Monomethyl fumarate (BioDeep_00000618700)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-Butenedioic acid (e)-, monomethyl ester

化学式: C5H6O4 (130.0266076)
中文名称: 富马酸单甲酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC(=O)/C=C/C(=O)O
InChI: InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+

描述信息

A dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1.
C26170 - Protective Agent > C1509 - Neuroprotective Agent
Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

同义名列表

10 个代谢物同义名

Monomethyl fumarate; 2-Butenedioic acid (e)-, monomethyl ester; (2E)-4-Methoxy-4-oxo-2-butenoic acid; (2Z)-4-methoxy-4-oxobut-2-enoic acid; Fumaric acid, monomethyl ester; Fumaric acid monomethyl ester; Fumaric acid, methyl ester; Methyl hydrogen fumarate; mono-Methyl fumarate; Monomethyl fumarate



数据库引用编号

10 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Thomas W Lategan, Laurene Wang, Tiffany N Sprague, Franck S Rousseau. Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam™ (Monomethyl Fumarate) or Tecfidera® (Dimethyl Fumarate). CNS drugs. 2021 05; 35(5):567-574. doi: 10.1007/s40263-021-00799-9. [PMID: 33797063]
  • Chhanda Biswas, Niansheng Chu, Thomas N Burn, Portia A Kreiger, Edward M Behrens. Amelioration of Murine Macrophage Activation Syndrome by Monomethyl Fumarate in Both a Heme Oxygenase 1-Dependent and Heme Oxygenase 1-Independent Manner. Arthritis & rheumatology (Hoboken, N.J.). 2021 05; 73(5):885-895. doi: 10.1002/art.41591. [PMID: 33191652]
  • Hua Tang, Jenny Ying-Lin Lu, Xiaomu Zheng, Yuhua Yang, Jeff D Reagan. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochemical and biophysical research communications. 2008 Oct; 375(4):562-5. doi: 10.1016/j.bbrc.2008.08.041. [PMID: 18722346]
  • Thomas J Schmidt, Muharrem Ak, Ulrich Mrowietz. Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine--preparation of S-substituted thiosuccinic acid esters. Bioorganic & medicinal chemistry. 2007 Jan; 15(1):333-42. doi: 10.1016/j.bmc.2006.09.053. [PMID: 17049250]