Thioxothiazolidine-4-carboxylic Acid (BioDeep_00000624654)

   


代谢物信息卡片


(4R)-2-sulfanyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid

化学式: C4H5NO2S2 (162.976171)
中文名称: 2-硫氧代噻唑烷-4-羧酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(NC(=S)S1)C(=O)O
InChI: InChI=1S/C4H5NO2S2/c6-3(7)2-1-9-4(8)5-2/h2H,1H2,(H,5,8)(H,6,7)



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • X Y Xiong, Q X Jiang, W Wang, S C Mao. [Determination of creatinine and 2-thiothiazolidine-4-carboxylic acid in urine by ultra high performance liquid chromatography tandem mass spectrometry]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2022 Mar; 40(3):226-230. doi: 10.3760/cma.j.cn121094-20210817-00399. [PMID: 35439869]
  • Dushani L Palliyaguru, Sonia R Salvatore, Francisco J Schopfer, Xuemei Cheng, Jingyang Zhou, Thomas W Kensler, Stacy G Wendell. Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake. Molecular nutrition & food research. 2019 02; 63(3):e1801029. doi: 10.1002/mnfr.201801029. [PMID: 30408325]
  • Xiang-Long Qu, Bing Yan. Stable Tb(III)-Based Metal-Organic Framework: Structure, Photoluminescence, and Chemical Sensing of 2-Thiazolidinethione-4-carboxylic Acid as a Biomarker of CS2. Inorganic chemistry. 2019 Jan; 58(1):524-534. doi: 10.1021/acs.inorgchem.8b02738. [PMID: 30547593]
  • Thomas Venet, Maria Carreres-Pons, Monique Chalansonnet, Aurélie Thomas, Lise Merlen, Hervé Nunge, Elodie Bonfanti, Frédéric Cosnier, Jordi Llorens, Pierre Campo. Continuous exposure to low-frequency noise and carbon disulfide: Combined effects on hearing. Neurotoxicology. 2017 Sep; 62(?):151-161. doi: 10.1016/j.neuro.2017.06.013. [PMID: 28655499]
  • Jérôme Domergue, Dominique Lison, Vincent Haufroid. No evidence of cardiovascular toxicity in workers exposed below 5 ppm carbon disulfide. International archives of occupational and environmental health. 2016 Jul; 89(5):835-45. doi: 10.1007/s00420-016-1122-x. [PMID: 26940896]
  • Thomas Göen, Axel Schramm, Thomas Baumeister, Wolfgang Uter, Hans Drexler. Current and historical individual data about exposure of workers in the rayon industry to carbon disulfide and their validity in calculating the cumulative dose. International archives of occupational and environmental health. 2014 Aug; 87(6):675-83. doi: 10.1007/s00420-013-0910-9. [PMID: 24085462]
  • Yan-yan Lu, Qing-feng Xiao, Kai-you Jiang, Wen-hua Qin, Shan-fa Yu. [The optimization of 2-thiothiazolidine-4-carboxylic acid back extraction in urine and determination by HPLC]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2012 Jun; 30(6):473-4. doi: NULL. [PMID: 22931784]
  • Kai-you Jiang, Hui Wu, Wen-hua Qin, Qing-feng Xiao, Yan-yan Lu, Shou-ming Cui, Shan-fa Yu. [The rervising of biological exposure index for carbon disulfide exposuring]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2012 Jun; 30(6):479-81. doi: NULL. [PMID: 22931787]
  • Huiqi Li, Bo A G Jönsson, Christian H Lindh, Maria Albin, Karin Broberg. N-nitrosamines are associated with shorter telomere length. Scandinavian journal of work, environment & health. 2011 Jul; 37(4):316-24. doi: 10.5271/sjweh.3150. [PMID: 21321788]
  • Karin S Engström, Maria Wennberg, Ulf Strömberg, Ingvar A Bergdahl, Göran Hallmans, Jan-Håkan Jansson, Thomas Lundh, Margareta Norberg, Gerda Rentschler, Bengt Vessby, Staffan Skerfving, Karin Broberg. Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study. Environmental health : a global access science source. 2011 Apr; 10(?):33. doi: 10.1186/1476-069x-10-33. [PMID: 21504558]
  • Karin Schläwicke Engström, Ulf Strömberg, Thomas Lundh, Ingegerd Johansson, Bengt Vessby, Göran Hallmans, Staffan Skerfving, Karin Broberg. Genetic variation in glutathione-related genes and body burden of methylmercury. Environmental health perspectives. 2008 Jun; 116(6):734-9. doi: 10.1289/ehp.10804. [PMID: 18560528]
  • P Lovreglio, R Bergonzi, G Meliddo, G Pesola, L Mascia, A Basso, M Imbriani, P Apostoli, L Soleo. [Validity of urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) as biomarker of exposure to very low concentrations of carbon disulphide: preliminary results]. Giornale italiano di medicina del lavoro ed ergonomia. 2008 Jan; 30(1):55-60. doi: NULL. [PMID: 18700678]
  • Lena S Jönsson, Karin Broberg, Anna Axmon, Bo Ag Jönsson, Margareta Littorin. Symptoms and immunologic markers among vulcanization workers in rubber industries in southern Sweden. Scandinavian journal of work, environment & health. 2007 Aug; 33(4):272-9. doi: 10.5271/sjweh.1143. [PMID: 17717619]
  • Lena S Jönsson, Karin Broberg, Ulf Bergendorf, Anna Axmon, Margareta Littorin, Bo A G Jönsson. Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries. International archives of occupational and environmental health. 2007 Jul; 80(7):589-98. doi: 10.1007/s00420-007-0171-6. [PMID: 17333241]
  • Gintautas Korinth, Tobias Weiss, Jürgen Angerer, Hans Drexler. Dermal absorption of aromatic amines in workers with different skin lesions: a report on 4 cases. Journal of occupational medicine and toxicology (London, England). 2006 Jul; 1(?):17. doi: 10.1186/1745-6673-1-17. [PMID: 16854230]
  • Roel Vermeulen, Bo A G Jönsson, Christian H Lindh, Hans Kromhout. Biological monitoring of carbon disulphide and phthalate exposure in the contemporary rubber industry. International archives of occupational and environmental health. 2005 Sep; 78(8):663-9. doi: 10.1007/s00420-005-0017-z. [PMID: 16041606]
  • Tzu-Chieh Chou, Tung-Sheng Shih, Hamm-Min Sheu, Shu-Ju Chang, Chin-Chang Huang, Ho-Yuan Chang. The effect of personal factors on the relationship between carbon disulfide exposure and urinary 2-thiothiazolidine-4-carboxylic acid levels in rayon manufacturing workers. The Science of the total environment. 2004 Apr; 322(1-3):51-62. doi: 10.1016/j.scitotenv.2003.08.001. [PMID: 15081737]
  • T Takebayashi, Y Nishiwaki, T Uemura, H Nakashima, T Nomiyama, H Sakurai, K Omae. A six year follow up study of the subclinical effects of carbon disulphide exposure on the cardiovascular system. Occupational and environmental medicine. 2004 Feb; 61(2):127-34. doi: 10.1136/oem.2002.006858. [PMID: 14739378]
  • Hong Luo, Yang Li, Feng-jie Wang, Xiao-qing Chen, Xiao-dong Tan. [Urinary excretion pattern of 2-thio-thiazolidine-4-carboxylic acid in workers exposed to carbon disulfide]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2003 Dec; 21(6):426-8. doi: NULL. [PMID: 14761353]
  • D J Johnson, V Amarnath, K Amarnath, H Valentine, W M Valentine. Characterizing the influence of structure and route of exposure on the disposition of dithiocarbamates using toluene-3,4-dithiol analysis of blood and urinary carbon disulfide metabolites. Toxicological sciences : an official journal of the Society of Toxicology. 2003 Nov; 76(1):65-74. doi: 10.1093/toxsci/kfg226. [PMID: 12972631]
  • Tung-Sheng Shih, Tzu-Chieh Chou, Ho-Yuan Chang, Cheng-Chao Wu, Peng-Yau Wang. Accumulation of urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) among workers occupationally exposed to carbon disulfide for 1 week. The Science of the total environment. 2003 Jun; 308(1-3):37-47. doi: 10.1016/s0048-9697(02)00617-4. [PMID: 12738199]
  • G Korinth, T Göen, K Ulm, R Hardt, M Hubmann, H Drexler. Cardiovascular function of workers exposed to carbon disulphide. International archives of occupational and environmental health. 2003 Feb; 76(1):81-5. doi: 10.1007/s00420-002-0384-7. [PMID: 12592587]
  • L Jian. Alcohol and urinary 2-thiothiazolidine-4-carboxylic acid. Toxicology letters. 2002 Aug; 134(1-3):277-83. doi: 10.1016/s0378-4274(02)00177-7. [PMID: 12191889]
  • Ho-Yuan Chang, Tzu-Chieh Chou, Peng-Yau Wang, Tung-Sheng Shih. Biological monitoring of carbon disulphide: kinetics of urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) in exposed workers. Toxicology and industrial health. 2002 Feb; 18(1):1-14. doi: 10.1191/0748233702th125oa. [PMID: 12703678]
  • X Tan, F Wang, Y Bi, Y Su, Y Li, J He, P Yi, J Yan, D de Bacquer, L Braeckman, M Vanhoorne. The cross-sectional study of the health effects of occupational exposure to carbon disulfide in a Chinese viscose plant. Environmental toxicology. 2001 Oct; 16(5):377-82. doi: 10.1002/tox.1046. [PMID: 11594023]
  • V Amarnath, K Amarnath, D G Graham, Q Qi, H Valentine, J Zhang, W M Valentine. Identification of a new urinary metabolite of carbon disulfide using an improved method for the determination of 2-thioxothiazolidine-4-carboxylic acid. Chemical research in toxicology. 2001 Sep; 14(9):1277-83. doi: 10.1021/tx010085x. [PMID: 11559044]
  • X Tan, Y Bi, Y Su, Y Li, J He, P Yi, J Yan, C Wang, F Wang, M Vanhoorne. Carbon disulfide at a Chinese viscose factory external and internal exposure assessment. Journal of environmental monitoring : JEM. 2000 Dec; 2(6):666-9. doi: 10.1039/b005810f. [PMID: 11296759]
  • H Kivistö. TTCA measurements in biomonitoring of low-level exposure to carbon disulphide. International archives of occupational and environmental health. 2000 May; 73(4):263-9. doi: 10.1007/s004200050426. [PMID: 10877032]
  • L Jian, W J Cao. Cigarette smoking and urinary organic sulfides. Biomedical and environmental sciences : BES. 2000 Mar; 13(1):7-11. doi: NULL. [PMID: 10853834]
  • S Ghittori, L Abatangelo, M Imbriani. [Biologic monitoring of carbon disulfide: role of glutathione]. Giornale italiano di medicina del lavoro ed ergonomia. 1999 Oct; 21(4):341-6. doi: . [PMID: 10771749]
  • J Roh, C N Kim, N G Lim, J H Chang, Y B Cho. Simultaneous analysis of urinary 2-thiothiazolidine-4-carboxylic acid and thiocarbamide as a biological exposure index for carbon disulfide exposure. Yonsei medical journal. 1999 Jun; 40(3):265-72. doi: 10.3349/ymj.1999.40.3.265. [PMID: 10412339]
  • C Wang, Y Bi, X Tan, J Yan. [Serum sex hormone and urinary metabolites of male workers exposed to carbon disulfide]. Wei sheng yan jiu = Journal of hygiene research. 1999 May; 28(3):132-3. doi: NULL. [PMID: 12712711]
  • T Weiss, J Hardt, J Angerer. Determination of urinary 2-thiazolidinethione-4-carboxylic acid after exposure to alkylene bisdithiocarbamates using gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1999 Apr; 726(1-2):85-94. doi: 10.1016/s0378-4347(99)00034-1. [PMID: 10348174]
  • E Daemen, M van Risseghem, D de Bacquer, P Bulat, L Braeckman, M Vanhoorne. Preliminary external quality assessment for the biological monitoring of carbon disulfide with urinary 2-thiothiazolidine-4-carboxylic acid. The Annals of occupational hygiene. 1999 Feb; 43(2):125-30. doi: NULL. [PMID: 10206041]
  • S Ghittori, L Maestri, I Contardi, P Zadra, P Marraccini, M Imbriani. Biological monitoring of workers exposed to carbon disulfide (CS2) in a viscose rayon fibers factory. American journal of industrial medicine. 1998 May; 33(5):478-84. doi: 10.1002/(sici)1097-0274(199805)33:5<478::aid-ajim7>3.0.co;2-o. [PMID: 9557171]
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  • C Cox, S S Hee, W P Tolos. Biological monitoring of workers exposed to carbon disulfide. American journal of industrial medicine. 1998 Jan; 33(1):48-54. doi: 10.1002/(sici)1097-0274(199801)33:1<48::aid-ajim6>3.0.co;2-s. [PMID: 9408528]
  • F Reinhardt, H Drexler, A Bickel, D Claus, J Angerer, K Ulm, G Lehnert, B Neundörfer. Neurotoxicity of long-term low-level exposure to carbon disulphide: results of questionnaire, clinical neurological examination and neuropsychological testing. International archives of occupational and environmental health. 1997; 69(5):332-8. doi: 10.1007/s004200050156. [PMID: 9192217]
  • D J Johnson, D G Graham, V Amarnath, K Amarnath, W M Valentine. The measurement of 2-thiothiazolidine-4-carboxylic acid as an index of the in vivo release of CS2 by dithiocarbamates. Chemical research in toxicology. 1996 Jul; 9(5):910-6. doi: 10.1021/tx960006v. [PMID: 8828929]
  • C Cox, S S Que Hee. Synthesis of 2-thiothiazolidine-4-carboxylic acid and its chromatography in rat and human urine. Journal of chromatography. B, Biomedical applications. 1996 Apr; 679(1-2):85-90. doi: 10.1016/0378-4347(96)00033-3. [PMID: 8998574]
  • C Cox, S S Que Hee, D W Lynch. Urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) as the major urinary marker of carbon disulfide vapor exposure in rats. Toxicology and industrial health. 1996 Jan; 12(1):81-92. doi: 10.1177/074823379601200105. [PMID: 8713716]
  • B L Lee, X F Yang, A L New, C N Ong. Liquid chromatographic determination of urinary 2-thiothiazolidine-4-carboxylic acid, a biomarker of carbon disulphide exposure. Journal of chromatography. B, Biomedical applications. 1995 Jun; 668(2):265-72. doi: 10.1016/0378-4347(95)00086-x. [PMID: 7581861]
  • H Kivistö, E Elovaara, V Riihimaki, A Aitio. Effect of cytochrome P450 isozyme induction and glutathione depletion on the metabolism of CS2 to TTCA in rats. Archives of toxicology. 1995; 69(3):185-90. doi: 10.1007/s002040050156. [PMID: 7717875]
  • H Drexler, T Göen, J Angerer. Carbon disulphide. II. Investigations on the uptake of CS2 and the excretion of its metabolite 2-thiothiazolidine-4-carboxylic acid after occupational exposure. International archives of occupational and environmental health. 1995; 67(1):5-10. doi: 10.1007/bf00383126. [PMID: 7622280]
  • H Drexler, T Göen, J Angerer, S Abou-el-ela, G Lehnert. Carbon disulphide. I. External and internal exposure to carbon disulphide of workers in the viscose industry. International archives of occupational and environmental health. 1994; 65(6):359-65. doi: 10.1007/bf00383244. [PMID: 8034359]
  • P Simon, T Nicot, M Dieudonné. Dietary habits, a non-negligible source of 2-thiothiazolidine-4-carboxylic acid and possible overestimation of carbon disulfide exposure. International archives of occupational and environmental health. 1994; 66(2):85-90. doi: 10.1007/bf00383362. [PMID: 7806401]
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