Tiropramide (BioDeep_00000624708)

   


代谢物信息卡片


N-(2-{4-[2-(diethylamino)ethoxy]phenyl}-1-(dipropylcarbamoyl)ethyl)benzenecarboximidic acid

化学式: C28H41N3O3 (467.3147756000001)
中文名称: 替瑞酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCN(CCC)C(=O)C(CC1=CC=C(C=C1)OCCN(CC)CC)NC(=O)C2=CC=CC=C2
InChI: InChI=1S/C28H41N3O3/c1-5-18-31(19-6-2)28(33)26(29-27(32)24-12-10-9-11-13-24)22-23-14-16-25(17-15-23)34-21-20-30(7-3)8-4/h9-17,26H,5-8,18-22H2,1-4H3,(H,29,32)

描述信息

A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AC - Synthetic antispasmodics, amides with tertiary amines
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent

同义名列表

3 个代谢物同义名

N-[3-[4-[2-(diethylamino)ethoxy]phenyl]-1-(dipropylamino)-1-oxopropan-2-yl]benzamide; Tiropramide; N-(2-{4-[2-(diethylamino)ethoxy]phenyl}-1-(dipropylcarbamoyl)ethyl)benzenecarboximidic acid



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Khan Imran, Loya Punnamchand, Saraf Madhusudan Natvarlal. A simple sample preparation with HPLC-UV method for estimation of tiropramide from plasma: application to bioequivalence study. Journal of pharmaceutical and biomedical analysis. 2007 Feb; 43(3):1135-40. doi: 10.1016/j.jpba.2006.10.001. [PMID: 17127027]
  • Ok Hwa Jhee, Yong Cheol Jeon, Ho Sun Choi, Min Ho Lee, Ae Son Om, Joo-Won Lee, Jung Wook Hong, Yong Seok Kim, Ju Chan Kang, Yun Sik Lee, Leslie M Shaw, Ju Seop Kang. Quantitative analysis of tiropramide in human plasma by gas chromatography coupled to mass spectrometry for application to a bioequivalence test. Clinica chimica acta; international journal of clinical chemistry. 2006 Apr; 366(1-2):179-84. doi: 10.1016/j.cca.2005.09.029. [PMID: 16352299]
  • Joo H Lee, Eun J Kim, Jong W Kwon, Moohi Yoo, Myung G Lee. Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats. Biopharmaceutics & drug disposition. 2006 Apr; 27(3):125-31. doi: 10.1002/bdd.491. [PMID: 16400709]
  • Hye Won Lee, Hye Young Ji, Hee Hyun Kim, Hea-Young Cho, Yong-Bok Lee, Hye Suk Lee. Determination of tiropramide in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Nov; 796(2):395-400. doi: 10.1016/j.jchromb.2003.08.027. [PMID: 14581078]
  • Oh-Seung Kwon, Young-Jin Park, Jae-Chun Ryu, Youn Bok Chung. Quantitative analysis of tiropramide in human blood by gas chromatography with nitrogen-phosphorus detector. Archives of pharmacal research. 2003 May; 26(5):416-20. doi: 10.1007/bf02976700. [PMID: 12785739]
  • Soo Kyoung Baek, Seung Seok Lee, Eun Jeon Park, Dong Hwan Sohn, Hye Suk Lee. Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching. Journal of pharmaceutical and biomedical analysis. 2003 Feb; 31(1):185-9. doi: 10.1016/s0731-7085(02)00570-8. [PMID: 12560063]
  • Oh-Seung Kwon, Young-Jin Park, Youn-Bok Chung. Pharmacokinetics and bioequivalence of tiropramide in healthy volunteers. Arzneimittel-Forschung. 2003; 53(8):578-83. doi: 10.1055/s-0031-1297152. [PMID: 13677248]
  • T Morita, M Ando, S Hirano, S Dokita, S Kondo, S Tsuchida. [Experimental studies of urinary incontinence. Effect of tiropramide on the urinary stage and evacuation]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 1992 Nov; 83(11):1835-40. doi: 10.5980/jpnjurol1989.83.1835. [PMID: 1336080]
  • I Setnikar, F Makovec, R Chistè, C Giachetti, G Zanolo. Distribution of tiropramide and metabolites after single intravenous or peroral administration of 14C-tiropramide to the rat. Arzneimittel-Forschung. 1989 May; 39(5):579-86. doi: NULL. [PMID: 2757674]
  • I Setnikar, F Makovec, R Chistè, C Giachetti, G Zanolo. Metabolism and excretion of 14C-tiropramide after single intravenous or peroral administration to the rat. Arzneimittel-Forschung. 1989 Mar; 39(3):328-34. doi: NULL. [PMID: 2757659]
  • I Setnikar, F Makovec, R Chistè, C Giachetti, G Zanolo. Tiropramide and metabolites in blood and plasma after intravenous or peroral administration of 14C-tiropramide to the rat. Arzneimittel-Forschung. 1988 Dec; 38(12):1815-9. doi: NULL. [PMID: 3245854]
  • R Arigoni, R Chistè, F Makovec, I Setnikar, E Benfenati, R Fanelli. Identification of metabolites of tiropramide in human urine. Biomedical & environmental mass spectrometry. 1988 Feb; 15(4):205-9. doi: 10.1002/bms.1200150404. [PMID: 3370360]
  • R Arigoni, R Chisté, A Drovanti, F Makovec, P Senin, I Setnikar. Pharmacokinetics of tiropramide after single doses in man. Arzneimittel-Forschung. 1986 Apr; 36(4):738-44. doi: NULL. [PMID: 3718598]