Azolidine (BioDeep_00000617108)

   

Volatile Flavor Compounds


代谢物信息卡片


Tetramethylenimine

化学式: C4H9N (71.0734954)
中文名称: 吡咯烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCNC1
InChI: InChI=1S/C4H9N/c1-2-4-5-3-1/h5H,1-4H2



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hannah M Parks, Maris A Cinelli, Matthew A Bedewitz, Josh M Grabar, Steven M Hurney, Kevin D Walker, A Daniel Jones, Cornelius S Barry. Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna. The New phytologist. 2023 03; 237(5):1810-1825. doi: 10.1111/nph.18651. [PMID: 36451537]
  • Shinji Nakamura, Masahiro Kamaura, Yuichiro Akao, Natsuko Nakamura, Atsushi Mizukami, Akihiko Goto, Naoki Furuyama, Nobuo Cho, Shizuo Kasai. Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers. Bioorganic & medicinal chemistry. 2022 01; 54(?):116553. doi: 10.1016/j.bmc.2021.116553. [PMID: 34953340]
  • Hai-Jiao Chen, Hao-Ran Yang, Ying Zhi, Qing-Qiang Yao, Bo Liu. Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis. Bioorganic & medicinal chemistry letters. 2021 02; 34(?):127754. doi: 10.1016/j.bmcl.2020.127754. [PMID: 33347967]
  • Gongquan Liu, Weiwei Wang, Fangyuan He, Peng Zhang, Ping Xu, Hongzhi Tang. Structural Insights into 6-Hydroxypseudooxynicotine Amine Oxidase from Pseudomonas geniculata N1, the Key Enzyme Involved in Nicotine Degradation. Applied and environmental microbiology. 2020 09; 86(19):. doi: 10.1128/aem.01559-20. [PMID: 32737127]
  • Yabing Gan, Guoxing Yin, Ting Yu, Youyu Zhang, Haitao Li, Peng Yin. A novel fluorescent probe for selective imaging of cellular cysteine with large Stokes shift and high quantum yield. Talanta. 2020 Apr; 210(?):120612. doi: 10.1016/j.talanta.2019.120612. [PMID: 31987202]
  • Dimitrios Triantafyllos Gerokonstantis, Aikaterini Nikolaou, Christiana Magkrioti, Antreas Afantitis, Vassilis Aidinis, George Kokotos, Panagiota Moutevelis-Minakakis. Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme. Bioorganic & medicinal chemistry. 2020 01; 28(2):115216. doi: 10.1016/j.bmc.2019.115216. [PMID: 31864778]
  • Juan Pablo González-Gutiérrez, Hernán Armando Pessoa-Mahana, Patricio Ernesto Iturriaga-Vásquez, Miguel Iván Reyes-Parada, Nicolas Esteban Guerra-Díaz, Martin Hodar-Salazar, Franco Viscarra, Pablo Paillali, Gabriel Núñez-Vivanco, Marcos Antonio Lorca-Carvajal, Jaime Mella-Raipán, María Carolina Zúñiga. Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters. Molecules (Basel, Switzerland). 2019 Oct; 24(20):. doi: 10.3390/molecules24203808. [PMID: 31652614]
  • Graham R Foster, Gregory J Dore, Stanley Wang, Jason Grebely, Kenneth E Sherman, Axel Baumgarten, Brian Conway, Daniel Jackson, Tarik Asselah, Michael Gschwantler, Krzysztof Tomasiewicz, Humberto Aguilar, Armen Asatryan, Yiran Hu, Federico J Mensa. Glecaprevir/pibrentasvir in patients with chronic HCV and recent drug use: An integrated analysis of 7 phase III studies. Drug and alcohol dependence. 2019 01; 194(?):487-494. doi: 10.1016/j.drugalcdep.2018.11.007. [PMID: 30529905]
  • Hak Kyun Yang, Woo Seung Son, Keon Seung Lim, Gun Hee Kim, Eun Jeong Lim, Changdev G Gadhe, Jae Yeol Lee, Kyu-Sung Jeong, Sang Min Lim, Ae Nim Pae. Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain. Journal of enzyme inhibition and medicinal chemistry. 2018 Dec; 33(1):1460-1471. doi: 10.1080/14756366.2018.1513926. [PMID: 30231778]
  • Brenda M Gannon, Michael H Baumann, Donna Walther, Cristian Jimenez-Morigosa, Agnieszka Sulima, Kenner C Rice, Gregory T Collins. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2018 11; 43(12):2399-2407. doi: 10.1038/s41386-018-0209-3. [PMID: 30305739]
  • Claudia Bello, Jianfei Bai, Bartosz K Zambron, Pilar Elías-Rodríguez, Consuelo Gajate, Inmaculada Robina, Irene Caffa, Michele Cea, Fabrizio Montecucco, Alessio Nencioni, Aimable Nahimana, Dominique Aubry, Caroline Breton, Michel A Duchosal, Faustino Mollinedo, Pierre Vogel. Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells. European journal of medicinal chemistry. 2018 Apr; 150(?):457-478. doi: 10.1016/j.ejmech.2018.02.086. [PMID: 29547833]
  • Esra Dilek, Sema Caglar, Kübra Erdogan, Bülent Caglar, Onur Sahin. Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity. Journal of biochemical and molecular toxicology. 2018 Apr; 32(4):e22043. doi: 10.1002/jbt.22043. [PMID: 29512227]
  • Christin Müller, Martin Hardt, Dominik Schwudke, Benjamin W Neuman, Stephan Pleschka, John Ziebuhr. Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture. Journal of virology. 2018 02; 92(4):. doi: 10.1128/jvi.01463-17. [PMID: 29167338]
  • Steven M Sparks, Paul K Spearing, Caroline J Diaz, David J Cowan, Channa Jayawickreme, Grace Chen, Thomas J Rimele, Claudia Generaux, Lindsey T Harston, Shane G Roller. Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration. Bioorganic & medicinal chemistry letters. 2017 10; 27(20):4673-4677. doi: 10.1016/j.bmcl.2017.09.008. [PMID: 28916340]
  • Macarena Martínez-Bailén, Ana T Carmona, Elena Moreno-Clavijo, Inmaculada Robina, Daisuke Ide, Atsushi Kato, Antonio J Moreno-Vargas. Tuning of β-glucosidase and α-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules. European journal of medicinal chemistry. 2017 Sep; 138(?):532-542. doi: 10.1016/j.ejmech.2017.06.055. [PMID: 28692917]
  • Jianwei Yan, Gaihong Wang, Xiangyu Dang, Binbin Guo, Wuhong Chen, Ting Wang, Limin Zeng, Heyao Wang, Youhong Hu. Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety. Bioorganic & medicinal chemistry. 2017 09; 25(17):4701-4714. doi: 10.1016/j.bmc.2017.07.007. [PMID: 28739155]
  • Lauren G Strange, Kerri Kochelek, Robert Keasling, Stacy D Brown, Brooks B Pond. The pharmacokinetic profile of synthetic cathinones in a pregnancy model. Neurotoxicology and teratology. 2017 Sep; 63(?):9-13. doi: 10.1016/j.ntt.2017.08.001. [PMID: 28811141]
  • Mark E Schnute, Matthew D McReynolds, Jeffrey Carroll, Jill Chrencik, Maureen K Highkin, Kaliapan Iyanar, Gina Jerome, John W Rains, Matthew Saabye, Jeffrey A Scholten, Matthew Yates, Marek M Nagiec. Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits. Journal of medicinal chemistry. 2017 03; 60(6):2562-2572. doi: 10.1021/acs.jmedchem.7b00070. [PMID: 28231433]
  • Xin Chao Liu, Daowan Lai, Qi Zhi Liu, Ligang Zhou, Qiyong Liu, Zhi Long Liu. Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121665. [PMID: 27918451]
  • Swaroop Kumar Pandey, Subhasish Biswas, Sarika Gunjan, Bhavana Singh Chauhan, Sunil Kumar Singh, Kumkum Srivastava, Sarika Singh, Sanjay Batra, Renu Tripathi. Pyrrolidine-Acridine hybrid in Artemisinin-based combination: a pharmacodynamic study. Parasitology. 2016 09; 143(11):1421-32. doi: 10.1017/s0031182016000937. [PMID: 27230403]
  • Wenying Li, Weiping Zhao, Xiaohong Liu, Xiaohua Huang, Omar D Lopez, John E Leet, R Marcus Fancher, Van Nguyen, Jason Goodrich, John Easter, Yang Hong, Janet Caceres-Cortes, Shu Y Chang, Li Ma, Makonen Belema, Lawrence G Hamann, Min Gao, Mingshe Zhu, Yue-Zhong Shu, W Griffith Humphreys, Benjamin M Johnson. Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement. Drug metabolism and disposition: the biological fate of chemicals. 2016 06; 44(6):809-20. doi: 10.1124/dmd.115.068866. [PMID: 27029743]
  • Hui-Chun Ku, Shih-Yi Lee, Kai-Chien Yang, Yueh-Hsiung Kuo, Ming-Jai Su. Modification of Caffeic Acid with Pyrrolidine Enhances Antioxidant Ability by Activating AKT/HO-1 Pathway in Heart. PloS one. 2016; 11(2):e0148545. doi: 10.1371/journal.pone.0148545. [PMID: 26845693]
  • Jutatip Kongpeth, Sakda Jampasa, Piyasak Chaumpluk, Orawon Chailapakul, Tirayut Vilaivan. Immobilization-free electrochemical DNA detection with anthraquinone-labeled pyrrolidinyl peptide nucleic acid probe. Talanta. 2016; 146(?):318-25. doi: 10.1016/j.talanta.2015.08.059. [PMID: 26695270]
  • Hao Yu, Hongzhi Tang, Yangyang Li, Ping Xu. Molybdenum-containing nicotine hydroxylase genes in a nicotine degradation pathway that is a variant of the pyridine and pyrrolidine pathways. Applied and environmental microbiology. 2015 Dec; 81(24):8330-8. doi: 10.1128/aem.02253-15. [PMID: 26407884]
  • Nahid Shahabadi, Saba Hadidi. Mechanistic and conformational studies on the interaction of a platinum(II) complex containing an antiepileptic drug, levetiracetam, with bovine serum albumin by optical spectroscopic techniques in aqueous solution. Applied biochemistry and biotechnology. 2015 Feb; 175(4):1843-57. doi: 10.1007/s12010-014-1423-z. [PMID: 25427597]
  • Audrey Hottin, Daniel W Wright, Gideon J Davies, Jean-Bernard Behr. Exploiting the hydrophobic terrain in fucosidases with aryl-substituted pyrrolidine iminosugars. Chembiochem : a European journal of chemical biology. 2015 Jan; 16(2):277-83. doi: 10.1002/cbic.201402509. [PMID: 25427942]
  • Jing-Yu He, Shu Zhu, Katsuko Komatsu. HPLC/UV analysis of polyacetylenes, phenylpropanoid and pyrrolidine alkaloids in medicinally used Codonopsis species. Phytochemical analysis : PCA. 2014 May; 25(3):213-9. doi: 10.1002/pca.2494. [PMID: 24453136]
  • Ren-Yi Yan, Hong-Qing Wang, Jie Kang, Ruo-Yun Chen. Pyrrolidine-type iminosugars from leaves of Suregada glomerulata. Carbohydrate research. 2014 Jan; 384(?):9-12. doi: 10.1016/j.carres.2013.11.004. [PMID: 24334235]
  • Matias Rey-Carrizo, Eva Torres, Chunlong Ma, Marta Barniol-Xicota, Jun Wang, Yibing Wu, Lieve Naesens, William F DeGrado, Robert A Lamb, Lawrence H Pinto, Santiago Vázquez. 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant. Journal of medicinal chemistry. 2013 Nov; 56(22):9265-74. doi: 10.1021/jm401340p. [PMID: 24237039]
  • Martyna Z Wróbel, Andrzej Chodkowski, Franciszek Herold, Anna Gomółka, Jerzy Kleps, Aleksander P Mazurek, Franciszek Pluciński, Andrzej Mazurek, Gabriel Nowak, Agata Siwek, Katarzyna Stachowicz, Anna Sławińska, Małgorzata Wolak, Bernadeta Szewczyk, Grzegorz Satała, Andrzej J Bojarski, Jadwiga Turło. Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1. European journal of medicinal chemistry. 2013 May; 63(?):484-500. doi: 10.1016/j.ejmech.2013.02.033. [PMID: 23524160]
  • Xueqing Zhao, Jörg Pabel, Georg C Höfner, Klaus T Wanner. Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors. Bioorganic & medicinal chemistry. 2013 Jan; 21(2):470-84. doi: 10.1016/j.bmc.2012.11.015. [PMID: 23245753]
  • Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto, Yoshiyuki Yoneda, Jun Chiba, Toshiyuki Watanabe, Fumihito Muro, Yutaka Iigo, Gensuke Takayama, Mika Yokoyama, Tomoe Taira, Misato Aonuma, Tohru Takashi, Atsushi Nakayama, Nobuo Machinaga. A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid. Bioorganic & medicinal chemistry. 2013 Jan; 21(1):42-61. doi: 10.1016/j.bmc.2012.11.003. [PMID: 23218775]
  • Raman Sharma, Hao Sun, David W Piotrowski, Tim F Ryder, Shawn D Doran, Haiqing Dai, Chandra Prakash. Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human. Drug metabolism and disposition: the biological fate of chemicals. 2012 Nov; 40(11):2143-61. doi: 10.1124/dmd.112.047316. [PMID: 22896728]
  • Thomas H Graham, Wensheng Liu, Andreas Verras, Iyassu K Sebhat, Yusheng Xiong, Kelly Bleasby, Urmi R Bhatt, Qing Chen, Margarita Garcia-Calvo, Wayne M Geissler, Judith N Gorski, Huaibing He, Michael E Lassman, JeanMarie Lisnock, Xiaohua Li, Zhu Shen, Xinchun Tong, Elaine C Tung, Judyann Wiltsie, Jianying Xiao, Dan Xie, Suoyu Xu, Jeffrey J Hale, Shirly Pinto, Dong-Ming Shen. A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation. Bioorganic & medicinal chemistry letters. 2012 Apr; 22(8):2811-7. doi: 10.1016/j.bmcl.2012.02.075. [PMID: 22444683]
  • Sébastien Ibanez, Christiane Gallet, Laurence Després. Plant insecticidal toxins in ecological networks. Toxins. 2012 Apr; 4(4):228-43. doi: 10.3390/toxins4040228. [PMID: 22606374]
  • Gang Chen, Jing Yang, Suo Gao, Hongping He, Shunlin Li, Yingtong Di, Ying Chang, Yang Lu, Xiaojiang Hao. Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions. Molecular diversity. 2012 Feb; 16(1):151-6. doi: 10.1007/s11030-011-9342-1. [PMID: 22134725]
  • Zhengle Tang, Feiyue Xing, Di Chen, Yu Yu, Chunyan Yu, Jingfang Di, Jing Liu. In vivo toxicological evaluation of Anisomycin. Toxicology letters. 2012 Jan; 208(1):1-11. doi: 10.1016/j.toxlet.2011.10.001. [PMID: 22004851]
  • Thomas H Graham, Hong C Shen, Wensheng Liu, Yusheng Xiong, Andreas Verras, Kelly Bleasby, Urmi R Bhatt, Renee M Chabin, Dunlu Chen, Qing Chen, Margarita Garcia-Calvo, Wayne M Geissler, Huaibing He, Michael E Lassman, Zhu Shen, Xinchun Tong, Elaine C Tung, Dan Xie, Suoyu Xu, Steven L Colletti, James R Tata, Jeffrey J Hale, Shirly Pinto, Dong-Ming Shen. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors. Bioorganic & medicinal chemistry letters. 2012 Jan; 22(1):658-65. doi: 10.1016/j.bmcl.2011.10.060. [PMID: 22079761]
  • Javier A Tello, Claire L Newton, Jerome Bouligand, Anne Guiochon-Mantel, Robert P Millar, Jacques Young. Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling. PloS one. 2012; 7(6):e38456. doi: 10.1371/journal.pone.0038456. [PMID: 22679506]
  • Melina Velasquez, Juan Salgado Salter, Javier Gloazzo Dorosz, Bent L Petersen, José M Estevez. Recent Advances on the Posttranslational Modifications of EXTs and Their Roles in Plant Cell Walls. Frontiers in plant science. 2012; 3(?):93. doi: 10.3389/fpls.2012.00093. [PMID: 22639676]
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  • Vanessa da Silva Carrara, Lara Zampar Serra, Lúcio Cardozo-Filho, Edézio F Cunha, Eduardo C Torres-Santos, Diógenes Aparício Garcia Cortez. HPLC analysis of supercritical carbon dioxide and compressed propane extracts from Piper amalago L. with antileishmanial activity. Molecules (Basel, Switzerland). 2011 Dec; 17(1):15-33. doi: 10.3390/molecules17010015. [PMID: 22193211]
  • D Velasco, E Collin, J San Roman, A Pandit, C Elvira. End functionalized polymeric system derived from pyrrolidine provide high transfection efficiency. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2011 Nov; 79(3):485-94. doi: 10.1016/j.ejpb.2011.06.004. [PMID: 21723390]
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  • Prabhakar Sripadi, Bindesh Shrestha, Rebecca L Easley, Lawrence Carpio, Kylene Kehn-Hall, Sebastien Chevalier, Renaud Mahieux, Fatah Kashanchi, Akos Vertes. Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry. PloS one. 2010 Sep; 5(9):e12590. doi: 10.1371/journal.pone.0012590. [PMID: 20830293]
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