Bryonolic acid (BioDeep_00000620691)

 

Secondary id: BioDeep_00000025020, BioDeep_00000396518

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2R,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-Hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,2,3,4,4a,5,6,6a,7,8,8a,9,10,11,12,12a,13,14,14a,14b-eicosahydro-picene-2-carboxylic acid

化学式: C30H48O3 (456.36032579999994)
中文名称: 泻根醇酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C[C@H](O)C(C)(C)C2([H])CCC3[C@@]4(CC[C@@]5(C)CC[C@](C(O)=O)(C)C[C@@]5([H])[C@]4(C)CCC=3[C@]12C)C
InChI: InChI=1S/C30H48O3/c1-25(2)21-9-8-20-19(28(21,5)12-11-23(25)31)10-13-30(7)22-18-27(4,24(32)33)15-14-26(22,3)16-17-29(20,30)6/h21-23,31H,8-18H2,1-7H3,(H,32,33)

描述信息

同义名列表

10 个代谢物同义名

Bryonolic acid; (2R,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-Hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,2,3,4,4a,5,6,6a,7,8,8a,9,10,11,12,12a,13,14,14a,14b-eicosahydro-picene-2-carboxylic acid; (2R,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid; AIDS-075058; 24480-44-2; AIDS075058; (20R)-3beta-hydroxy-D:C-friedoolean-8-en-29-oic acid; 10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,2,3,4,4a,5,6,6a,7,8,8a,9,10,11,12,12a,13,14,14a,14b-icosahydropicene-2-carboxylic acid; 10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,3,4,5,6,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-2-carboxylic acid; 3beta-hydroxy-D-C-friedoolean-8-en-29-oic acid



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

37 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pornpatsorn Lertphadungkit, Xue Qiao, Supaart Sirikantaramas, Veena Satitpatipan, Min Ye, Somnuk Bunsupa. De novo transcriptome analysis and identification of candidate genes associated with triterpenoid biosynthesis in Trichosanthes cucumerina L. Plant cell reports. 2021 Oct; 40(10):1845-1858. doi: 10.1007/s00299-021-02748-8. [PMID: 34228189]
  • Jinhua Que, Miao Ye, Yuqin Zhang, Wen Xu, Huang Li, Wei Xu, Kedan Chu. Bryonolic Acid, a Triterpenoid, Protect Against N-methyl-d-Aspartate-Induced Neurotoxicity in PC12 Cells. Molecules (Basel, Switzerland). 2016 Mar; 21(4):418. doi: 10.3390/molecules21040418. [PMID: 27043504]
  • Shamim Sahranavard, Farzaneh Naghibi, Karsten Siems, Kristina Jenett-Siems. New cucurbitane-type triterpenoids from Bryonia aspera. Planta medica. 2010 Jul; 76(10):1014-7. doi: 10.1055/s-0029-1240840. [PMID: 20108178]
  • Emily C Barker, Tonibelle N Gatbonton-Schwager, Yong Han, Jennifer E Clay, John J Letterio, Gregory P Tochtrop. Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages. Journal of natural products. 2010 Jun; 73(6):1064-8. doi: 10.1021/np1000076. [PMID: 20481554]
  • F Khallouki, W E Hull, R W Owen. Characterization of a rare triterpenoid and minor phenolic compounds in the root bark of Anisophyllea dichostyla R. Br. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Aug; 47(8):2007-12. doi: 10.1016/j.fct.2009.05.018. [PMID: 19460411]
  • Sumonthip Kongtun, Weena Jiratchariyakul, Tanawan Kummalue, Peerapan Tan-ariya, Somyos Kunnachak, August Wilhelm Frahm. Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. Planta medica. 2009 Jun; 75(8):839-42. doi: 10.1055/s-0029-1185455. [PMID: 19288406]
  • Kohki Akiyama, Hideo Hayashi. Arbuscular mycorrhizal fungus-promoted accumulation of two new triterpenoids in cucumber roots. Bioscience, biotechnology, and biochemistry. 2002 Apr; 66(4):762-9. doi: 10.1271/bbb.66.762. [PMID: 12036048]
  • T Akihisa, J Ogihara, J Kato, K Yasukawa, M Ukiya, S Yamanouchi, K Oishi. Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase. Lipids. 2001 May; 36(5):507-12. doi: 10.1007/s11745-001-0750-4. [PMID: 11432464]
  • T Kondo, M Inoue, H Mizukami, Y Ogihara. Cytotoxic activity of bryonolic acid isolated from transformed hairy roots of Trichosanthes kirilowii var. japonica. Biological & pharmaceutical bulletin. 1995 May; 18(5):726-9. doi: 10.1248/bpb.18.726. [PMID: 7492990]
  • T Takeda, T Kondo, H Mizukami, Y Ogihara. Bryonolic acid production in hairy roots of Trichosanthes kirilowii Max. var Japonica Kitam. Transformed with Agrobacterium rhizogenes and its cytotoxic activity. Chemical & pharmaceutical bulletin. 1994 Mar; 42(3):730-2. doi: 10.1248/cpb.42.730. [PMID: 8004724]
  • L Q Huang, S T Yao. [Studies on the chemical constituents of Trichosanthes hupehensis C.Y. Cheng et Yueh]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1993 Aug; 18(8):491-2, 510. doi: ". [PMID: 8011097]
  • M Tabata, S Tanaka, H J Cho, C Uno, J Shimakura, M Ito, W Kamisako, C Honda. Production of an anti-allergic triterpene bryonolic acid, by plant cell cultures. Journal of natural products. 1993 Feb; 56(2):165-74. doi: 10.1021/np50092a001. [PMID: 8463793]
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