FA 18:1;O2 (BioDeep_00000629098)

Main id: BioDeep_00000018475

Secondary id: BioDeep_00000006488, BioDeep_00000405363, BioDeep_00000629076

PANOMIX_OTCML-2023


代谢物信息卡片


9-Octadecenoic acid, 12,13-dihydroxy-, (9Z,12S,13S)-

化学式: C18H34O4 (314.2456964)
中文名称: 十八烷二酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.46%

分子结构信息

SMILES: C(/C=C/C(O)CCCCC)C(O)CCCCCCCC(=O)O
InChI: InChI=1S/C18H34O4/c19-17(20)15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18(21)22/h1-16H2,(H,19,20)(H,21,22)

描述信息

Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome[1].
Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome[1].

同义名列表

39 个代谢物同义名

7,10-dihydroxy-8E-octadecenoic acid; FA 18:1;O2; 9-Octadecenoic acid, 12,13-dihydroxy-, (9Z,12S,13S)-; 12S,13S-dihydroxy-9Z-Octadecenoic acid; 12,13-Dihydroxyoleic acid; (9Z)-(7S,8S)-Dihydroxyoctadecenoic acid; 7S,8S-dihydroxy-9Z-octadecenoic acid; (7S,8S)-dihydroxyoleic acid; 7S,8S-DiHOME(9Z); 7S,8S-DiHOME; 12,13-dihydroxy-9-octadecenoic acid; 12,13-DiHOME(9); 9,13-dihydroxy-11-octadecenoic acid; 9,13-DiHOME(11); 9,13-dihydroxy-10-octadecenoic acid; 9,13-DiHOME(10); 9,10-dihydroxy-12-octadecenoic acid; 9,10-DiHOME(12); 8R,11S-dihydroxy-9Z-octadecenoic acid; 8R,11S-DiHOME; 5S,8R-dihydroxy-9Z-octadecenoic acid; 5S,8R-DiHOME; 7S,10S-dihydroxy-8E-octadecenoic acid; 7S,10S-diHOME; 18-hydroxy-9S,10R-epoxy-octadecanoic acid; 18-hydroxy-9S,10R-epoxy-stearic acid; 18-hydroxy-9R,10S-epoxy-octadecanoic acid; 18-hydroxy-9R,10S-epoxy-stearic acid; Octadecanedioic acid; 9-Hydroxy-10-ketooctadecanoic acid; 9-Hydroxy-10-oxooctadecanoic acid; 2-keto-3-hydroxyoctadecanoic acid; 2-oxo-3-hydroxyoctadecanoic acid; Hydroxyketooctadecanoic acid; Hydroxyketostearic acid; 3-Acetoxy-hexadecanoic acid; 3-Acetoxy-palmitic acid; 10-Hydroxy-9-ketooctadecanoic acid; 10-Hydroxy-9-oxooctadecanoic acid



数据库引用编号

47 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • John Paul Savaryn, Xiazi Qiu, David B Duignan, Christian Goess, Sami Osman, Qin C Ji, Gary Jenkins. Fit-for-purpose LC-MS/MS quantification of leukotoxin and leukotoxin diol in mouse plasma without sample pre-concentration. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Aug; 1180(?):122897. doi: 10.1016/j.jchromb.2021.122897. [PMID: 34450476]
  • Kelsey Hildreth, Sean D Kodani, Bruce D Hammock, Ling Zhao. Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies. The Journal of nutritional biochemistry. 2020 12; 86(?):108484. doi: 10.1016/j.jnutbio.2020.108484. [PMID: 32827665]
  • Cassandra E Callmann, Clare L M LeGuyader, Spencer T Burton, Matthew P Thompson, Robert Hennis, Christopher Barback, Niel M Henriksen, Warren C Chan, Matt J Jaremko, Jin Yang, Arnold Garcia, Michael D Burkart, Michael K Gilson, Jeremiah D Momper, Paul A Bertin, Nathan C Gianneschi. Antitumor Activity of 1,18-Octadecanedioic Acid-Paclitaxel Complexed with Human Serum Albumin. Journal of the American Chemical Society. 2019 07; 141(30):11765-11769. doi: 10.1021/jacs.9b04272. [PMID: 31317744]
  • Kai Yu Chen, In Hwan Kim, Ching T Hou, Yomi Watanabe, Hak-Ryul Kim. Monoacylglycerol of 7,10-Dihydroxy-8(E)-octadecenoic Acid Enhances Antibacterial Activities against Food-Borne Bacteria. Journal of agricultural and food chemistry. 2019 Jul; 67(29):8191-8196. doi: 10.1021/acs.jafc.9b03063. [PMID: 31282662]
  • Hye-Ran Sohn, Jae-Han Bae, Ching T Hou, Hak-Ryul Kim. Antibacterial activity of a 7,10-dihydroxy-8(E)-octadecenoic acid against plant pathogenic bacteria. Enzyme and microbial technology. 2013 Aug; 53(3):152-3. doi: 10.1016/j.enzmictec.2013.02.009. [PMID: 23830454]
  • Patricia L Podolin, Brian J Bolognese, Joseph F Foley, Edward Long, Brian Peck, Sandra Umbrecht, Xiaojun Zhang, Penny Zhu, Benjamin Schwartz, Wensheng Xie, Chad Quinn, Hongwei Qi, Sharon Sweitzer, Stephanie Chen, Marc Galop, Yun Ding, Svetlana L Belyanskaya, David I Israel, Barry A Morgan, David J Behm, Joseph P Marino, Edit Kurali, Mary S Barnette, Ruth J Mayer, Catherine L Booth-Genthe, James F Callahan. In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. Prostaglandins & other lipid mediators. 2013 Jul; 104-105(?):25-31. doi: 10.1016/j.prostaglandins.2013.02.001. [PMID: 23434473]
  • Ketul R Chaudhary, Beshay N M Zordoky, Matthew L Edin, Nasser Alsaleh, Ayman O S El-Kadi, Darryl C Zeldin, John M Seubert. Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. Prostaglandins & other lipid mediators. 2013 Jul; 104-105(?):8-17. doi: 10.1016/j.prostaglandins.2012.08.001. [PMID: 22922020]
  • Penny Zhu, Brian Peck, Hermes Licea-Perez, James F Callahan, Catherine Booth-Genthe. Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Sep; 879(25):2487-93. doi: 10.1016/j.jchromb.2011.06.042. [PMID: 21798825]
  • Jung Pyo Lee, Seung Hee Yang, Dong Ki Kim, Hajeong Lee, Bora Kim, Joo-Youn Cho, Kyung-Sang Yu, Jin Ho Paik, Myounghee Kim, Chun Soo Lim, Yon Su Kim. In vivo activity of epoxide hydrolase according to sequence variation affects the progression of human IgA nephropathy. American journal of physiology. Renal physiology. 2011 Jun; 300(6):F1283-90. doi: 10.1152/ajprenal.00733.2010. [PMID: 21429967]
  • Min-Jung Suh, Ka-Yeon Baek, Beom-Soo Kim, Ching T Hou, Hak-Ryul Kim. Production of 7,10-dihydroxy-8(E)-octadecenoic acid from olive oil by Pseudomonas aeruginosa PR3. Applied microbiology and biotechnology. 2011 Mar; 89(6):1721-7. doi: 10.1007/s00253-010-3040-2. [PMID: 21153811]
  • In-Ae Chang, Jae-Han Bae, Min-Jung Suh, In-Hwan Kim, Ching T Hou, Hak-Ryul Kim. Environmental optimization for bioconversion of triolein into 7,10-dihydroxy-8(E)-octadecenoic acid by Pseudomonas aeruginosa PR3. Applied microbiology and biotechnology. 2008 Mar; 78(4):581-6. doi: 10.1007/s00253-007-1342-9. [PMID: 18210104]
  • Vukic Soskic, Gerhard Schwall, Elke Nyakatura, Slobodan Poznanovic, Werner Stegmann, Andre Schrattenholz. Hexadecanedionic acid-sepharose 4B: A new tool for preparation of albumin-depleted plasma. Journal of proteome research. 2006 Dec; 5(12):3453-8. doi: 10.1021/pr060387q. [PMID: 17137348]
  • Tsung Min Kuo, Karen J Ray, Linda K Manthey. A facile reactor process for producing 7,10-dihydroxy-8(E)-octadecenoic acid from oleic acid conversion by Pseudomonas aeruginosa. Biotechnology letters. 2003 Jan; 25(1):29-33. doi: 10.1023/a:1021765727998. [PMID: 12882302]
  • H Sun, J Gao, D A Ferrington, H Biesiada, T D Williams, T C Squier. Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase. Biochemistry. 1999 Jan; 38(1):105-12. doi: 10.1021/bi981295k. [PMID: 9890888]