Pogostone (BioDeep_00000616459)
Main id: BioDeep_00000017313
PANOMIX_OTCML-2023
代谢物信息卡片
4-Hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one, 9CI
化学式: C12H16O4 (224.10485359999998)
中文名称: 广藿香酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=C(C(=O)O1)C(=O)CCC(C)C)O
InChI: InChI=1S/C12H16O4/c1-7(2)4-5-9(13)11-10(14)6-8(3)16-12(11)15/h6-7,14H,4-5H2,1-3H3
描述信息
Pogostone is isolated from patchouli oil?with anti-bacterial and anti-cancer activities.?Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 μg/ml [2].?Pogostone induces cell apoptosis and autophagy[2].
Pogostone is isolated from patchouli oil?with anti-bacterial and anti-cancer activities.?Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 μg/ml [2].?Pogostone induces cell apoptosis and autophagy[2].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:138756
- PubChem: 54695756
- Metlin: METLIN87144
- CAS: 23800-56-8
- medchemexpress: HY-N1416
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 33090 - Plants: -
- 28511 - Pogostemon cablin: 10.1016/J.JEP.2014.09.023
- 28511 - Pogostemon Cablin (Blanco) Benth.: -
- 33090 - 广藿香: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shengzhao Tang, Shangyi Huang, Jiaxin Huang, Xinger Lai, Jingyi Guo, Jiawen Huang, Yanhua Zhong. Pogostone attenuated high-fat diet-induced nonalcoholic fatty liver disease in mice through inhibition of NLRP3 inflammasome signaling.
European journal of pharmacology.
2024 May; 970(?):176463. doi:
10.1016/j.ejphar.2024.176463. [PMID: 38461909] - Delong Wang, Chunxia Yuan, Yunpeng Li, Shuhong Bai, Juntao Feng, Yong Wang, Yali Fang, Zhijia Zhang. Chelation of the Optimal Antifungal Pogostone Analogue with Copper(II) to Explore the Dual Antifungal and Antibacterial Agent.
Journal of agricultural and food chemistry.
2024 Feb; 72(8):3894-3903. doi:
10.1021/acs.jafc.3c07050. [PMID: 38366986] - Dan Li, Ziwei Xing, Tingting Yu, Wei Dong, Zhiwei Wang, Cheng Peng, Chao Yang. Pogostone attenuates adipose tissue inflammation by regulating the adipocyte-macrophage crosstalk via activating SIRT1.
Food & function.
2022 Nov; 13(22):11853-11864. doi:
10.1039/d2fo01450e. [PMID: 36314728] - Chu Wang, Ying Wang, Jing Chen, Lang Liu, Mingxia Yang, Zhengguo Li, Chengyuan Wang, Eran Pichersky, Haiyang Xu. Synthesis of 4-methylvaleric acid, a precursor of pogostone, involves a 2-isobutylmalate synthase related to 2-isopropylmalate synthase of leucine biosynthesis.
The New phytologist.
2022 08; 235(3):1129-1145. doi:
10.1111/nph.18186. [PMID: 35485988] - Shengnan Xie, Li Li, Baihe Zhan, Xue Shen, Xuming Deng, Wenxi Tan, Tianqi Fang. Pogostone Enhances the Antibacterial Activity of Colistin against MCR-1-Positive Bacteria by Inhibiting the Biological Function of MCR-1.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092819. [PMID: 35566163] - Jing Chen, Lang Liu, Ying Wang, Zhengguo Li, Guodong Wang, George A Kraus, Eran Pichersky, Haiyang Xu. Characterization of a Cytosolic Acyl-Activating Enzyme Catalyzing the Formation of 4-Methylvaleryl-CoA for Pogostone Biosynthesis in Pogostemon Cablin.
Plant & cell physiology.
2021 Dec; 62(10):1556-1571. doi:
10.1093/pcp/pcab111. [PMID: 34255851] - Qingyan Ye, Qihua Ling, Jian Shen, Lei Shi, Jianjie Chen, Tao Yang, Zhijun Hou, Jun Zhao, Hua Zhou. Protective effect of pogostone on murine norovirus infected-RAW264.7 macrophages through inhibition of NF-κB/NLRP3-dependent pyroptosis.
Journal of ethnopharmacology.
2021 Oct; 278(?):114250. doi:
10.1016/j.jep.2021.114250. [PMID: 34089810] - Hong-Mei Yang, Jian-Yi Zhuo, Chao-Yue Sun, Juan Nie, Jie Yuan, Yan-Lu Liu, Rong-Feng Lin, Xiao-Ping Lai, Zi-Ren Su, Yu-Cui Li. Pogostone attenuates TNF-α-induced injury in A549 cells via inhibiting NF-κB and activating Nrf2 pathways.
International immunopharmacology.
2018 Sep; 62(?):15-22. doi:
10.1016/j.intimp.2018.06.029. [PMID: 29966943] - Jiyan Su, Jingjin He, Ziren Su, Lian Zhou, Yaoying Zeng, Xiaoping Lai, Yucui Li. T cell inhibition by pogostone from Pogostemon cablin (Blanco) Benth: In vitro and in vivo immunosuppressive analysis.
Molecular medicine reports.
2017 Oct; 16(4):4511-4520. doi:
10.3892/mmr.2017.7147. [PMID: 28791344] - Biao Wang, Wei Huang, Jin Zhou, Xue Tang, Yang Chen, Cheng Peng, Bo Han. Drug design based on pentaerythritol tetranitrate reductase: synthesis and antibacterial activity of Pogostone derivatives.
Organic & biomolecular chemistry.
2017 Aug; 15(31):6548-6556. doi:
10.1039/c7ob01429e. [PMID: 28745773] - Zhi-Xing Cao, Yu-Ting Yang, Si Yu, Yu-Zhi Li, Wen-Wen Wang, Jing Huang, Xiao-Fang Xie, Liang Xiong, Song Lei, Cheng Peng. Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells.
Journal of ethnopharmacology.
2017 Apr; 202(?):20-27. doi:
10.1016/j.jep.2016.07.028. [PMID: 27416805] - Han-Bin Chen, Jiang-Tao Zhou, Yu-Hong Liu, Zhen-Biao Zhang, Ya-Xian Zhan, Zi-Ren Su, Hui-Fang Zeng. Synthesis of pogostone by one-step.
Journal of Asian natural products research.
2017 Feb; 19(2):172-175. doi:
10.1080/10286020.2016.1184253. [PMID: 27243631] - Puyue Ouyang, Yongliang Liu, Ying Wang, Xiaolu Mo, Shaohua Zeng. Aging and/or tissue-specific regulation of patchoulol and pogostone in two Pogostemon cablin (Blanco) Benth. cultivars.
Physiologia plantarum.
2016 Nov; 158(3):272-283. doi:
10.1111/ppl.12466. [PMID: 27167188] - Yinhui Yang, Weijun Kong, Huanhuan Feng, Xiaowen Dou, Lianhua Zhao, Qiang Xiao, Meihua Yang. Quantitative and fingerprinting analysis of Pogostemon cablin based on GC-FID combined with chemometrics.
Journal of pharmaceutical and biomedical analysis.
2016 Mar; 121(?):84-90. doi:
10.1016/j.jpba.2016.01.012. [PMID: 26799976] - Chao-Yue Sun, Lie-Qiang Xu, Zhen-Biao Zhang, Chao-Hui Chen, Yong-Zhong Huang, Zu-Qing Su, Hui-Zhen Guo, Xiao-Ying Chen, Xie Zhang, Yu-Hong Liu, Jian-Nan Chen, Xiao-Ping Lai, Yu-Cui Li, Zi-Ren Su. Protective effects of pogostone against LPS-induced acute lung injury in mice via regulation of Keap1-Nrf2/NF-κB signaling pathways.
International immunopharmacology.
2016 Mar; 32(?):55-61. doi:
10.1016/j.intimp.2016.01.007. [PMID: 26800098] - Zheng-Wei Tang, Cheng Peng, Min Dai, Bo Han. Cytotoxic and antibacterial activities of the analogues of pogostone.
Fitoterapia.
2015 Oct; 106(?):41-5. doi:
10.1016/j.fitote.2015.08.003. [PMID: 26272659] - Mallappa Kumara Swamy, Uma Rani Sinniah. A Comprehensive Review on the Phytochemical Constituents and Pharmacological Activities of Pogostemon cablin Benth.: An Aromatic Medicinal Plant of Industrial Importance.
Molecules (Basel, Switzerland).
2015 May; 20(5):8521-47. doi:
10.3390/molecules20058521. [PMID: 25985355] - Haiming Chen, Huijun Liao, Yuhong Liu, Yifeng Zheng, Xiaoli Wu, Zuqing Su, Xie Zhang, Zhengquan Lai, Xiaoping Lai, Zhi-Xiu Lin, Ziren Su. Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats.
Fitoterapia.
2015 Jan; 100(?):110-7. doi:
10.1016/j.fitote.2014.11.017. [PMID: 25481373] - Yu-Cui Li, Yan-Fang Xian, Zi-Ren Su, Siu-Po Ip, Jian-Hui Xie, Jin-Bin Liao, Dian-Wei Wu, Chu-Wen Li, Jian-Nan Chen, Zhi-Xiu Lin, Xiao-Ping Lai. Pogostone suppresses proinflammatory mediator production and protects against endotoxic shock in mice.
Journal of ethnopharmacology.
2014 Nov; 157(?):212-21. doi:
10.1016/j.jep.2014.09.023. [PMID: 25256685] - Ruoqi Zhang, Cheng Peng, Yunxia Li, Liang Xiong, Xiaohong Gong. A gas chromatography-mass spectrometry method for the determination of pogostone in canine plasma and its application to a pharmacokinetic study.
Journal of chromatographic science.
2014 Nov; 52(10):1151-6. doi:
10.1093/chromsci/bmt201. [PMID: 24714140] - Si-Han Huang, Ji-Dong Xian, Song-Zhi Kong, Yu-Cui Li, Jian-Hui Xie, Ji Lin, Jian-Nan Chen, Hong-Feng Wang, Zi-Ren Su. Insecticidal activity of pogostone against Spodoptera litura and Spodoptera exigua (Lepidoptera: Noctuidae).
Pest management science.
2014 Mar; 70(3):510-6. doi:
10.1002/ps.3635. [PMID: 23966130] - Yucui Li, Ziren Su, Shuhai Lin, Chuwen Li, Ya Zhao, Xiang Gao, Yongquan Lai, Xiaoli Wu, Hanzhi Wu, Zongwei Cai. Characterisation of the metabolism of pogostone in vitro and in vivo using liquid chromatography with mass spectrometry.
Phytochemical analysis : PCA.
2014 Mar; 25(2):97-105. doi:
10.1002/pca.2471. [PMID: 24605365] - Fu Peng, Feng Wan, Liang Xiong, Cheng Peng, Min Dai, Jianping Chen. In vitro and in vivo antibacterial activity of Pogostone.
Chinese medical journal.
2014; 127(23):4001-5. doi:
". [PMID: 25430439] - Haiming Chen, Yucui Li, Xiaoli Wu, Chuwen Li, Qingguo Li, Zhen Qin, Yuyang Yi, Jiannan Chen, Xiaoping Lai, Ziren Su. LC-MS/MS determination of pogostone in rat plasma and its application in pharmacokinetic studies.
Biomedical chromatography : BMC.
2013 Sep; 27(9):1092-9. doi:
10.1002/bmc.2897. [PMID: 23505096] - Meiwan Chen, Jinming Zhang, Yunfeng Lai, Shengpeng Wang, Peng Li, Jian Xiao, Chaomei Fu, Hao Hu, Yitao Wang. Analysis of Pogostemon cablin from pharmaceutical research to market performances.
Expert opinion on investigational drugs.
2013 Feb; 22(2):245-57. doi:
10.1517/13543784.2013.754882. [PMID: 23252885] - Yu-Cui Li, Hai-Chun Liang, Hai-Ming Chen, Li-Rong Tan, Yu-Yang Yi, Zhen Qin, Wei-Min Zhang, Dian-Wei Wu, Chu-Wen Li, Rong-Feng Lin, Zi-Ren Su, Xiao-Ping Lai. Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Dec; 20(1):77-83. doi:
10.1016/j.phymed.2012.08.008. [PMID: 23159370] - Xuening Cheng, Hongwu Zhang, Liwei Yang, Zhirong Lin, Zhongmei Zou, Changyuan Yu. [Identification method with significant specificity of volatile oil of Pogostemon cablin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Sep; 35(17):2270-2. doi:
10.4268/cjcmm20101711. [PMID: 21137335] - Yoshiaki Amakura, Morio Yoshimura, Chika Mouri, Masayuki Mikage, Nobuo Kawahara, Yukihiro Goda, Takashi Yoshida. Convenient TLC-based Identification Test for the Crude Drug "Pogostemoni Herba".
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2008 Dec; 128(12):1833-7. doi:
10.1248/yakushi.128.1833. [PMID: 19043303] - Xiaoling Guo, Yifan Feng, Jipeng Luo. [Re-study on characteristic fingerprint of volatile oil from Herba Pogostemonis by GC].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2004 Dec; 27(12):903-8. doi:
". [PMID: 15807239] - Wei Li, Gang Wei, Chao-mei Pan, Xiang-xiang Liu, Sheng Huang, Hong-hua Xiu. [Investigation on the influential factors of the volatile oil and main constituent content in Pogostemon cablin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2004 Jan; 29(1):28-31. doi:
". [PMID: 15709374] - Ji-peng Luo, Yu-ping Liu, Yi-fan Feng, Xiao-ling Guo, Hui Cao. [Two chemotypes of Pogostemon cablin and influence of region of cultivation and harvesting time on volatile oil composition].
Yao xue xue bao = Acta pharmaceutica Sinica.
2003 Apr; 38(4):307-10. doi:
". [PMID: 12889135]