Muskone (BioDeep_00000618893)

Main id: BioDeep_00000018197

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-Methylcyclopentadecan-1-one

化学式: C16H30O (238.2297)
中文名称: 麝香酮, 酮麝香
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCCCCCCCCCCCC(=O)C1
InChI: InChI=1S/C16H30O/c1-15-12-10-8-6-4-2-3-5-7-9-11-13-16(17)14-15/h15H,2-14H2,1H3

描述信息

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].

同义名列表

15 个代谢物同义名

3-Methylcyclopentadecan-1-one; 5-Methyl-1-cyclopentadecanone; 3-Methyl-1-cyclopentadecanone; DL-3-Methylcyclopentadecanone; 3-Methyl-cyclopentadecanone; 3-Methylcyclopentadecanone; Moschus ketone; Methylexaltone; (+/-)-muscone; DL-MUSCONE; FEMA 3434; Exaltone; Muskone; Muscone; Muscone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Li Li, Shaowei Zhuang, Shengyang Jiang. Muscone inhibits the progression of atherosclerotic plaques in mice aorta by inhibiting the NF-κB/p65 pathway. Biochemical and biophysical research communications. 2024 Apr; 702(?):149628. doi: 10.1016/j.bbrc.2024.149628. [PMID: 38335704]
  • Bin Sun, Jing Luo, Zhen Li, Dongfeng Chen, Qizhang Wang, Wenwen Si. Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke. Experimental neurology. 2024 Jan; 373(?):114678. doi: 10.1016/j.expneurol.2024.114678. [PMID: 38185313]
  • Ping Huang, Mei-Ling Yuan, Lei Wang, Yu-Ang Chen, Ning Wang, Si-Peng Wu. [Muscone inhibits opening of mPTP to alleviate OGD/R-induced injury of HT22 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(22):6154-6163. doi: 10.19540/j.cnki.cjcmm.20230712.703. [PMID: 38114222]
  • Shuang Yang, Yingying Bi, Yanzhao Wei, Wei Li, Jiangwen Liu, Tuohua Mao, Yanhong Tang. Muscone attenuates susceptibility to ventricular arrhythmia by inhibiting NLRP3 inflammasome activation in rats after myocardial infarction. Journal of biochemical and molecular toxicology. 2023 Nov; 37(11):e23458. doi: 10.1002/jbt.23458. [PMID: 37455625]
  • Gang Shen, Zongyuan Zhou, Yanlei Guo, Li Li, Jin Zeng, Jianbo Wang, Junning Zhao. Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+ antagonism and maintaining mitochondrial function. Journal of ethnopharmacology. 2023 Sep; 319(Pt 2):117192. doi: 10.1016/j.jep.2023.117192. [PMID: 37734472]
  • Pei Zhang, Suxin You, Xinyue Ding, Pengwei Luan, Jiazhen Xu, Qianfei Cui, Feiyun Wang, Ruixiang Li, Yuying Zhu, Jiange Zhang. Protective effect and underlying mechanism of muscone on acute cerebral ischemia-reperfusion injury in rats. Journal of ethnopharmacology. 2023 May; 308(?):116287. doi: 10.1016/j.jep.2023.116287. [PMID: 36841376]
  • Jiao Song, Wei Liao, Xuan Deng, Dingkun Zhang, Junzhi Lin, Runchun Xu, Li Han. Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics. Journal of ethnopharmacology. 2023 Jan; 300(?):115723. doi: 10.1016/j.jep.2022.115723. [PMID: 36115600]
  • Li-Li Zhu, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Zhao-Qing Meng, Xin He, Chun-Feng Zhang, Chong-Zhi Wang, Chun-Su Yuan. Muscone suppresses myocardial ischemia damage by regulating PI3K/Akt signaling pathway. Biochimica et biophysica acta. Molecular basis of disease. 2022 12; 1868(12):166539. doi: 10.1016/j.bbadis.2022.166539. [PMID: 36100155]
  • Bingbing Han, Yangang Zhao, Jing Yao, Na Li, Tianhe Fang, Yuan Wang, Zhaoqing Meng, Wei Liu. Proteomics on the role of muscone in the "consciousness-restoring resuscitation" effect of musk on ischemic stroke. Journal of ethnopharmacology. 2022 Oct; 296(?):115475. doi: 10.1016/j.jep.2022.115475. [PMID: 35718056]
  • Xin-Yu Zhao, Jing-Yan Wang, Li-Li Deng, Yu-Juan Liu, Zi-You Guo, Qing Wu. [Enhancing effect and mechanism of muscone on transdermal penetration of traditional Chinese medicine ingredients with different log P value]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Oct; 46(20):5284-5290. doi: 10.19540/j.cnki.cjcmm.20210129.303. [PMID: 34738431]
  • Jun Wang, Hui Xing, Xiaomin Qin, Qun Ren, Jiang Yang, Lin Li. Pharmacological effects and mechanisms of muscone. Journal of ethnopharmacology. 2020 Nov; 262(?):113120. doi: 10.1016/j.jep.2020.113120. [PMID: 32668321]
  • Hung Manh Phung, Sullim Lee, Ji Hye Hwang, Ki Sung Kang. Preventive Effect of Muscone against Cisplatin Nephrotoxicity in LLC-PK1 Cells. Biomolecules. 2020 10; 10(10):. doi: 10.3390/biom10101444. [PMID: 33076219]
  • Long-Yun Zhou, Min Yao, Zi-Rui Tian, Shu-Fen Liu, Yong-Jia Song, Jie Ye, Gan Li, Yue-Li Sun, Xue-Jun Cui, Yong-Jun Wang. Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1-dependent mitochondrial fission. Journal of neurochemistry. 2020 09; 155(2):154-176. doi: 10.1111/jnc.15011. [PMID: 32215908]
  • Ming Li, Liang Yao, Hao Chen, Xuan Ni, Yao Xu, Wengjing Dong, Mingliang Fang, Da Chen, Aowuliji, Liang Xu, Baoquan Zhao, Jiang Deng, Kevin Wh Kwok, Jingfeng Yang, Wu Dong. Chiral toxicity of muscone to embryonic zebrafish heart. Aquatic toxicology (Amsterdam, Netherlands). 2020 May; 222(?):105451. doi: 10.1016/j.aquatox.2020.105451. [PMID: 32097808]
  • Wenchuan Qi, Zhenhua Li, Chunlan Yang, Jiangshan Jiangshan Dai, Qiao Zhang, Di Wang, Chuanfang Wu, Longjiang Xia, Si Xu. Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy. Oncology reports. 2020 03; 43(3):839-850. doi: 10.3892/or.2020.7484. [PMID: 32020222]
  • Yi Liu, Huijie Bian, Siyi Xu, Shu Shu, Junqiu Jia, Jian Chen, Xiang Cao, Xinyu Bao, Yue Gu, Shengnan Xia, Hui Yang, Linjie Yu, Yun Xu, Xiaolei Zhu. Muscone Ameliorates Synaptic Dysfunction and Cognitive Deficits in APP/PS1 Mice. Journal of Alzheimer's disease : JAD. 2020; 76(2):491-504. doi: 10.3233/jad-200188. [PMID: 32538849]
  • Ming-Chao He, Zhe Shi, Meng Qin, Nan-Nan Sha, Yue Li, Duan-Fang Liao, Fu-Hui Lin, Bing Shu, Yue-Li Sun, Ti-Fei Yuan, Yong-Jun Wang, Yan Zhang. Muscone Ameliorates LPS-Induced Depressive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice. The American journal of Chinese medicine. 2020; 48(3):559-577. doi: 10.1142/s0192415x20500287. [PMID: 32345030]
  • Shuangming Kang, Wenjuan Duan, Shangqian Zhang, Dawei Chen, Jianfang Feng, Na Qi. Muscone/RI7217 co-modified upward messenger DTX liposomes enhanced permeability of blood-brain barrier and targeting glioma. Theranostics. 2020; 10(10):4308-4322. doi: 10.7150/thno.41322. [PMID: 32292496]
  • Chun-Ying Wu, Lu Bai, Feng Gu, Wei Wei, Li-Xiu Guo, Dong-Mei Wen. Elimination of typical polycyclic musks in a full-scale membrane bioreactor combined with anaerobic-anoxic-oxic process in municipal wastewater treatment plant. Water science and technology : a journal of the International Association on Water Pollution Research. 2018 Nov; 78(7):1459-1465. doi: 10.2166/wst.2018.423. [PMID: 30427785]
  • Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang, Jianghua Chen. Novel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury. Stem cell research & therapy. 2018 08; 9(1):225. doi: 10.1186/s13287-018-0973-3. [PMID: 30139368]
  • Zhi-Shu Tang, Yan-Ru Liu, Yang Lv, Jin-Ao Duan, Shi-Zhong Chen, Jing Sun, Zhong-Xing Song, Xiao-Min Wu, Li Liu. Quality markers of animal medicinal materials: Correlative analysis of musk reveals distinct metabolic changes induced by multiple factors. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):258-269. doi: 10.1016/j.phymed.2018.03.008. [PMID: 29551642]
  • Lucky Ahmed, Yuetian Zhang, Eric Block, Michael Buehl, Michael J Corr, Rodrigo A Cormanich, Sivaji Gundala, Hiroaki Matsunami, David O'Hagan, Mehmet Ozbil, Yi Pan, Sivakumar Sekharan, Nicholas Ten, Mingan Wang, Mingyan Yang, Qingzhi Zhang, Ruina Zhang, Victor S Batista, Hanyi Zhuang. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds. Proceedings of the National Academy of Sciences of the United States of America. 2018 04; 115(17):E3950-E3958. doi: 10.1073/pnas.1713026115. [PMID: 29632183]
  • Yunfei Song, Yang Chu, Xiaohui Ma, Haoran Zheng, Xiaolin Bai, Shuiping Zhou, Boyang Yu. GC-MS/MS method for the determination and pharmacokinetic analysis of borneol and muscone in rat after the intravenous administration of Xingnaojing injection. Journal of separation science. 2017 Nov; 40(21):4264-4271. doi: 10.1002/jssc.201700341. [PMID: 28834206]
  • Tao Jiang, Li-fa Huang, Shui-jing Zhou, Jian-jun Cui, Qiang Ye. [Brain Protection of Muscone in Rats with Brain Injury]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2016 Jun; 36(6):724-8. doi: ". [PMID: 27491233]
  • Zhou Kailiang, Zhang Yihui, Lin Dingsheng, Tao Xianyao. Effects of Muscone on Random Skin Flap Survival in Rats. Journal of reconstructive microsurgery. 2016 Mar; 32(3):200-7. doi: 10.1055/s-0035-1565264. [PMID: 26473795]
  • Diyan Li, Binlong Chen, Long Zhang, Uma Gaur, Tianyuan Ma, Hang Jie, Guijun Zhao, Nan Wu, Zhongxian Xu, Huailiang Xu, Yongfang Yao, Ting Lian, Xiaolan Fan, Deying Yang, Mingyao Yang, Qing Zhu, Jessica Satkoski Trask. The musk chemical composition and microbiota of Chinese forest musk deer males. Scientific reports. 2016 Jan; 6(?):18975. doi: 10.1038/srep18975. [PMID: 26744067]
  • Wanlin Chang, Lin Han, Huimei Huang, Bo Wen, Chengcheng Peng, Chao Lv, Weidong Zhang, Runhui Liu. Simultaneous determination of four volatile compounds in rat plasma after oral administration of Shexiang Baoxin Pill (SBP) by HS-SPDE-GC-MS/MS and its application to pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jul; 963(?):47-53. doi: 10.1016/j.jchromb.2014.05.047. [PMID: 24929549]
  • Zhen-Zhen Chen, Shou-Ying Du, Yang Lu, Pan Xu, Bing Yang, Hui-Min Liu. [Mechanism research of aromatics borneol and muscone]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Mar; 37(3):460-4. doi: NULL. [PMID: 25174113]
  • Pengfei Liu, Yetong Feng, Chao Dong, Dandan Yang, Bo Li, Xin Chen, Zhongjun Zhang, Yi Wang, Yulai Zhou, Lei Zhao. Administration of BMSCs with muscone in rats with gentamicin-induced AKI improves their therapeutic efficacy. PloS one. 2014; 9(5):e97123. doi: 10.1371/journal.pone.0097123. [PMID: 24824427]
  • Zhen-Zhen Chen, Yang Lu, Shou-Ying Du, Ke-Xin Shang, Cheng-Bo Cai. Influence of borneol and muscone on geniposide transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. International journal of pharmaceutics. 2013 Nov; 456(1):73-9. doi: 10.1016/j.ijpharm.2013.08.017. [PMID: 23973509]
  • Cheng Jin, Chunxia Yan, Yun Luo, Baocai Li, Jing He, Xiaohe Xiao. Fast and direct quantification of underivatized muscone by ultra performance liquid chromatography coupled with evaporative light scattering detection. Journal of separation science. 2013 Jun; 36(11):1762-7. doi: 10.1002/jssc.201200946. [PMID: 23520031]
  • Ning Wang, Guo-Jie Chang, Qi-Zhong Jin, Qun He, Jing-Song Liu, Dai-Yin Peng. [Analysis of muscone from serum and cerebrospinal fluid of rabbits after intragastric administration of tongqiao huoxue granules]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Aug; 35(8):1291-4. doi: NULL. [PMID: 23320364]
  • Bo Jiang, Fei Cai, Shouhong Gao, Liyuan Meng, Fengying Liang, Xiao Dai, Wen Xu, Wansheng Chen. Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components. Chemico-biological interactions. 2012 Jan; 195(2):105-13. doi: 10.1016/j.cbi.2011.12.001. [PMID: 22178124]
  • Rong Sun, Zuoping Zhang, Wei Huang, Lili Lv, Jianwei Yin. [Protective effects and machanism of muskone on pheochromocytoma cell injure induced by glutamate]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Jul; 34(13):1701-4. doi: ". [PMID: 19873786]
  • Yikui Li, Jinyan Zhang, Lianda Li. Comparison of the therapeutic effects of different compositions of muskone in the treatment of experimental myocardial infarct in rats and analgesia in mice. Phytotherapy research : PTR. 2008 Sep; 22(9):1219-23. doi: 10.1002/ptr.2444. [PMID: 18729258]
  • Yong-Tao Zhang, Kun Ma, Jin-Yan Zhang, Yi-Kui Li, Li-Mao Wu, Xiang-Ri Li, Li Pan, Hi-Li Gao, Lian-Da Li. [Effects of series of Muskone on heart hemodynamics and myocardial consumption of oxygen in experimental dogs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 May; 32(9):827-30. doi: ". [PMID: 17639986]
  • Liu-qing Di, Chun-qin Mao, Hui Xie, Rong Guo, Ming Xue, Ke Yan, Li Zhang, Hong-yan Li. [Study of diffusion of muscone in different inclusion complexes and liposome through mouse (correction of rat) skin in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 Feb; 30(4):260-3. doi: ". [PMID: 15724399]
  • Wen-Kai Chen, Yu-Fang Huang, Hai-Dong Wang. [An experimental study on distribution of musk into the brain through blood brain barrier]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2004 Jul; 2(4):288-91. doi: 10.3736/jcim20040417. [PMID: 15339420]
  • Y W Zhu, G F Cheng, X Y Zhu. [Pharmacokinetics of muscone in rats, rabbits and dogs]. Yao xue xue bao = Acta pharmaceutica Sinica. 1993; 28(3):177-80. doi: NULL. [PMID: 8368076]
  • X Hong, Z Wang. [A preliminary research on the quality of musk]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1991 Apr; 16(4):230-2, 255. doi: ". [PMID: 1863335]
  • E Tanaka, N Kurata, M Kohno, T Yoshida, Y Kuroiwa. Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats. Biochemical pharmacology. 1987 Dec; 36(24):4263-7. doi: 10.1016/0006-2952(87)90668-x. [PMID: 3689452]
  • Z H Zhang, H J Fang. [The analysis of synthetic muscone (DL-3-methylcyclopentadecanone) and its impurities (author's transl)]. Yao xue xue bao = Acta pharmaceutica Sinica. 1981 May; 16(5):371-8. doi: ". [PMID: 7246184]