3-Isomangostin (BioDeep_00000624422)

Main id: BioDeep_00000017218

 

PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one

化学式: C24H26O6 (410.1729)
中文名称: 3-异倒捻子素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C(C)=C\CC1=C2C(OC3=C(C(O)=C4C(OC(C)(C)CC4)=C3)C2=O)=CC(O)=C1OC
InChI: InChI=1S/C24H26O6/c1-12(2)6-7-14-19-17(10-15(25)23(14)28-5)29-18-11-16-13(8-9-24(3,4)30-16)21(26)20(18)22(19)27/h6,10-11,25-26H,7-9H2,1-5H3

描述信息

3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52?nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents[1].
3-Isomangostin, extracted from Garciniamangostana.L. shell, is a potent MutT homologue 1 (MTH1) inhibitor with an IC50 value of 52?nM. 3-Isomangostin would be an attractive chemical tool for the development of anticancer agents[1].

同义名列表

3 个代谢物同义名

5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one; 5,9-DIHYDROXY-8-METHOXY-2,2-DIMETHYL-7-(3-METHYLBUT-2-EN-1-YL)-2,3,4,6-TETRAHYDRO-1,11-DIOXATETRACEN-6-ONE; 3-Isomangostin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Edwin Risky Sukandar, Sutin Kaennakam, Kitiya Rassamee, Taslim Ersam, Pongpun Siripong, Santi Tip-Pyang. Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra. Journal of natural products. 2019 05; 82(5):1312-1318. doi: 10.1021/acs.jnatprod.9b00046. [PMID: 30978023]
  • Sri Fatmawati, Taslim Ersam, Kuniyoshi Shimizu. The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Jan; 22(1):49-51. doi: 10.1016/j.phymed.2014.11.001. [PMID: 25636870]
  • K Y Khaw, S B Choi, S C Tan, H A Wahab, K L Chan, V Murugaiyah. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Sep; 21(11):1303-9. doi: 10.1016/j.phymed.2014.06.017. [PMID: 25172794]
  • Gwendoline Cheng Lian Ee, Shaari Daud, Sheikh Ahmad Izzaddin, Mawardi Rahmani. Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line. Journal of Asian natural products research. 2008 May; 10(5-6):475-9. doi: 10.1080/10286020801948490. [PMID: 18464091]