Drotaverin (BioDeep_00000615069)

   


代谢物信息卡片


(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline

化学式: C24H31NO4 (397.22529660000004)
中文名称: 盐酸屈他维林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC1=C(C=C(C=C1)C=C2C3=CC(=C(C=C3CCN2)OCC)OCC)OCC
InChI: InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3/b20-13-

描述信息

A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AD - Papaverine and derivatives
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

4 个代谢物同义名

(1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline; Drotaverin hydrochloride; Drotaverine; Drotaverin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ying Shi, Guangya Shi, Zhenyu Li, Yanfang Chen, Shaohui Tang, Wei Huang. Superior mesenteric artery syndrome coexists with Nutcracker syndrome in a female: a case report. BMC gastroenterology. 2019 Jan; 19(1):15. doi: 10.1186/s12876-019-0932-1. [PMID: 30674275]
  • Anikó Lajtai, Mátyás Mayer, Ágnes Lakatos, Zoltán Porpáczy, Attila Miseta. Embutramide, a Component of Tanax(®) (T-61) as a New Drug of Abuse?. Journal of forensic sciences. 2016 Mar; 61(2):573-575. doi: 10.1111/1556-4029.13010. [PMID: 27404634]
  • L S Babinets', Iu V Droniak, K O Pliashko, A I Babinets'. [Efficiency of etiologic correction of concomitant ascaridosis in the complex treatment of chronic pancreatitis]. Likars'ka sprava. 2014 Nov; ?(11):116-8. doi: NULL. [PMID: 25528847]
  • Szende Vancea, Zsolt Gáll, Gabriella Donáth-Nagy, Réka Borka-Balás. Rapid LC-MS/MS method for determination of drotaverine in a bioequivalence study. Journal of pharmaceutical and biomedical analysis. 2014 Sep; 98(?):417-23. doi: 10.1016/j.jpba.2014.06.029. [PMID: 25005892]
  • Sally Adel, Nermeen Adel ElKasabgy. Design of innovated lipid-based floating beads loaded with an antispasmodic drug: in-vitro and in-vivo evaluation. Journal of liposome research. 2014 Jun; 24(2):136-49. doi: 10.3109/08982104.2013.857355. [PMID: 24236529]
  • Prasad P Dahivelkar, Suvarna I Bhoir, Sanjay B Bari, Sanjay J Surana, Ashok M Bhagwat. Simultaneous determination of diclofenac potassium and drotaverine hydrochloride in human plasma using reversed-phase high-performance liquid chromatography. Journal of chromatographic science. 2012 Sep; 50(8):694-701. doi: 10.1093/chromsci/bms026. [PMID: 22573800]
  • N N Pshenkina. [Influence of Perftoran nanoemulsion on blood plasma concentrations of lipophilic drugs]. Eksperimental'naia i klinicheskaia farmakologiia. 2012; 75(2):30-4. doi: NULL. [PMID: 22550857]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • S I M Zayed, Y M Issa. Cathodic adsorptive stripping voltammetry of drotaverine hydrochloride and its determination in tablets and human urine by differential pulse voltammetry. Bioelectrochemistry (Amsterdam, Netherlands). 2009 Apr; 75(1):9-12. doi: 10.1016/j.bioelechem.2008.11.008. [PMID: 19138886]
  • Igor L Khalif, Eamonn M M Quigley, P A Makarchuk, O V Golovenko, L F Podmarenkova, Y A Dzhanayev. Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). Journal of gastrointestinal and liver diseases : JGLD. 2009 Mar; 18(1):17-22. doi: ". [PMID: 19337628]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Y S El-Saharty, F H Metwaly, M Refaat, S Z El-Khateeb. Application of new membrane selective electrodes for the determination of drotaverine hydrochloride in tablets and plasma. Journal of pharmaceutical and biomedical analysis. 2006 Jun; 41(3):720-4. doi: 10.1016/j.jpba.2005.11.045. [PMID: 16469468]
  • Jolanta Bianketti, Agnieszka Lipniacka, Urszula Szlendak, Anita Gregor. [Acute intermittent porphyria and oral contraception. Case report]. Ginekologia polska. 2006 Mar; 77(3):223-6. doi: NULL. [PMID: 16871841]
  • Stanisław Dyderski, Edmund Grześkowiak, Leon Drobnik, Edyta Szałek, Monika Balcerkiewicz, Vitali Dubai. Bioavailability study of drotaverine from capsule and tablet preparations in healthy volunteers. Arzneimittel-Forschung. 2004; 54(5):298-302. doi: 10.1055/s-0031-1296974. [PMID: 15212193]
  • I Romics, D L Molnár, G Timberg, B Mrklic, B Jelakovic, G Köszegi, G Blaskó. The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones. BJU international. 2003 Jul; 92(1):92-6. doi: 10.1046/j.1464-410x.2003.04262.x. [PMID: 12823389]
  • O S Garmish, S I Zabashnyĭ, E V Smirnova, Iu Iu Kobeliatskiĭ. [Preparation no-shpa forte for the treatment of renal colic]. Klinichna khirurhiia. 2003 Feb; ?(2):47-50. doi: NULL. [PMID: 12784437]
  • O O Bolaji, C O Onyeji, A O Ogundaini, T A Olugbade, F A Ogunbona. Pharmacokinetics and bioavailability of drotaverine in humans. European journal of drug metabolism and pharmacokinetics. 1996 Jul; 21(3):217-21. doi: 10.1007/bf03189716. [PMID: 8980918]
  • O O Bolaji, C O Onyeji, F O Ogungbamila, F A Ogunbona, E O Ogunlana. High-performance liquid chromatographic method for the determination of drotaverine in human plasma and urine. Journal of chromatography. 1993 Dec; 622(1):93-7. doi: 10.1016/0378-4347(93)80254-2. [PMID: 8120119]
  • J K Lalla, M U Shah, M B Jain, A H Sharma. Modified high-performance liquid chromatographic method for analysis of drotaverine in human plasma. Journal of pharmaceutical and biomedical analysis. 1993 Apr; 11(4-5):385-8. doi: 10.1016/0731-7085(93)80033-w. [PMID: 8357876]
  • Z Kapui, I Hermecz, B Sarkadi, P Szentmiklósi, L Tardos, G Blaskó. Comparative studies of drotaverine--acephyllinate (Depogen) and pentoxifylline (Trental). Thrombosis research. 1992 Jun; 66(6):693-706. doi: 10.1016/0049-3848(92)90045-c. [PMID: 1519228]
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  • J Mezei, S Küttel, P Szentmiklósi, S Marton, I Rácz. A new method for high-performance liquid chromatographic determination of drotaverine in plasma. Journal of pharmaceutical sciences. 1984 Oct; 73(10):1489-91. doi: 10.1002/jps.2600731044. [PMID: 6502505]
  • L A Leshchinskiĭ, L T Pimenov, V V Trusov. [Changes in renal hemodynamics and renal function in patients with cardiac insufficiency treated with vasodilators]. Terapevticheskii arkhiv. 1981; 53(8):80-4. doi: NULL. [PMID: 7292349]
  • A Ia Ivleva, V F Kremneva, S I Zolotukhin. [Effect of no-shpa, halidor, dibazol and euphylline on the fibrinogen content and fibrinolytic activity of blood]. Farmakologiia i toksikologiia. 1976 May; 39(3):304-8. doi: NULL. [PMID: 1026513]
  • V F Kremeva, I B Zagorskaia. [Effect of dibazol, euphylline, No-Spa and galidor on thrombocyte osmotic resistance and blood clot retraction]. Farmakologiia i toksikologiia. 1975 May; 38(3):324-7. doi: NULL. [PMID: 1227905]
  • L Gyarmati, A Dávid, Z Mészáros, I Rácz, P Szentmiklósi. Data on the metabolism of benzylisoquinoline derivatives. The metabolism of drotaverin. Die Pharmazie. 1975 Mar; 30(3):174-7. doi: NULL. [PMID: 1153473]
  • L MAKLARI. EXPERIENCE OBTAINED WITH A NEW SPASMOLYTIC DRUG (NO-SPA). Therapia Hungarica (English edition). 1963; 11(?):20-3. doi: NULL. [PMID: 14133123]