Dimethyloxalylglycine (BioDeep_00000624958)
代谢物信息卡片
Dimethyloxalylglycine
化学式: C6H9NO5 (175.0480704)
中文名称: 二甲基乙二酰氨基乙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)CNC(=O)C(=O)OC
InChI: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
描述信息
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation?in vitro and in vivo[1]. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG?acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal[2][4]. DMOG induces cell autophagy[5].
同义名列表
3 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:102218
- PubChem: 560326
- Metlin: METLIN96529
- ChEMBL: CHEMBL92309
- CAS: 89464-63-1
- medchemexpress: HY-15893
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kang Qin, Yuan Gui, Yanchun Li, Xinyi Li, Fei Meng, Dianpeng Han, Lianqun Du, Shuang Li, Yu Wang, Huanying Zhou, Hongyuan Yan, Yuan Peng, Zhixian Gao. Biodegradable Microneedle Array-Mediated Transdermal Delivery of Dimethyloxalylglycine-Functionalized Zeolitic Imidazolate Framework-8 Nanoparticles for Bacteria-Infected Wound Treatment.
ACS applied materials & interfaces.
2023 Feb; 15(5):6338-6353. doi:
10.1021/acsami.2c17328. [PMID: 36701257] - Li Chen, Xiao Huang, Hong Chen, Dingsu Bao, Xudong Su, Li Wei, Ning Hu, Wei Huang, Zhou Xiang. Hypoxia-mimicking scaffolds with controlled release of DMOG and PTHrP to promote cartilage regeneration via the HIF-1α/YAP signaling pathway.
International journal of biological macromolecules.
2023 Jan; 226(?):716-729. doi:
10.1016/j.ijbiomac.2022.12.094. [PMID: 36526060] - Xiuan Zeng, Meng Li, Qibing Yang, Qiyuan Wang, Yongxin Chen, Xiangli Luo, Jidong Li, Xu Lan. [Effect of dimethyloxalylglycine on angiogenesis in Choke Ⅱ zone of cross-zone perforator flap and its mechanism].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
2022 Feb; 36(2):224-230. doi:
10.7507/1002-1892.202107103. [PMID: 35172410] - Xiuzhen Lei, Wenbin Teng, Ying Fan, Yeke Zhu, Liuxu Yao, Yuhong Li, Shengmei Zhu. The protective effects of HIF-1α activation on sepsis induced intestinal mucosal barrier injury in rats model of sepsis.
PloS one.
2022; 17(5):e0268445. doi:
10.1371/journal.pone.0268445. [PMID: 35576220] - Mohammad Sanaei-Ardekani, Shyreen Kamal, Whitney Handy, Sidrah Alam, Aya Salaheldin, Anderson Moore, Shahrzad Movafagh. Suppression of collagen IV alpha-2 subunit by prolyl hydroxylase domain inhibition via hypoxia-inducible factor-1 in chronic kidney disease.
Pharmacology research & perspectives.
2021 10; 9(5):e00872. doi:
10.1002/prp2.872. [PMID: 34617686] - Senthilnathan Palaniyandi, Reena Kumari, Sabarinath Venniyil Radhakrishnan, Ethan Strattan, Natalya Hakim, Reinhold Munker, Melissa V Kesler, Gerhard C Hildebrandt. The Prolyl Hydroxylase Inhibitor Dimethyl Oxalyl Glycine Decreases Early Gastrointestinal GVHD in Experimental Allogeneic Hematopoietic Cell Transplantation.
Transplantation.
2020 12; 104(12):2507-2515. doi:
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Aging.
2020 11; 13(1):578-597. doi:
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The Journal of pharmacology and experimental therapeutics.
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Phytochemistry.
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The Journal of clinical investigation.
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Cell death & disease.
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BMC biotechnology.
2014 Dec; 14(?):112. doi:
10.1186/s12896-014-0112-x. [PMID: 25543909] - Hao Ding, You-Shui Gao, Yang Wang, Chen Hu, Yuan Sun, Changqing Zhang. Dimethyloxaloylglycine increases the bone healing capacity of adipose-derived stem cells by promoting osteogenic differentiation and angiogenic potential.
Stem cells and development.
2014 May; 23(9):990-1000. doi:
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Acta biochimica et biophysica Sinica.
2014 Feb; 46(2):112-8. doi:
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American journal of nephrology.
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PloS one.
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2013 Dec; 110(49):E4743-52. doi:
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PloS one.
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The American journal of pathology.
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Pflugers Archiv : European journal of physiology.
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Journal of hepatology.
2012 Feb; 56(2):441-7. doi:
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PloS one.
2012; 7(11):e48952. doi:
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Molecular and cellular biochemistry.
2011 Dec; 358(1-2):287-95. doi:
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British journal of cancer.
2011 Mar; 104(7):1151-9. doi:
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2011 Feb; 406(1):1-8. doi:
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2010 Dec; 299(6):F1365-73. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
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Basic research in cardiology.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Nov; 24(11):3319-25. doi:
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Journal of cellular biochemistry.
2009 Apr; 106(5):903-11. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2008 Dec; 105(50):19898-903. doi:
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2008 Dec; 105(49):19426-31. doi:
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Acta physiologica (Oxford, England).
2007 Jun; 190(2):163-9. doi:
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Microvascular research.
2007 May; 73(3):163-72. doi:
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Molecular biology of the cell.
2006 Apr; 17(4):1549-58. doi:
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