Loramet (BioDeep_00000624682)
代谢物信息卡片
7-Chloro-5-(O-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
化学式: C16H12Cl2N2O2 (334.0276)
中文名称: 双氯苯卓醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl
InChI: InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
同义名列表
16 个代谢物同义名
7-Chloro-5-(O-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-chloro-5-(2-Chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; (±)-Lorazepam; N-Methyllorazepam; O-Chlorooxazepam; O-Chloroxazepam; Methyllorazepam; Lormetazepamum; Lormetazepam; Loramet (TN); Noctamide; lorazepam; Noctamid; Ergocalm; Loramet
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:52993
- PubChem: 13314
- Metlin: METLIN96179
- DrugBank: DB13872
- ChEMBL: CHEMBL22097
- CAS: 848-75-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 4113 - Solanum tuberosum:
- 4565 - Triticum aestivum: 10.1016/0024-3205(91)90347-E
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Kimberly N Shudofsky, Paddy K C Janssen, Norbert Foudraine, Jos L M L le Noble. Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome.
Journal of clinical pharmacology.
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Forensic science international.
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International journal of legal medicine.
2017 Jul; 131(4):979-988. doi:
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Revista espanola de salud publica.
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2010 Nov; 34(9):539-42. doi:
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2010 May; 397(2):677-85. doi:
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International journal of legal medicine.
2006 Nov; 120(6):323-30. doi:
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2004 Aug; 39(8):856-72. doi:
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2004 Feb; 47(5):1242-50. doi:
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2002 Jun; 773(2):151-8. doi:
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2002 Jun; 45(13):2867-76. doi:
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2001 Dec; 765(2):187-97. doi:
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Archives of gynecology and obstetrics.
2000 Apr; 263(4):193-7. doi:
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1998 Dec; 18(4-5):681-7. doi:
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Soudni lekarstvi.
1998 Jan; 43(1):2-4. doi:
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Acta physiologica Hungarica.
1997 199; 85(1):77-82. doi:
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Der Anaesthesist.
1993 Sep; 42(9):592-6. doi:
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Journal of affective disorders.
1993 Jul; 28(3):179-88. doi:
10.1016/0165-0327(93)90103-q. [PMID: 8104964] - L A Berrueta, B Gallo, F Vicente. Biopharmacological data and high-performance liquid chromatographic analysis of 1,4-benzodiazepines in biological fluids: a review.
Journal of pharmaceutical and biomedical analysis.
1992 Feb; 10(2-3):109-36. doi:
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Der Anaesthesist.
1991 Dec; 40(12):675-9. doi:
NULL. [PMID: 1685875] - M Ozawa, Y Nakada, K Sugimachi, T Akai, M Yamaguchi. [Interaction of the hypnotic lormetazepam with central benzodiazepine receptor subtypes omega 1, omega 2 and omega 3].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1991 Nov; 98(5):399-408. doi:
10.1254/fpj.98.5_399. [PMID: 1687574] - A Hellstern, M Hildebrand, M Hümpel, D Hellenbrecht, R Saller, C Madetzki. Minimal biliary excretion and enterohepatic recirculation of lormetazepam in man as investigated by a new nasobiliary drainage technique.
International journal of clinical pharmacology, therapy, and toxicology.
1990 Jun; 28(6):256-61. doi:
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European journal of drug metabolism and pharmacokinetics.
1990 Jan; 15(1):19-26. doi:
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1988 Dec; 157(3):1436-43. doi:
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1986 Jun; 21(3):113-6. doi:
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1982; 21(5):421-5. doi:
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