dimethindene (BioDeep_00000615076)

   


代谢物信息卡片


dimethyl(2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine

化学式: C20H24N2 (292.1939384)
中文名称: 二甲茚定
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
InChI: InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3

描述信息

D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AB - Substituted alkylamines
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents

同义名列表

4 个代谢物同义名

dimethindene; dimethyl(2-{3-[1-(pyridin-2-yl)ethyl]-1H-inden-2-yl}ethyl)amine; (+/-)-dimetahindene; Dimethylpyrindene



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elgaly K Salman, Kamal E Ghoniem, Elsayedalaa S Badr, Amero A Emeran. The potential of dimetindene maleate inducing resistance to blast fungus Magnaporthe oryzae through activating the salicylic acid signaling pathway in rice plants. Pest management science. 2022 Feb; 78(2):633-642. doi: 10.1002/ps.6673. [PMID: 34661333]
  • Gregory Christodoulidis, Irene Tsilioni, Michail-Evangelos Spyridakis, Theodoros Kiropoulos, Smaragda Oikonomidi, George Koukoulis, Konstantinos Tepetes. Matrix metaloproteinase-2 and -9 serum levels as potential markers of intraperitoneal adhesions. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2013 Jun; 26(3):134-40. doi: 10.3109/08941939.2012.730599. [PMID: 23514055]
  • Vilelmine J Carayanni, Evangelia G Tsati, Georgia C H Spyropoulou, Fotini N Antonopoulou, John D Ioannovich. Comparing oil based ointment versus standard practice for the treatment of moderate burns in Greece: a trial based cost effectiveness evaluation. BMC complementary and alternative medicine. 2011 Dec; 11(?):122. doi: 10.1186/1472-6882-11-122. [PMID: 22132709]
  • V Vovolis, L Kalogiros, D Ivanova, N Koutsostathis. Garlic-induced severe anaphylaxis in a nonatopic patient. Journal of investigational allergology & clinical immunology. 2010; 20(4):356. doi: ". [PMID: 20815318]
  • M A Martínez-Gómez, M M Carril-Avilés, S Sagrado, R M Villanueva-Camañas, M J Medina-Hernández. Characterization of antihistamine-human serum protein interactions by capillary electrophoresis. Journal of chromatography. A. 2007 Apr; 1147(2):261-9. doi: 10.1016/j.chroma.2007.02.054. [PMID: 17339039]
  • Peter Mikus, Peter Kubacák, Iva Valásková, Emil Havránek. Analysis of enantiomers in biological matrices by charged cyclodextrin-mediated capillary zone electrophoresis in column-coupling arrangement with capillary isotachophoresis. Talanta. 2006 Nov; 70(4):840-6. doi: 10.1016/j.talanta.2006.02.013. [PMID: 18970848]
  • Wolfgang Uhl, Arno Nolting, Georg Golor, Karl Ludwig Rost, Andreas Kovar. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clinical toxicology (Philadelphia, Pa.). 2006; 44 Suppl 1(?):17-28. doi: 10.1080/15563650600811755. [PMID: 16990190]
  • YongTae Kim, Naoki Yoshimura, Hitoshi Masuda, Fernando de Miguel, Michael B Chancellor. Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways. Urology. 2005 Feb; 65(2):238-42. doi: 10.1016/j.urology.2004.11.021. [PMID: 15708029]
  • D Duda, W Lorenz, I Celik. [Mesenteric traction syndrome during the operation of aneurysms of the abdominal aorta--histamine release and prophylaxis with antihistaminics]. Anaesthesiologie und Reanimation. 2003; 28(4):97-103. doi: NULL. [PMID: 14528656]
  • D Duda, W Lorenz, I Celik. Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2002 Oct; 51(10):495-9. doi: 10.1007/pl00012418. [PMID: 12477078]
  • N Tsavaris, C Kosmas, M Vadiaka, P Kanelopoulos, D Boulamatsis. Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes. British journal of cancer. 2002 Jul; 87(1):21-7. doi: 10.1038/sj.bjc.6600347. [PMID: 12085250]
  • B J Hughes-Formella, A Filbry, J Gassmueller, F Rippke. Anti-inflammatory efficacy of topical preparations with 10\% hamamelis distillate in a UV erythema test. Skin pharmacology and applied skin physiology. 2002 Mar; 15(2):125-32. doi: 10.1159/000049400. [PMID: 11867970]
  • J Rudolf, G Blaschke. Stereoselectivity of the phase-II-metabolism of the H1 antihistaminic drug dimethindene investigated by capillary electrophoresis. Enantiomer. 1999; 4(3-4):317-23. doi: NULL. [PMID: 10550890]
  • D Prien, D Rehn, G Blaschke. Enantioselective biotransformation of the chiral antihistaminic drug dimethindene in humans and rats. Arzneimittel-Forschung. 1997 May; 47(5):653-8. doi: NULL. [PMID: 9205781]
  • A Doenicke, J Moss, A Toledano, R Hoernecke, W Lorenz, P Ostwald. Administration of H1 and H2 antagonists for chemoprophylaxis: a double-blind, placebo-controlled study in healthy volunteers. Journal of clinical pharmacology. 1997 Feb; 37(2):140-6. doi: 10.1002/j.1552-4604.1997.tb04772.x. [PMID: 9055140]
  • D Prien, G Blaschke. Studies of the metabolism of the antihistaminic drug dimethindene by high-performance liquid chromatography and capillary electrophoresis including enantioselective aspects. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jan; 688(2):309-18. doi: 10.1016/s0378-4347(96)00311-8. [PMID: 9061469]
  • A Doenicke, J Moss, W Lorenz, M Mayer, J Rau, A Jedrzejewski, P Ostwald. Effect of oral antihistamine premedication on mivacurium-induced histamine release and side effects. British journal of anaesthesia. 1996 Sep; 77(3):421-3. doi: 10.1093/bja/77.3.421. [PMID: 8949824]
  • S Radler, M Wermeille, G Blaschke. Metabolism of dimetindene in rats. Arzneimittel-Forschung. 1995 Oct; 45(10):1086-92. doi: NULL. [PMID: 8595065]
  • S Dimmeler, A Lechleuthner, M Auweiler, C Troost, M Nagelschmidt, E Neugebauer. Effect of H1-antagonism on cardiovascular, pulmonary, and immunological dysfunction in porcine endotoxic shock. Shock (Augusta, Ga.). 1995 Jun; 3(6):416-21. doi: NULL. [PMID: 7656065]
  • S Radler, G Blaschke. Transdermal absorption of dimethindene in man. Archiv der Pharmazie. 1995 Feb; 328(2):127-9. doi: 10.1002/ardp.19953280207. [PMID: 7726737]
  • M Heuermann, G Blaschke. Simultaneous enantioselective determination and quantification of dimethindene and its metabolite N-demethyl-dimethindene in human urine using cyclodextrins as chiral additives in capillary electrophoresis. Journal of pharmaceutical and biomedical analysis. 1994 Jun; 12(6):753-60. doi: 10.1016/0731-7085(93)e0024-h. [PMID: 7918777]
  • A Doenicke, J Moss, W Lorenz, R Hoernecke, M Gottardis. Are hypotension and rash after atracurium really caused by histamine release?. Anesthesia and analgesia. 1994 May; 78(5):967-72. doi: 10.1213/00000539-199405000-00023. [PMID: 7512805]
  • W Lorenz, D Duda, W Dick, H Sitter, A Doenicke, A Black, D Weber, H Menke, B Stinner, T Junginger. Incidence and clinical importance of perioperative histamine release: randomised study of volume loading and antihistamines after induction of anaesthesia. Trial Group Mainz/Marburg. Lancet (London, England). 1994 Apr; 343(8903):933-40. doi: 10.1016/s0140-6736(94)90063-9. [PMID: 7512679]
  • M Mayer, A Doenicke, A E Nebauer, C Rosenberger, W Lorenz, K Peter. [Pharmacodynamics and clinical adverse effects of mivacurium. The effect of oral premedication with H1/H2 antagonists]. Der Anaesthesist. 1993 Sep; 42(9):592-6. doi: NULL. [PMID: 8105716]
  • G Kauert, I Herrle, M Wermeille. Quantification of dimethindene in plasma by gas chromatography-mass fragmentography using ammonia chemical ionization. Journal of chromatography. 1993 Aug; 617(2):318-23. doi: 10.1016/0378-4347(93)80506-y. [PMID: 8408399]
  • M Wermeille, E Moret, J P Siest, S Ghribi, A M Petit, M Wellman. The determination of dimethindene in human serum by enzyme-linked immunosorbent assay (EIA). Journal of pharmaceutical and biomedical analysis. 1993 Jul; 11(7):619-23. doi: 10.1016/0731-7085(93)80014-r. [PMID: 8399538]
  • D Chollet, P Künstner, M Wermeille. High-performance liquid chromatographic method for the determination of dimethindene in urine. Journal of chromatography. 1993 Jan; 629(1):89-93. doi: 10.1016/0021-9673(93)80358-f. [PMID: 8429078]
  • I Kuhn, U Theiss, D Rehn, L Gegenheimer, P W Lücker. Dialysability of dimethindene maleate (Fenistil) from blood after intravenous injection. Methods and findings in experimental and clinical pharmacology. 1992 Apr; 14(3):225-7. doi: NULL. [PMID: 1625505]
  • S Radler, G Blaschke. Enantioselective determination of dimethindene in urine after oral administration of racemic dimethindene. Journal of chromatography. 1991 Jun; 567(1):229-39. doi: 10.1016/0378-4347(91)80326-8. [PMID: 1918250]
  • W Lorenz, H Sitter, B Stinner, D Duda, B Kapp, B Gstrein, W Dietz, A Doenicke, W Dick. Controlled clinical trials and cross-sectional studies with plasma histamine measurements and histamine receptor antagonists: solving the problem of preoperative H1- + H2-prophylaxis by asking new questions?. Agents and actions. Supplements. 1991; 33(?):197-230. doi: 10.1007/978-3-0348-7309-3_14. [PMID: 1711274]
  • V Arnera, M Wermeille, M Wellman, J B Llull, M A Althaus, L P Balant. Pharmacokinetics of dimetindene after intravenous and oral administration to healthy volunteers. Arzneimittel-Forschung. 1990 Dec; 40(12):1346-8. doi: NULL. [PMID: 2095130]
  • C P Siegers, B Steffen. [The effect of dimetindene on liver and kidney function in the cholestatic rat]. Arzneimittel-Forschung. 1989 Nov; 39(11):1440-3. doi: NULL. [PMID: 2619778]
  • M Adt, P Schmucker, J H Baumert, H J Reimann. Cardiovascular reaction and plasma histamine concentration after application of atracurium and pancuronium with and without previous prophylaxis with H1- and H2-receptor antagonists. Journal of cardiothoracic anesthesia. 1989 Oct; 3(5 Suppl 1):23. doi: 10.1016/0888-6296(89)90766-7. [PMID: 2485222]
  • T Duka, M Hoehe, A Doenicke, U Stephan, N Matussek. Influence of the histaminergic system on opiate-induced neurosecretion and behaviour. Psychoneuroendocrinology. 1987; 12(4):271-80. doi: 10.1016/0306-4530(87)90051-5. [PMID: 3659227]
  • H J Reimann, R Tauber, B Kramann, J Gmeinwieser, U Schmidt, M Reiser. [Premedication with H1- and H2-receptor antagonists for intravenous urography using contrast media]. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 1986 Feb; 144(2):169-73. doi: 10.1055/s-2008-1048766. [PMID: 2869551]
  • B Schöning, W Lorenz, A Doenicke. [Histamine H1 and H2 receptor blockade as a supplementary premedication principle in elective surgery]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis. 1985 Mar; 74(13):315-22. doi: NULL. [PMID: 2859648]
  • P W Lücker, J Venitz, G Hennings, D Rehn, H Albrecht, G Alcorn. [The anti-inflammatory effect of a combination of dimethindene maleate and betamethasone in topical formulations]. Arzneimittel-Forschung. 1985; 35(2):539-42. doi: NULL. [PMID: 4039577]
  • D Rehn, D Haack, P Vecsei, G Hennings. The influence of dimetindene maleate on the endogenous hydrocortisone synthesis suppressing potency of betamethasone. Arzneimittel-Forschung. 1985; 35(6):970-2. doi: NULL. [PMID: 2862878]
  • J Venitz, P W Lücker, H Niehaus. [Effect of a betamethasone-dimethidine-maleate combination on dermatologic diseases. Determination of plasma cortisol levels before, during and after several days' therapy]. Fortschritte der Medizin. 1984 Sep; 102(35):882-4. doi: NULL. [PMID: 6489896]
  • B Schöning, W Lorenz, A Doenicke. Prophylaxis of anaphylactoid reactions to a polypeptidal plasma substitute by H1- plus H2-receptor antagonists: synopsis of three randomized controlled trials. Klinische Wochenschrift. 1982 Sep; 60(17):1048-55. doi: 10.1007/bf01716970. [PMID: 6752563]
  • M M Wermeille, G A Huber. Gas--liquid chromatographic determination of free dimethindene in human serum and urine at low concentrations. Journal of chromatography. 1982 Mar; 228(?):187-94. doi: 10.1016/s0378-4347(00)80431-4. [PMID: 7076743]
  • W Lorenz, A Doenicke, I Dittmann, P Hug, B Schwarz. [Anaphylactoid reactions following administration of plasma substitutes in man. Prevention of this side-effect of haemaccel by premedication with H1- and H2-receptor antagonists (author's transl)]. Der Anaesthesist. 1977 Dec; 26(12):644-8. doi: NULL. [PMID: 23706]
  • M Thermann, W Lorenz, A Schmal, F Schingale, P Dormann, H Hamelmann. Influence of H1- and H2-receptor antagonists on the circulatory system and on the endogenous plasma histamine concentrations in dogs. Agents and actions. 1977 Mar; 7(1):97-101. doi: 10.1007/bf01964888. [PMID: 871096]
  • L von Meyer, G Hauck. [The detection of usual antihistaminics after therapeutic dosage]. Beitrage zur gerichtlichen Medizin. 1976; 34(?):129-35. doi: NULL. [PMID: 9933]
  • M Thermann, W Lorenz, A Schmal, F Schingale, P Dormann, H Hamelmann. Alterations in the circulatory system of anaesthesized dogs following administration of histamine and histamine H1- and H2-Receptor antagonists in relation to plasma histamine levels. Agents and actions. 1975 Dec; 5(5):450-4. doi: 10.1007/bf01972666. [PMID: 3955]
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