Garcinone C (BioDeep_00000615711)

Main id: BioDeep_00000017365

 

PANOMIX_OTCML-2023


代谢物信息卡片


1,3,6,7-TETRAHYDROXY-8-(3-HYDROXY-3-METHYLBUTYL)-2-(3-METHYLBUT-2-EN-1-YL)-9H-XANTHEN-9-ONE

化学式: C23H26O7 (414.1678446)
中文名称: 伽升沃 C
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCC1=C(C2=C(C=C1O)OC3=C(C2=O)C(=C(C(=C3)O)O)CCC(C)(C)O)O)C
InChI: InChI=1S/C23H26O7/c1-11(2)5-6-12-14(24)9-17-19(21(12)27)22(28)18-13(7-8-23(3,4)29)20(26)15(25)10-16(18)30-17/h5,9-10,24-27,29H,6-8H2,1-4H3

描述信息

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time? and dose?dependent manner[1].

同义名列表

2 个代谢物同义名

1,3,6,7-TETRAHYDROXY-8-(3-HYDROXY-3-METHYLBUTYL)-2-(3-METHYLBUT-2-EN-1-YL)-9H-XANTHEN-9-ONE; Garcinone C



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sabrin Ragab Mohamed Ibrahim, Gamal Abdallah Mohamed, Maan Talaat Abdullah Khayat, Sahar Ahmed, Hany Abo-Haded. α-Amylase inhibition of xanthones from Garcinia mangostana pericarps and their possible use for the treatment of diabetes with molecular docking studies. Journal of food biochemistry. 2019 05; 43(5):e12844. doi: 10.1111/jfbc.12844. [PMID: 31353530]
  • Yudui Xia, Xia Liu, Chunlin Zou, Shixiu Feng, Hongwei Guo, Yeguo Yang, Yong Lei, Jian Zhang, Yi Lu. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells. Oncology reports. 2018 Mar; 39(3):1485-1493. doi: 10.3892/or.2018.6218. [PMID: 29344638]
  • Nur Kusaira Khairul Ikram, Jacob D Durrant, Muchtaridi Muchtaridi, Ayunni Salihah Zalaludin, Neny Purwitasari, Nornisah Mohamed, Aisyah Saad Abdul Rahim, Chan Kit Lam, Yahaya M Normi, Noorsaadah Abd Rahman, Rommie E Amaro, Habibah A Wahab. A virtual screening approach for identifying plants with anti H5N1 neuraminidase activity. Journal of chemical information and modeling. 2015 Feb; 55(2):308-16. doi: 10.1021/ci500405g. [PMID: 25555059]
  • K Y Khaw, S B Choi, S C Tan, H A Wahab, K L Chan, V Murugaiyah. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Sep; 21(11):1303-9. doi: 10.1016/j.phymed.2014.06.017. [PMID: 25172794]
  • Weeranuch Seesom, Amornmart Jaratrungtawee, Sunit Suksamrarn, Chantana Mekseepralard, Piniti Ratananukul, Wasana Sukhumsirichart. Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G. BMC complementary and alternative medicine. 2013 Jul; 13(?):182. doi: 10.1186/1472-6882-13-182. [PMID: 23866810]