FA 16:4;O5 (BioDeep_00000629502)

   


代谢物信息卡片


9S-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid

化学式: C16H24O7 (328.1521954)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(C(C1=O)CCC(=O)CCCCC(=O)O)CCC(=O)O)O
InChI: InChI=1S/C16H24O7/c17-10(3-1-2-4-15(20)21)5-6-11-12(7-8-16(22)23)14(19)9-13(11)18/h11-13,18H,1-9H2,(H,20,21)(H,22,23)/t11-,12-,13-/m1/s1

描述信息

同义名列表

6 个代谢物同义名

9S-hydroxy-11,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid; tetranor-PGDM; FA 16:4;O5; 11R-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostan-1,20-dioic acid; Tetranor-Prostaglandin EM; tetranor-PGEM



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mami Ishibashi, Tomohiro Oiwa, Takashi Nomura, Yoshiaki Yoshikawa, Hironori Niizeki, Kenji Kabashima. Role of Prostaglandin E-Major Urinary Metabolite Levels in Identifying the Phenotype of Pachydermoperiostosis. The Journal of investigative dermatology. 2021 12; 141(12):2973-2975. doi: 10.1016/j.jid.2021.04.025. [PMID: 34089722]
  • Natsuki Ishida, Kiichi Sugiura, Takahiro Miyazu, Satoshi Tamura, Satoshi Suzuki, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Ken Sugimoto. Prostaglandin E-Major Urinary Metabolite Predicts Relapse in Patients With Ulcerative Colitis in Clinical Remission. Clinical and translational gastroenterology. 2020 12; 11(12):e00289. doi: 10.14309/ctg.0000000000000289. [PMID: 33512810]
  • Yuichi Matsuno, Junji Umeno, Motohiro Esaki, Yoichiro Hirakawa, Yuta Fuyuno, Yasuharu Okamoto, Atsushi Hirano, Shigeyoshi Yasukawa, Fumihito Hirai, Toshiyuki Matsui, Shuhei Hosomi, Kenji Watanabe, Naoki Hosoe, Haruhiko Ogata, Tadakazu Hisamatsu, Shunichi Yanai, Shuji Kochi, Koichi Kurahara, Tsuneyoshi Yao, Takehiro Torisu, Takanari Kitazono, Takayuki Matsumoto. Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations. World journal of gastroenterology. 2019 Apr; 25(14):1753-1763. doi: 10.3748/wjg.v25.i14.1753. [PMID: 31011259]
  • Shin-Ichiro Hagiwara, Isao Okayasu, Mutsunori Fujiwara, Masaaki Matsuura, Hiromitsu Ohnishi, Satoru Ito, Hiroshi Kishimoto, Ryusuke Nambu, Seiichi Kagimoto. Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity. Journal of pediatric gastroenterology and nutrition. 2017 06; 64(6):955-961. doi: 10.1097/mpg.0000000000001477. [PMID: 27906804]
  • Dimitrios Tsikas. GC-ECNICI-MS/MS of eicosanoids as pentafluorobenzyl-trimethylsilyl (TMS) derivatives: Evidence of CAD-induced intramolecular TMS ether-to-ester rearrangement using carboxy-18O-labelled eicosanoids and possible implications in quantitative analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Mar; 1047(?):185-196. doi: 10.1016/j.jchromb.2016.06.018. [PMID: 27352806]
  • Tsugumi Horikiri, Hiromichi Hara, Nayuta Saito, Jun Araya, Naoki Takasaka, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Yutaka Yoshii, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Kenichiro Shimizu, Takanori Numata, Seiji Arihiro, Yumi Kaneko, Katsutoshi Nakayama, Tomokazu Matsuura, Masaaki Matsuura, Mutsunori Fujiwara, Isao Okayasu, Satoru Ito, Kazuyoshi Kuwano. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia. Respiratory medicine. 2017 01; 122(?):43-50. doi: 10.1016/j.rmed.2016.11.017. [PMID: 27993290]
  • Yoshinori Arai, Tomokazu Matsuura, Masaaki Matsuura, Mutsunori Fujiwara, Isao Okayasu, Satoru Ito, Seiji Arihiro. Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis: Prostaglandins Revisited. Digestion. 2016; 93(1):32-9. doi: 10.1159/000441665. [PMID: 26788915]
  • Saki Kakutani, Yoshiyuki Ishikura, Norifumi Tateishi, Chika Horikawa, Hisanori Tokuda, Masanori Kontani, Hiroshi Kawashima, Yutaka Sakakibara, Yoshinobu Kiso, Hiroshi Shibata, Ikuo Morita. Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: a randomized controlled study. Lipids in health and disease. 2011 Dec; 10(?):241. doi: 10.1186/1476-511x-10-241. [PMID: 22188761]
  • Marek Sanak, Anna Gielicz, Krzysztof Nagraba, Marek Kaszuba, Jagoda Kumik, Andrew Szczeklik. Targeted eicosanoids lipidomics of exhaled breath condensate in healthy subjects. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jul; 878(21):1796-800. doi: 10.1016/j.jchromb.2010.05.012. [PMID: 20627827]
  • Linda M Dong, Xiao-Ou Shu, Yu-Tang Gao, Ginger Milne, Bu-Tian Ji, Gong Yang, Hong-Lan Li, Nathaniel Rothman, Wei Zheng, Wong-Ho Chow, Christian C Abnet. Urinary prostaglandin E2 metabolite and gastric cancer risk in the Shanghai women's health study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009 Nov; 18(11):3075-8. doi: 10.1158/1055-9965.epi-09-0680. [PMID: 19861525]
  • Robert Mutter, Bo Lu, David P Carbone, Ildiko Csiki, Luigi Moretti, David H Johnson, Jason D Morrow, Alan B Sandler, Yu Shyr, Fei Ye, Hak Choy. A phase II study of celecoxib in combination with paclitaxel, carboplatin, and radiotherapy for patients with inoperable stage IIIA/B non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Mar; 15(6):2158-65. doi: 10.1158/1078-0432.ccr-08-0629. [PMID: 19276291]
  • Ildiko Csiki, Jason D Morrow, Alan Sandler, Yu Shyr, John Oates, Myles K Williams, Thao Dang, David P Carbone, David H Johnson. Targeting cyclooxygenase-2 in recurrent non-small cell lung cancer: a phase II trial of celecoxib and docetaxel. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Sep; 11(18):6634-40. doi: 10.1158/1078-0432.ccr-05-0436. [PMID: 16166442]
  • Laine J Murphey, Myles K Williams, Stephanie C Sanchez, Loretta M Byrne, Ildiko Csiki, John A Oates, David H Johnson, Jason D Morrow. Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Analytical biochemistry. 2004 Nov; 334(2):266-75. doi: 10.1016/j.ab.2004.08.019. [PMID: 15494133]
  • M Fujiwara, I Okayasu, M Oritsu, J Komatsu, M Yoshitsugu, Y Katoh, T Bandoh, H Toyoshima, Y Kase, K Sugihara, J Kanno, Y Hayashi. Significant increase in prostaglandin E-main urinary metabolite by laxative administration: comparison with ulcerative colitis. Digestion. 2000; 61(3):201-6. doi: 10.1159/000007758. [PMID: 10773726]
  • A Nishikawa, Y Kase, T Hayakawa, T Yanagisawa, J Kanno, Y Hayashi. Enhancement of cell proliferation and prostaglandin biosynthesis by 1,8-dihydroxyanthraquinone in the rat large intestine. Carcinogenesis. 1997 Jun; 18(6):1259-63. doi: 10.1093/carcin/18.6.1259. [PMID: 9214611]
  • H Schweer, C O Meese, H W Seyberth. Determination of 11 alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostan oic acid and 9 alpha,11 alpha-dihydroxy-15-oxo-2,3,4,5,20-pentanor-19-carboxyprostanoi c acid by gas chromatography/negative ion chemical ionization triple-stage quadrupole mass spectrometry. Analytical biochemistry. 1990 Aug; 189(1):54-8. doi: 10.1016/0003-2697(90)90043-9. [PMID: 2278391]
  • U Förstermann, T J Feuerstein. Decreased systemic formation of prostaglandin E and prostacyclin, and unchanged thromboxane formation, in alcoholics during withdrawal as estimated from metabolites in urine. Clinical science (London, England : 1979). 1987 Sep; 73(3):277-83. doi: 10.1042/cs0730277. [PMID: 3308287]
  • A Ferretti, V P Flanagan, J M Roman. Quantitative analysis of 11 alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid, the major urinary metabolite of E prostaglandins in man. Analytical biochemistry. 1983 Feb; 128(2):351-8. doi: 10.1016/0003-2697(83)90385-8. [PMID: 6846812]