Dexketoprofen (BioDeep_00000624666)

   


代谢物信息卡片


(2S)-2-(3-benzoylphenyl)propanoic acid

化学式: C16H14O3 (254.0942894)
中文名称: (S)-(+)-酮洛芬
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
InChI: InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1

描述信息

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

3 个代谢物同义名

S-(+)-Ketoprofen; Dexketoprofen; (2S)-2-(3-benzoylphenyl)propanoic acid



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ersin Koksal, Yasemin Burcu Ustun, Sezgin Bilgin, Abdurrahman Aksoy, Yavuz Kursad Das, Murat Yarim, Fatih Ozkan, Cengiz Kaya, Burhan Dost. The effects of dexketoprofen on renal ischemia-reperfusion injury: an experimental study. Brazilian journal of anesthesiology (Elsevier). 2022 May; 72(3):365-371. doi: 10.1016/j.bjane.2021.07.033. [PMID: 34411625]
  • Álvaro J Gutiérrez-Bautista, Juan Morgaz, María Del Mar Granados, Rafael J Gómez-Villamandos, Juan M Dominguez, José A Fernandez-Sarmiento, Daniel Aguilar-García, Rocío Navarrete-Calvo. Evaluation and comparison of postoperative analgesic effects of dexketoprofen and methadone in dogs. Veterinary anaesthesia and analgesia. 2018 Nov; 45(6):820-830. doi: 10.1016/j.vaa.2018.06.016. [PMID: 30316696]
  • Sibel Ilbasmis-Tamer, Fatmanur Tugcu-Demiroz, Ismail Tuncer Degim. Carbon nanotube membranes to predict skin permeability of compounds. Pharmaceutical development and technology. 2017 Jun; 22(4):606-616. doi: 10.1080/10837450.2016.1221430. [PMID: 27491272]
  • Annika Piirainen, Hannu Kokki, Satu Immonen, Matti Eskelinen, Merja R Häkkinen, Heidi Hautajärvi, Merja Kokki. A Dose-Finding Study of Dexketoprofen in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Clinical Trial on Effects on the Analgesic Concentration of Oxycodone. Drugs in R&D. 2015 Dec; 15(4):319-28. doi: 10.1007/s40268-015-0107-7. [PMID: 26364041]
  • Z K Saritas, T B Saritas, K Pamuk, M Korkmaz, M V Yaprakci, O Yilmaz, I Demirkan. Evaluation of preemptive dexketoprofen trometamol effect on blood chemistry, vital signs and postoperative pain in dogs undergoing ovariohysterectomy. Bratislavske lekarske listy. 2015; 116(3):191-5. doi: 10.4149/bll_2015_038. [PMID: 25869569]
  • Sema Avcı, Selim Genç, Macit Aydın, Fatih Büyükcam, Seda Özkan. Ataxia caused by a single dose of dexketoprofen trometamol. Acta bio-medica : Atenei Parmensis. 2014 Dec; 85(3):269-70. doi: NULL. [PMID: 25567464]
  • Federico Mainardi, Ferdinando Maggioni, Deborha Pezzola, Dario Zava, Giorgio Zanchin. Dexketoprofen trometamol in the acute treatment of migraine attack: a phase II, randomized, double-blind, crossover, placebo-controlled, dose optimization study. The journal of pain. 2014 Apr; 15(4):388-94. doi: 10.1016/j.jpain.2013.12.006. [PMID: 24412801]
  • Sermet Inal, Sahin Kabay, M Kasim Cayci, H Isa Kuru, Sayit Altikat, Gizem Akkas, Aysenur Deger. Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: an experimental rat model. Injury. 2014 Mar; 45(3):494-500. doi: 10.1016/j.injury.2013.10.002. [PMID: 24246878]
  • Ozlem Sagir, Fatma Bahar Sunay, Hatice Yildirim, Elif Aksoz, Sabri Ozaslan, Ahmet Koroglu, Tugsen Aydemir, Ali Engin Ulusal, Feray Kockar. Evaluation of the effects of dexketoprofen trometamol on knee joınt: an in vivo & in vitro study. The Indian journal of medical research. 2013 Dec; 138(6):912-8. doi: NULL. [PMID: 24521635]
  • Tansu Sav, Aydin Unal, Abdulsamet Erden, Ali Ihsan Gunal. Single-dose-dexketoprofen-induced acute kidney injury due to massive rhabdomyolysis. International urology and nephrology. 2012 Oct; 44(5):1581-3. doi: 10.1007/s11255-011-9982-1. [PMID: 21553112]
  • Hugo F Miranda, Maria Asunción Romero, Margarita M Puig. Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice. Fundamental & clinical pharmacology. 2012 Jun; 26(3):373-82. doi: 10.1111/j.1472-8206.2010.00922.x. [PMID: 22081874]
  • Juan Sánchez-Carpena, Fermín Domínguez-Hervella, Ignasi García, Emili Gene, Rosendo Bugarín, Angel Martín, Santiago Tomás-Vecina, Dolors García, José Antonio Serrano, Antonio Roman, Miguel Mariné, María Luisa Mosteiro. Comparison of intravenous dexketoprofen and dipyrone in acute renal colic. European journal of clinical pharmacology. 2007 Aug; 63(8):751-60. doi: 10.1007/s00228-007-0322-4. [PMID: 17571256]
  • J Valles, R Artigas, M Bertolotti, A Crea, F Muller, I Paredes, A Capriati. Single and repeated dose pharmacokinetics of dexketoprofen trometamol in young and elderly subjects. Methods and findings in experimental and clinical pharmacology. 2006 Jun; 28 Suppl A(?):13-9. doi: NULL. [PMID: 16801988]
  • J Valles, R Artigas, A Crea, F Muller, I Paredes, A Zapata, A Capriati. Clinical pharmacokinetics of parenteral dexketoprofen trometamol in healthy subjects. Methods and findings in experimental and clinical pharmacology. 2006 Jun; 28 Suppl A(?):7-12. doi: NULL. [PMID: 16801987]
  • J Valles, R Artigas, M Bertolotti, A Crea, F Muller, I Paredes, A Capriati. Single and repeated dose pharmacokinetics of dexketoprofen trometamol in patients with impaired liver function. Methods and findings in experimental and clinical pharmacology. 2006 Jun; 28 Suppl A(?):29-36. doi: NULL. [PMID: 16801990]
  • G Iohom, M Walsh, G Higgins, G Shorten. Effect of perioperative administration of dexketoprofen on opioid requirements and inflammatory response following elective hip arthroplasty. British journal of anaesthesia. 2002 Apr; 88(4):520-6. doi: 10.1093/bja/88.4.520. [PMID: 12066728]
  • J McEwen, M De Luca, A Casini, I Gich, M J Barbanoj, D Tost, R Artigas, D Mauleón. The effect of food and an antacid on the bioavailability of dexketoprofen trometamol. Journal of clinical pharmacology. 1998 12; 38(S1):41S-45S. doi: NULL. [PMID: 9882081]
  • M L García, D Tost, J Vilageliu, S López, G Carganico, D Mauleón. Bioavailability of S(+)-ketoprofen after oral administration of different mixtures of ketoprofen enantiomers to dogs. Journal of clinical pharmacology. 1998 12; 38(S1):22S-26S. doi: NULL. [PMID: 9882078]
  • A R Kendall. Cost containment: why unnecessary urine cultures?. The Journal of urology. 1979 May; 121(5):691. doi: 10.1016/s0022-5347(17)56955-4. [PMID: 439280]