Chloropyramine (BioDeep_00000615075)

   


代谢物信息卡片


N-[(4-chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]pyridin-2-amine

化学式: C16H20ClN3 (289.134567)
中文名称: 氯吡拉敏
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)CCN(CC1=CC=C(C=C1)Cl)C2=CC=CC=N2
InChI: InChI=1S/C16H20ClN3/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14/h3-10H,11-13H2,1-2H3

描述信息

D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist

同义名列表

3 个代谢物同义名

Chloropyramine; N-[(4-chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]pyridin-2-amine; Anaphylline;Chlorpyramine;Chlorpyraminum;Halopyramine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Barbara Tóth, Loránd Bartho, Andrea Vasas, Zsolt Sándor, Nikoletta Jedlinszki, Gyula Pinke, Judit Hohmann. Dual excitatory and smooth muscle-relaxing effect of Sideritis montana extract on guinea-pig ileum. Natural product communications. 2015 Mar; 10(3):487-90. doi: ". [PMID: 25924535]
  • T Irman-Florjanc. Kinetics of injected histamine in cat plasma after antihistamine prophylaxis. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2000 Apr; 49 Suppl 1(?):S74-5. doi: 10.1007/pl00000192. [PMID: 10864430]
  • A Fazekas, A Györfi, F Irmes, L Rosivall. Effect of substance P administration on vascular permeability in the rat dental pulp and submandibular gland. Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia. 1992; 88 Suppl 1(?):481-6. doi: NULL. [PMID: 1380715]
  • S Sipka, M Koltai, P Braquet, G Szegedi. Histamine potentiates human platelet aggregation induced by platelet-activating factor. International archives of allergy and immunology. 1992; 97(1):89-92. doi: 10.1159/000236101. [PMID: 1582704]
  • K I Bender, A N Lutsevich. [Dependence of the absorption through the human oral mucosa of antihistaminic (H1) preparations on their physicochemical properties]. Farmakologiia i toksikologiia. 1988 Jan; 51(1):75-9. doi: NULL. [PMID: 2896132]
  • L E Kholodov, L P Kaverina, V V Dorokhov. [Experimental study of the antiedema activity of antihistamine preparations compared to the dynamics of their concentration in the blood serum]. Farmakologiia i toksikologiia. 1985 Jan; 48(1):43-5. doi: NULL. [PMID: 2858404]
  • K I Bender, A N Lutsevich. [Interaction of pipolfen and suprastin with human serum albumin depending on the pH of the medium and its calcium ion content]. Farmakologiia i toksikologiia. 1983 Nov; 46(6):59-63. doi: . [PMID: 6653761]