4-Ipomeanol (BioDeep_00000624796)

   

Chemicals and Drugs


代谢物信息卡片


4-Ipomeanol

化学式: C9H12O3 (168.0786)
中文名称: 1-戊酮，1-（3-呋喃基）-4-羟基
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC(=O)C1=COC=C1)O
InChI: InChI=1S/C9H12O3/c1-7(10)2-3-9(11)8-4-5-12-6-8/h4-7,10H,2-3H2,1H3

描述信息

C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product
D000970 - Antineoplastic Agents
C1907 - Drug, Natural Product

同义名列表

2 个代谢物同义名

4-Ipomeanol; 1-Pentanone, 1-(3-furanyl)-4-hydroxy-



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Aaron M Teitelbaum, Matthew G McDonald, John P Kowalski, Oliver T Parkinson, Michele Scian, Dale Whittington, Katharina Roellecke, Helmut Hanenberg, Constanze Wiek, Allan E Rettie. Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol. The Journal of pharmacology and experimental therapeutics. 2019 02; 368(2):308-316. doi: 10.1124/jpet.118.249771. [PMID: 30409834]
  • Oliver T Parkinson, Aaron M Teitelbaum, Dale Whittington, Edward J Kelly, Allan E Rettie. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug metabolism and disposition: the biological fate of chemicals. 2016 10; 44(10):1598-602. doi: 10.1124/dmd.116.070003. [PMID: 27468999]
  • Remya Mohanraj, S Subha. Production of 4-ipomeanol, an anticancer agent from the root tubers and rhizogenic callus of Ipomoea batatas Lam.: a comparative study. Indian journal of experimental biology. 2015 May; 53(5):297-304. doi: ". [PMID: 26040027]
  • Eva M Schmidt, Constanze Wiek, Oliver T Parkinson, Katharina Roellecke, Marcel Freund, Michael Gombert, Nadine Lottmann, Charles A Steward, Christof M Kramm, Vladimir Yarov-Yarovoy, Allan E Rettie, Helmut Hanenberg. Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution. PloS one. 2015; 10(9):e0137110. doi: 10.1371/journal.pone.0137110. [PMID: 26355749]
  • Oliver T Parkinson, H Denny Liggitt, Allan E Rettie, Edward J Kelly. Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Aug; 134(2):243-50. doi: 10.1093/toxsci/kft123. [PMID: 23748241]
  • Michael S Thibodeau, Matthew H Poore, Winston M Hagler, Glenn M Rogers. Effect of fermentation on Sweetpotato (Ipomoea batatas) toxicity in mice. Journal of agricultural and food chemistry. 2004 Jan; 52(2):380-4. doi: 10.1021/jf034885k. [PMID: 14733525]
  • H Hsu, N G Rainov, A Quinones, D J Eling, K M Sakamoto, M A Spear. Combined radiation and cytochrome CYP4B1/4-ipomeanol gene therapy using the EGR1 promoter. Anticancer research. 2003 May; 23(3B):2723-8. doi: NULL. [PMID: 12894565]
  • S Lakhanpal, R C Donehower, E K Rowinsky. Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma. Investigational new drugs. 2001; 19(1):69-76. doi: 10.1023/a:1006408803734. [PMID: 11291834]
  • V K Kasturi, M P Dearing, S C Piscitelli, E K Russell, G G Sladek, K O'Neil, G A Turner, T L Morton, M C Christian, B E Johnson, M J Kelley. Phase I study of a five-day dose schedule of 4-Ipomeanol in patients with non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 1998 Sep; 4(9):2095-102. doi: NULL. [PMID: 9748125]
  • X Li, C J Czuprynski, W L Castleman. Effects of 4-ipomeanol on bovine alveolar macrophage function. Veterinary immunology and immunopathology. 1997 Sep; 58(2):133-45. doi: 10.1016/s0165-2427(97)00022-6. [PMID: 9336881]
  • D A Cummings, H A Schut. Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in male CDF1 mice. Carcinogenesis. 1995 Oct; 16(10):2523-9. doi: 10.1093/carcin/16.10.2523. [PMID: 7586161]
  • E K Rowinsky, D A Noe, D S Ettinger, M C Christian, B G Lubejko, E K Fishman, S E Sartorius, M R Boyd, R C Donehower. Phase I and pharmacological study of the pulmonary cytotoxin 4-ipomeanol on a single dose schedule in lung cancer patients: hepatotoxicity is dose limiting in humans. Cancer research. 1993 Apr; 53(8):1794-801. doi: NULL. [PMID: 8467498]
  • J H Smith. The use of renal cortical slices from the Fischer 344 rat as an in vitro model to evaluate nephrotoxicity. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1988 Jul; 11(1):132-42. doi: 10.1016/0272-0590(88)90277-1. [PMID: 2905310]
  • P Larsson, H Tjälve. Tracing tissues with 4-ipomeanol-metabolizing capacity in rats. Chemico-biological interactions. 1988; 67(1-2):1-24. doi: 10.1016/0009-2797(88)90082-8. [PMID: 3168078]
  • R Breeze. Respiratory disease in adult cattle. The Veterinary clinics of North America. Food animal practice. 1985 Jul; 1(2):311-46. doi: 10.1016/s0749-0720(15)31329-3. [PMID: 3907777]
  • S K Durham, M R Boyd, W L Castleman. Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice. The American journal of pathology. 1985 Jan; 118(1):66-75. doi: NULL. [PMID: 3966538]
  • G F Rush, J H Smith, J F Newton, J B Hook. Chemically induced nephrotoxicity: role of metabolic activation. Critical reviews in toxicology. 1984; 13(2):99-160. doi: 10.3109/10408448409034079. [PMID: 6380963]
  • C N Statham, M R Boyd. Effects of phenobarbital and 3-methylcholanthrene on the in vivo distribution, metabolism and covalent binding of 4-ipomeanol in the rat; implications for target organ toxicity. Biochemical pharmacology. 1982 Dec; 31(24):3973-7. doi: 10.1016/0006-2952(82)90643-8. [PMID: 7159474]
  • C N Statham, J S Dutcher, S H Kim, M R Boyd. Ipomeanol 4-glucuronide, a major urinary metabolite of 4-ipomeanol in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1982 May; 10(3):264-7. doi: NULL. [PMID: 6125360]
  • R G Breeze, J R Carlson. Chemical-induced lung injury in domestic animals. Advances in veterinary science and comparative medicine. 1982; 26(?):201-31. doi: ". [PMID: 6758539]
  • M R Boyd, J S Dutcher. Renal toxicity due to reactive metabolites formed in situ in the kidney: investigations with 4-ipomeanol in the mouse. The Journal of pharmacology and experimental therapeutics. 1981 Mar; 216(3):640-6. doi: NULL. [PMID: 7205642]