akt phosphorylation signaling. Neurochemical research. 2010 Dec; 35(12):1944-7. doi: 10.1007/s11064-010-0351-8. [PMID: 21136150]
  • Nicolas G Bazan, Jorgelina M Calandria, Charles N Serhan. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. Journal of lipid research. 2010 Aug; 51(8):2018-31. doi: 10.1194/jlr.r001131. [PMID: 20382842]
  • R Palacios-Pelaez, Walter J Lukiw, Nicolas G Bazan. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Molecular neurobiology. 2010 Jun; 41(2-3):367-74. doi: 10.1007/s12035-010-8139-z. [PMID: 20467837]
  • Tiffany D Niemoller, Nicolas G Bazan. Docosahexaenoic acid neurolipidomics. Prostaglandins & other lipid mediators. 2010 Apr; 91(3-4):85-9. doi: 10.1016/j.prostaglandins.2009.09.005. [PMID: 19804838]
  • Kristopher G Sheets, Yongdong Zhou, Monica K Ertel, Eric J Knott, Cornelius E Regan, Jasmine R Elison, William C Gordon, Per Gjorstrup, Nicolas G Bazan. Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse. Molecular vision. 2010 Mar; 16(?):320-9. doi: ". [PMID: 20216940]
  • Jorgelina M Calandria, Nicolas G Bazan. Neuroprotectin D1 modulates the induction of pro-inflammatory signaling and promotes retinal pigment epithelial cell survival during oxidative stress. Advances in experimental medicine and biology. 2010; 664(?):663-70. doi: 10.1007/978-1-4419-1399-9_76. [PMID: 20238071]
  • Victor L Marcheselli, Pranab K Mukherjee, Makoto Arita, Song Hong, Rajee Antony, Kristopher Sheets, Jeremy W Winkler, Nicos A Petasis, Charles N Serhan, Nicolas G Bazan. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins, leukotrienes, and essential fatty acids. 2010 Jan; 82(1):27-34. doi: 10.1016/j.plefa.2009.10.010. [PMID: 19931440]
  • Gerard L Bannenberg. Resolvins: Current understanding and future potential in the control of inflammation. Current opinion in drug discovery & development. 2009 Sep; 12(5):644-58. doi: ". [PMID: 19736623]
  • Jorgelina M Calandria, Victor L Marcheselli, Pranab K Mukherjee, Jasim Uddin, Jeremy W Winkler, Nicos A Petasis, Nicolas G Bazan. Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. The Journal of biological chemistry. 2009 Jun; 284(26):17877-82. doi: 10.1074/jbc.m109.003988. [PMID: 19403949]
  • Ana González-Périz, Raquel Horrillo, Natàlia Ferré, Karsten Gronert, Baiyan Dong, Eva Morán-Salvador, Esther Titos, Marcos Martínez-Clemente, Marta López-Parra, Vicente Arroyo, Joan Clària. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 Jun; 23(6):1946-57. doi: 10.1096/fj.08-125674. [PMID: 19211925]
  • Nicolas G Bazan. Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease. Journal of lipid research. 2009 Apr; 50 Suppl(?):S400-5. doi: 10.1194/jlr.r800068-jlr200. [PMID: 19018037]
  • Iram R Hassan, Karsten Gronert. Acute changes in dietary omega-3 and omega-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1. Journal of immunology (Baltimore, Md. : 1950). 2009 Mar; 182(5):3223-32. doi: 10.4049/jimmunol.0802064. [PMID: 19234220]
  • Charles N Serhan, Rong Yang, Kimberly Martinod, Kie Kasuga, Padmini S Pillai, Timothy F Porter, Sungwhan F Oh, Matthew Spite. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. The Journal of experimental medicine. 2009 Jan; 206(1):15-23. doi: 10.1084/jem.20081880. [PMID: 19103881]
  • Qiong Qin, Kiran A Patil, Karsten Gronert, Sansar C Sharma. Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy. Prostaglandins, leukotrienes, and essential fatty acids. 2008 Dec; 79(6):201-7. doi: 10.1016/j.plefa.2008.09.022. [PMID: 19019647]
  • Aksam J Merched, Kerry Ko, Katherine H Gotlinger, Charles N Serhan, Lawrence Chan. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Oct; 22(10):3595-606. doi: 10.1096/fj.08-112201. [PMID: 18559988]
  • Charles N Serhan. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. Journal of periodontology. 2008 Aug; 79(8 Suppl):1520-6. doi: 10.1902/jop.2008.080231. [PMID: 18673006]
  • Yangxin Chen, Jingfeng Wang, Ruqiong Nie, Shuxian Zhou. Endogenous pro-resolving and anti-inflammatory lipid mediators: the new hope of atherosclerotic diseases. Medical hypotheses. 2008 Aug; 71(2):237-40. doi: 10.1016/j.mehy.2008.03.026. [PMID: 18448265]
  • Nicolas G Bazan. Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. Advances in experimental medicine and biology. 2008; 613(?):39-44. doi: 10.1007/978-0-387-74904-4_3. [PMID: 18188926]
  • P K Mukherjee, A Chawla, M S Loayza, N G Bazan. Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. Prostaglandins, leukotrienes, and essential fatty acids. 2007 Nov; 77(5-6):233-8. doi: 10.1016/j.plefa.2007.10.022. [PMID: 18060755]
  • Pranab K Mukherjee, Victor L Marcheselli, Sebastian Barreiro, Jane Hu, Dean Bok, Nicolas G Bazan. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proceedings of the National Academy of Sciences of the United States of America. 2007 Aug; 104(32):13152-7. doi: 10.1073/pnas.0705949104. [PMID: 17670936]
  • Pranab K Mukherjee, Victor L Marcheselli, Juan Carlos de Rivero Vaccari, William C Gordon, Fannie E Jackson, Nicolas G Bazan. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. Proceedings of the National Academy of Sciences of the United States of America. 2007 Aug; 104(32):13158-63. doi: 10.1073/pnas.0705963104. [PMID: 17670935]
  • Karsten H Weylandt, Jing X Kang, Bertram Wiedenmann, Daniel C Baumgart. Lipoxins and resolvins in inflammatory bowel disease. Inflammatory bowel diseases. 2007 Jun; 13(6):797-9. doi: 10.1002/ibd.20109. [PMID: 17262807]
  • Song Hong, Yan Lu, Rong Yang, Katherine H Gotlinger, Nicos A Petasis, Charles N Serhan. Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. Journal of the American Society for Mass Spectrometry. 2007 Jan; 18(1):128-44. doi: 10.1016/j.jasms.2006.09.002. [PMID: 17055291]
  • Ana González-Périz, Anna Planagumà, Karsten Gronert, Rosa Miquel, Marta López-Parra, Esther Titos, Raquel Horrillo, Natàlia Ferré, Ramon Deulofeu, Vicente Arroyo, Juan Rodés, Joan Clària. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Dec; 20(14):2537-9. doi: 10.1096/fj.06-6250fje. [PMID: 17056761]
  • Igor A Butovich, Svetlana M Lukyanova, Carl Bachmann. Dihydroxydocosahexaenoic acids of the neuroprotectin D family: synthesis, structure, and inhibition of human 5-lipoxygenase. Journal of lipid research. 2006 Nov; 47(11):2462-74. doi: 10.1194/jlr.m600280-jlr200. [PMID: 16899822]
  • Jeremy S Duffield, Song Hong, Vishal S Vaidya, Yan Lu, Gabrielle Fredman, Charles N Serhan, Joseph V Bonventre. Resolvin D series and protectin D1 mitigate acute kidney injury. Journal of immunology (Baltimore, Md. : 1950). 2006 Nov; 177(9):5902-11. doi: 10.4049/jimmunol.177.9.5902. [PMID: 17056514]
  • Nicolas G Bazan. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cellular and molecular neurobiology. 2006 Jul; 26(4-6):901-13. doi: 10.1007/s10571-006-9064-6. [PMID: 16897369]
  • Nicolas G Bazan. Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. Advances in experimental medicine and biology. 2006; 572(?):531-40. doi: 10.1007/0-387-32442-9_74. [PMID: 17249620]
  • Amiram Ariel, Pin-Lan Li, Wei Wang, Wang-Xian Tang, Gabrielle Fredman, Song Hong, Katherine H Gotlinger, Charles N Serhan. The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. The Journal of biological chemistry. 2005 Dec; 280(52):43079-86. doi: 10.1074/jbc.m509796200. [PMID: 16216871]
  • Igor A Butovich. On the structure and synthesis of neuroprotectin D1, a novel anti-inflammatory compound of the docosahexaenoic acid family. Journal of lipid research. 2005 Nov; 46(11):2311-4. doi: 10.1194/jlr.c500015-jlr200. [PMID: 16150835]
  • Nicolas G Bazan, Victor L Marcheselli, Kasie Cole-Edwards. Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Annals of the New York Academy of Sciences. 2005 Aug; 1053(?):137-47. doi: 10.1196/annals.1344.011. [PMID: 16179516]
  • Nicolas G Bazan. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Molecular neurobiology. 2005 Aug; 32(1):89-103. doi: 10.1385/mn:32:1:089. [PMID: 16077186]
  • Karsten Gronert, Neha Maheshwari, Nabeela Khan, Iram R Hassan, Michael Dunn, Michal Laniado Schwartzman. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. The Journal of biological chemistry. 2005 Apr; 280(15):15267-78. doi: 10.1074/jbc.m410638200. [PMID: 15708862]
  • Nicolas G Bazan. Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain pathology (Zurich, Switzerland). 2005 Apr; 15(2):159-66. doi: 10.1111/j.1750-3639.2005.tb00513.x. [PMID: 15912889]
  • Pranab K Mukherjee, Victor L Marcheselli, Charles N Serhan, Nicolas G Bazan. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jun; 101(22):8491-6. doi: 10.1073/pnas.0402531101. [PMID: 15152078]