Oxazepam glucuronide (BioDeep_00000618928)
代谢物信息卡片
化学式: C21H19ClN2O8 (462.083)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)OC4C(C(C(C(O4)C(=O)O)O)O)O
InChI: InChI=1S/C21H19ClN2O8/c22-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)24-19(18(28)23-12)32-21-16(27)14(25)15(26)17(31-21)20(29)30/h1-8,14-17,19,21,25-27H,(H,23,28)(H,29,30)/t14-,15-,16+,17-,19?,21-/m0/s1
数据库引用编号
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相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Brittany Malik-Wolf, Shawn Vorce, Justin Holler, Thomas Bosy. Evaluation of abalone β-glucuronidase substitution in current urine hydrolysis procedures.
Journal of analytical toxicology.
2014 Apr; 38(3):171-6. doi:
10.1093/jat/bku003. [PMID: 24488113] - Beitske E Smink, Berendina J A Hofman, Albert Dijkhuizen, Klaas J Lusthof, Johan J de Gier, Antoine C G Egberts, Donald R A Uges. The concentration of oxazepam and oxazepam glucuronide in oral fluid, blood and serum after controlled administration of 15 and 30 mg oxazepam.
British journal of clinical pharmacology.
2008 Oct; 66(4):556-60. doi:
10.1111/j.1365-2125.2008.03252.x. [PMID: 18662285] - Stephanie J Marin, Rebecka Coles, Miles Merrell, Gwendolyn A McMillin. Quantitation of benzodiazepines in urine, serum, plasma, and meconium by LC-MS-MS.
Journal of analytical toxicology.
2008 Sep; 32(7):491-8. doi:
10.1093/jat/32.7.491. [PMID: 18713517] - Michael H Court, Su X Duan, Chantal Guillemette, Kim Journault, Soundararajan Krishnaswamy, Lisa L Von Moltke, David J Greenblatt. Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Nov; 30(11):1257-65. doi:
10.1124/dmd.30.11.1257. [PMID: 12386133] - J Sonne. Factors and conditions affecting the glucuronidation of oxazepam.
Pharmacology & toxicology.
1993; 73 Suppl 1(?):1-23. doi:
10.1111/j.1600-0773.1993.tb01924.x. [PMID: 8415417] - M V St-Pierre, D van den Berg, K S Pang. Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation.
Journal of pharmacokinetics and biopharmaceutics.
1990 Oct; 18(5):423-48. doi:
10.1007/bf01061703. [PMID: 2266497] - J Sonne, S Loft, M Døssing, A Vollmer-Larsen, K L Olesen, M Victor, F Andreasen, P B Andreasen. Bioavailability and pharmacokinetics of oxazepam.
European journal of clinical pharmacology.
1988; 35(4):385-9. doi:
10.1007/bf00561369. [PMID: 3197746] - S F Sisenwine, C O Tio. The metabolic disposition of oxazepam in rats.
Drug metabolism and disposition: the biological fate of chemicals.
1986 Jan; 14(1):41-5. doi:
NULL. [PMID: 2868863] - A M van Hecken, T B Tjandramaga, R Verbesselt, P J de Schepper. The influence of diflunisal on the pharmacokinetics of oxazepam.
British journal of clinical pharmacology.
1985 Sep; 20(3):225-34. doi:
10.1111/j.1365-2125.1985.tb05065.x. [PMID: 4041343] - E J Pantuck, C B Pantuck, K E Anderson, L W Wattenberg, A H Conney, A Kappas. Effect of brussels sprouts and cabbage on drug conjugation.
Clinical pharmacology and therapeutics.
1984 Feb; 35(2):161-9. doi:
10.1038/clpt.1984.22. [PMID: 6692645] - S F Sisenwine, C O Tio, F V Hadley, A L Liu, H B Kimmel, H W Ruelius. Species-related differences in the stereoselective glucuronidation of oxazepam.
Drug metabolism and disposition: the biological fate of chemicals.
1982 Nov; 10(6):605-8. doi:
NULL. [PMID: 6130908] - L Kangas, R Erkkola, J Kanto, M Eronen. Transfer of free and conjugated oxazepam across the human placenta.
European journal of clinical pharmacology.
1980 Apr; 17(4):301-4. doi:
10.1007/bf00625804. [PMID: 7398730] - H Isaacs, J J Heffron, M Badenhorst. 'Picture frame' fibres in a carrier of the trait for malignant hyperpyrexia.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
1975 Nov; 49(46):1923-6. doi:
NULL. [PMID: 795]
