Isepamicin (BioDeep_00000624679)

   


代谢物信息卡片


(2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy}-2-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxypropanimidic acid

化学式: C22H43N5O12 (569.2908078)
中文名称: 异帕米星
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(C(C(C(O3)CN)O)O)O)N)NC(=O)C(CN)O)O
InChI: InChI=1S/C22H43N5O12/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-/m0/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D005839 - Gentamicins
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

3 个代谢物同义名

Isepamicin; (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy}-2-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxypropanimidic acid; Isepamicin sulfate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ryunosuke Nakagawa, Kazuyoshi Shigehara, Shuhei Aoyama, Satoko Urata, Mitsuo Ofude, Tohru Miyagi, Takao Nakashima, Kouji Izumi, Atsushi Mizokami. Efficacy of combined prophylactic use of levofloxacin and isepamicin for transrectal prostate needle biopsy: A retrospective single-center study. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2019 May; 25(5):337-340. doi: 10.1016/j.jiac.2019.01.004. [PMID: 30718193]
  • G Samonis, S Maraki, E K Vouloumanou, G G Georgantzi, D P Kofteridis, M E Falagas. Antimicrobial susceptibility of non-fermenting Gram-negative isolates to isepamicin in a region with high antibiotic resistance. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2012 Nov; 31(11):3191-8. doi: 10.1007/s10096-012-1684-9. [PMID: 22752194]
  • Lei Wang, Juanjuan Peng, Zhengwen Liu, Youqiu He. Resonance Rayleigh-scattering spectral method for the determination of some aminoglycoside antibiotics using CdTe quantum dots as a probe. Luminescence : the journal of biological and chemical luminescence. 2010 Nov; 25(6):424-30. doi: 10.1002/bio.1170. [PMID: 19743528]
  • Shin Hosokawa, Katsunori Nakamura, Yukiyoshi Fujita, Ryuya Horiuchi, Koujirou Yamamoto. Determination of isepamicin in human plasma by HPLC with fluorescence detection after derivatization using 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate. Biological & pharmaceutical bulletin. 2008 Oct; 31(10):1866-9. doi: 10.1248/bpb.31.1866. [PMID: 18827345]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • J C Yombi, P Wallemacq, T Leal, J L Gala, B Vandercam. Key pharmacokinetic parameters of isepamicin in febrile neutropenic cancer patients and in women with acute pelvic inflammatory disease. Journal of chemotherapy (Florence, Italy). 2005 Oct; 17(5):521-6. doi: 10.1179/joc.2005.17.5.521. [PMID: 16323441]
  • Nam-Hee Ryoo, Jung-Sook Ha, Dong-Seok Jeon, Jae-Ryong Kim, Hyun-Chul Kim. A case of pneumonia caused by Ewingella americana in a patient with chronic renal failure. Journal of Korean medical science. 2005 Feb; 20(1):143-5. doi: 10.3346/jkms.2005.20.1.143. [PMID: 15716620]
  • Gianluca Aguiari, Manuela Banzi, Stefania Gessi, Yiqiang Cai, Emanuela Zeggio, Elisa Manzati, Roberta Piva, Elisabetta Lambertini, Luisa Ferrari, Dorien J Peters, Francesco Lanza, Peter C Harris, Pier Andrea Borea, Stefan Somlo, Laura Del Senno. Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 May; 18(7):884-6. doi: 10.1096/fj.03-0687fje. [PMID: 15001556]
  • Toyoji Okubo, Shizuko Iyobe. [Antibacterial activities and PK/PD parameters of aminoglycosides against recent clinical isolates of gram-negative rods]. The Japanese journal of antibiotics. 2002 Oct; 55(5):514-23. doi: NULL. [PMID: 12532635]
  • E Boselli, D Breilh, J C Bel, R Debon, M C Saux, D Chassard, B Allaouchiche. Diffusion of isepamicin into cancellous and cortical bone tissue. Journal of chemotherapy (Florence, Italy). 2002 Aug; 14(4):361-5. doi: 10.1179/joc.2002.14.4.361. [PMID: 12420853]
  • Tomoko Yazaki, Yuji Yoshiyama, Paul Wong, Denis Beauchamp, Motoko Kanke. Protective effect of fleroxacin against the nephrotoxicity of isepamicin in rats. Biological & pharmaceutical bulletin. 2002 Apr; 25(4):516-9. doi: 10.1248/bpb.25.516. [PMID: 11995935]
  • H C Maltezou, M Baka, N Gombakis, D E Koliouskas, H Kosmidou, E Malaka-Zafiriou, D A Kafetzis. Comparison of isepamicin with amikacin for the empirical treatment of febrile neutropenic children with malignancies. International journal of antimicrobial agents. 2001 Oct; 18(4):383-6. doi: 10.1016/s0924-8579(01)00420-4. [PMID: 11691573]
  • F Fauvelle, J M Coulaud, K Lecointre, D Tardy, J F Poussel, G Trape. Comparison of two methods to obtain a desired first isepamicin peak in intensive care patients. Fundamental & clinical pharmacology. 2001 Apr; 15(2):151-6. doi: 10.1046/j.1472-8206.2001.00020.x. [PMID: 11468025]
  • M El Mouedden, G Laurent, M P Mingeot-Leclercq, H S Taper, J Cumps, P M Tulkens. Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides. Antimicrobial agents and chemotherapy. 2000 Mar; 44(3):665-75. doi: 10.1128/aac.44.3.665-675.2000. [PMID: 10681336]
  • M Tod, C Padoin, O Petitjean. Clinical pharmacokinetics and pharmacodynamics of isepamicin. Clinical pharmacokinetics. 2000 Mar; 38(3):205-23. doi: 10.2165/00003088-200038030-00002. [PMID: 10749517]
  • D A Kafetzis, H C Maltezou, M Mavrikou, C Siafas, I Paraskakis, D Delis, C Bartsokas. Isepamicin versus amikacin for the treatment of acute pyelonephritis in children. International journal of antimicrobial agents. 2000 Feb; 14(1):51-5. doi: 10.1016/s0924-8579(99)00138-7. [PMID: 10717501]
  • D Breilh, B Allaouchiche, H Jaumain, P Boulétreau, D Chassard, I Malbec, D Ducint, M C Saux. Pharmacokinetics of isepamicin during continuous venovenous hemodiafiltration. Antimicrobial agents and chemotherapy. 1999 Oct; 43(10):2409-11. doi: 10.1128/aac.43.10.2409. [PMID: 10508016]
  • M Tod, C Minozzi, G Beaucaire, D Ponsonnet, J Cougnard, O Petitjean. Isepamicin in intensive care unit patients with nosocomial pneumonia: population pharmacokinetic-pharmacodynamic study. The Journal of antimicrobial chemotherapy. 1999 Jul; 44(1):99-108. doi: 10.1093/jac/44.1.99. [PMID: 10459816]
  • Y Yoshiyama, T Yazaki, D Beauchamp, M Kanke. Protective effect of ceftriaxone against the nephrotoxicity of isepamicin administered once daily in rats. Biological & pharmaceutical bulletin. 1998 May; 21(5):520-3. doi: 10.1248/bpb.21.520. [PMID: 9635511]
  • E Eber, T Uhlig, C McMenamin, P D Sly. Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 1998 Mar; 28(3):376-84. doi: 10.1046/j.1365-2222.1998.00240.x. [PMID: 9543089]
  • F Fuentes, J Izquierdo, M M Martín, M L Gomez-Lus, J Prieto. Postanitbiotic and sub-MIC effects of azithromycin and isepamicin against Staphylococcus aureus and Escherichia coli. Antimicrobial agents and chemotherapy. 1998 Feb; 42(2):414-8. doi: 10.1128/aac.42.2.414. [PMID: 9527796]
  • C C Lin, J Veals, C Korduba, M J Hilbert, A Nomeir. Analysis of isepamicin in human plasma by radioimmunoassay, microbiologic assay, and high-performance liquid chromatography. Therapeutic drug monitoring. 1997 Dec; 19(6):675-81. doi: 10.1097/00007691-199712000-00012. [PMID: 9421110]
  • A A Nomeir, E Radwanski, D Cutler, M Affrime, D Christopher, C Korduba, V Batra, C C Lin, M N Cayen. Single-dose pharmacokinetics of isepamicin in young and geriatric volunteers. Journal of clinical pharmacology. 1997 Nov; 37(11):1021-30. doi: 10.1002/j.1552-4604.1997.tb04283.x. [PMID: 9505995]
  • E Radwanski, V Batra, M Cayen, C Korduba, D Cutler, M Affrime, A Nomeir, C C Lin. Pharmacokinetics of isepamicin following a single administration by intravenous infusion or intramuscular injections. Antimicrobial agents and chemotherapy. 1997 Aug; 41(8):1794-6. doi: 10.1128/aac.41.8.1794. [PMID: 9257763]
  • C C Lin, E Radwanski, C Korduba, M Affrime, M N Cayen. Pharmacokinetics of intramuscularly administered isepamicin in man. Chemotherapy. 1997 Mar; 43(2):86-93. doi: 10.1159/000239541. [PMID: 9084916]
  • M Tod, C Padoin, C Minozzi, J Cougnard, O Petitjean. Population pharmacokinetic study of isepamicin with intensive care unit patients. Antimicrobial agents and chemotherapy. 1996 Apr; 40(4):983-7. doi: 10.1128/aac.40.4.983. [PMID: 8849264]
  • F van Bambeke, M P Mingeot-Leclercq, R Brasseur, P M Tulkens, A Schanck. Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents. Chemistry and physics of lipids. 1996 Mar; 79(2):123-35. doi: 10.1016/0009-3084(95)02520-0. [PMID: 8640900]
  • Y Yoshiyama, L Grenier, P Gourde, M Simard, L Lin, N J Morin, M G Bergeron, G Labrecque, D Beauchamp. Temporal variation in nephrotoxicity of low doses of isepamicin in rats. Antimicrobial agents and chemotherapy. 1996 Mar; 40(3):802-6. doi: 10.1128/aac.40.3.802. [PMID: 8851618]
  • C C Lin, E Radwanski, C Korduba, M Cayen, M Affrime. Pharmacokinetics of intravenously administered isepamicin in men. Antimicrobial agents and chemotherapy. 1995 Dec; 39(12):2774-8. doi: 10.1128/aac.39.12.2774. [PMID: 8593018]
  • K Hara, H Koga, S Kohno, H Kobayashi, R Soejima, M Nasu, A Saito, K Shimizu, M Konno. The administration regimen of isepamicin in patients with chronic respiratory tract infection. Chemotherapy. 1995 Nov; 41(6):462-9. doi: 10.1159/000239383. [PMID: 8529437]
  • C Lin, C Korduba, M Affrime, E Radwanski, A Nomeir, V Batra, D Cutler, M N Cayen. Pharmacokinetics and metabolism of 14C-isepamicin in humans following intravenous administration. Antimicrobial agents and chemotherapy. 1995 Oct; 39(10):2201-3. doi: 10.1128/aac.39.10.2201. [PMID: 8619567]
  • F Scaglione, A Viganò, R Colucci, N Zampaglione, C C Lin, D Cutler, R Guerciolini, M Elliott, M Affrime, E Radwanski. Pharmacokinetics of isepamicin in paediatric patients. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):63-9. doi: NULL. [PMID: 8622112]
  • A Viganò, N Principi. A randomised comparison of isepamicin and amikacin in the treatment of bacterial infections in paediatric patients. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):95-101. doi: NULL. [PMID: 8622117]
  • D Blum. An overview of the safety of isepamicin in adults. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):87-93. doi: NULL. [PMID: 8622116]
  • R Herbrecht, D Blaise, D Espinouse, V Leblond, A Sadoun, C Sauvage, C Cordonnier, C Minozzi. Isepamicin once daily plus ceftriaxone versus amikacin plus ceftriaxone in febrile neutropenic patients. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):103-10. doi: NULL. [PMID: 8622099]
  • W A Craig. Once-daily versus multiple-daily dosing of aminoglycosides. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):47-52. doi: NULL. [PMID: 8622110]
  • W Sturm. Isepamicin versus amikacin in the treatment of urinary tract infection. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):149-54. doi: NULL. [PMID: 8622104]
  • W H Barr, R Colucci, E Radwanski, N Zampaglione, D Cutler, C C Lin, M Elliott, M B Affrime. Pharmacokinetics of isepamicin. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):53-61. doi: NULL. [PMID: 8622111]
  • E Rodriguez-Noriega, S Esparza-Ahumada, R Morfin-Otero. Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of skin and skin structure infections. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):155-60. doi: NULL. [PMID: 8622105]
  • R N Jones. Isepamicin (SCH 21420, 1-N-HAPA gentamicin B): microbiological characteristics including antimicrobial potency of spectrum of activity. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):7-16. doi: NULL. [PMID: 8622113]
  • G Petrikkos, H Giamarellou, C Tsagaraki, A Pefanis. Evaluation of the efficacy and safety of isepamicin in the treatment of various bacterial infections. Journal of chemotherapy (Florence, Italy). 1995 Jun; 7 Suppl 2(?):161-4. doi: NULL. [PMID: 8622106]
  • T Uematsu. Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug. International journal of clinical pharmacology, therapy, and toxicology. 1993 Dec; 31(12):606-10. doi: . [PMID: 8314363]
  • M Kuranari, T Nawata, Y Sato, T Sakata, Y Kodama, M Takeyama. Effect of hemodialysis on serum concentration of isepamicin in a patient with endstage renal failure. The Annals of pharmacotherapy. 1993 Oct; 27(10):1284-5. doi: 10.1177/106002809302701022. [PMID: 8251702]
  • Y Yoshiyama, S Nishikawa, T Sugiyama, T Kobayashi, H Shimada, F Tomonaga, S Ohdo, N Ogawa, S Nakano. Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. Antimicrobial agents and chemotherapy. 1993 Sep; 37(9):2042-3. doi: 10.1128/aac.37.9.2042. [PMID: 8239630]
  • C E Halstenson, M O Wong, C S Herman, K L Heim-Duthoy, M A Teal, M B Affrime, J H Kelloway, W F Keane, W M Awni. Effect of concomitant administration of piperacillin on the dispositions of isepamicin and gentamicin in patients with end-stage renal disease. Antimicrobial agents and chemotherapy. 1992 Sep; 36(9):1832-6. doi: 10.1128/aac.36.9.1832. [PMID: 1416875]
  • M Shoshihara, K Kase, Y Tsuda, E Yoshizawa, T Fujimoto. [Fluorescence polarization immunoassay of isepamicin in blood spotted on filter paper]. The Japanese journal of antibiotics. 1992 Jul; 45(7):757-62. doi: ". [PMID: 1522667]
  • M Nishimura, Y Kumamoto, T Hirose, A Shibuya, T Tsukamoto, S Ohya. [Significance of the combined treatment with isepamicin and piperacillin in an in vitro model for complicated cystitis operated by automatic simulator apparatus for urinary concentration]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 1992 Jan; 66(1):6-13. doi: 10.11150/kansenshogakuzasshi1970.66.6. [PMID: 1402064]
  • P J Govaerts, J Claes, P H Van de Heyning, M P Derde, L Kaufman, J F Marquet, M E De Broe. Effect of isepamicin dosing scheme on concentration in cochlear tissue. Antimicrobial agents and chemotherapy. 1991 Nov; 35(11):2401-6. doi: 10.1128/aac.35.11.2401. [PMID: 1804014]
  • C E Halstenson, J S Kelloway, M B Affrime, C C Lin, M A Teal, B E Shapiro, W M Awni. Isepamicin disposition in subjects with various degrees of renal function. Antimicrobial agents and chemotherapy. 1991 Nov; 35(11):2382-7. doi: 10.1128/aac.35.11.2382. [PMID: 1804011]
  • J N Walterspiel, S Feldman, R Van, W R Ravis. Comparative inactivation of isepamicin, amikacin, and gentamicin by nine beta-lactams and two beta-lactamase inhibitors, cilastatin and heparin. Antimicrobial agents and chemotherapy. 1991 Sep; 35(9):1875-8. doi: 10.1128/aac.35.9.1875. [PMID: 1952861]
  • J Blaser. Efficacy of once- and thrice-daily dosing of aminoglycosides in in-vitro models of infection. The Journal of antimicrobial chemotherapy. 1991 May; 27 Suppl C(?):21-8. doi: 10.1093/jac/27.suppl_c.21. [PMID: 1906863]
  • S Dionisotti, F Bamonte, F Scaglione, E Ongini. Simple measurement of isepamicin, a new aminoglycoside antibiotic, in guinea pig and human plasma, using high-performance liquid chromatography with ultraviolet detection. Therapeutic drug monitoring. 1991 Jan; 13(1):73-8. doi: 10.1097/00007691-199101000-00011. [PMID: 2057996]
  • K Suzuki, M Horiba, Y Nagata. [Pharmacokinetic and clinical studies on isepamicin in chronic complicated urinary tract infection using daily single dose treatment]. The Japanese journal of antibiotics. 1990 Sep; 43(9):1649-59. doi: NULL. [PMID: 2262969]
  • J A Maloney, W M Awni. High-performance liquid chromatographic determination of isepamicin in plasma, urine and dialysate. Journal of chromatography. 1990 Apr; 526(2):487-96. doi: 10.1016/s0378-4347(00)82530-x. [PMID: 2361987]
  • T Uematsu, A Mizuno, Y Suzuki, R Sato, T Yamazaki, M Nakashima. Evaluation of a fluorescence polarization immunoassay procedure for quantitation of isepamicin, a new aminoglycoside antibiotic. Therapeutic drug monitoring. 1988; 10(4):459-62. doi: 10.1097/00007691-198804000-00014. [PMID: 3201531]
  • T Suzuki, K Serizawa, Y Somiya, M Shirai, S Endo, M Morishita. [Studies on the metabolic fate of isepamicin sulfate (HAPA-B). I. Absorption, distribution, metabolism and excretion in rats]. The Japanese journal of antibiotics. 1987 Jan; 40(1):188-201. doi: NULL. [PMID: 3586328]
  • T Suzuki, M Shirai, S Endo, Y Somiya, A Sakai, D Nakanishi, M Morishita. [Studies on the metabolic fate of isepamicin sulfate (HAPA-B). V. Plasma concentrations of HAPA-B in dogs after multiple administrations]. The Japanese journal of antibiotics. 1987 Jan; 40(1):232-7. doi: NULL. [PMID: 3586332]
  • K Shibata, I Mita, Y Shinoda, U Nakano, H Kinoshita, M Noguchi, T Uzawa, Y Sohmiya, N Takayanagi. [General pharmacological studies on isepamicin sulfate (HAPA-B)]. The Japanese journal of antibiotics. 1987 Jan; 40(1):145-69. doi: NULL. [PMID: 3586327]
  • M Iwasaki, K Serizawa, T Suzuki, M Morishita, T Takahashi, S Muranishi. [Metabolic fate of 14C-isepamicin sulfate (14C-HAPA-B) in rats. III. Placental transfer and excretion into milk]. The Japanese journal of antibiotics. 1987 Jan; 40(1):259-66. doi: NULL. [PMID: 3586335]
  • M Iwasaki, K Serizawa, T Suzuki, M Morishita, T Takahashi, S Muranishi. [Metabolic fate of 14C-isepamicin sulfate (14C-HAPA-B) in rats. II. Distribution and excretion after the successive administration]. The Japanese journal of antibiotics. 1987 Jan; 40(1):253-8. doi: NULL. [PMID: 3586334]
  • T Suzuki, K Serizawa, Y Somiya, M Shirai, S Endo, M Morishita. [Studies on the metabolic fate of isepamicin sulfate (HAPA-B). II. Accumulation of HAPA-B after multiple administration in rats]. The Japanese journal of antibiotics. 1987 Jan; 40(1):202-7. doi: NULL. [PMID: 3586329]
  • K Serizawa, M Shirai, S Endo, T Suzuki, M Morishita. [Studies on the metabolic fate of isepamicin sulfate (HAPA-B). IV. Intramuscular, intravenous and drip intravenous administration of HAPA-B in dogs]. The Japanese journal of antibiotics. 1987 Jan; 40(1):220-31. doi: NULL. [PMID: 3586331]
  • M Iwasaki, K Serizawa, T Suzuki, M Morishita, T Takahashi, S Muranishi. [Metabolic fate of 14C-isepamicin sulfate (14C-HAPA-B) in rats. I. Absorption, distribution, metabolism and excretion after a single intramuscular and intravenous administration]. The Japanese journal of antibiotics. 1987 Jan; 40(1):239-52. doi: NULL. [PMID: 3586333]
  • M Morishita, T Suzuki, K Serizawa, M Hayashi, K Kinoshita, Y Nakano. [Evaluation of assay methods for isepamicin sulfate (HAPA-B) in body fluids. Bioassay, HPLC and EIA methods]. The Japanese journal of antibiotics. 1987 Jan; 40(1):170-87. doi: NULL. [PMID: 3295322]
  • T Suzuki, Y Somiya, M Shirai, A Sakai, M Iwasaki, M Morishita. [Studies on the metabolic fate of isepamicin sulfate (HAPA-B). III. Intramuscular, intravenous and drip intravenous administration of HAPA-B in rabbits]. The Japanese journal of antibiotics. 1987 Jan; 40(1):208-19. doi: NULL. [PMID: 3586330]
  • T Morino, H Endo, K Shiraiwa, K Sano, M Miura, K Matsumoto, H Yamamoto. [Toxicological studies on isepamicin (HAPA-B). II. Intramuscular subacute toxicity test in the rat]. The Japanese journal of antibiotics. 1986 Dec; 39(12):3179-200. doi: NULL. [PMID: 3560436]
  • H Fujii, K Shiraiwa, M Miura, T Morino, K Matsumoto, H Yamamoto. [Toxicological studies on isepamicin (HAPA-B). VII. Chronic intramuscular test in the rat]. The Japanese journal of antibiotics. 1986 Dec; 39(12):3245-82. doi: NULL. [PMID: 3560438]
  • M Sasaki, K Kawaguchi, H Yamada, Y Kobayashi, H Yamamoto. [Effect of isepamicin (HAPA-B) on reproduction. I. Fertility study in rats (intramuscular administration)]. The Japanese journal of antibiotics. 1986 Dec; 39(12):3283-90. doi: NULL. [PMID: 3560439]
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