Loramet (BioDeep_00000624682)

   


代谢物信息卡片


7-Chloro-5-(O-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one

化学式: C16H12Cl2N2O2 (334.0275792)
中文名称: 双氯苯卓醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl
InChI: InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

16 个代谢物同义名

7-Chloro-5-(O-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-chloro-5-(2-Chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; (±)-Lorazepam; N-Methyllorazepam; O-Chlorooxazepam; O-Chloroxazepam; Methyllorazepam; Lormetazepamum; Lormetazepam; Loramet (TN); Noctamide; lorazepam; Noctamid; Ergocalm; Loramet



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kimberly N Shudofsky, Paddy K C Janssen, Norbert Foudraine, Jos L M L le Noble. Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome. Journal of clinical pharmacology. 2022 04; 62(4):568-570. doi: 10.1002/jcph.2005. [PMID: 34793610]
  • Sabrina Lehmann, Alissa Sczyslo, Judith Froch-Cortis, Markus Alexander Rothschild, Mario Thevis, Hilke Andresen-Streichert, Katja Mercer-Chalmers-Bender. Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine. Forensic science international. 2019 Oct; 303(?):109959. doi: 10.1016/j.forsciint.2019.109959. [PMID: 31546164]
  • Victoria López-Corominas, Nuria Gilabert Iriondo, Isabel Gomila Muñiz, Bernardino Barceló Martín. Double false result in a drug screen after accidental pediatric poisoning. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2018 02; 30(1):64-65. doi: NULL. [PMID: 29437315]
  • Souleiman El Balkhi, Maxime Chaslot, Nicolas Picard, Sylvain Dulaurent, Martine Delage, Olivier Mathieu, Franck Saint-Marcoux. Characterization and identification of eight designer benzodiazepine metabolites by incubation with human liver microsomes and analysis by a triple quadrupole mass spectrometer. International journal of legal medicine. 2017 Jul; 131(4):979-988. doi: 10.1007/s00414-017-1541-6. [PMID: 28160051]
  • María Pilar Vicente Sánchez, Diego Macías Saint-Gerons, César de la Fuente Honrubia, Diana González Bermejo, Dolores Montero Corominas, Ferrán Catalá-López. [Trends of use of anxiolytics and hypnotics in Spain from 2000 to 2011]. Revista espanola de salud publica. 2013 May; 87(3):247-55. doi: 10.4321/s1135-57272013000300004. [PMID: 23892676]
  • Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. Journal of chromatography. A. 2012 Aug; 1249(?):147-54. doi: 10.1016/j.chroma.2012.06.023. [PMID: 22749457]
  • P Cabarcos, M J Tabernero, I Álvarez, P López, P Fernández, A M Bermejo. Analysis of six benzodiazepines in vitreous humor by high-performance liquid chromatography-photodiode-array detection. Journal of analytical toxicology. 2010 Nov; 34(9):539-42. doi: 10.1093/jat/34.9.539. [PMID: 21073805]
  • P Fernández, C Vázquez, R A Lorenzo, A M Carro, I Alvarez, P Cabarcos. Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma. Analytical and bioanalytical chemistry. 2010 May; 397(2):677-85. doi: 10.1007/s00216-010-3572-4. [PMID: 20204329]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Jaime M Monti, S R Pandi-Perumal. Eszopiclone: its use in the treatment of insomnia. Neuropsychiatric disease and treatment. 2007 Aug; 3(4):441-53. doi: NULL. [PMID: 19300573]
  • Franz E Dussy, Cornelia Hamberg, Thomas A Briellmann. Quantification of benzodiazepines in whole blood and serum. International journal of legal medicine. 2006 Nov; 120(6):323-30. doi: 10.1007/s00414-005-0042-1. [PMID: 16220317]
  • Carsten Kratzsch, Oliver Tenberken, Frank T Peters, Armin A Weber, Thomas Kraemer, Hans H Maurer. Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. Journal of mass spectrometry : JMS. 2004 Aug; 39(8):856-72. doi: 10.1002/jms.599. [PMID: 15329838]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • J J Berzas Nevado, G Castañeda Peñalvo, M J Pinilla Calderón. Determination of lormetazepam and its main metabolite in serum using micellar electrokinetic capillary chromatography with direct injection and ultraviolet absorbance detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Jun; 773(2):151-8. doi: 10.1016/s1570-0232(02)00139-3. [PMID: 12031841]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry. 2002 Jun; 45(13):2867-76. doi: 10.1021/jm0200409. [PMID: 12061889]
  • D Borrey, E Meyer, W Lambert, C Van Peteghem, A P De Leenheer. Simultaneous determination of fifteen low-dosed benzodiazepines in human urine by solid-phase extraction and gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 2001 Dec; 765(2):187-97. doi: 10.1016/s0378-4347(01)00419-4. [PMID: 11767312]
  • B Marc, F Baudry, P Vaquero, L Zerrouki, S Hassnaoui, H Douceron. Sexual assault under benzodiazepine submission in a Paris suburb. Archives of gynecology and obstetrics. 2000 Apr; 263(4):193-7. doi: 10.1007/s004040050282. [PMID: 10834331]
  • M Augsburger, L Rivier, P Mangin. Comparison of different immunoassays and GC-MS screening of benzodiazepines in urine. Journal of pharmaceutical and biomedical analysis. 1998 Dec; 18(4-5):681-7. doi: 10.1016/s0731-7085(98)00266-0. [PMID: 9919969]
  • E Nováková. [Detection of lorazepam and lormetazepam metabolites in urine using thin-layer chromatography]. Soudni lekarstvi. 1998 Jan; 43(1):2-4. doi: NULL. [PMID: 9560883]
  • J Horák, A Horák, A Lenghel, B Cuparencu. Effects of lormetazepam on glycemia and serum lipids in hyperlipidemic rats. Acta physiologica Hungarica. 1997 199; 85(1):77-82. doi: NULL. [PMID: 9530438]
  • M Mayer, A Doenicke, A E Nebauer, C Rosenberger, W Lorenz, K Peter. [Pharmacodynamics and clinical adverse effects of mivacurium. The effect of oral premedication with H1/H2 antagonists]. Der Anaesthesist. 1993 Sep; 42(9):592-6. doi: NULL. [PMID: 8105716]
  • W A Nolen, P M Haffmans, P F Bouvy, H J Duivenvoorden. Hypnotics as concurrent medication in depression. A placebo-controlled, double-blind comparison of flunitrazepam and lormetazepam in patients with major depression, treated with a (tri)cyclic antidepressant. Journal of affective disorders. 1993 Jul; 28(3):179-88. doi: 10.1016/0165-0327(93)90103-q. [PMID: 8104964]
  • L A Berrueta, B Gallo, F Vicente. Biopharmacological data and high-performance liquid chromatographic analysis of 1,4-benzodiazepines in biological fluids: a review. Journal of pharmaceutical and biomedical analysis. 1992 Feb; 10(2-3):109-36. doi: 10.1016/0731-7085(92)80019-j. [PMID: 1356446]
  • A Doenicke, R Dorow, U Täuber. [The pharmacokinetics of lormetazepam following cimetidine]. Der Anaesthesist. 1991 Dec; 40(12):675-9. doi: NULL. [PMID: 1685875]
  • M Ozawa, Y Nakada, K Sugimachi, T Akai, M Yamaguchi. [Interaction of the hypnotic lormetazepam with central benzodiazepine receptor subtypes omega 1, omega 2 and omega 3]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1991 Nov; 98(5):399-408. doi: 10.1254/fpj.98.5_399. [PMID: 1687574]
  • A Hellstern, M Hildebrand, M Hümpel, D Hellenbrecht, R Saller, C Madetzki. Minimal biliary excretion and enterohepatic recirculation of lormetazepam in man as investigated by a new nasobiliary drainage technique. International journal of clinical pharmacology, therapy, and toxicology. 1990 Jun; 28(6):256-61. doi: NULL. [PMID: 1973917]
  • M Hildebrand, A Hellstern, M Hümpel, D Hellenbrecht, R Saller. Plasma levels and urinary excretion of lormetazepam in patients with liver cirrhosis and in healthy volunteers. European journal of drug metabolism and pharmacokinetics. 1990 Jan; 15(1):19-26. doi: 10.1007/bf03190123. [PMID: 1974495]
  • J Wildmann. Increase of natural benzodiazepines in wheat and potato during germination. Biochemical and biophysical research communications. 1988 Dec; 157(3):1436-43. doi: 10.1016/s0006-291x(88)81036-2. [PMID: 2849941]
  • U Klotz. Drug interactions and clinical pharmacokinetics of flumazenil. European journal of anaesthesiology. Supplement. 1988; 2(?):103-8. doi: NULL. [PMID: 2842128]
  • W Heipertz, H Vontin, V Hempel, V Eichinger. [Plasma concentration and amnesia following lormetazepam and flunitrazepam in i.v. premedication]. Anasthesie, Intensivtherapie, Notfallmedizin. 1986 Jun; 21(3):113-6. doi: NULL. [PMID: 3752422]
  • L Zecca, P Ferrario, F Fraschini, F Zambotti, N Zonta, R Pirola. Determination of lormetazepam in plasma by gas chromatography and electron-capture detection. Journal of chromatography. 1986 Apr; 377(?):368-72. doi: 10.1016/s0378-4347(00)80795-1. [PMID: 2872224]
  • T Duka, M Ackenheil, J Noderer, A Doenicke, R Dorow. Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788. Psychopharmacology. 1986; 90(3):351-7. doi: 10.1007/bf00179190. [PMID: 2878461]
  • U Klotz, T Duka, R Dorow, A Doenicke. Flunitrazepam and lormetazepam do not affect the pharmacokinetics of the benzodiazepine antagonist Ro 15-1788. British journal of clinical pharmacology. 1985 Jan; 19(1):95-8. doi: 10.1111/j.1365-2125.1985.tb02619.x. [PMID: 3919752]
  • T Vu Duc, A Vernay. [Validation of a method for detecting benzodiazepines in the urine by acid extraction of their benzophenones and thin layer chromatography]. Annales de biologie clinique. 1985; 43(3):261-5. doi: NULL. [PMID: 2862815]
  • L Zecca, L Reina, F Scaglione, P Ferrario, R Pirola, G Ceccarelli, M Ciampini, F Fraschini. Relative bioavailability in humans for oral tablets and solutions of lormetazepam. Arzneimittel-Forschung. 1985; 35(12):1870-2. doi: NULL. [PMID: 2869762]
  • D M Pierce, R A Franklin, T V Harry, A N Nicholson. Pharmacodynamic correlates of modified absorption: studies with lormetazepam. British journal of clinical pharmacology. 1984 Jul; 18(1):31-5. doi: 10.1111/j.1365-2125.1984.tb05018.x. [PMID: 6146348]
  • D K Luscombe. Lormetazepam--plasma concentrations in volunteers following sublingual and oral dosing. Psychopharmacology. Supplementum. 1984; 1(?):99-104. doi: NULL. [PMID: 6147846]
  • H Ott. Are electroencephalographic and psychomotor measures sensitive in detecting residual sequelae of benzodiazepine hypnotics?. Psychopharmacology. Supplementum. 1984; 1(?):133-51. doi: 10.1007/978-3-642-69659-6_12. [PMID: 6147836]
  • M Kurowski, H Ott, W M Herrmann. Relationship between EEG dynamics and pharmacokinetics of the benzodiazepine lormetazepam. Pharmacopsychiatria. 1982 May; 15(3):77-83. doi: 10.1055/s-2007-1019513. [PMID: 6124982]
  • R G Dorow, J Seidler, H H Schneider. A radioreceptor assay to study the affinity of benzodiazepines and their receptor binding activity in human plasma including their active metabolites. British journal of clinical pharmacology. 1982 Apr; 13(4):561-5. doi: 10.1111/j.1365-2125.1982.tb01422.x. [PMID: 6121579]
  • M Hümpel, I Stoppelli, S Milia, E Rainer. Pharmacokinetics and biotransformation of the new benzodiazepine, lormetazepam, in man. III. Repeated administration and transfer to neonates via breast milk. European journal of clinical pharmacology. 1982; 21(5):421-5. doi: 10.1007/bf00542330. [PMID: 6122580]
  • M Hümpel, B Nieuweboer, W Milius, H Hanke, H Wendt. Kinetics and biotransformation of lormetazepam. II. Radioimmunologic determinations in plasma and urine of young and elderly subjects: first-pass effect. Clinical pharmacology and therapeutics. 1980 Nov; 28(5):673-9. doi: 10.1038/clpt.1980.220. [PMID: 6108174]
  • M Hümpel, V Illi, W Milius, H Wendt, M Kurowski. The pharmacokinetics and biotransformation of the new benzodiazepine lormetazepam in humans. I. Absorption, distribution, elimination and metabolism of lormetazepam-5-14C. European journal of drug metabolism and pharmacokinetics. 1979; 4(4):237-43. doi: 10.1007/bf03189433. [PMID: 43806]