FA 18:3;O4 (BioDeep_00000629528)
代谢物信息卡片
化学式: C18H30O6 (342.204228)
中文名称: 2,3-二正凝血噁烷 B2
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1[C@H](O)[C@H](C/C=C\CC(=O)O)[C@@H](/C=C/[C@@H](O)CCCCC)OC1O
InChI: InChI=1S/C18H30O6/c1-2-3-4-5-12(19)6-8-14-15(17(22)11-16(14)21)10-13(20)7-9-18(23)24/h6,8,12,14-17,19,21-22H,2-5,7,9-11H2,1H3,(H,23,24)/b8-6+/t12-,14+,15+,16+,17-/m0/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:89991
- PubChem: 5283138
- LipidMAPS: LMFA03030003
- LipidMAPS: LMFA03010089
- CAS: 63250-09-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Crystal M Hoh, Stephanie A Smith, Maureen A McMichael, Julie K Byron. Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs.
American journal of veterinary research.
2011 Aug; 72(8):1038-45. doi:
10.2460/ajvr.72.8.1038
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Basic & clinical pharmacology & toxicology.
2009 Apr; 104(4):322-8. doi:
10.1111/j.1742-7843.2008.00361.x
. [PMID: 19175368] - L Zhao, T Ding, T Cyrus, Y Cheng, H Tian, M Ma, R Falotico, D Praticò. Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor.
British journal of pharmacology.
2009 Mar; 156(5):774-85. doi:
10.1111/j.1476-5381.2008.00080.x
. [PMID: 19220291] - Frazer J Lowe, Evan O Gregg, Michael McEwan. Evaluation of biomarkers of exposure and potential harm in smokers, former smokers and never-smokers.
Clinical chemistry and laboratory medicine.
2009; 47(3):311-20. doi:
10.1515/cclm.2009.069
. [PMID: 19676143] - Jennifer C Sullivan, Jennifer M Sasser, David M Pollock, Jennifer S Pollock. Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2005 Mar; 45(3):406-11. doi:
10.1161/01.hyp.0000156879.83448.93
. [PMID: 15699443] - Pertti Saloheimo, Seppo Juvela, Asko Riutta, Juhani Pyhtinen, Matti Hillbom. Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage.
Thrombosis research.
2005; 115(5):367-73. doi:
10.1016/j.thromres.2004.08.026
. [PMID: 15733969] - D O Stichtenoth, F J Kreutzer, F M Gutzki, D Tsikas, V Nowak, J C Frölich. Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease.
Prostaglandins, leukotrienes, and essential fatty acids.
2001 Oct; 65(4):211-4. doi:
10.1054/plef.2001.0313
. [PMID: 11728174] - R Kaaja, V Pettilä, P Leinonen, O Ylikorkala. Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins.
British journal of haematology.
2001 Sep; 114(3):655-9. doi:
10.1046/j.1365-2141.2001.03001.x
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Brain research bulletin.
2001 Mar; 54(5):565-8. doi:
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. [PMID: 11397549] - D Praticò, C Tillmann, Z B Zhang, H Li, G A FitzGerald. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America.
2001 Mar; 98(6):3358-63. doi:
10.1073/pnas.061607398
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Blood.
2000 Dec; 96(12):3823-6. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2000 Oct; 63(4):209-15. doi:
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. [PMID: 11049696] - D Tsikas, F M Gutzki, M Böhme, I Fuchs, J C Frölich. Solid- and liquid-phase extraction for the gas chromatographic-tandem mass spectrometric quantification of 2,3-dinor-thromboxane B2 and 2,3-dinor-6-oxo-prostaglandin F1 alpha in human urine.
Journal of chromatography. A.
2000 Jul; 885(1-2):351-9. doi:
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Stroke.
2000 Jun; 31(6):1269-73. doi:
10.1161/01.str.31.6.1269
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Prostaglandins & other lipid mediators.
1999 Nov; 58(5-6):285-90. doi:
10.1016/s0090-6980(99)00043-x
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Lipids.
1999; 34 Suppl(?):S317. doi:
10.1007/bf02562331
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Thrombosis and haemostasis.
1998 Oct; 80(4):649-55. doi:
NULL
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Thrombosis and haemostasis.
1998 Apr; 79(4):747-51. doi:
10.1055/s-0037-1615058
. [PMID: 9569186] - S M Bode-Böger, R H Böger, S Kienke, M Böhme, L Phivthong-ngam, D Tsikas, J C Frölich. Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo.
Cardiovascular research.
1998 Mar; 37(3):756-64. doi:
10.1016/s0008-6363(97)00295-2
. [PMID: 9659460] - J M Moutquin, C Lindsay, N Arial, P De Grandpré, R C-Gaudreault, J C Forest, J Massé. Do prostacyclin and thromboxane contribute to the 'protective effect' of pregnancies with chronic hypertension? A preliminary prospective longitudinal study.
American journal of obstetrics and gynecology.
1997 Dec; 177(6):1483-90. doi:
10.1016/s0002-9378(97)70095-4
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Prostaglandins.
1997 Sep; 54(3):655-64. doi:
10.1016/s0090-6980(97)00131-7
. [PMID: 9373880] - M Tulppala, M Marttunen, V Söderstrom-Anttila, T Foudila, K Ailus, T Palosuo, O Ylikorkala. Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production.
Human reproduction (Oxford, England).
1997 Jul; 12(7):1567-72. doi:
10.1093/humrep/12.7.1567
. [PMID: 9262298] - D Henrion, E Dechaux, F J Dowell, J Maclour, J L Samuel, B I Lévy, J B Michel. Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2.
British journal of pharmacology.
1997 May; 121(1):83-90. doi:
10.1038/sj.bjp.0701109
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Atherosclerosis.
1997 May; 131(1):97-106. doi:
10.1016/s0021-9150(97)06087-5
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The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
1996 Oct; 15(10):999-1004. doi:
NULL
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The Journal of laboratory and clinical medicine.
1996 Jul; 128(1):115-21. doi:
10.1016/s0022-2143(96)90120-1
. [PMID: 8759943] - J Nowak, L Barregård, G Benthin, G Granung, A Wennmalm. Thromboxane metabolite excretion in patients with hand-arm vibration syndrome.
Clinical physiology (Oxford, England).
1996 Jul; 16(4):361-7. doi:
10.1111/j.1475-097x.1996.tb00725.x
. [PMID: 8842572] - G Laffi, S Cinotti, E Filimberti, G Ciabattoni, R Caporale, F Marra, L Melani, A Grossi, V Carloni, P Gentilini. Defective aggregation in cirrhosis is independent of in vivo platelet activation.
Journal of hepatology.
1996 Apr; 24(4):436-43. doi:
10.1016/s0168-8278(96)80164-4
. [PMID: 8738730] - P Pancera, E Arosio, P Minuz, F Pirante, M Ribul, A Lechi. Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients.
Prostaglandins, leukotrienes, and essential fatty acids.
1996 Mar; 54(3):217-22. doi:
10.1016/s0952-3278(96)90020-4
. [PMID: 8860111] - R M van der Weiden, F M Helmerhorst, M J Keirse. Prostanoid excretion before in vitro fertilization relates to the likelihood of pregnancy.
Prostaglandins, leukotrienes, and essential fatty acids.
1995 Dec; 53(6):419-21. doi:
10.1016/0952-3278(95)90106-x
. [PMID: 8821123] - R T Mathie, J S Fleming, S E Barrow, J V Arnold, J J Brannan, J M Becket, J M Ritter, K M Taylor. The haemodynamic effects of the thromboxane A2 receptor antagonist GR32191B during cardiopulmonary bypass in the dog.
Perfusion.
1995 Nov; 10(6):403-13. doi:
10.1177/026765919501000604
. [PMID: 8747897] - D O Stichtenoth, N Selve, D Tsikas, F M Gutzki, J C Frölich. Increased total body synthesis of prostacyclin in rats with adjuvant arthritis.
Prostaglandins.
1995 Nov; 50(5-6):331-40. doi:
10.1016/0090-6980(95)00137-9
. [PMID: 8838242] - I Rauramo, S Ilmonen, L Viinikka, O Ylikorkala. Prostacyclin and thromboxane in pregnant and nonpregnant women in response to exercise.
Obstetrics and gynecology.
1995 Jun; 85(6):1027-30. doi:
10.1016/0029-7844(95)00048-v
. [PMID: 7770249] - R H Böger, S M Bode-Böger, E P Schröder, D Tsikas, J C Frölich. Increased prostacyclin production during exercise in untrained and trained men: effect of low-dose aspirin.
Journal of applied physiology (Bethesda, Md. : 1985).
1995 May; 78(5):1832-8. doi:
10.1152/jappl.1995.78.5.1832
. [PMID: 7649919] - G Rasmanis, O Vesterqvist, K Gréen, P Henriksson. Implications of the prognostic importance of exercise-induced thromboxane formation in survivors of an acute myocardial infarction.
Prostaglandins.
1995 Apr; 49(4):247-53. doi:
10.1016/0090-6980(95)00019-7
. [PMID: 7667506] - M Kawamura, Y Harada, M Katori. Evaluation of plasma 11-dehydro-thromboxane B2 as an indicator for thromboxane A2 synthesis in vivo in laboratory animals.
Thrombosis research.
1995 Mar; 77(5):465-74. doi:
10.1016/0049-3848(95)93882-z
. [PMID: 7778061] - J Roselló-Catafau, G Hotter, D Closa, M A Ortiz, J M Pou-Torello, M Gimeno, G Bioque, E Gelpí. Liver lipoxygenase arachidonic acid metabolites in streptozotocin-induced diabetes in rats.
Prostaglandins, leukotrienes, and essential fatty acids.
1994 Dec; 51(6):411-3. doi:
10.1016/0952-3278(94)90057-4
. [PMID: 7708806] - R Landolfi, E De Candia, B Rocca, G Ciabattoni, A Antinori, R Masetti, C Patrono. Effects of unfractionated and low molecular weight heparins on platelet thromboxane biosynthesis 'in vivo'.
Thrombosis and haemostasis.
1994 Dec; 72(6):942-6. doi:
10.1055/s-0038-1648988
. [PMID: 7740468] - I Adatia, S E Barrow, P D Stratton, J M Ritter, S G Haworth. Effect of intracardiac repair on biosynthesis of thromboxane A2 and prostacyclin in children with a left to right shunt.
British heart journal.
1994 Nov; 72(5):452-6. doi:
10.1136/hrt.72.5.452
. [PMID: 7818962] - C Prakash, G J Nelson, M M Wu, P C Schmidt, M A Phillips, I A Blair. Decreased systemic thromboxane A2 biosynthesis in normal human subjects fed a salmon-rich diet.
The American journal of clinical nutrition.
1994 Sep; 60(3):369-73. doi:
10.1093/ajcn/60.3.369
. [PMID: 8074067] - J Kurantsin-Mills, B O Ibe, C L Natta, J U Raj, R S Siegel, L S Lessin. Elevated urinary levels of thromboxane and prostacyclin metabolities in sickle cell disease reflects activated platelets in the circulation.
British journal of haematology.
1994 Jul; 87(3):580-5. doi:
10.1111/j.1365-2141.1994.tb08316.x
. [PMID: 7993800] - J Neiman, J Nowak, G Benthin, H Numminen, M Hillbom. Increased urinary excretion of a major thromboxane metabolite in early alcohol withdrawal.
Clinical physiology (Oxford, England).
1994 Jul; 14(4):405-9. doi:
10.1111/j.1475-097x.1994.tb00399.x
. [PMID: 7955938] - B J O'Connor, S Uden, T J Carty, J D Eskra, P J Barnes, K F Chung. Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans.
American journal of respiratory and critical care medicine.
1994 Jul; 150(1):35-40. doi:
10.1164/ajrccm.150.1.8025768
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Prostaglandins.
1994 Jun; 47(6):409-22. doi:
10.1016/0090-6980(94)90042-6
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Biochimica et biophysica acta.
1994 Apr; 1226(1):44-8. doi:
10.1016/0925-4439(94)90057-4
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Prostaglandins.
1994 Apr; 47(4):293-306. doi:
10.1016/0090-6980(94)90024-8
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Journal of chromatography.
1994 Feb; 652(2):221-7. doi:
10.1016/0378-4347(93)e0408-i
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Journal of internal medicine.
1994 Feb; 235(2):153-61. doi:
10.1111/j.1365-2796.1994.tb01049.x
. [PMID: 8308478] - J Fauler, A Thon, D Tsikas, H von der Hardt, J C Frölich. Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis.
Arthritis and rheumatism.
1994 Jan; 37(1):93-7. doi:
10.1002/art.1780370114
. [PMID: 8129769] - S R Smith, V B Kubacki, A Rakhit, L L Martin, A V Schaffer, M K Jasani, D J Hefty, T Johnston, C Cannon, W M Bennett. Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity.
Transplantation.
1993 Dec; 56(6):1422-6. doi:
10.1097/00007890-199312000-00029
. [PMID: 8279014] - R Djurup, C Chiabrando, A Jörres, R Fanelli, M Foegh, H U Soerensen, P N Joergensen. Rapid, direct enzyme immunoassay of 11-keto-thromboxane B2 in urine, validated by immunoaffinity/gas chromatography-mass spectrometry.
Clinical chemistry.
1993 Dec; 39(12):2470-7. doi:
10.1093/clinchem/39.12.2470
. [PMID: 8252718] - I Adatia, S E Barrow, P D Stratton, V M Miall-Allen, J M Ritter, S G Haworth. Thromboxane A2 and prostacyclin biosynthesis in children and adolescents with pulmonary vascular disease.
Circulation.
1993 Nov; 88(5 Pt 1):2117-22. doi:
10.1161/01.cir.88.5.2117
. [PMID: 8222105] - D Hofmann, C W Hamm, R L Lorenz, W Terres, P C Weber. Evidence for sustained platelet activation in patients with early postinfarction angina.
Thrombosis research.
1993 Oct; 72(2):139-43. doi:
10.1016/0049-3848(93)90215-a
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Circulation.
1993 Aug; 88(2):556-61. doi:
10.1161/01.cir.88.2.556
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Journal of internal medicine.
1993 Jul; 234(1):9-15. doi:
10.1111/j.1365-2796.1993.tb00698.x
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Prostaglandins.
1993 May; 45(5):401-11. doi:
10.1016/0090-6980(93)90117-p
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The American journal of clinical nutrition.
1993 Feb; 57(2):154-60. doi:
10.1093/ajcn/57.2.154
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British heart journal.
1993 Feb; 69(2):179-82. doi:
10.1136/hrt.69.2.179
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American journal of obstetrics and gynecology.
1993 Jan; 168(1 Pt 1):84-7. doi:
10.1016/s0002-9378(12)90890-x
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Digestive diseases and sciences.
1993 Jan; 38(1):33-8. doi:
10.1007/bf01296770
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Zentralblatt fur Gynakologie.
1993; 115(4):163-6. doi:
NULL
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Thrombosis and haemostasis.
1992 Nov; 68(5):583-8. doi:
. [PMID: 1455405]
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Circulation.
1992 Nov; 86(5):1495-500. doi:
10.1161/01.cir.86.5.1495
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Blood.
1992 Oct; 80(8):1965-71. doi:
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The New England journal of medicine.
1992 Jul; 327(2):70-5. doi:
10.1056/nejm199207093270202
. [PMID: 1603138] - A Leonhardt, C Busch, H Schweer, H W Seyberth. Reference intervals and developmental changes in urinary prostanoid excretion in healthy newborns, infants and children.
Acta paediatrica (Oslo, Norway : 1992).
1992 Mar; 81(3):191-6. doi:
10.1111/j.1651-2227.1992.tb12202.x
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Nihon rinsho. Japanese journal of clinical medicine.
1992 Feb; 50(2):349-54. doi:
NULL
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Transactions of the Association of American Physicians.
1992; 105(?):149-56. doi:
NULL
. [PMID: 1308991] - T Kurki, L Viinikka, O Ylikorkala. Urinary excretion of prostacyclin and thromboxane metabolites in threatened preterm labor: effect of indomethacin and nylidrin.
American journal of obstetrics and gynecology.
1992 Jan; 166(1 Pt 1):150-4. doi:
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