Vangard BT (BioDeep_00000618047)

   

PANOMIX_OTCML-2023


代谢物信息卡片


1-Thia-3-azaindene

化学式: C7H5NS (135.014269)
中文名称: 苯并噻唑
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 90%

分子结构信息

SMILES: C12=CC=CC=C1SC=N2
InChI: InChI=1S/C7H5NS/c1-2-4-7-6(3-1)8-5-9-7/h1-5H

描述信息

Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral[1].

同义名列表

9 个代谢物同义名

1-Thia-3-azaindene; 1,3-Benzothiazole; Benzo[d]thiazole; Benzosulfonazole; BENZOTHIAZOLE; Benzothiazol; Vangard BT; BOT; BT



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Anthi Petrou, Panagiotis Zagaliotis, Nikoleta F Theodoroula, George A Mystridis, Ioannis S Vizirianakis, Thomas J Walsh, Athina Geronikaki. Thiazole/Thiadiazole/Benzothiazole Based Thiazolidin-4-One Derivatives as Potential Inhibitors of Main Protease of SARS-CoV-2. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072180. [PMID: 35408577]
  • Matthew Mahoney, Vishnu C Damalanka, Michael A Tartell, Dong Hee Chung, André Luiz Lourenço, Dustin Pwee, Anne E Mayer Bridwell, Markus Hoffmann, Jorine Voss, Partha Karmakar, Nurit P Azouz, Andrea M Klingler, Paul W Rothlauf, Cassandra E Thompson, Melody Lee, Lidija Klampfer, Christina L Stallings, Marc E Rothenberg, Stefan Pöhlmann, Sean P J Whelan, Anthony J O'Donoghue, Charles S Craik, James W Janetka. A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Proceedings of the National Academy of Sciences of the United States of America. 2021 10; 118(43):. doi: 10.1073/pnas.2108728118. [PMID: 34635581]
  • Spyridon Mourtas, Barbara Mavroidi, Antonia Marazioti, Maria Kannavou, Marina Sagnou, Maria Pelecanou, Sophia G Antimisiaris. Liposomes Decorated with 2-(4'-Aminophenyl)benzothiazole Effectively Inhibit Aβ1-42 Fibril Formation and Exhibit in Vitro Brain-Targeting Potential. Biomacromolecules. 2020 12; 21(12):4685-4698. doi: 10.1021/acs.biomac.0c00811. [PMID: 33112137]
  • Jian Song, Qiu-Lei Gao, Bo-Wen Wu, Ting Zhu, Xin-Xin Cui, Cheng-Jun Jin, Shu-Yu Wang, Sheng-Hui Wang, Dong-Jun Fu, Hong-Min Liu, Sai-Yang Zhang, Yan-Bing Zhang, Yong-Chun Li. Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway. European journal of medicinal chemistry. 2020 Oct; 203(?):112618. doi: 10.1016/j.ejmech.2020.112618. [PMID: 32682200]
  • Boris Itkin, Alastair Breen, Lyudmila Turyanska, Eduardo Omar Sandes, Tracey D Bradshaw, Andrea Irene Loaiza-Perez. New Treatments in Renal Cancer: The AhR Ligands. International journal of molecular sciences. 2020 May; 21(10):. doi: 10.3390/ijms21103551. [PMID: 32443455]
  • Andraž Lamut, Marina Gjorgjieva, Lieve Naesens, Sandra Liekens, Katja-Emilia Lillsunde, Päivi Tammela, Danijel Kikelj, Tihomir Tomašič. Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90. Bioorganic chemistry. 2020 05; 98(?):103733. doi: 10.1016/j.bioorg.2020.103733. [PMID: 32171985]
  • Chaoqun You, Hongshuai Wu, Zhiguo Gao, Fanghui Chen, Like Ning, Yu Zhang, Yixin Dong, Baiwang Sun, Fei Wang. Enhanced Reactive Oxygen Species Levels by an Active Benzothiazole Complex-Mediated Fenton Reaction for Highly Effective Antitumor Therapy. Molecular pharmaceutics. 2019 12; 16(12):4929-4939. doi: 10.1021/acs.molpharmaceut.9b00819. [PMID: 31661289]
  • Priyanka Yadav, Jitendra Kumar Yadav, Arvind Kumar Dixit, Alka Agarwal, Satish Kumar Awasthi. Insight into the interaction of benzothiazole tethered triazole analogues with human serum albumin: Spectroscopy and molecular docking approaches. Luminescence : the journal of biological and chemical luminescence. 2019 Dec; 34(8):812-822. doi: 10.1002/bio.3676. [PMID: 31317650]
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  • Bo Luo, Ding Li, An-Ling Zhang, Jin-Ming Gao. Synthesis, Antifungal Activities and Molecular Docking Studies of Benzoxazole and Benzothiazole Derivatives. Molecules (Basel, Switzerland). 2018 Sep; 23(10):. doi: 10.3390/molecules23102457. [PMID: 30257495]
  • Huseyin Bozkurt, Emel Cicek Bozkurt, Hulya Ozpinar, Densel Arac, Ismail Kaya, Hidir Ozer, Reyhan Egilmez. Comparison of the Effects of Contractubex Gel and Benzothiazole After Topical Application in an Experimental Model of Epidural Fibrosis in Rats. World neurosurgery. 2018 Sep; 117(?):e403-e410. doi: 10.1016/j.wneu.2018.06.044. [PMID: 29913295]
  • Youming Shen, Xiangyang Zhang, Youyu Zhang, Haitao Li, Lingcong Dai, Xinju Peng, Zhen Peng, Yingting Xie. A fluorescent sensor for fast detection of peroxynitrite by removing of C=N in a benzothiazole derivative. Analytica chimica acta. 2018 Jul; 1014(?):71-76. doi: 10.1016/j.aca.2018.01.046. [PMID: 29523254]
  • Michelyne Haroun, Christophe Tratrat, Katerina Kositsi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki, Katharigatta N Venugopala, Heba S Elsewedy, Marina Sokovic, Jasna Glamoclija, Ana Ciric. New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation. Current topics in medicinal chemistry. 2018; 18(1):75-87. doi: 10.2174/1568026618666180206101814. [PMID: 29412109]
  • Faheem Uddin Rajer, Huijun Wu, Yongli Xie, Shanshan Xie, Waseem Raza, Hafiz Abdul Samad Tahir, Xuewen Gao. Volatile organic compounds produced by a soil-isolate, Bacillus subtilis FA26 induce adverse ultra-structural changes to the cells of Clavibacter michiganensis ssp. sepedonicus, the causal agent of bacterial ring rot of potato. Microbiology (Reading, England). 2017 04; 163(4):523-530. doi: 10.1099/mic.0.000451. [PMID: 28418289]
  • Abbas Ahmadi, Mohsen Khalili, Lida Sohrabi, Nazanin Delzendeh, Babak Nahri-Niknafs, Fariba Ansari. Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione. Mini reviews in medicinal chemistry. 2017; 17(8):721-726. doi: 10.2174/1389557516666161130095407. [PMID: 27903228]
  • Yunhe Zhao, Kaidi Cui, Chunmei Xu, Qiuhong Wang, Yao Wang, Zhengqun Zhang, Feng Liu, Wei Mu. Proteomic profile of the Bradysia odoriphaga in response to the microbial secondary metabolite benzothiazole. Scientific reports. 2016 11; 6(?):37730. doi: 10.1038/srep37730. [PMID: 27883048]
  • Yunhe Zhao, Chunmei Xu, Qiuhong Wang, Yan Wei, Feng Liu, Shuangyu Xu, Zhengqun Zhang, Wei Mu. Effects of the microbial secondary metabolite benzothiazole on the nutritional physiology and enzyme activities of Bradysia odoriphaga (Diptera: Sciaridae). Pesticide biochemistry and physiology. 2016 May; 129(?):49-55. doi: 10.1016/j.pestbp.2015.10.017. [PMID: 27017881]
  • Bhupendra M Mistry, Rahul V Patel, Young-Soo Keum, Doo Hwan Kim. Chrysin-benzothiazole conjugates as antioxidant and anticancer agents. Bioorganic & medicinal chemistry letters. 2015 Dec; 25(23):5561-5. doi: 10.1016/j.bmcl.2015.10.052. [PMID: 26514745]
  • Weihai Xu, Wen Yan, Tobias Licha. Simultaneous determination of trace benzotriazoles and benzothiazoles in water by large-volume injection/gas chromatography–mass spectrometry. Journal of chromatography. A. 2015 Nov; 1422(?):270-276. doi: 10.1016/j.chroma.2015.10.017. [PMID: 26601711]
  • Zhiqin Ji, Fengxing Zhou, Shaopeng Wei. Synthesis and herbicidal activities of benzothiazole N,O-acetals. Bioorganic & medicinal chemistry letters. 2015 Oct; 25(19):4065-8. doi: 10.1016/j.bmcl.2015.08.051. [PMID: 26318996]
  • Preetpal Singh Sidhu, Qibing Zhou, Umesh R Desai. A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds. Bioorganic & medicinal chemistry letters. 2014 Dec; 24(24):5716-5720. doi: 10.1016/j.bmcl.2014.10.059. [PMID: 25453807]
  • Carla Cruz, Renato E F Boto, Anna K Drzazga, Paulo Almeida, João A Queiroz. NMR screening of new carbocyanine dyes as ligands for affinity chromatography. Journal of molecular recognition : JMR. 2014 Apr; 27(4):197-204. doi: 10.1002/jmr.2351. [PMID: 24591177]
  • Alexandros G Asimakopoulos, Lei Wang, Nikolaos S Thomaidis, Kurunthachalam Kannan. Benzotriazoles and benzothiazoles in human urine from several countries: a perspective on occurrence, biotransformation, and human exposure. Environment international. 2013 Sep; 59(?):274-81. doi: 10.1016/j.envint.2013.06.007. [PMID: 23850588]
  • Sabina Pecchi, Zhi-Jie Ni, Wooseok Han, Aaron Smith, Jiong Lan, Matthew Burger, Hanne Merritt, Marion Wiesmann, John Chan, Susan Kaufman, Mark S Knapp, Johanna Janssen, Kay Huh, Charles F Voliva. Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K. Bioorganic & medicinal chemistry letters. 2013 Aug; 23(16):4652-6. doi: 10.1016/j.bmcl.2013.06.010. [PMID: 23820386]
  • Clara H Loi, Francesco Busetti, Kathryn L Linge, Cynthia A Joll. Development of a solid-phase extraction liquid chromatography tandem mass spectrometry method for benzotriazoles and benzothiazoles in wastewater and recycled water. Journal of chromatography. A. 2013 Jul; 1299(?):48-57. doi: 10.1016/j.chroma.2013.04.073. [PMID: 23768537]
  • Ella Meltzer-Mats, Gali Babai-Shani, Lily Pasternak, Neta Uritsky, Tamar Getter, Olga Viskind, Jürgen Eckel, Erol Cerasi, Hanoch Senderowitz, Shlomo Sasson, Arie Gruzman. Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. Journal of medicinal chemistry. 2013 Jul; 56(13):5335-50. doi: 10.1021/jm4001488. [PMID: 23750537]
  • Gabriel Navarrete-Vazquez, Marleth Ramírez-Martínez, Samuel Estrada-Soto, Carlos Nava-Zuazo, Paolo Paoli, Guido Camici, Jaime Escalante-García, José L Medina-Franco, Fabian López-Vallejo, Rolffy Ortiz-Andrade. Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors. European journal of medicinal chemistry. 2012 Jul; 53(?):346-55. doi: 10.1016/j.ejmech.2012.04.025. [PMID: 22583779]
  • Ashok Arasappan, Frank Bennett, Vinay Girijavallabhan, Yuhua Huang, Regina Huelgas, Carmen Alvarez, Lei Chen, Stephen Gavalas, Seong-Heon Kim, Aneta Kosinski, Patrick Pinto, Razia Rizvi, Randall Rossman, Bandarpalle Shankar, Ling Tong, Francisco Velazquez, Srikanth Venkatraman, Vishal A Verma, Joseph Kozlowski, Neng-Yang Shih, John J Piwinski, Malcolm MacCoss, Cecil D Kwong, Jeremy L Clark, Anita T Fowler, Feng Geng, Hollis S Kezar, Abhijit Roychowdhury, Robert C Reynolds, Joseph A Maddry, Subramaniam Ananthan, John A Secrist, Cheng Li, Robert Chase, Stephanie Curry, Hsueh-Cheng Huang, Xiao Tong, F George Njoroge. 5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors. Bioorganic & medicinal chemistry letters. 2012 May; 22(9):3229-34. doi: 10.1016/j.bmcl.2012.03.036. [PMID: 22472692]
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  • Mu-Yi Hua, Hsiao-Chien Chen, Cheng-Keng Chuang, Rung-Ywan Tsai, Jyh-Long Jeng, Hung-Wei Yang, Yaw-Terng Chern. The intrinsic redox reactions of polyamic acid derivatives and their application in hydrogen peroxide sensor. Biomaterials. 2011 Jul; 32(21):4885-95. doi: 10.1016/j.biomaterials.2011.03.051. [PMID: 21496921]
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