tapentadol (BioDeep_00000624803)
代谢物信息卡片
Tapentadole
化学式: C14H23NO (221.178)
中文名称: 他喷他多
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C1=CC(=CC=C1)O)C(C)CN(C)C
InChI: InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics > N02A - Opioids
D049990 - Membrane Transport Modulators
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135935
- KEGGdrug: D06007
- PubChem: 9838022
- Metlin: METLIN96332
- DrugBank: DB06204
- ChEMBL: CHEMBL1201776
- MeSH: Tapentadol
- CAS: 175591-23-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Claudia Carelli, Francesca Freni, Matteo Moretti, Claudia Vignali, Marco Ballardini, Luca Morini. A case report on fatal intoxication by tapentadol: Study of distribution and metabolism.
Forensic science international.
2021 Jul; 324(?):110825. doi:
10.1016/j.forsciint.2021.110825. [PMID: 34000617] - Abigail Duvall, Thomas N Tully, James W Carpenter, Butch KuKanich, Hugues Beaufrère, Geraldine C Magnin. Pilot Study of a Single Dose of Orally Administered Tapentadol Suspension in Hispaniolan Amazon Parrots (Amazona ventralis).
Journal of avian medicine and surgery.
2021 Apr; 35(1):45-50. doi:
10.1647/1082-6742-35.1.45. [PMID: 33892588] - Adam Rzetelny, Diana Meske, Parag Patel, Steven Passik. Tapentadol is the least common opioid found in admission urine drug-test results at an intensive outpatient opioid-use disorder treat-ment program in Ohio: A brief report.
Journal of opioid management.
2021 Jan; 17(1):13-17. doi:
10.5055/jom.2021.0610. [PMID: 33735424] - Agnieszka Karbownik, Miłosz Miedziaszczyk, Tomasz Grabowski, Joanna Stanisławiak-Rudowicz, Radosław Jaźwiec, Anna Wolc, Edmund Grześkowiak, Edyta Szałek. In vivo assessment of potential for UGT-inhibition-based drug-drug interaction between sorafenib and tapentadol.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110530. doi:
10.1016/j.biopha.2020.110530. [PMID: 32712531] - Nina R Kieves, James Howard, Phillip Lerche, Jeffrey Lakritz, Turi K Aarnes. Effectiveness of tapentadol hydrochloride for treatment of orthopedic pain in dogs: A pilot study.
The Canadian veterinary journal = La revue veterinaire canadienne.
2020 03; 61(3):289-293. doi:
NULL. [PMID: 32165753] - Isabel Gomila Muñiz, Miguel Ángel Elorza Guerrero, Miguel Ángel Servera Pieras, Jordi Puiguriguer Ferrando, Jordi Tarradas Torras, Bernardino Barceló Martín. False positives in urine methadone screening secondary to tapentadol.
Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.
2020 Ago; 32(4):290-292. doi:
NULL. [PMID: 32692011] - Cuiru Liu, Yingchao Li, Rujie Yang, Shuqi Zhang, Longshan Zhao, Tianhong Zhang. Simultaneous determination of tapentadol and its carbamate prodrug in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2018 Oct; 32(10):e4300. doi:
10.1002/bmc.4300. [PMID: 29799633] - Yingchao Li, Yongjun Wang, Ran Zhang, Cuiru Liu, Yue Wei, Jin Sun, Zhonggui He, Youjun Xu, Tianhong Zhang. Improving the oral bioavailability of tapentadol via a carbamate prodrug approach: synthesis, bioactivation, and pharmacokinetics.
Drug delivery and translational research.
2018 10; 8(5):1335-1344. doi:
10.1007/s13346-018-0524-6. [PMID: 29777509] - Emma Partridge, Eric Teoh, Christine Nash, Timothy Scott, Cheryl Charlwood, Chris Kostakis. The Increasing Use and Abuse of Tapentadol and Its Incorporation Into a Validated Quantitative Method.
Journal of analytical toxicology.
2018 Sep; 42(7):485-490. doi:
10.1093/jat/bky027. [PMID: 29912416] - Renata Zajączkowska, Barbara Przewłocka, Magdalena Kocot-Kępska, Joanna Mika, Wojciech Leppert, Jerzy Wordliczek. Tapentadol - A representative of a new class of MOR-NRI analgesics.
Pharmacological reports : PR.
2018 Aug; 70(4):812-820. doi:
10.1016/j.pharep.2018.01.005. [PMID: 29921501] - James Howard, Turi K Aarnes, Jonathan Dyce, Phillip Lerche, Larry W Wulf, Johann F Coetzee, Jeffrey Lakritz. Pharmacokinetics and pharmacodynamics after oral administration of tapentadol hydrochloride in dogs.
American journal of veterinary research.
2018 Apr; 79(4):367-375. doi:
10.2460/ajvr.79.4.367. [PMID: 29583048] - V De Vito, H Owen, M Marzoni, T W Kim, A Poapolathep, M Giorgi. Pharmacokinetics of tapentadol in laying hens and its residues in eggs after multiple oral dose administration.
British poultry science.
2018 Feb; 59(1):128-133. doi:
10.1080/00071668.2017.1401705. [PMID: 29115161] - Ahsan F Bairam, Mohammed I Rasool, Katsuhisa Kurogi, Ming-Cheh Liu. On the Molecular Basis Underlying the Metabolism of Tapentadol Through Sulfation.
European journal of drug metabolism and pharmacokinetics.
2017 Oct; 42(5):793-800. doi:
10.1007/s13318-016-0392-8. [PMID: 28070880] - Joana Barbosa, Juliana Faria, Sandra Leal, Luís Pedro Afonso, João Lobo, Odília Queirós, Roxana Moreira, Félix Carvalho, Ricardo Jorge Dinis-Oliveira. Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato- and nephrotoxic effects in Wistar rats.
Toxicology.
2017 08; 389(?):118-129. doi:
10.1016/j.tox.2017.07.001. [PMID: 28689766] - Gertrud Haeseler, Dirk Schaefers, Natalie Prison, Jörg Ahrens, Xiaofei Liu, Annika Karch. Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone.
BMC anesthesiology.
2017 07; 17(1):91. doi:
10.1186/s12871-017-0383-6. [PMID: 28693439] - Juliana Faria, Joana Barbosa, Sandra Leal, Luís Pedro Afonso, João Lobo, Roxana Moreira, Odília Queirós, Félix Carvalho, Ricardo Jorge Dinis-Oliveira. Effective analgesic doses of tramadol or tapentadol induce brain, lung and heart toxicity in Wistar rats.
Toxicology.
2017 06; 385(?):38-47. doi:
10.1016/j.tox.2017.05.003. [PMID: 28499616] - Fang Wu, Matthew H Slawson, Kamisha L Johnson-Davis. Metabolic Patterns of Fentanyl, Meperidine, Methylphenidate, Tapentadol and Tramadol Observed in Urine, Serum or Plasma.
Journal of analytical toxicology.
2017 May; 41(4):289-299. doi:
10.1093/jat/bkx003. [PMID: 28119437] - F Lee Cantrell, Phyllis Mallett, Lenore Aldridge, Kimi Verilhac, Iain M McIntyre. A tapentadol related fatality: Case report with postmortem concentrations.
Forensic science international.
2016 Sep; 266(?):e1-e3. doi:
10.1016/j.forsciint.2016.08.020. [PMID: 27568082] - Matthew J Snyder, Lawrence M Gibbs, Tammy J Lindsay. Treating Painful Diabetic Peripheral Neuropathy: An Update.
American family physician.
2016 Aug; 94(3):227-34. doi:
". [PMID: 27479625] - Ge Liang, You-ming Lu, Xiao-jian Dai, Min-jian Qin, Da-fang Zhong, Xiao-yan Chen. [A simple method for quantification of tapentadol in dog plasma by liquid chromatography-tandem mass spectrometry and evaluation of the effects of conjugated metabolites on tapentadol].
Yao xue xue bao = Acta pharmaceutica Sinica.
2016 03; 51(3):434-8. doi:
NULL. [PMID: 29859025] - S Monti, R Caporali. Chronic pain: the burden of disease and treatment innovations.
Reumatismo.
2015 Oct; 67(2):35-44. doi:
10.4081/reumatismo.2015.840. [PMID: 26492961] - Michael E Mullins, Karl Hock, Mitchell G Scott. Does therapeutic use of tapentadol cause false-positive urine screens for methadone or opiates?.
Clinical toxicology (Philadelphia, Pa.).
2015 Jun; 53(5):493-4. doi:
10.3109/15563650.2015.1020114. [PMID: 25951899] - Gary Eichenbaum, Karin Göhler, Mila Etropolski, Ilona Steigerwald, Joseph Pergolizzi, Myoung Kim, Gary Vorsanger. Does tapentadol affect sex hormone concentrations differently from morphine and oxycodone? An initial assessment and possible implications for opioid-induced androgen deficiency.
Journal of opioid management.
2015 May; 11(3):211-27. doi:
10.5055/jom.2015.0270. [PMID: 25985806] - Vera Hillewaert, Klaus Pusecker, Luc Sips, Tom Verhaeghe, Ronald de Vries, Manfred Langhans, Rolf Terlinden, Philip Timmerman. Determination of tapentadol and tapentadol-O-glucuronide in human serum samples by UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Feb; 981-982(?):40-7. doi:
10.1016/j.jchromb.2014.12.013. [PMID: 25600054] - Mahsa Sadeghi, Thomas M Tzschentke, MacDonald J Christie. μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons.
British journal of pharmacology.
2015 Jan; 172(2):460-8. doi:
10.1111/bph.12566. [PMID: 24372103] - E Lavy, H-K Lee, S J Mabjeesh, C Sabastian, Y Baker, M Giorgi. Use of the novel atypical opioid tapentadol in goats (Capra hircus): pharmacokinetics after intravenous, and intramuscular administration.
Journal of veterinary pharmacology and therapeutics.
2014 Oct; 37(5):518-21. doi:
10.1111/jvp.12123. [PMID: 24611613] - Babette Kögel, Rolf Terlinden, Johannes Schneider. Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs.
Veterinary anaesthesia and analgesia.
2014 May; 41(3):297-304. doi:
10.1111/vaa.12140. [PMID: 24576316] - Hiroko Ono, Atsushi Nakamura, Tomoe Kanbara, Kazuhisa Minami, Shunji Shinohara, Gaku Sakaguchi, Toshiyuki Kanemasa. Effect of the norepinephrine transporter (NET) inhibition on μ-opioid receptor (MOR)-induced anti-nociception in a bone cancer pain model.
Journal of pharmacological sciences.
2014; 125(3):264-73. doi:
10.1254/jphs.14081fp. [PMID: 24965165] - H-K Lee, B Lebkowska-Wieruszewska, T-W Kim, C-J Kowaski, M Giorgi. Pharmacokinetics of the novel atypical opioid tapentadol after intravenous, intramuscular and subcutaneous administration in cats.
Veterinary journal (London, England : 1997).
2013 Dec; 198(3):620-4. doi:
10.1016/j.tvjl.2013.09.011. [PMID: 24206632] - Peter N Zannikos, Johan W Smit, Hans-Jürgen Stahlberg, Birger Wenge, Vera M Hillewaert, Mila S Etropolski. Pharmacokinetic evaluation of tapentadol extended-release tablets in healthy subjects.
Journal of opioid management.
2013 Jul; 9(4):291-300. doi:
10.5055/jom.2013.0171. [PMID: 24353023] - Swati C Jagdale, Somnath Patil, Bhanudas S Kuchekar. Application of design of experiment for floating drug delivery of tapentadol hydrochloride.
Computational and mathematical methods in medicine.
2013; 2013(?):625729. doi:
10.1155/2013/625729. [PMID: 23878616] - Mario Giorgi, Alon Meizler, Paul C Mills. Pharmacokinetics of the novel atypical opioid tapentadol following oral and intravenous administration in dogs.
Veterinary journal (London, England : 1997).
2012 Dec; 194(3):309-13. doi:
10.1016/j.tvjl.2012.05.019. [PMID: 22771148] - Schirin Tang, Michael E Mullins, Benjamin M Braun, Karl G Hock, Mitchell G Scott, Anthony H Guarino, Richard D Brasington. Can tapentadol cause a false-positive urine drug screen result for amphetamine?.
Clinical toxicology (Philadelphia, Pa.).
2012 Dec; 50(10):1174-5. doi:
10.3109/15563650.2012.735367. [PMID: 23088194] - Ayodele A Collins, A Paola Merritt, James A Bourland. Cross-reactivity of tapentadol specimens with DRI methadone enzyme immunoassay.
Journal of analytical toxicology.
2012 Oct; 36(8):582-7. doi:
10.1093/jat/bks064. [PMID: 22879537] - M Giorgi, A Meizler, P C Mills. Quantification of tapentadol in canine plasma by HPLC with spectrofluorimetric detection: development and validation of a new methodology.
Journal of pharmaceutical and biomedical analysis.
2012 Aug; 67-68(?):148-53. doi:
10.1016/j.jpba.2012.04.020. [PMID: 22621882] - Nai-Kuei Huang, Jung-Hsin Lin, Jiun-Tsai Lin, Chia-I Lin, Eric Minwei Liu, Chun-Jung Lin, Wan-Ping Chen, Yuh-Chiang Shen, Hui-Mei Chen, Jhih-Bin Chen, Hsing-Lin Lai, Chieh-Wen Yang, Ming-Chang Chiang, Yu-Shuo Wu, Chen Chang, Jiang-Fan Chen, Jim-Min Fang, Yun-Lian Lin, Yijuang Chern. A new drug design targeting the adenosinergic system for Huntington's disease.
PloS one.
2011; 6(6):e20934. doi:
10.1371/journal.pone.0020934. [PMID: 21713039] - Xu Steven Xu, Johan W Smit, Rachel Lin, Kim Stuyckens, Rolf Terlinden, Partha Nandy. Population pharmacokinetics of tapentadol immediate release (IR) in healthy subjects and patients with moderate or severe pain.
Clinical pharmacokinetics.
2010 Oct; 49(10):671-82. doi:
10.2165/11535390-000000000-00000. [PMID: 20818833] - James A Bourland, Ayodele A Collins, Scot A Chester, Sumankalai Ramachandran, Ronald C Backer. Determination of tapentadol (Nucynta®) and N-desmethyltapentadol in authentic urine specimens by ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of analytical toxicology.
2010 Oct; 34(8):450-7. doi:
10.1093/jat/34.8.450. [PMID: 21819789] - Cynthia Coulter, Margaux Taruc, James Tuyay, Christine Moore. Determination of tapentadol and its metabolite N-desmethyltapentadol in urine and oral fluid using liquid chromatography with tandem mass spectral detection.
Journal of analytical toxicology.
2010 Oct; 34(8):458-63. doi:
10.1093/jat/34.8.458. [PMID: 21819790] - Johan W Smit, Charles Oh, Jens Rengelshausen, Rolf Terlinden, Paulien G M Ravenstijn, Shean-Sheng Wang, David Upmalis, Bernhard Mangold. Effects of acetaminophen, naproxen, and acetylsalicylic acid on tapentadol pharmacokinetics: results of two randomized, open-label, crossover, drug-drug interaction studies.
Pharmacotherapy.
2010 Jan; 30(1):25-34. doi:
10.1592/phco.30.1.25. [PMID: 20030470] - Rolf Terlinden, Joachim Ossig, Frank Fliegert, Claudia Lange, Karin Göhler. Absorption, metabolism, and excretion of 14C-labeled tapentadol HCl in healthy male subjects.
European journal of drug metabolism and pharmacokinetics.
2007 Jul; 32(3):163-9. doi:
10.1007/bf03190478. [PMID: 18062408]
