Nipasol (BioDeep_00000617759)

Main id: BioDeep_00000017251

 

PANOMIX_OTCML-2023 Industrial Pollutants


代谢物信息卡片


Benzoic acid, p-hydroxy-, propyl ester

化学式: C10H12O3 (180.0786)
中文名称: 对羟基苯甲酸丙酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCOC(=O)C1=CC=C(C=C1)O
InChI: InChI=1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

描述信息

D010592 - Pharmaceutic Aids > D011310 - Preservatives, Pharmaceutical > D010226 - Parabens
Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats[1][2][3].
Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben also decreases sperm number and motile activity in rats[1][2][3].

同义名列表

43 个代谢物同义名

Benzoic acid, p-hydroxy-, propyl ester; Benzoic acid, 4-hydroxy-, propyl ester; p-Hydroxybenzoic acid n-propyl ester; p-Hydroxybenzoic acid, propyl ester; 4-Hydroxybenzoic acid, propyl ester; 4-hydroxybenzoic acid propyl ester; p-hydroxybenzoic acid propyl ester; 4-Hydroxybenzoic acid propylester; p-Hydroxybenzoic propyl ester; N-Propyl p-hydroxybenzoate; n-Propyl 4-hydroxybenzoate; n-PROPYL-p-HYDROXYBENZOATE; Propyl parahydroxybenzoate; Propyl-4-hydroxybenzoate; p-Hydroxypropyl benzoate; propyl p-hydroxybenzoate; propyl 4-hydroxybenzoate; Propylparaben, USAN; Propyl aseptoform; Propyl Chemosept; Propyl Parasept; N-Propylparaben; Propyl chemsept; Propylparasept; Propyl paraben; Propyl-paraben; Propylparaben; Chemacide pk; Aseptoform P; Propyl Butex; Chemocide pk; Chemoside PK; Tegosept P; Betacine P; Protaben P; Betacide P; Lexgard P; Solbrol P; Nipagin P; Propagin; Nipasol; PrP; Propylparaben



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Carmine Merola, Giulia Caioni, Cristiano Bertolucci, Tyrone Lucon-Xiccato, Beste Başak Savaşçı, Sabrina Tait, Marialuisa Casella, Serena Camerini, Elisabetta Benedetti, Monia Perugini. Embryonic and larval exposure to propylparaben induces developmental and long-term neurotoxicity in zebrafish model. The Science of the total environment. 2024 Feb; 912(?):168925. doi: 10.1016/j.scitotenv.2023.168925. [PMID: 38040379]
  • Xu Zhang, Ying Zhang, Hao Lu, Fan Yu, Xueting Shi, Bingchan Ma, Shuang Zhou, Lin Wang, Qing Lu. Environmental exposure to paraben and its association with blood pressure: A cross-sectional study in China. Chemosphere. 2023 Oct; 339(?):139656. doi: 10.1016/j.chemosphere.2023.139656. [PMID: 37499807]
  • Yousun Lee, Sujin Lee, Sungjun Kim, Dogyeong Lee, Keehoon Won. Solvent-free enzymatic synthesis and evaluation of vanillyl propionate as an effective and biocompatible preservative. Bioprocess and biosystems engineering. 2023 Sep; ?(?):. doi: 10.1007/s00449-023-02921-1. [PMID: 37682355]
  • Rami M Mosaoa, Taha A Kumosani, Soonham S Yaghmoor, Shaimaa Rihan, Said S Moselhy. Rhus tripartite methanolic extract alleviates propylparaben-induced reproductive toxicity via anti-inflammatory, antioxidant, 5-α reductase in male rats. Environmental science and pollution research international. 2023 May; ?(?):. doi: 10.1007/s11356-023-27802-8. [PMID: 37249771]
  • Christy Lite, Ajay Guru, Melita Juliet, Jesu Arockiaraj. Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety-like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae. Environmental toxicology. 2022 Aug; 37(8):1988-2004. doi: 10.1002/tox.23545. [PMID: 35470536]
  • Paulina Jedynak, Jörg Tost, Antonia M Calafat, Ekaterina Bourova-Flin, Florence Busato, Anne Forhan, Barbara Heude, Milan Jakobi, Sophie Rousseaux, Joel Schwartz, Rémy Slama, Daniel Vaiman, Claire Philippat, Johanna Lepeule. Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environmental pollution (Barking, Essex : 1987). 2021 Dec; 290(?):118024. doi: 10.1016/j.envpol.2021.118024. [PMID: 34523531]
  • Luwei Jiao, Shang Li, Junyu Zhai, Dongshuang Wang, Hongwanyu Li, Weiwei Chu, Xueying Geng, Yanzhi Du. Propylparaben concentrations in the urine of women and adverse effects on ovarian function in mice in vivo and ovarian cells in vitro. Journal of applied toxicology : JAT. 2021 11; 41(11):1719-1731. doi: 10.1002/jat.4225. [PMID: 34365652]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yujin Lee, Eun Lee, Dong Keon Yon, Hye Mi Jee, Hey Sung Baek, Seung Won Lee, Joo-Youn Cho, Man Yong Han. The potential pathways underlying the association of propyl-paraben exposure with aeroallergen sensitization and EASI score using metabolomics analysis. Scientific reports. 2021 02; 11(1):3772. doi: 10.1038/s41598-021-83288-9. [PMID: 33580129]
  • Yaghoub Hajizadeh, Ghasem Kiani Feizabadi, Awat Feizi. Dietary Habits and Personal Care Product Use as Predictors of Urinary Concentrations of Parabens in Iranian Adolescents. Environmental toxicology and chemistry. 2020 12; 39(12):2378-2388. doi: 10.1002/etc.4861. [PMID: 32845562]
  • Ghasem Kiani Feizabadi, Yaghoub Hajizadeh, Awat Feizi, Karim Ebrahimpour. Urinary Concentrations of Parabens in a Population of Iranian Adolescent and Their Association with Sociodemographic Indicators. Archives of environmental contamination and toxicology. 2020 Aug; 79(2):195-207. doi: 10.1007/s00244-020-00746-7. [PMID: 32572517]
  • Monia Perugini, Carmine Merola, Michele Amorena, Michele D'Angelo, Annamaria Cimini, Elisabetta Benedetti. Sublethal exposure to propylparaben leads to lipid metabolism impairment in zebrafish early-life stages. Journal of applied toxicology : JAT. 2020 04; 40(4):493-503. doi: 10.1002/jat.3921. [PMID: 31889330]
  • Prabin Dhangada Majhi, Aman Sharma, Amy L Roberts, Elizabeth Daniele, Aliza R Majewski, Lynn M Chuong, Amye L Black, Laura N Vandenberg, Sallie S Schneider, Karen A Dunphy, D Joseph Jerry. Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Environmental health perspectives. 2020 01; 128(1):17002. doi: 10.1289/ehp5221. [PMID: 31939680]
  • Traci N Bethea, Amelia K Wesselink, Jennifer Weuve, Michael D McClean, Russ Hauser, Paige L Williams, Xiaoyun Ye, Antonia M Calafat, Donna D Baird, Lauren A Wise. Correlates of exposure to phenols, parabens, and triclocarban in the Study of Environment, Lifestyle and Fibroids. Journal of exposure science & environmental epidemiology. 2020 01; 30(1):117-136. doi: 10.1038/s41370-019-0114-9. [PMID: 30692588]
  • Lesa Aylward, Giulia Vilone, Christina Cowan-Ellsberry, Jon A Arnot, John N Westgate, Cian O'Mahony, Sean M Hays. Exposure to selected preservatives in personal care products: case study comparison of exposure models and observational biomonitoring data. Journal of exposure science & environmental epidemiology. 2020 01; 30(1):28-41. doi: 10.1038/s41370-018-0104-3. [PMID: 30518793]
  • Na-Youn Park, Yoon Hee Cho, Kyungho Choi, Eun-Hee Lee, Yang Jee Kim, Jung Hoan Kim, Younglim Kho. Parabens in breast milk and possible sources of exposure among lactating women in Korea. Environmental pollution (Barking, Essex : 1987). 2019 Dec; 255(Pt 2):113142. doi: 10.1016/j.envpol.2019.113142. [PMID: 31563777]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shaoyou Lu, Lu Ren, Yanlin Liu, Huimin Ma, Shan Liu, Zhou Zhu, Zhi Tang, Li Kang, Shicheng Liao. Urinary parabens in children from South China: Implications for human exposure and health risks. Environmental pollution (Barking, Essex : 1987). 2019 Nov; 254(Pt A):113007. doi: 10.1016/j.envpol.2019.113007. [PMID: 31421570]
  • Yingxin Yu, Wenbo Li, Shaoyou Lu, Suyang Wu, Feng Wang, Lap Ah Tse, Li Kang, Shengtao Ma. Urinary parabens in adults from South China: Implications for human exposure and health risks. Ecotoxicology and environmental safety. 2019 Oct; 182(?):109419. doi: 10.1016/j.ecoenv.2019.109419. [PMID: 31301591]
  • Mi-Yeon Shin, Chorong Shin, Jeong Weon Choi, Jangwoo Lee, Seungho Lee, Sungkyoon Kim. Pharmacokinetic profile of propyl paraben in humans after oral administration. Environment international. 2019 09; 130(?):104917. doi: 10.1016/j.envint.2019.104917. [PMID: 31234001]
  • L Kolatorova, M Sramkova, J Vitku, J Vcelak, O Lischkova, L Starka, M Duskova. Parabens and their relation to obesity. Physiological research. 2018 11; 67(Suppl 3):S465-S472. doi: 10.33549/physiolres.934004. [PMID: 30484673]
  • Daniele C Silva, Lenard Serrano, Thiessa M A Oliveira, Adrislaine S Mansano, Eduardo A Almeida, Eny M Vieira. Effects of parabens on antioxidant system and oxidative damages in Nile tilapia (Oreochromis niloticus). Ecotoxicology and environmental safety. 2018 Oct; 162(?):85-91. doi: 10.1016/j.ecoenv.2018.06.076. [PMID: 29990743]
  • Chenlu Wang, Wei Zhou, Xiaoyan Liao, Xuemei Wang, Zilin Chen. Covalent immobilization of metal organic frameworks onto chemical resistant poly(ether ether ketone) jacket for stir bar extraction. Analytica chimica acta. 2018 Sep; 1025(?):124-133. doi: 10.1016/j.aca.2018.04.056. [PMID: 29801601]
  • María Cecilia García-Espiñeira, Lesly Patricia Tejeda-Benítez, Jesus Olivero-Verbel. Toxic Effects of Bisphenol A, Propyl Paraben, and Triclosan on Caenorhabditis elegans. International journal of environmental research and public health. 2018 04; 15(4):. doi: 10.3390/ijerph15040684. [PMID: 29621162]
  • Amira M Aker, Lauren Johns, Thomas F McElrath, David E Cantonwine, Bhramar Mukherjee, John D Meeker. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environment international. 2018 04; 113(?):341-349. doi: 10.1016/j.envint.2018.01.006. [PMID: 29366524]
  • Tyler Pollock, Rachel E Weaver, Ramtin Ghasemi, Denys deCatanzaro. A mixture of five endocrine-disrupting chemicals modulates concentrations of bisphenol A and estradiol in mice. Chemosphere. 2018 Feb; 193(?):321-328. doi: 10.1016/j.chemosphere.2017.11.030. [PMID: 29145094]
  • Han Wang, David J Cocovi-Solberg, Bin Hu, Manuel Miró. 3D-Printed Microflow Injection Analysis Platform for Online Magnetic Nanoparticle Sorptive Extraction of Antimicrobials in Biological Specimens as a Front End to Liquid Chromatographic Assays. Analytical chemistry. 2017 11; 89(22):12541-12549. doi: 10.1021/acs.analchem.7b03767. [PMID: 29039944]
  • Ulla N Joensen, Niels Jørgensen, Jacob P Thyssen, Jørgen Holm Petersen, Pal B Szecsi, Steen Stender, Anne-Maria Andersson, Niels E Skakkebæk, Hanne Frederiksen. Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population. Environment international. 2017 08; 105(?):105-111. doi: 10.1016/j.envint.2017.05.013. [PMID: 28525834]
  • Tyler Pollock, Rachel E Weaver, Ramtin Ghasemi, Denys deCatanzaro. Butyl paraben and propyl paraben modulate bisphenol A and estradiol concentrations in female and male mice. Toxicology and applied pharmacology. 2017 06; 325(?):18-24. doi: 10.1016/j.taap.2017.04.001. [PMID: 28390971]
  • Sudhanshu Shekhar, Surbhi Sood, Sadiya Showkat, Christy Lite, Anjalakshi Chandrasekhar, Mariappanadar Vairamani, S Barathi, Winkins Santosh. Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population. General and comparative endocrinology. 2017 01; 241(?):100-107. doi: 10.1016/j.ygcen.2016.05.025. [PMID: 27235644]
  • Janna Frombach, Anna Sonnenburg, Björn-Dirk Krapohl, Torsten Zuberbier, Ralf Stahlmann, Maximilian Schreiner. A novel method to generate monocyte-derived dendritic cells during coculture with HaCaT facilitates detection of weak contact allergens in cosmetics. Archives of toxicology. 2017 Jan; 91(1):339-350. doi: 10.1007/s00204-016-1722-y. [PMID: 27136899]
  • I Jiménez-Díaz, F Artacho-Cordón, F Vela-Soria, H Belhassen, J P Arrebola, M F Fernández, R Ghali, A Hedhili, N Olea. Urinary levels of bisphenol A, benzophenones and parabens in Tunisian women: A pilot study. The Science of the total environment. 2016 08; 562(?):81-88. doi: 10.1016/j.scitotenv.2016.03.203. [PMID: 27096629]
  • Gabriella Padovani Tahan, Nayara de Kássia Souza Santos, Ana Carolina Albuquerque, Isarita Martins. Determination of parabens in serum by liquid chromatography-tandem mass spectrometry: Correlation with lipstick use. Regulatory toxicology and pharmacology : RTP. 2016 Aug; 79(?):42-48. doi: 10.1016/j.yrtph.2016.05.001. [PMID: 27154569]
  • Linda Schlittenbauer, Bettina Seiwert, Thorsten Reemtsma. Ultrasound-assisted hydrolysis of conjugated parabens in human urine and their determination by UPLC-MS/MS and UPLC-HRMS. Analytical and bioanalytical chemistry. 2016 Feb; 408(6):1573-83. doi: 10.1007/s00216-015-9265-2. [PMID: 26753983]
  • Lei Wang, Tianzhen Liu, Fang Liu, Junjie Zhang, Yinghong Wu, Hongwen Sun. Occurrence and Profile Characteristics of the Pesticide Imidacloprid, Preservative Parabens, and Their Metabolites in Human Urine from Rural and Urban China. Environmental science & technology. 2015 Dec; 49(24):14633-40. doi: 10.1021/acs.est.5b04037. [PMID: 26571198]
  • Priscilla Rocío-Bautista, Carla Martínez-Benito, Verónica Pino, Jorge Pasán, Juan H Ayala, Catalina Ruiz-Pérez, Ana M Afonso. The metal-organic framework HKUST-1 as efficient sorbent in a vortex-assisted dispersive micro solid-phase extraction of parabens from environmental waters, cosmetic creams, and human urine. Talanta. 2015 Jul; 139(?):13-20. doi: 10.1016/j.talanta.2015.02.032. [PMID: 25882402]
  • Jerry L Campbell, Miyoung Yoon, Harvey J Clewell. A case study on quantitative in vitro to in vivo extrapolation for environmental esters: Methyl-, propyl- and butylparaben. Toxicology. 2015 Jun; 332(?):67-76. doi: 10.1016/j.tox.2015.03.010. [PMID: 25839974]
  • Deborah J Watkins, Kelly K Ferguson, Liza V Anzalota Del Toro, Akram N Alshawabkeh, José F Cordero, John D Meeker. Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico. International journal of hygiene and environmental health. 2015 Mar; 218(2):212-9. doi: 10.1016/j.ijheh.2014.11.001. [PMID: 25435060]
  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Ivana Klopčič, Katra Kolšek, Marija Sollner Dolenc. Glucocorticoid-like activity of propylparaben, butylparaben, diethylhexyl phthalate and tetramethrin mixtures studied in the MDA-kb2 cell line. Toxicology letters. 2015 Jan; 232(2):376-83. doi: 10.1016/j.toxlet.2014.11.019. [PMID: 25448277]
  • Ghada Mansour, Soliman Ouda, Ahmed Shaker, Hossam M Abdallah. Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2014 Jul; 43(6):405-9. doi: 10.1111/jop.12130. [PMID: 24164309]
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