etizolam (BioDeep_00000624672)

   


代谢物信息卡片


7-(2-chlorophenyl)-4-ethyl-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaene

化学式: C17H15ClN4S (342.07059000000004)
中文名称: 依替唑仑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=CC2=C(S1)N3C(=NN=C3CN=C2C4=CC=CC=C4Cl)C
InChI: InChI=1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

2 个代谢物同义名

etizolam; 7-(2-chlorophenyl)-4-ethyl-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaene



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guillaume Drevin, Marie Briet, Severine Ferec, Chadi Abbara. Toxicity of designer benzodiazepines: A case of etizolam and cocaine intoxication. Forensic science international. 2022 Jul; 336(?):111324. doi: 10.1016/j.forsciint.2022.111324. [PMID: 35525006]
  • Jirair Gevorkyan, Juliet Kinyua, Sue Pearring, Luke N Rodda. A Case Series of Etizolam in Opioid-Related Deaths. Journal of analytical toxicology. 2021 Aug; 45(7):e4-e17. doi: 10.1093/jat/bkaa146. [PMID: 33031544]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Laura J Hikin, Paul R Smith, Peter D Maskell, Hassan Kurimbokus, Emily Ashong, Lewis Couchman, Stephen R Morley. Femoral blood concentrations of the designer benzodiazepine etizolam in post-mortem cases. Medicine, science, and the law. 2021 Apr; 61(2):122-129. doi: 10.1177/0025802420973814. [PMID: 33236683]
  • Erin Johnson, Jasper van Heemst, Jeshurun Benavides, Bobby Gray. Metabolism and excretion of the benzodiazepine analogue etizolam in the horse. Drug testing and analysis. 2021 Mar; 13(3):583-594. doi: 10.1002/dta.2967. [PMID: 33169539]
  • Szabolcs Sofalvi, Eric S Lavins, Claire K Kaspar, Haley M Michel, Christie L Mitchell-Mata, Marilyn A Huestis, Luigino G Apollonio. Development and Validation of an LC-MS-MS Method for the Detection of 40 Benzodiazepines and Three Z-Drugs in Blood and Urine by Solid-Phase Extraction. Journal of analytical toxicology. 2020 Oct; 44(7):708-717. doi: 10.1093/jat/bkaa072. [PMID: 32808043]
  • V Kolbe, D Rentsch, D Boy, B Schmidt, R Kegler, A Büttner. The adulterated XANAX pill: a fatal intoxication with etizolam and caffeine. International journal of legal medicine. 2020 Sep; 134(5):1727-1731. doi: 10.1007/s00414-020-02352-7. [PMID: 32607751]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Xander M R van Wijk, Cassandra Yun, Shirin Hooshfar, Ann M Arens, Derrick Lung, Alan H B Wu, Kara L Lynch. A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines. Journal of analytical toxicology. 2019 May; 43(4):316-320. doi: 10.1093/jat/bky092. [PMID: 30462225]
  • Sadaharu Miyazono, Kaede Hasegawa, Seri Miyazaki, Hikari Sakakima, Shun Konno, Saori Meguro, Hitoshi Sasajima, Tomohiro Noguchi, Kazumi Osada, Makoto Kashiwayanagi. Etizolam attenuates the reduction in cutaneous temperature induced in mice by exposure to synthetic predator odor. European journal of pharmacology. 2018 Apr; 824(?):157-162. doi: 10.1016/j.ejphar.2018.02.015. [PMID: 29438703]
  • Takehito Yamamoto, Kenichi Furihata, Akihiro Hisaka, Takashi Moritoyo, Kazuaki Ogoe, Shizuko Kusayama, Keiju Motohashi, Akiko Mori, Takeshi Iwatsubo, Hiroshi Suzuki. Notable Drug-Drug Interaction Between Etizolam and Itraconazole in Poor Metabolizers of Cytochrome P450 2C19. Journal of clinical pharmacology. 2017 Nov; 57(11):1491-1499. doi: 10.1002/jcph.956. [PMID: 28679023]
  • Liang Meng, Binling Zhu, Kefang Zheng, Shanlin Fu. Ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction for the determination of 4 designer benzodiazepines in urine samples by gas chromatography-triple quadrupole mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 May; 1053(?):9-15. doi: 10.1016/j.jchromb.2017.04.008. [PMID: 28399467]
  • Aiko Torikoshi, Akira Namera, Yousuke Arima, Hirokazu Toubou, Takashi Tajima, Hiroaki Shiraishi, Masataka Nagao. [Cross-reactivity of Instant-View M-1 for detection of benzodiazepine-related drugs and their metabolites in urine]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2014 Mar; 27(1):33-8. doi: NULL. [PMID: 24724359]
  • K Watanabe, K Hasegawa, O Suzuki. A double-suicide autopsy case of potassium poisoning by intravenous administration of potassium aspartate after intake of some psychopharmaceuticals. Human & experimental toxicology. 2011 Jul; 30(7):777-81. doi: 10.1177/0960327110379250. [PMID: 20670988]
  • Keigo Ueda, Takao Namiki, Yuji Kasahara, Atsushi Chino, Hideki Okamoto, Keiko Ogawa, Katsutoshi Terasawa. A case of thalamic pain successfully treated with Kampo medicine. Journal of alternative and complementary medicine (New York, N.Y.). 2011 Jun; 17(6):567-70. doi: 10.1089/acm.2010.0390. [PMID: 21574822]
  • Akira Namera, Masakata Nagao, Akihiro Nakamoto, Shota Miyazaki, Takeshi Saito. Monolithic spin column: a new extraction device for analysis of drugs in urine and serum by GC/MS and HPLC/MS. Journal of AOAC International. 2011 May; 94(3):765-74. doi: 10.1093/jaoac/94.3.765. [PMID: 21797004]
  • Akira Namera, Ryosuke Makita, Masataka Nagao. [Comparison of four immunoassay screening devices for detection of benzodiazepine and its metabolites in urine: mainly detection of etizolam, thienodiazepine and its metabolites]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2011 Mar; 24(1):27-34. doi: NULL. [PMID: 21485120]
  • T Fukasawa, N Yasui-Furukori, A Suzuki, Y Inoue, T Tateishi, K Otani. Pharmacokinetics and pharmacodynamics of etizolam are influenced by polymorphic CYP2C19 activity. European journal of clinical pharmacology. 2005 Dec; 61(11):791-5. doi: 10.1007/s00228-005-0032-8. [PMID: 16261363]
  • S Kondo, T Fukasawa, N Yasui-Furukori, T Aoshima, A Suzuki, Y Inoue, T Tateishi, K Otani. Induction of the metabolism of etizolam by carbamazepine in humans. European journal of clinical pharmacology. 2005 May; 61(3):185-8. doi: 10.1007/s00228-005-0904-y. [PMID: 15776275]
  • Toshiaki Makino, Takahiro Inagaki, Ken-ichi Komatsu, Yoshihiro Kano. Pharmacokinetic interactions between Japanese traditional Kampo medicine and modern medicine (IV). Effect of Kamisyoyosan and Tokisyakuyakusan on the pharmacokinetics of etizolam in rats. Biological & pharmaceutical bulletin. 2005 Feb; 28(2):280-4. doi: 10.1248/bpb.28.280. [PMID: 15684484]
  • Yutaro Suzuki, Yoshiaki Kawashima, Toshiki Shioiri, Toshiyuki Someya. Effects of concomitant fluvoxamine on the plasma concentration of etizolam in Japanese psychiatric patients: wide interindividual variation in the drug interaction. Therapeutic drug monitoring. 2004 Dec; 26(6):638-42. doi: 10.1097/00007691-200412000-00009. [PMID: 15570188]
  • K Araki, N Yasui-Furukori, T Fukasawa, T Aoshima, A Suzuki, Y Inoue, T Tateishi, K Otani. Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism. European journal of clinical pharmacology. 2004 Aug; 60(6):427-30. doi: 10.1007/s00228-004-0789-1. [PMID: 15232663]
  • Yasushi Hori, Keiko Kudo, Mikio Yashiki, Yumiko Kuroki, Yoshihiro Yamaguchi. [Practical analysis of toxic substances useful for clinical toxicology--10--benzodiazepine]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2004 Apr; 17(2):163-8. doi: NULL. [PMID: 15266852]
  • Masakazu Kawajiri, Yasumasa Ohyagi, Hirokazu Furuya, Takehisa Araki, Naohide Inoue, Shigemitsu Esaki, Takeshi Yamada, Junichi Kira. [A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam]. Rinsho shinkeigaku = Clinical neurology. 2002 Feb; 42(2):136-9. doi: NULL. [PMID: 12424963]
  • C Fracasso, S Confalonieri, S Garattini, S Caccia. Single and multiple dose pharmacokinetics of etizolam in healthy subjects. European journal of clinical pharmacology. 1991; 40(2):181-5. doi: 10.1007/bf00280074. [PMID: 2065698]
  • M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study. Cancer treatment reports. 1979 Sep; 63(9-10):1663-7. doi: . [PMID: 91435]