Halofuginona (BioDeep_00000617207)
Main id: BioDeep_00000396325
PANOMIX_OTCML-2023
代谢物信息卡片
7-bromo-6-chloro-3-[3-(3-hydroxypiperidin-2-yl)-2-oxopropyl]-3,4-dihydroquinazolin-4-one
化学式: C16H17BrClN3O3 (413.01417420000007)
中文名称: 常山酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O
InChI: InChI=1S/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
D006133 - Growth Substances > D006131 - Growth Inhibitors
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:184758
- PubChem: 62894
- Metlin: METLIN87935
- ChEMBL: CHEMBL1197091
- CAS: 64544-01-0
- CAS: 55837-20-2
- medchemexpress: HY-N1584
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Junping Zhu, Jiaming Wei, Ye Lin, Yuanyuan Tang, Zhaoli Su, Liqing Li, Bin Liu, Xiong Cai. Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.
BMC complementary medicine and therapies.
2024 Feb; 24(1):105. doi:
10.1186/s12906-024-04397-2. [PMID: 38413973] - Jiali Ni, Xiaoying Li, Xiaodi Tu, Haiyan Zhu, Shiqi Wang, Yayi Hou, Huan Dou. Halofuginone ameliorates systemic lupus erythematosus by targeting Blk in myeloid-derived suppressor cells.
International immunopharmacology.
2023 Jan; 114(?):109487. doi:
10.1016/j.intimp.2022.109487. [PMID: 36493694] - Jasmita Gill, Amit Sharma. Prospects of halofuginone as an antiprotozoal drug scaffold.
Drug discovery today.
2022 09; 27(9):2586-2592. doi:
10.1016/j.drudis.2022.05.020. [PMID: 35636724] - Ryotaro Matsumoto, Shin Hamada, Yu Tanaka, Keiko Taguchi, Masayuki Yamamoto, Atsushi Masamune. Nuclear Factor Erythroid 2-Related Factor 2 Depletion Sensitizes Pancreatic Cancer Cells to Gemcitabine via Aldehyde Dehydrogenase 3a1 Repression.
The Journal of pharmacology and experimental therapeutics.
2021 10; 379(1):33-40. doi:
10.1124/jpet.121.000744. [PMID: 34321315] - Pritesh P Jain, Tengteng Zhao, Mingmei Xiong, Shanshan Song, Ning Lai, Qiuyu Zheng, Jiyuan Chen, Shane G Carr, Aleksandra Babicheva, Amin Izadi, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Shayan Rahimi, Tatum Simonson, Daniela Valdez-Jasso, Patricia A Thistlethwaite, John Y-J Shyy, Jian Wang, Ayako Makino, Jason X-J Yuan. Halofuginone, a promising drug for treatment of pulmonary hypertension.
British journal of pharmacology.
2021 09; 178(17):3373-3394. doi:
10.1111/bph.15442. [PMID: 33694155] - Yuchen Bai, Yahui Wang, Qiang Li, Leina Dou, Minggang Liu, Shibei Shao, Jianyu Zhu, Jianzhong Shen, Zhanhui Wang, Kai Wen, Wenbo Yu. Binding affinity-guided design of a highly sensitive noncompetitive immunoassay for small molecule detection.
Food chemistry.
2021 Jul; 351(?):129270. doi:
10.1016/j.foodchem.2021.129270. [PMID: 33640770] - Yanwen Chen, Travis B Lear, John W Evankovich, Mads B Larsen, Bo Lin, Irene Alfaras, Jason R Kennerdell, Laura Salminen, Daniel P Camarco, Karina C Lockwood, Ferhan Tuncer, Jie Liu, Michael M Myerburg, John F McDyer, Yuan Liu, Toren Finkel, Bill B Chen. A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry.
Nature communications.
2021 06; 12(1):3907. doi:
10.1038/s41467-021-24156-y. [PMID: 34162861] - Julii Brainard, Charlotte C Hammer, Paul R Hunter, Frank Katzer, Georgina Hurle, Kevin Tyler. Efficacy of halofuginone products to prevent or treat cryptosporidiosis in bovine calves: a systematic review and meta-analyses.
Parasitology.
2021 04; 148(4):408-419. doi:
10.1017/s0031182020002267. [PMID: 33261668] - Mingyuan Duan, Xiaobing Wei, Zhe Cheng, Dunjiang Liu, Hanna Fotina, Xiaojing Xia, Jianhe Hu. Involvement of eIF2α in halofuginone-driven inhibition of TGF-β1-induced EMT.
Journal of biosciences.
2020; 45(?):. doi:
10.1007/s12038-020-00042-5. [PMID: 32457283] - Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Evdokia Nikolaou, Spyridon Golfinopoulos, Vassilios Liakopoulos, Ioannis Stefanidis. Activation of General Control Nonderepressible-2 Kinase Ameliorates Glucotoxicity in Human Peritoneal Mesothelial Cells, Preserves Their Integrity, and Prevents Mesothelial to Mesenchymal Transition.
Biomolecules.
2019 12; 9(12):. doi:
10.3390/biom9120832. [PMID: 31817562] - Sumbul Afroz, Shama, Srikanth Battu, Shaikh Matin, Sabrina Solouki, Jessica P Elmore, Gillipsie Minhas, Weishan Huang, Avery August, Nooruddin Khan. Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production.
Science signaling.
2019 11; 12(607):. doi:
10.1126/scisignal.aav4717. [PMID: 31719173] - Xiaojing Xia, Xin Wang, Shouping Zhang, Yi Zheng, Lei Wang, Yanzhao Xu, Bolin Hang, Yawei Sun, Liancheng Lei, YueYu Bai, Jianhe Hu. miR-31 shuttled by halofuginone-induced exosomes suppresses MFC-7 cell proliferation by modulating the HDAC2/cell cycle signaling axis.
Journal of cellular physiology.
2019 08; 234(10):18970-18984. doi:
10.1002/jcp.28537. [PMID: 30916359] - Juan Vélez, Malin K Lange, Peter Zieger, Ilkyu Yoon, Klaus Failing, Christian Bauer. Long-term use of yeast fermentation products in comparison to halofuginone for the control of cryptosporidiosis in neonatal calves.
Veterinary parasitology.
2019 May; 269(?):57-64. doi:
10.1016/j.vetpar.2019.04.008. [PMID: 31079829] - Xiaojing Xia, Lei Wang, Xiaojian Zhang, Shan Wang, Lianchen Lei, Likun Cheng, Yanzhao Xu, Yawei Sun, Bolin Hang, Gaiping Zhang, YueYu Bai, JianHe Hu. Halofuginone-induced autophagy suppresses the migration and invasion of MCF-7 cells via regulation of STMN1 and p53.
Journal of cellular biochemistry.
2018 05; 119(5):4009-4020. doi:
10.1002/jcb.26559. [PMID: 29231257] - Linghui Luo, Yong Gao, Cao Yang, Zengwu Shao, Xinghuo Wu, Shuai Li, Liming Xiong, Chao Chen. Halofuginone attenuates intervertebral discs degeneration by suppressing collagen I production and inactivating TGFβ and NF-кB pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 May; 101(?):745-753. doi:
10.1016/j.biopha.2018.01.100. [PMID: 29524883] - Remigiusz Gałęcki, Rajmund Sokół. Treatment of cryptosporidiosis in captive green iguanas (Iguana iguana).
Veterinary parasitology.
2018 Mar; 252(?):17-21. doi:
10.1016/j.vetpar.2018.01.018. [PMID: 29559143] - Zeng Li, Hao Fei, Zhen Wang, Tianyi Zhu. Low‑dose halofuginone inhibits the synthesis of type I collagen without influencing type II collagen in the extracellular matrix of chondrocytes.
Molecular medicine reports.
2017 Sep; 16(3):3290-3298. doi:
10.3892/mmr.2017.7009. [PMID: 28713920] - Shi-Qi Wang, Ze-Hua Duan, Ya-Rong Zhao, Huan Dou. [Advances in studies on autoimmune diseases treated by halofuginone].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Jun; 42(11):2042-2045. doi:
10.19540/j.cnki.cjcmm.20170224.006. [PMID: 28822145] - Xin Hou, Jin Zhou, Rong Yang, Shanshan Liu, Mei Bi, Tong Liu, Chenling Fan, Haixia Guan, Weiping Teng, Zhongyan Shan, Yushu Li. Effect of Halofuginone on the Pathogenesis of Autoimmune Thyroid Disease in Different Mice Models.
Endocrine, metabolic & immune disorders drug targets.
2017; 17(2):141-148. doi:
10.2174/1871530317666170424101256. [PMID: 28440200] - Weili Zhan, Yanhong Kang, Ning Chen, Chongshan Mao, Yi Kang, Jia Shang. Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation.
Drug design, development and therapy.
2017; 11(?):2947-2955. doi:
10.2147/dddt.s149623. [PMID: 29066866] - Kivilcim Karadeniz Cerit, Berna Karakoyun, Meral Yüksel, Feriha Ercan, Halil Tuğtepe, Tolga E Dagli, Berrak Ç Yeğen. Halofuginone Alleviates Burn-Induced Hepatic and Renal Damage in Rats.
Journal of burn care & research : official publication of the American Burn Association.
2017 Jan; 38(1):e384-e394. doi:
10.1097/bcr.0000000000000400. [PMID: 27388880] - Yang Chen, Weishuai Liu, Peng Wang, Hailing Hou, Ningbo Liu, Linlin Gong, Youyou Wang, Kai Ji, Lujun Zhao, Ping Wang. Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer.
Oncotarget.
2016 Nov; 7(44):71341-71352. doi:
10.18632/oncotarget.11217. [PMID: 27533085] - Guoqing Chen, Ruihong Gong, Xianli Shi, Dajian Yang, Ge Zhang, Aiping Lu, Jianbo Yue, Zhaoxiang Bian. Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1.
Oncotarget.
2016 Aug; 7(31):50302-50314. doi:
10.18632/oncotarget.10367. [PMID: 27385212] - S E Weber, C Lippuner, S Corti, P Deplazes, M Hässig. [Clinical epidemiology of cryptosporidiosis in calves].
Schweizer Archiv fur Tierheilkunde.
2016 May; 158(5):341-50. doi:
10.17236/sat00062. [PMID: 27518579] - Hisashi Oishi, Tereza Martinu, Masaaki Sato, Yasushi Matsuda, Shin Hirayama, Stephen C Juvet, Zehong Guan, Tomohito Saito, Marcelo Cypel, David M Hwang, Tracy L Keller, Malcolm R Whitman, Mingyao Liu, Shaf Keshavjee. Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2016 Apr; 35(4):518-27. doi:
10.1016/j.healun.2015.12.003. [PMID: 26787621] - Yao Yao, Bin Pan, Yue-Ping Bian, Dan-Dan Xia, Hai Cheng, Guo-Liang Song, Ling-Yu Zeng, Kai-Lin Xu. [Significance of Th1/Th17 Imbalance in Mice with Acute Graft-versus-Host Disease].
Zhongguo shi yan xue ye xue za zhi.
2015 Oct; 23(5):1488-92. doi:
10.7534/j.issn.1009-2137.2015.05.051. [PMID: 26524063] - Guo-Qing Chen, Cheng-Fang Tang, Xiao-Ke Shi, Cheng-Yuan Lin, Sarwat Fatima, Xiao-Hua Pan, Da-Jian Yang, Ge Zhang, Ai-Ping Lu, Shu-Hai Lin, Zhao-Xiang Bian. Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism.
Oncotarget.
2015 Sep; 6(27):24148-62. doi:
10.18632/oncotarget.4376. [PMID: 26160839] - Jonathan D Herman, Lauren R Pepper, Joseph F Cortese, Guillermina Estiu, Kevin Galinsky, Vanessa Zuzarte-Luis, Emily R Derbyshire, Ulf Ribacke, Amanda K Lukens, Sofia A Santos, Vishal Patel, Clary B Clish, William J Sullivan, Huihao Zhou, Selina E Bopp, Paul Schimmel, Susan Lindquist, Jon Clardy, Maria M Mota, Tracy L Keller, Malcolm Whitman, Olaf Wiest, Dyann F Wirth, Ralph Mazitschek. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Science translational medicine.
2015 May; 7(288):288ra77. doi:
10.1126/scitranslmed.aaa3575. [PMID: 25995223] - Mark Pines, Itai Spector. Halofuginone - the multifaceted molecule.
Molecules (Basel, Switzerland).
2015 Jan; 20(1):573-94. doi:
10.3390/molecules20010573. [PMID: 25569515] - Tony L H Chu, Qiunong Guan, Christopher Y C Nguan, Caigan Du. Halofuginone Synergistically Enhances Anti-Proliferation of Rapamycin in T Cells and Reduces Cytotoxicity of Cyclosporine in Cultured Renal Tubular Epithelial Cells.
PloS one.
2015; 10(12):e0144735. doi:
10.1371/journal.pone.0144735. [PMID: 26671563] - Julie Petermann, Carine Paraud, Isabelle Pors, Christophe Chartier. Efficacy of halofuginone lactate against experimental cryptosporidiosis in goat neonates.
Veterinary parasitology.
2014 May; 202(3-4):326-9. doi:
10.1016/j.vetpar.2014.02.027. [PMID: 24636788] - J Liang, B Zhang, R-W Shen, J-B Liu, M-H Gao, X Geng, Y Li, Y-Y Li, W Zhang. The effect of antifibrotic drug halofugine on Th17 cells in concanavalin A-induced liver fibrosis.
Scandinavian journal of immunology.
2014 Mar; 79(3):163-72. doi:
10.1111/sji.12144. [PMID: 24383550] - Mei Ling Jin, Sun Young Park, Young Hun Kim, Geuntae Park, Sang Joon Lee. Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9.
International journal of oncology.
2014 Jan; 44(1):309-18. doi:
10.3892/ijo.2013.2157. [PMID: 24173318] - J Almawly, D Prattley, N P French, N Lopez-Villalobos, B Hedgespeth, A Grinberg. Utility of halofuginone lactate for the prevention of natural cryptosporidiosis of calves, in the presence of co-infection with rotavirus and Salmonella Typhimurium.
Veterinary parasitology.
2013 Oct; 197(1-2):59-67. doi:
10.1016/j.vetpar.2013.04.029. [PMID: 23707392] - Guler Yavas, Mustafa Calik, Goknil Calik, Cagdas Yavas, Ozlem Ata, Hidir Esme. The effect of Halofuginone in the amelioration of radiation induced-lung fibrosis.
Medical hypotheses.
2013 Apr; 80(4):357-9. doi:
10.1016/j.mehy.2013.01.001. [PMID: 23352286] - Kıvılcım Karadeniz Cerit, Berna Karakoyun, Meral Yüksel, Naziye Özkan, Şule Cetinel, E Tolga Dağli, Berrak Ç Yeğen, Halil Tuğtepe. The antifibrotic drug halofuginone reduces ischemia/reperfusion-induced oxidative renal damage in rats.
Journal of pediatric urology.
2013 Apr; 9(2):174-83. doi:
10.1016/j.jpurol.2012.01.015. [PMID: 22373656] - Huihao Zhou, Litao Sun, Xiang-Lei Yang, Paul Schimmel. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature.
2013 Feb; 494(7435):121-4. doi:
10.1038/nature11774. [PMID: 23263184] - Jie Liang, Bei Zhang, Ruo-wu Shen, Jia-Bao Liu, Mei-hua Gao, Ying Li, Yuan-Yuan Li, Wen Zhang. Preventive effect of halofuginone on concanavalin A-induced liver fibrosis.
PloS one.
2013; 8(12):e82232. doi:
10.1371/journal.pone.0082232. [PMID: 24358159] - Charles C Peyton, Tristan Keys, Seth Tomblyn, David Burmeister, Jan H Beumer, Juliane L Holleran, Joseph Sirintrapun, Scott Washburn, Steve J Hodges. Halofuginone infused keratin hydrogel attenuates adhesions in a rodent cecal abrasion model.
The Journal of surgical research.
2012 Dec; 178(2):545-52. doi:
10.1016/j.jss.2012.07.053. [PMID: 22901798] - Patricia Juárez, Khalid S Mohammad, Juan Juan Yin, Pierrick G J Fournier, Ryan C McKenna, Holly W Davis, Xiang H Peng, Maria Niewolna, Delphine Javelaud, John M Chirgwin, Alain Mauviel, Theresa A Guise. Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Cancer research.
2012 Dec; 72(23):6247-56. doi:
10.1158/0008-5472.can-12-1444. [PMID: 23002206] - Merav Leiba, Jana Jakubikova, Steffen Klippel, Constantine S Mitsiades, Teru Hideshima, Yu-Tzu Tai, Adi Leiba, Mark Pines, Paul G Richardson, Arnon Nagler, Kenneth C Anderson. Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents.
British journal of haematology.
2012 Jun; 157(6):718-31. doi:
10.1111/j.1365-2141.2012.09120.x. [PMID: 22533681] - Tracy L Keller, Davide Zocco, Mark S Sundrud, Margaret Hendrick, Maja Edenius, Jinah Yum, Yeon-Jin Kim, Hak-Kyo Lee, Joseph F Cortese, Dyann F Wirth, John David Dignam, Anjana Rao, Chang-Yeol Yeo, Ralph Mazitschek, Malcolm Whitman. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Nature chemical biology.
2012 Feb; 8(3):311-7. doi:
10.1038/nchembio.790. [PMID: 22327401] - Wei Peng, Lauren Robertson, Jordan Gallinetti, Pedro Mejia, Sarah Vose, Allison Charlip, Timothy Chu, James R Mitchell. Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.
Science translational medicine.
2012 Jan; 4(118):118ra11. doi:
10.1126/scitranslmed.3002629. [PMID: 22277968] - L A Trotz-Williams, B D Jarvie, A S Peregrine, T F Duffield, K E Leslie. Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in dairy calves.
The Veterinary record.
2011 May; 168(19):509. doi:
10.1136/vr.d1492. [PMID: 21546409] - Louis S Krane, Ilya Gorbachinsky, Joseph Sirintrapun, James J Yoo, Anthony Atala, Steve J Hodges. Halofuginone-coated urethral catheters prevent periurethral spongiofibrosis in a rat model of urethral injury.
Journal of endourology.
2011 Jan; 25(1):107-12. doi:
10.1089/end.2010.0514. [PMID: 21204688] - V De Waele, N Speybroeck, D Berkvens, G Mulcahy, T M Murphy. Control of cryptosporidiosis in neonatal calves: use of halofuginone lactate in two different calf rearing systems.
Preventive veterinary medicine.
2010 Sep; 96(3-4):143-51. doi:
10.1016/j.prevetmed.2010.06.017. [PMID: 20692058] - John A Cook, Rajani Choudhuri, William Degraff, Janet Gamson, James B Mitchell. Halofuginone enhances the radiation sensitivity of human tumor cell lines.
Cancer letters.
2010 Mar; 289(1):119-26. doi:
10.1016/j.canlet.2009.08.009. [PMID: 19713035] - Orit Zion, Olga Genin, Norifumi Kawada, Katsutoshi Yoshizato, Suzy Roffe, Arnon Nagler, Juan L Iovanna, Orna Halevy, Mark Pines. Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention.
Pancreas.
2009 May; 38(4):427-35. doi:
10.1097/mpa.0b013e3181967670. [PMID: 19188864] - Berna Karakoyun, Meral Yuksel, Pinar Turan, Serap Arbak, Inci Alican. Halofuginone has a beneficial effect on gentamicin-induced acute nephrotoxicity in rats.
Drug and chemical toxicology.
2009; 32(4):312-8. doi:
10.1080/01480540902976911. [PMID: 19793022] - Kasamyra Zylan, Tom Bailey, Huw V Smith, Christudas Silvanose, Joerg Kinne, Rolf K Schuster, Kevin Hyland. An outbreak of cryptosporidiosis in a collection of Stone curlews (Burhinus oedicnemus) in Dubai.
Avian pathology : journal of the W.V.P.A.
2008 Oct; 37(5):521-6. doi:
10.1080/03079450802357019. [PMID: 18798028] - Pavel Klein. Preventive and therapeutic efficacy of halofuginone-lactate against Cryptosporidium parvum in spontaneously infected calves: a centralised, randomised, double-blind, placebo-controlled study.
Veterinary journal (London, England : 1997).
2008 Sep; 177(3):429-31. doi:
10.1016/j.tvjl.2007.05.007. [PMID: 17606389] - Adem Karatas, Melih Paksoy, Yusuf Erzin, Sinan Carkman, Murat Gonenc, Fadil Ayan, Fatih Aydogan, Hafize Uzun, Haydar Durak. The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of pancreatic fibrosis in an experimental model of severe hyperstimulation and obstruction pancreatitis.
The Journal of surgical research.
2008 Jul; 148(1):7-12. doi:
10.1016/j.jss.2008.03.015. [PMID: 18570924] - Charlotte Tacheau, Laurence Michel, Dominique Farge, Alain Mauviel, Franck Verrecchia. Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices.
European journal of pharmacology.
2007 Nov; 573(1-3):65-9. doi:
10.1016/j.ejphar.2007.07.030. [PMID: 17706637] - Y Gnainsky, Z Kushnirsky, G Bilu, Y Hagai, O Genina, H Volpin, R Bruck, G Spira, A Nagler, N Kawada, K Yoshizato, D P Reinhardt, T A Libermann, M Pines. Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signaling.
Cell and tissue research.
2007 Apr; 328(1):153-66. doi:
10.1007/s00441-006-0330-1. [PMID: 17180598] - A Jiménez, J Sánchez, S Andrés, J M Alonso, L Gómez, F López, J Rey. Evaluation of endotoxaemia in the prognosis and treatment of scouring merino lambs.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2007 Mar; 54(2):103-6. doi:
10.1111/j.1439-0442.2007.00871.x. [PMID: 17305974] - Sydney Benchetrit, Shy Yarkoni, Mauro Rathaus, Marc Pines, Gloria Rashid, Joelle Bernheim, Jacques Bernheim. Halofuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats.
The Israel Medical Association journal : IMAJ.
2007 Jan; 9(1):30-4. doi:
NULL. [PMID: 17274353] - M Lallemand, A Villeneuve, J Belda, P Dubreuil. Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves.
The Veterinary record.
2006 Nov; 159(20):672-6. doi:
10.1136/vr.159.20.672. [PMID: 17099176] - M Leiba, L Cahalon, A Shimoni, O Lider, A Zanin-Zhorov, I Hecht, U Sela, I Vlodavsky, A Nagler. Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.
Journal of leukocyte biology.
2006 Aug; 80(2):399-406. doi:
10.1189/jlb.0705409. [PMID: 16769768] - M J A de Jonge, H Dumez, J Verweij, S Yarkoni, D Snyder, D Lacombe, S Marréaud, T Yamaguchi, C J A Punt, A van Oosterom. Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours.
European journal of cancer (Oxford, England : 1990).
2006 Aug; 42(12):1768-74. doi:
10.1016/j.ejca.2005.12.027. [PMID: 16815702] - Yury Popov, Eleonora Patsenker, Michael Bauer, Edith Niedobitek, Anja Schulze-Krebs, Detlef Schuppan. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.
The Journal of biological chemistry.
2006 Jun; 281(22):15090-8. doi:
10.1074/jbc.m600030200. [PMID: 16489207] - Nurit Haran, Ludmila Leschinski, Mark Pines, Jayson Rapoport. Inhibition of rat renal fibroblast proliferation by halofuginone.
Nephron. Experimental nephrology.
2006; 104(1):e35-40. doi:
10.1159/000093674. [PMID: 16735800] - Jehonathan H Pinthus, Yuval Sheffer, Arnon Nagler, Eduard Fridman, Yoram Mor, Olga Genina, Mark Pines. Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression.
The Journal of urology.
2005 Oct; 174(4 Pt 2):1527-31. doi:
10.1097/01.ju.0000179218.16587.d2. [PMID: 16148645] - B D Jarvie, L A Trotz-Williams, D R McKnight, K E Leslie, M M Wallace, C G Todd, P H Sharpe, A S Peregrine. Effect of halofuginone lactate on the occurrence of Cryptosporidium parvum and growth of neonatal dairy calves.
Journal of dairy science.
2005 May; 88(5):1801-6. doi:
10.3168/jds.s0022-0302(05)72854-x. [PMID: 15829673] - Robert A Parise, Barney R Sparrow, John W Merrill, Irma M Grossi, Joseph M Covey, James O Peggins, Merrill J Egorin. Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of halofuginone in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Oct; 810(1):35-40. doi:
10.1016/j.jchromb.2004.07.010. [PMID: 15358305] - Douglas C Marchion, Patricia A Weber, Liat Lomnitski, Carlos M G Duran, David T Cheung. Halofuginone inhibits serum-stimulated pericardial tissue retraction in vitro.
Tissue engineering.
2004 Jul; 10(7-8):1076-83. doi:
10.1089/ten.2004.10.1076. [PMID: 15363165] - A Nagler, M Ohana, O Shibolet, M Y Shapira, R Alper, I Vlodavsky, M Pines, Y Ilan. Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone.
European journal of cancer (Oxford, England : 1990).
2004 Jun; 40(9):1397-403. doi:
10.1016/j.ejca.2003.11.036. [PMID: 15177499] - Mark Pines, David Snyder, Shai Yarkoni, Arnon Nagler. Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2003 Jul; 9(7):417-25. doi:
10.1016/s1083-8791(03)00151-4. [PMID: 12869955] - A Joachim, T Krull, J Schwarzkopf, A Daugschies. Prevalence and control of bovine cryptosporidiosis in German dairy herds.
Veterinary parasitology.
2003 Mar; 112(4):277-88. doi:
10.1016/s0304-4017(03)00006-2. [PMID: 12623207] - Zohar Gavish, Jehonathan H Pinthus, Vivian Barak, Jacob Ramon, Arnon Nagler, Zelig Eshhar, Mark Pines. Growth inhibition of prostate cancer xenografts by halofuginone.
The Prostate.
2002 May; 51(2):73-83. doi:
10.1002/pros.10059. [PMID: 11948962] - K P Stecklair, D R Hamburger, M J Egorin, R A Parise, J M Covey, J L Eiseman. Pharmacokinetics and tissue distribution of halofuginone (NSC 713205) in CD2F1 mice and Fischer 344 rats.
Cancer chemotherapy and pharmacology.
2001 Nov; 48(5):375-82. doi:
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The Veterinary record.
2001 Jan; 148(4):108-12. doi:
10.1136/vr.148.4.108. [PMID: 11232925] - A Nagler, M Pines. Topical treatment of cutaneous chronic graft versus host disease with halofuginone: a novel inhibitor of collagen type I synthesis.
Transplantation.
1999 Dec; 68(11):1806-9. doi:
10.1097/00007890-199912150-00027. [PMID: 10609960] - A Daugschies, U Gässlein, M Rommel. Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.
Veterinary parasitology.
1998 Apr; 76(3):163-71. doi:
10.1016/s0304-4017(97)00203-3. [PMID: 9615950] - L R McDougald, B P Seibert. Residual activity of anticoccidial drugs in chickens after withdrawal of medicated feeds.
Veterinary parasitology.
1998 Jan; 74(2-4):91-9. doi:
10.1016/s0304-4017(97)00172-6. [PMID: 9561697] - A Nagler, A Katz, H Aingorn, H Q Miao, R Condiotti, O Genina, M Pines, I Vlodavsky. Inhibition of glomerular mesangial cell proliferation and extracellular matrix deposition by halofuginone.
Kidney international.
1997 Dec; 52(6):1561-9. doi:
10.1038/ki.1997.486. [PMID: 9407501] - M Pines, V Knopov, O Genina, I Lavelin, A Nagler. Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis.
Journal of hepatology.
1997 Aug; 27(2):391-8. doi:
10.1016/s0168-8278(97)80186-9. [PMID: 9288615] - A Ramadan, K Abo el-Sooud, M M el-Bahy. Anticoccidial efficacy of toltrazuril and halofuginone against Eimeria tenella infection in broiler chickens in Egypt.
Research in veterinary science.
1997 Mar; 62(2):175-8. doi:
10.1016/s0034-5288(97)90142-9. [PMID: 9243719] - A Nagler, H Q Miao, H Aingorn, M Pines, O Genina, I Vlodavsky. Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone.
Arteriosclerosis, thrombosis, and vascular biology.
1997 Jan; 17(1):194-202. doi:
10.1161/01.atv.17.1.194. [PMID: 9012656] - O Halevy, A Nagler, F Levi-Schaffer, O Genina, M Pines. Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone.
Biochemical pharmacology.
1996 Oct; 52(7):1057-63. doi:
10.1016/0006-2952(96)00427-3. [PMID: 8831725] - T K Graczyk, M R Cranfield, S L Hill. Therapeutic efficacy of halofuginone and spiramycin treatment against Cryptosporidium serpentis (Apicomplexa: Cryptosporidiidae) infections in captive snakes.
Parasitology research.
1996; 82(2):143-8. doi:
10.1007/s004360050085. [PMID: 8825209] - F Levi-Schaffer, A Nagler, S Slavin, V Knopov, M Pines. Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone.
The Journal of investigative dermatology.
1996 Jan; 106(1):84-8. doi:
10.1111/1523-1747.ep12328014. [PMID: 8592087] - M Nyska, A Nyska, E Rivlin, S Porat, M Pines, S Shoshan, A Nagler. Topically applied halofuginone, an inhibitor of collagen type I transcription, reduces peritendinous fibrous adhesions following surgery.
Connective tissue research.
1996; 34(2):97-103. doi:
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The Journal of antimicrobial chemotherapy.
1995 Mar; 35(3):391-7. doi:
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Infection and immunity.
1993 Oct; 61(10):4440-5. doi:
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Poultry science.
1993 Apr; 72(4):658-63. doi:
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Biochimica et biophysica acta.
1993 Feb; 1156(2):107-12. doi:
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Veterinary parasitology.
1993 Jan; 45(3-4):199-207. doi:
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Poultry science.
1991 Jul; 70(7):1559-63. doi:
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Poultry science.
1991 Feb; 70(2):289-92. doi:
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Antimicrobial agents and chemotherapy.
1991 Feb; 35(2):283-7. doi:
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The British veterinary journal.
1989 Nov; 145(6):546-51. doi:
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Biomedical chromatography : BMC.
1989 May; 3(3):136-8. doi:
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Veterinary microbiology.
1988 May; 17(1):59-64. doi:
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Parasitology research.
1988; 74(5):441-7. doi:
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The Journal of parasitology.
1983 Jun; 69(3):577-83. doi:
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Zentralblatt fur Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie.
1981 Feb; 248(4):565-74. doi:
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