Musaril (BioDeep_00000624704)

   


代谢物信息卡片


7-chloro-5-(cyclohex-1-en-1-yl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

化学式: C16H17ClN2O (288.1029342)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CCCCC3
InChI: InChI=1S/C16H17ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h5,7-9H,2-4,6,10H2,1H3

描述信息

M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents

同义名列表

5 个代谢物同义名

7-chloro-5-(cyclohex-1-en-1-yl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; Tetrazepam; Myolastan; Clinoxan; Musaril



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rui Zhang, Esrat Jahan Rupa, Siwen Zheng, Jinnatun Nahar, Deok Chun Yang, Se Chan Kang, Yingping Wang. Panos-Fermented Extract-Mediated Nanoemulsion: Preparation, Characterization, and In Vitro Anti-Inflammatory Effects on RAW 264.7 Cells. Molecules (Basel, Switzerland). 2021 Dec; 27(1):. doi: 10.3390/molecules27010218. [PMID: 35011448]
  • Lalitha Kaliraj, Jong Chan Ahn, Esrat Jahan Rupa, Suleman Abid, Jing Lu, Deok Chun Yang. Synthesis of panos extract mediated ZnO nano-flowers as photocatalyst for industrial dye degradation by UV illumination. Journal of photochemistry and photobiology. B, Biology. 2019 Oct; 199(?):111588. doi: 10.1016/j.jphotobiol.2019.111588. [PMID: 31450132]
  • Daniela Remane, Diana Wetzel, Frank T Peters. Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) procedure for screening of urine specimens for 100 analytes relevant in drug-facilitated crime (DFC). Analytical and bioanalytical chemistry. 2014 Jul; 406(18):4411-24. doi: 10.1007/s00216-014-7841-5. [PMID: 24817357]
  • Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. Journal of chromatography. A. 2012 Aug; 1249(?):147-54. doi: 10.1016/j.chroma.2012.06.023. [PMID: 22749457]
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  • P Fernández, C Vázquez, R A Lorenzo, A M Carro, I Alvarez, P Cabarcos. Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma. Analytical and bioanalytical chemistry. 2010 May; 397(2):677-85. doi: 10.1007/s00216-010-3572-4. [PMID: 20204329]
  • Radim Vrzal, Katerina Kubesova, Petr Pavek, Zdenek Dvorak. Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines. Toxicology letters. 2010 Mar; 193(2):183-8. doi: 10.1016/j.toxlet.2010.01.004. [PMID: 20080160]
  • Anne Baumann, Wiebke Lohmann, Birthe Schubert, Herbert Oberacher, Uwe Karst. Metabolic studies of tetrazepam based on electrochemical simulation in comparison to in vivo and in vitro methods. Journal of chromatography. A. 2009 Apr; 1216(15):3192-8. doi: 10.1016/j.chroma.2009.02.001. [PMID: 19233363]
  • Birthe Schubert, Marion Pavlic, Kathrin Libiseller, Herbert Oberacher. Unraveling the metabolic transformation of tetrazepam to diazepam with mass spectrometric methods. Analytical and bioanalytical chemistry. 2008 Dec; 392(7-8):1299-308. doi: 10.1007/s00216-008-2447-4. [PMID: 18949465]
  • Marleen Laloup, Maria Del Mar Ramirez Fernandez, Michelle Wood, Viviane Maes, Gert De Boeck, Yvan Vanbeckevoort, Nele Samyn. Detection of diazepam in urine, hair and preserved oral fluid samples with LC-MS-MS after single and repeated administration of Myolastan and Valium. Analytical and bioanalytical chemistry. 2007 Aug; 388(7):1545-56. doi: 10.1007/s00216-007-1297-9. [PMID: 17468852]
  • Marion Pavlic, Kathrin Libiseller, Petra Grubwieser, Heinrich Schubert, Walter Rabl. Medicolegal aspects of tetrazepam metabolism. International journal of legal medicine. 2007 May; 121(3):169-74. doi: 10.1007/s00414-006-0118-6. [PMID: 17021899]
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  • Franck Delesalle, Olivier Carpentier, Sophie Guatier, Emmanuel Delaporte. Toxic epidermal necrolysis caused by tetrazepam. International journal of dermatology. 2006 Apr; 45(4):480. doi: 10.1111/j.1365-4632.2006.02654.x. [PMID: 16650186]
  • J J Berzas Nevado, J Rodríguez Flores, G Castañeda Peñalvo, R M Rodríguez Dorado. Determination of ibuprofen and tetrazepam in human urine by micellar electrokinetic capillary chromatography. Analytical and bioanalytical chemistry. 2006 Jan; 384(1):208-14. doi: 10.1007/s00216-005-0128-0. [PMID: 16328252]
  • Marta Concheiro, Marion Villain, Stéphane Bouchet, Bertrand Ludes, Manuel López-Rivadulla, Pascal Kintz. Windows of detection of tetrazepam in urine, oral fluid, beard, and hair, with a special focus on drug-facilitated crimes. Therapeutic drug monitoring. 2005 Oct; 27(5):565-70. doi: 10.1097/01.ftd.0000164610.14808.45. [PMID: 16175127]
  • Carsten Kratzsch, Oliver Tenberken, Frank T Peters, Armin A Weber, Thomas Kraemer, Hans H Maurer. Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. Journal of mass spectrometry : JMS. 2004 Aug; 39(8):856-72. doi: 10.1002/jms.599. [PMID: 15329838]
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  • Maria Elisa Capella-Peiró, Devasish Bose, Adrià Martinavarro-Domínguez, Mayte Gil-Agustí, Josep Esteve-Romero. Direct injection micellar liquid chromatographic determination of benzodiazepines in serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Nov; 780(2):241-9. doi: 10.1016/s1570-0232(02)00523-8. [PMID: 12401349]
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