Talinolol (BioDeep_00000624702)
代谢物信息卡片
N-{4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-N-cyclohexylcarbamimidic acid
化学式: C20H33N3O3 (363.2521788)
中文名称: 他林洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)NCC(COC1=CC=C(C=C1)NC(=O)NC2CCCCC2)O
InChI: InChI=1S/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25)
描述信息
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135533
- KEGGdrug: D07184
- PubChem: 68770
- Metlin: METLIN96207
- DrugBank: DB11770
- ChEMBL: CHEMBL152067
- CAS: 38649-73-9
- CAS: 57460-41-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zeliha Pala Kara, Dilek Ozturk Civelek, Narin Ozturk, Alper Okyar. The effects of P-glycoprotein inhibitor zosuquidar on the sex and time-dependent pharmacokinetics of parenterally administered talinolol in mice.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Jan; 156(?):105589. doi:
10.1016/j.ejps.2020.105589. [PMID: 33049306] - Z Pala Kara, D Ozturk, N Ozturk, M N Orman, G Baktir, A Okyar. Effects of atorvastatin on talinolol absorption: A potential drug-drug interaction.
Die Pharmazie.
2020 03; 75(2):70-74. doi:
10.1691/ph.2020.9904. [PMID: 32213237] - Alper Okyar, Swati A Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta. Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling.
Scientific reports.
2019 07; 9(1):10505. doi:
10.1038/s41598-019-46977-0. [PMID: 31324853] - N Ozturk, D Ozturk, Z Pala-Kara, A Okyar. Pharmacokinetics of talinolol is modified by barnidipine: implication of P-glycoprotein modulation.
Die Pharmazie.
2017 Jan; 72(1):29-34. doi:
10.1691/ph.2017.6786. [PMID: 29441894] - M A Nguyen, P Staubach, I Tamai, P Langguth. High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Feb; 68(?):36-42. doi:
10.1016/j.ejps.2014.12.001. [PMID: 25486333] - Emmanuel Bourgogne, Chantal Grivet, Emmanuel Varesio, Gérard Hopfgartner. Generic on-line solid phase extraction sample preparation strategies for the analysis of drugs in biological matrices by LC-MS/MS.
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2015 Jan; 102(?):290-8. doi:
10.1016/j.jpba.2014.09.030. [PMID: 25459926] - M A Nguyen, P Staubach, S Wolffram, P Langguth. Effect of single-dose and short-term administration of quercetin on the pharmacokinetics of talinolol in humans - Implications for the evaluation of transporter-mediated flavonoid-drug interactions.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Sep; 61(?):54-60. doi:
10.1016/j.ejps.2014.01.003. [PMID: 24472704] - Kazi Mohsin, Safar Al-Qahtani, Fars K Alanazi. Rapid and sensitive bioanalytical stability-indicating method for quantification of talinolol, a selective β1 adrenoceptor antagonist in lipid based formulations using ultrafast UHPLC systems.
Acta poloniae pharmaceutica.
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2010 Jan; 2(1):95-104. doi:
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2009 Nov; 39(11):844-9. doi:
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The Annals of pharmacotherapy.
2009 May; 43(5):944-9. doi:
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2009 May; 98(5):1905-18. doi:
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