Vilazodone (BioDeep_00000615057)
代谢物信息卡片
5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide
化学式: C26H27N5O2 (441.2165)
中文名称: 维拉佐酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
InChI: InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
D049990 - Membrane Transport Modulators
Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active?serotonin?reuptake inhibitor (SSRI) and partial?5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders[1][2].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:70707
- KEGGdrug: D09698
- PubChem: 6918314
- Metlin: METLIN85563
- DrugBank: DB06684
- ChEMBL: CHEMBL439849
- MeSH: Vilazodone Hydrochloride
- CAS: 163521-12-8
- medchemexpress: HY-14262
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ling Zhou, Chengyang Ni, Ruixue Liao, Xiaoqin Tang, Taian Yi, Mei Ran, Miao Huang, Rui Liao, Xiaogang Zhou, Dalian Qin, Long Wang, Feihong Huang, Xiang Xie, Ying Wan, Jiesi Luo, Yiwei Wang, Jianming Wu. Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia.
eLife.
2024 Apr; 13(?):. doi:
10.7554/elife.94765. [PMID: 38573820] - Samantha Smith, Jordan Sergio, Michael Coyle, Kayla Elder, Ashley Centner, Sophie Cohen, Michelle Terry, Natalie Lipari, John Glinski, Emily Wheelis, Carla Budrow, Christopher Bishop. The effects of Vilazodone, YL-0919 and Vortioxetine in hemiparkinsonian rats.
Psychopharmacology.
2022 Jul; 239(7):2119-2132. doi:
10.1007/s00213-022-06078-9. [PMID: 35275226] - Chao Zhang, Lan Wang, Yixiang Xu, Yunyuan Huang, Junyang Huang, Jin Zhu, Wei Wang, Wangsheng Li, Annan Sun, Xiaokang Li, Haiyan Zhang, Jian Li. Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.
European journal of medicinal chemistry.
2022 Jun; 236(?):114347. doi:
10.1016/j.ejmech.2022.114347. [PMID: 35430560] - Xiaokang Li, Jinwen Li, Yunyuan Huang, Qi Gong, Yan Fu, Yixiang Xu, Junyang Huang, Haolan You, Dong Zhang, Dan Zhang, Fei Mao, Jin Zhu, Huan Wang, Haiyan Zhang, Jian Li. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
European journal of medicinal chemistry.
2022 Feb; 229(?):114045. doi:
10.1016/j.ejmech.2021.114045. [PMID: 34922191] - Per Plenge, Dongxue Yang, Kristine Salomon, Louise Laursen, Iris E Kalenderoglou, Amy H Newman, Eric Gouaux, Jonathan A Coleman, Claus J Loland. The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Nature communications.
2021 08; 12(1):5063. doi:
10.1038/s41467-021-25363-3. [PMID: 34417466] - Erica Schlichting, Chris Welter, Tammi Schaeffer, Tania D Strout. Serotonin Syndrome Associated With Vilazodone Overdose in a 22-Month-Old Treated With Dexmedetomidine.
The Journal of emergency medicine.
2021 Feb; 60(2):e19-e21. doi:
10.1016/j.jemermed.2020.10.012. [PMID: 33158691] - Yang Zhang, Guoxun Zheng, Tingting Fu, Jiajun Hong, Fengcheng Li, Xiaojun Yao, Weiwei Xue, Feng Zhu. The binding mode of vilazodone in the human serotonin transporter elucidated by ligand docking and molecular dynamics simulations.
Physical chemistry chemical physics : PCCP.
2020 Mar; 22(9):5132-5144. doi:
10.1039/c9cp05764a. [PMID: 32073004] - Irene Sartini, Małgorzata Gbylik-Sikorska, Beata Łebkowska-Wieruszewska, Anna Gajda, Andrzej Lisowski, Cezary J Kowalski, Andrzej Posyniak, Amnart Poapolathep, Mario Giorgi. Effect of feeding on the pharmacokinetics of vilazodone in dogs.
Research in veterinary science.
2019 Aug; 125(?):309-314. doi:
10.1016/j.rvsc.2019.07.013. [PMID: 31351201] - Amira M El-Kosasy, Mona Hamdy Abdel Rahman, Sarah H Abdelaal. Graphene nanoplatelets in potentiometry: A nanocomposite carbon paste and PVC based membrane sensors for analysis of Vilazodone HCl in plasma and milk samples.
Talanta.
2019 Feb; 193(?):9-14. doi:
10.1016/j.talanta.2018.09.091. [PMID: 30368303] - Wen-Qiang Cui, Wen-Shan Sun, Fei Xu, Xue-Ming Hu, Wei Yang, Yang Zhou, Li-Xia Du, Wen-Wen Zhang, Qi-Liang Mao-Ying, Wen-Li Mi, Yu-Xia Chu, Yan-Qing Wang. Spinal Serotonin 1A Receptor Contributes to the Analgesia of Acupoint Catgut Embedding by Inhibiting Phosphorylation of the N-Methyl-d-Aspartate Receptor GluN1 Subunit in Complete Freund's Adjuvant-Induced Inflammatory Pain in Rats.
The journal of pain.
2019 01; 20(1):16.e1-16.e16. doi:
10.1016/j.jpain.2018.07.011. [PMID: 30102991] - Balasaheb B Chavan, Pradipbhai D Kalariya, Shristy Tiwari, Rakesh D Nimbalkar, Prabha Garg, R Srinivas, M V N Kumar Talluri. Identification and characterization of vilazodone metabolites in rats and microsomes by ultrahigh-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2017 Dec; 31(23):1974-1984. doi:
10.1002/rcm.7982. [PMID: 28875544] - Anna Petruczynik, Karol Wroblewski, Malgorzata Szultka-Mlynska, Boguslaw Buszewsk, Hanna Karakula-Juchnowicz, Jacek Gajewski, Justyna Morylowska-Topolska, Monika Waksmundzka-Hajnosi. DETERMINATION OF VENLAFAXINE, VILAZODONE AND THEIR MAIN ACTIVE METABOLITES IN HUMAN SERUM BY HPLC-DAD AND HPLC-MS.
Acta poloniae pharmaceutica.
2017 May; 74(3):765-775. doi:
NULL. [PMID: 29513945] - Anita H Clayton, Suresh Durgam, Dayong Li, Changzheng Chen, Laishun Chen, Maju Mathews, Carl P Gommoll, Armin Szegedi. Effects of vilazodone on sexual functioning in healthy adults: results from a randomized, double-blind, placebo-controlled, and active-controlled study.
International clinical psychopharmacology.
2017 01; 32(1):27-35. doi:
10.1097/yic.0000000000000145. [PMID: 27643885] - Ramzia El-Bagary, Hanaa Hashem, Marwa Fouad, Sally Tarek. UPLC-MS-MS Method for the Determination of Vilazodone in Human Plasma: Application to a Pharmacokinetic Study.
Journal of chromatographic science.
2016 Sep; 54(8):1365-72. doi:
10.1093/chromsci/bmw084. [PMID: 27209054] - Christoffer Bundgaard, Elin Eneberg, Connie Sánchez. P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in vivo.
Neuropharmacology.
2016 Apr; 103(?):104-11. doi:
10.1016/j.neuropharm.2015.12.009. [PMID: 26700248] - Ronald S Oosting, Johnny S Chan, Berend Olivier, Pradeep Banerjee, Yong Kee Choi, Frank Tarazi. Differential effects of vilazodone versus citalopram and paroxetine on sexual behaviors and serotonin transporter and receptors in male rats.
Psychopharmacology.
2016 Mar; 233(6):1025-34. doi:
10.1007/s00213-015-4198-1. [PMID: 26758283] - Zeyad T Sahli, Pradeep Banerjee, Frank I Tarazi. The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder.
Expert opinion on drug discovery.
2016; 11(5):515-23. doi:
10.1517/17460441.2016.1160051. [PMID: 26971593] - Aimee L McRae-Clark, Nathaniel L Baker, Kevin M Gray, Therese Killeen, Karen J Hartwell, Susan J Simonian. Vilazodone for cannabis dependence: A randomized, controlled pilot trial.
The American journal on addictions.
2016 Jan; 25(1):69-75. doi:
10.1111/ajad.12324. [PMID: 26685701] - Ramesh Boinpally, Dahlia Henry, Samir Gupta, John Edwards, James Longstreth, Antonia Periclou. Pharmacokinetics and Safety of Vilazodone in Hepatic Impairment.
American journal of therapeutics.
2015 Jul; 22(4):269-77. doi:
10.1097/mjt.0000000000000173. [PMID: 25474324] - Muzaffar Iqbal, Essam Ezzeldin, Khalid A Al-Rashood, Amal A Bajrai. A simple and fast UHPLC-MS-MS assay for rapid determination of vilazodone in plasma sample.
Journal of analytical toxicology.
2015 Mar; 39(2):106-12. doi:
10.1093/jat/bku126. [PMID: 25404657] - Ling-ling Zeng, Li-li Sun, Qiaogen Zou, Fan Zhou, Ping Wei, Ping-kai Ouyang. Bioavailability comparison of a new form of vilazodone XVII to IV in beagles using liquid chromatography/mass spectrometry.
Biomedical chromatography : BMC.
2014 Dec; 28(12):1738-43. doi:
10.1002/bmc.3215. [PMID: 24853720] - Wenwen Sui, Xiaojing Yang, Wenhong Yu, Yi Jin, Xinyi Luan, Xiangjun Wang, Haiyan Xu. A validated LC-MS/MS method for the rapid quantification of vilazodone in rat plasma: application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2014 Sep; 98(?):228-34. doi:
10.1016/j.jpba.2014.05.034. [PMID: 24937809] - Ramesh Boinpally, Harry Alcorn, Marijke H Adams, James Longstreth, John Edwards. Pharmacokinetics of vilazodone in patients with mild or moderate renal impairment.
Clinical drug investigation.
2013 Mar; 33(3):199-206. doi:
10.1007/s40261-013-0061-5. [PMID: 23417352] - Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppey. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants.
European journal of medicinal chemistry.
2012 Jul; 53(?):124-32. doi:
10.1016/j.ejmech.2012.03.042. [PMID: 22520153] - Edoardo Spina, Gianluca Trifirò, Filippo Caraci. Clinically significant drug interactions with newer antidepressants.
CNS drugs.
2012 Jan; 26(1):39-67. doi:
10.2165/11594710-000000000-00000. [PMID: 22171584] - Thomas P Laughren, Jogarao Gobburu, Robert J Temple, Ellis F Unger, Atul Bhattaram, Phillip V Dinh, Linda Fossom, H M James Hung, Violetta Klimek, Jee Eun Lee, Robert L Levin, Cheri Y Lindberg, Mitchell Mathis, Barry N Rosloff, Sue-Jane Wang, Yaning Wang, Peiling Yang, Bei Yu, Huixia Zhang, Li Zhang, Issam Zineh. Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant.
The Journal of clinical psychiatry.
2011 Sep; 72(9):1166-73. doi:
10.4088/jcp.11r06984. [PMID: 21951984] - Lee A Dawson, Jeannette M Watson. Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders.
CNS neuroscience & therapeutics.
2009; 15(2):107-17. doi:
10.1111/j.1755-5949.2008.00067.x. [PMID: 19499624]
