GANODERIC ACID A (BioDeep_00000619394)
Main id: BioDeep_00000396315
PANOMIX_OTCML-2023
代谢物信息卡片
(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid
化学式: C30H44O7 (516.3086874)
中文名称: 灵芝酸A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC(=O)CC(C)C(=O)O)C1CC(C2(C1(CC(=O)C3=C2C(CC4C3(CCC(=O)C4(C)C)C)O)C)C)O
InChI: InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)
描述信息
Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.
Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway, also inhibit proliferation, viability, ROS.
同义名列表
4 个代谢物同义名
(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid; 6-{9,12-dihydroxy-2,6,6,11,15-pentamethyl-5,17-dioxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-1(10)-en-14-yl}-2-methyl-4-oxoheptanoic acid; 7beta,15alpha-Dihydroxy-3,11,23-trioxo-5alpha-lanost-8-en-26-oic acid; GANODERIC ACID A
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan Li, Guangyu Li, Chenwei Zuo, Xiaolin Wang, Fang Han, Yi Jia, Hai Shang, Yu Tian. Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer.
European journal of medicinal chemistry.
2024 Apr; 270(?):116367. doi:
10.1016/j.ejmech.2024.116367. [PMID: 38581732] - Feifei Ma, Jing Wang, Wenming Jiang, Jiahao Luo, Rui Yang, Liying Zhang, Chunchao Han. Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review.
International journal of medicinal mushrooms.
2024; 26(2):11-23. doi:
10.1615/intjmedmushrooms.2023051918. [PMID: 38421693] - Yi Jia, Yan Li, Hai Shang, Yun Luo, Yu Tian. Ganoderic Acid A and Its Amide Derivatives as Potential Anti-Cancer Agents by Regulating the p53-MDM2 Pathway: Synthesis and Biological Evaluation.
Molecules (Basel, Switzerland).
2023 Mar; 28(5):. doi:
10.3390/molecules28052374. [PMID: 36903622] - Xu-Cong Lv, Qi Wu, Ying-Jia Cao, Yi-Chen Lin, Wei-Ling Guo, Ping-Fan Rao, Yan-Yan Zhang, You-Ting Chen, Lian-Zhong Ai, Li Ni. Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition.
Food & function.
2022 May; 13(10):5820-5837. doi:
10.1039/d1fo03219d. [PMID: 35543349] - Dan Wang, Xianhua Cai, Feng Xu, Hui Kang, Yanjin Li, Ruibing Feng. Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway.
Bioengineered.
2022 05; 13(5):11684-11693. doi:
10.1080/21655979.2022.2070996. [PMID: 35506157] - B Sangeetha, A S Krishnamoorthy, D Jeya Sundara Sharmila, P Renukadevi, V G Malathi, D Amirtham. Molecular modelling of coat protein of the Groundnut bud necrosis tospovirus and its binding with Squalene as an antiviral agent: In vitro and in silico docking investigations.
International journal of biological macromolecules.
2021 Oct; 189(?):618-634. doi:
10.1016/j.ijbiomac.2021.08.143. [PMID: 34437921] - Tao Wang, Huihe Lu. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2021 Oct; 30(10):1031-1041. doi:
10.17219/acem/137914. [PMID: 34329545] - Yuyuan Li, He Liu, Huawen Qi, Wei Tang, Caihua Zhang, Zhaiyi Liu, Yinhui Liu, Xiaoqing Wei, Zhen Kong, Shangyi Jia, Borong Du, Jieli Yuan, Chaoran Wang, Ming Li. Probiotic fermentation of Ganoderma lucidum fruiting body extracts promoted its immunostimulatory activity in mice with dexamethasone-induced immunosuppression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111909. doi:
10.1016/j.biopha.2021.111909. [PMID: 34328088] - Jie-Qiong Ma, Yu-Jia Zhang, Zhi-Kai Tian. Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway.
Chemico-biological interactions.
2021 Aug; 344(?):109529. doi:
10.1016/j.cbi.2021.109529. [PMID: 34029542] - Yue Jia, Dandan Zhang, Hua Yin, Haoran Li, Jing Du, Hongkun Bao. Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor.
Neurochemical research.
2021 Jul; 46(7):1725-1736. doi:
10.1007/s11064-021-03303-3. [PMID: 33821438] - Mahfoozur Rahman, Waleed H Almalki, Imran Kazmi, Obaid Afzal, Hanadi A Katouah, Majed Alrobaian, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Mohammed S Alshammari, Rehan Abdur Rub, Sarwar Beg, Vikas Kumar. Development and validation of a new UPLC-MS/MS method for quantification of ganoderic acid-A loaded nanolipidic carrier in rat plasma and application to pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Jan; 1163(?):122501. doi:
10.1016/j.jchromb.2020.122501. [PMID: 33388522] - Wei-Ling Guo, Jian-Bin Guo, Bin-Yu Liu, Jin-Qiang Lu, Min Chen, Bin Liu, Wei-Dong Bai, Ping-Fan Rao, Li Ni, Xu-Cong Lv. Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet.
Food & function.
2020 Aug; 11(8):6818-6833. doi:
10.1039/d0fo00436g. [PMID: 32686808] - Fuli Liu, Kejian Shi, Jiaojiao Dong, Zhousheng Jin, Yiquan Wu, Yaoyao Cai, Tingting Lin, Qianqian Cai, Le Liu, Yujian Zhang. Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation.
Archives of pharmacal research.
2020 Jul; 43(7):744-754. doi:
10.1007/s12272-020-01256-9. [PMID: 32715385] - Jia Meng, Sai-Zhen Wang, Jin-Zhao He, Shuai Zhu, Bo-Yue Huang, Shu-Yuan Wang, Min Li, Hong Zhou, Shu-Qian Lin, Bao-Xue Yang. Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease.
Acta pharmacologica Sinica.
2020 Jun; 41(6):782-790. doi:
10.1038/s41401-019-0329-2. [PMID: 31911637] - Gaoyan Wen, Tian Li, Hua He, Xianmei Zhou, Jia Zhu. Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice.
Pharmacology.
2020; 105(9-10):568-575. doi:
10.1159/000505297. [PMID: 31940650] - Xu Lixin, Yan Lijun, Huang Songping. Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice.
Journal of biochemical and molecular toxicology.
2019 Apr; 33(4):e22271. doi:
10.1002/jbt.22271. [PMID: 30506662] - Guohua Yao, Yuhan Ma, Muhammad Muhammad, Qing Huang. Understanding the infrared and Raman spectra of ganoderic acid A: An experimental and DFT study.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Mar; 210(?):372-380. doi:
10.1016/j.saa.2018.11.019. [PMID: 30502725] - Jing Zhu, Jie Jin, Jiexia Ding, Siying Li, Panpan Cen, Keyi Wang, Hai Wang, Junbo Xia. Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway.
Chemico-biological interactions.
2018 Jun; 290(?):77-87. doi:
10.1016/j.cbi.2018.05.014. [PMID: 29852127] - Fang-Rui Cao, Bing-Xin Xiao, Li-Sha Wang, Xue Tao, Ming-Zhu Yan, Rui-Le Pan, Yong-Hong Liao, Xin-Min Liu, Qi Chang. Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1052(?):19-26. doi:
10.1016/j.jchromb.2017.03.009. [PMID: 28346885] - Arabinda Das, Rickey Miller, Philip Lee, Chrysanthe Alyssa Holden, Scott M Lindhorst, Jerry Jaboin, William A Vandergrift, Naren L Banik, Pierre Giglio, Abhay K Varma, Jeffery J Raizer, Sunil J Patel. A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2015 Sep; 36(9):7027-34. doi:
10.1007/s13277-015-3388-0. [PMID: 25864108] - Yuka Yajima, Minoru Miyazaki, Noriyasu Okita, Tamotsu Hoshino. Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A.
International journal of medicinal mushrooms.
2013; 15(2):175-82. doi:
10.1615/intjmedmushr.v15.i2.60. [PMID: 23557369] - Sohini Chakrabortee, Yun Liu, Liao Zhang, Helena R Matthews, Hanrui Zhang, Ni Pan, Chun-ru Cheng, Shu-hong Guan, De-an Guo, Zebo Huang, Yizhi Zheng, Alan Tunnacliffe. Macromolecular and small-molecule modulation of intracellular Aβ42 aggregation and associated toxicity.
The Biochemical journal.
2012 Mar; 442(3):507-15. doi:
10.1042/bj20111661. [PMID: 22150318] - Jie-Qing Liu, Cui-Fang Wang, Yan Li, Huai-Rong Luo, Ming-Hua Qiu. Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense.
Planta medica.
2012 Mar; 78(4):368-76. doi:
10.1055/s-0031-1280441. [PMID: 22161763] - Juan Lu, Jia-Zhang Qin, Ping Chen, Xi Chen, Ying-Zhi Zhang, Si-Jia Zhao. Quality Difference Study of Six Varieties of Ganoderma lucidum with Different Origins.
Frontiers in pharmacology.
2012; 3(?):57. doi:
10.3389/fphar.2012.00057. [PMID: 22509164] - Noorlidah Abdullah, Siti Marjiana Ismail, Norhaniza Aminudin, Adawiyah Suriza Shuib, Beng Fye Lau. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):464238. doi:
10.1155/2012/464238. [PMID: 21716693] - Swee Keong Yeap, Abdul Rahman Omar, Abdul Manaf Ali, Wan Yong Ho, Boon Kee Beh, Noorjahan Banu Alitheen. Immunomodulatory Effect of Rhaphidophora korthalsii on Natural Killer Cell Cytotoxicity.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):786487. doi:
10.1155/2012/786487. [PMID: 21941589] - Supanimit Teekachunhatean, Sasinun Sadja, Chadarat Ampasavate, Natthakarn Chiranthanut, Noppamas Rojanasthien, Chaichan Sangdee. Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):780892. doi:
10.1155/2012/780892. [PMID: 22577465] - Tze-Chen Hsieh, Joseph M Wu. Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3.
International journal of molecular medicine.
2011 Dec; 28(6):1065-9. doi:
10.3892/ijmm.2011.788. [PMID: 21887458] - Ulrike Grienke, Judit Mihály-Bison, Daniela Schuster, Taras Afonyushkin, Markus Binder, Shu-hong Guan, Chun-ru Cheng, Gerhard Wolber, Hermann Stuppner, De-an Guo, Valery N Bochkov, Judith M Rollinger. Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum.
Bioorganic & medicinal chemistry.
2011 Nov; 19(22):6779-91. doi:
10.1016/j.bmc.2011.09.039. [PMID: 22014750] - Bingji Ma, Wei Ren, Yan Zhou, Jinchuan Ma, Yuan Ruan, Chun-Nan Wen. Triterpenoids from the spores of Ganoderma lucidum.
North American journal of medical sciences.
2011 Nov; 3(11):495-8. doi:
10.4297/najms.2011.3495. [PMID: 22361494] - Xiao-Qi Zhang, Fanny C F Ip, Dong-Mei Zhang, Li-Xin Chen, Wei Zhang, Yao-Lan Li, Nancy Y Ip, Wen-Cai Ye. Triterpenoids with neurotrophic activity from Ganoderma lucidum.
Natural product research.
2011 Oct; 25(17):1607-13. doi:
10.1080/14786419.2010.496367. [PMID: 21671206] - Anita Thyagarajan-Sahu, Brandon Lane, Daniel Sliva. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK.
BMC complementary and alternative medicine.
2011 Sep; 11(?):74. doi:
10.1186/1472-6882-11-74. [PMID: 21929808] - Chao Ma, Yan Yao, Qing-Xi Yue, Xin-Wen Zhou, Peng-Yuan Yang, Wan-Ying Wu, Shu-Hong Guan, Bao-Hong Jiang, Min Yang, Xuan Liu, De-An Guo. Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B.
PloS one.
2011 Feb; 6(2):e14692. doi:
10.1371/journal.pone.0014692. [PMID: 21379382] - Fenglin Li, Yiming Zhang, Zhijian Zhong. Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice.
International journal of molecular sciences.
2011; 12(9):6135-45. doi:
10.3390/ijms12096135. [PMID: 22016649] - Yonghong Wang, Xiangling Fang, Yongpeng Cheng, Xing Zhang. Manipulation of pH shift to enhance the growth and antibiotic activity of Xenorhabdus nematophila.
Journal of biomedicine & biotechnology.
2011; 2011(?):672369. doi:
10.1155/2011/672369. [PMID: 21660139] - Rahmad Akbar, Wai Keat Yam. Interaction of ganoderic acid on HIV related target: molecular docking studies.
Bioinformation.
2011; 7(8):413-7. doi:
10.6026/97320630007413. [PMID: 22347784] - Q-X Yue, X-Y Song, C Ma, L-X Feng, S-H Guan, W-Y Wu, M Yang, B-H Jiang, X Liu, Y-J Cui, D-A Guo. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2010 Jul; 17(8-9):606-13. doi:
10.1016/j.phymed.2009.12.013. [PMID: 20092987] - Jiri Adamec, Amber Jannasch, Shailesh Dudhgaonkar, Andrej Jedinak, Miroslav Sedlak, Daniel Sliva. Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds.
Journal of separation science.
2009 Dec; 32(23-24):4052-8. doi:
10.1002/jssc.200900496. [PMID: 19937965] - Qun Zhang, Feng Zuo, Norio Nakamura, Chao-Mei Ma, Masao Hattori. Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum.
Journal of natural medicines.
2009 Jul; 63(3):304-10. doi:
10.1007/s11418-009-0337-5. [PMID: 19407927] - Ichiko Miyamoto, Jie Liu, Kuniyoshi Shimizu, Masao Sato, Akiko Kukita, Toshio Kukita, Ryuichiro Kondo. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.
European journal of pharmacology.
2009 Jan; 602(1):1-7. doi:
10.1016/j.ejphar.2008.11.005. [PMID: 19026632] - Yu-Ching Fang, Hsuan-Cheng Huang, Hsin-Hsi Chen, Hsueh-Fen Juan. TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining.
BMC complementary and alternative medicine.
2008 Oct; 8(?):58. doi:
10.1186/1472-6882-8-58. [PMID: 18854039] - Fei Wang, Ji-Kai Liu. Highly oxygenated lanostane triterpenoids from the fungus Ganoderma applanatum.
Chemical & pharmaceutical bulletin.
2008 Jul; 56(7):1035-7. doi:
10.1248/cpb.56.1035. [PMID: 18591828] - Qing-Xi Yue, Zhi-Wei Cao, Shu-Hong Guan, Xiao-Hui Liu, Lin Tao, Wan-Ying Wu, Yi-Xue Li, Peng-Yuan Yang, Xuan Liu, De-An Guo. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.
Molecular & cellular proteomics : MCP.
2008 May; 7(5):949-61. doi:
10.1074/mcp.m700259-mcp200. [PMID: 18166740] - Xiao-qi Zhang, Guo-liang Pang, Yan Cheng, Ying Wang, Wen-cai Ye. [Chemical constituents of the spores of Ganoderma lucidum].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2008 Jan; 31(1):41-4. doi:
". [PMID: 18589746] - Anita Thyagarajan, Jiahua Jiang, Amber Hopf, Jiri Adamec, Daniel Sliva. Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion.
International journal of molecular medicine.
2006 Oct; 18(4):657-64. doi:
10.3892/ijmm.18.4.657. [PMID: 16964420] - Chyi-Hann Li, Pei-Yu Chen, Ue-Min Chang, Lou-Sing Kan, Woei-Horng Fang, Keh-Sung Tsai, Shwu-Bin Lin. Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells.
Life sciences.
2005 Jun; 77(3):252-65. doi:
10.1016/j.lfs.2004.09.045. [PMID: 15878354] - K Koyama, T Imaizumi, M Akiba, K Kinoshita, K Takahashi, A Suzuki, S Yano, S Horie, K Watanabe, Y Naoi. Antinociceptive components of Ganoderma lucidum.
Planta medica.
1997 Jun; 63(3):224-7. doi:
10.1055/s-2006-957658. [PMID: 9225603]