Udenafil (BioDeep_00000615053)
代谢物信息卡片
3-{1-methyl-7-oxo-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzene-1-sulfonamide
化学式: C25H36N6O4S (516.2518616)
中文名称: 乌地那非
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)NCCC4CCCN4C)OCCC)C
InChI: InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32)
描述信息
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BE - Drugs used in erectile dysfunction
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058986 - Phosphodiesterase 5 Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135926
- KEGGdrug: D70636
- KEGGdrug: D10027
- PubChem: 135413547
- PubChem: 6918523
- Metlin: METLIN85559
- DrugBank: DB06267
- ChEMBL: CHEMBL2103849
- CAS: 268203-93-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Hea Min Yu, Hyo Kyun Chung, Kang Seo Park. The PDE5 inhibitor udenafil ameliorates nonalcoholic fatty liver disease by improving mitochondrial function.
Biochemical and biophysical research communications.
2021 06; 558(?):57-63. doi:
10.1016/j.bbrc.2021.04.038. [PMID: 33895552] - Jong-Hwa Lee, Dae Young Lee, Kyung Koo Kang, Eun Ju Jeong, Christine E Staatz, In-Hwan Baek. Gender differences and dose proportionality in the toxicokinetics of udenafil and its active metabolite following oral administration in rodents.
Toxicology and applied pharmacology.
2021 01; 410(?):115339. doi:
10.1016/j.taap.2020.115339. [PMID: 33221319] - David J Goldberg, Victor Zak, Bryan H Goldstein, Kurt R Schumacher, Jonathan Rhodes, Daniel J Penny, Christopher J Petit, Salil Ginde, Shaji C Menon, Seong-Ho Kim, Gi Beom Kim, Todd T Nowlen, Michael V DiMaria, Benjamin P Frischhertz, Jonathan B Wagner, Kimberly E McHugh, Brian W McCrindle, Amanda J Shillingford, Arash A Sabati, Anji T Yetman, Anitha S John, Marc E Richmond, Matthew D Files, R Mark Payne, Andrew S Mackie, Christopher K Davis, Shabana Shahanavaz, Kevin D Hill, Ruchira Garg, Jeffrey P Jacobs, Michelle S Hamstra, Stacy Woyciechowski, Kathleen A Rathge, Michael G McBride, Peter C Frommelt, Mark W Russell, Elaine M Urbina, James L Yeager, Victoria L Pemberton, Mario P Stylianou, Gail D Pearson, Stephen M Paridon. Results of the FUEL Trial.
Circulation.
2020 02; 141(8):641-651. doi:
10.1161/circulationaha.119.044352. [PMID: 31736357] - Liang Dong, Xiaojin Zhang, Xuhong Yan, Yifeng Shen, Xujun Yu, Yulin Li. Effect of phosphodiesterase-5 inhibitors (PDE5is) on the treatment of male infertility: A protocol for systematic review and meta-analysis.
Medicine.
2019 Dec; 98(50):e18317. doi:
10.1097/md.0000000000018317. [PMID: 31852117] - Yong-Soon Cho, Yook-Hwan Noh, Hyeong-Seok Lim, Sang-Heon Cho, Jong-Lyul Ghim, Sangmin Choe, Soon-Bae Kim, Jung-Sik Park, Sang-Koo Lee, Won-Seok Yang, Jai-Won Chang, Mi-Young Bahng, Kyun-Seop Bae. Effects of Renal Impairment on the Pharmacokinetics and Safety of Udenafil.
Journal of clinical pharmacology.
2018 07; 58(7):905-912. doi:
10.1002/jcph.1095. [PMID: 29537612] - Seung T Han, Jae S Kim, Jun Y Lee, Min K Kim, Jin S Yoo, Byoung G Han, Seung O Choi, Jae W Yang. The mechanism of attenuation of epithelial-mesenchymal transition by a phosphodiesterase 5 inhibitor via renal klotho expression.
Clinical and experimental pharmacology & physiology.
2018 03; 45(3):269-277. doi:
10.1111/1440-1681.12872. [PMID: 29029361] - Yusuf Özlülerden, Cihan Toktaş, Hülya Aybek, Vural Küçükatay, Nilay Şen Türk, Ali Ersin Zumrutbas. The renoprotective effects of mannitol and udenafil in renal ischemia-reperfusion injury model.
Investigative and clinical urology.
2017 07; 58(4):289-295. doi:
10.4111/icu.2017.58.4.289. [PMID: 28681040] - David J Goldberg, Victor Zak, Bryan H Goldstein, Shan Chen, Michelle S Hamstra, Elizabeth A Radojewski, Eileen Maunsell, Seema Mital, Shaji C Menon, Kurt R Schumacher, R Mark Payne, Mario Stylianou, Jonathan R Kaltman, Tina M deVries, James L Yeager, Stephen M Paridon. Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation.
American heart journal.
2017 Jun; 188(?):42-52. doi:
10.1016/j.ahj.2017.02.030. [PMID: 28577680] - Hamit H Alp, Zübeyir Huyut, Serkan Yildirim, Yıldıray Başbugan, Levent Ediz, Mehmet R Şekeroğlu. The effect of PDE5 inhibitors on bone and oxidative damage in ovariectomy-induced osteoporosis.
Experimental biology and medicine (Maywood, N.J.).
2017 05; 242(10):1051-1061. doi:
10.1177/1535370217703352. [PMID: 28399643] - Hyang-Ki Choi, Jin Ah Jung, Jihong Shon, Mi Young Bahng, Doo-Yeoun Cho, Chang Woo Yeo, Eun-Young Kim, Jae-Gook Shin. The Effect of Age on the Pharmacokinetics of Udenafil in Healthy Subjects.
Journal of clinical pharmacology.
2016 11; 56(11):1372-1377. doi:
10.1002/jcph.739. [PMID: 27006150] - Lokman Irkilata, Hasan Riza Aydin, Ismail Ozer, Mustafa Aydin, Hüseyin Cihan Demirel, Caner Moral, Mustafa Kemal Atilla. The efficacy of udenafil in end-stage renal disease patients undergoing hemodialysis.
Renal failure.
2016; 38(3):357-61. doi:
10.3109/0886022x.2015.1128840. [PMID: 26727286] - B R Choi, S K Kumar, C Zhao, L T Zhang, C Y Kim, S W Lee, J-H Jeon, K K Soní, I So, S H Kim, N C Park, H K Kim, J K Park. Additive effects of Artemisia capillaris extract and scopoletin on the relaxation of penile corpus cavernosum smooth muscle.
International journal of impotence research.
2015 Nov; 27(6):225-32. doi:
10.1038/ijir.2015.23. [PMID: 26447600] - Yo Han Kim, Hee Youn Choi, Shi Hyang Lee, Hae Sun Jeon, Hyeong-Seok Lim, Mi Young Bahng, Kyun-Seop Bae. Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers.
Drug design, development and therapy.
2015; 9(?):1209-16. doi:
10.2147/dddt.s78713. [PMID: 25759565] - Jae Won Yang, Jae Seok Kim, Min Keun Kim, Jun Young Lee, Byoung-Geun Han, Seung Ok Choi. The renoprotective effect of cGMP phosphodiesterase inhibitor and nitroprusside in a rat model of cyclosporin A-induced nephrotoxicity.
Clinical nephrology.
2013 Jul; 80(1):53-62. doi:
10.5414/cn107571. [PMID: 23442254] - Kyung-Hee Kim, Hyung-Kwan Kim, In-Chang Hwang, Seung-Pyo Lee, Hyun-Jai Cho, Hyun-Jae Kang, Yong-Jin Kim, Dae-Won Sohn. ULTIMATE-SHF trial (UdenafiL Therapy to Improve symptoMAtology, exercise Tolerance and hEmodynamics in patients with chronic systolic heart failure): study protocol for a randomized, placebo-controlled, double-blind trial.
Trials.
2013 Jun; 14(?):188. doi:
10.1186/1745-6215-14-188. [PMID: 23799908] - Doo-Yeoun Cho, Soo Hyeon Bae, Ji-Hong Shon, Soo Kyung Bae. High-sensitive LC-MS/MS method for the simultaneous determination of mirodenafil and its major metabolite, SK-3541, in human plasma: application to microdose clinical trials of mirodenafil.
Journal of separation science.
2013 Mar; 36(5):840-8. doi:
10.1002/jssc.201200919. [PMID: 23390072] - Ji-Hong Shon, Hei-Young Ku, Seol-Youn Bae, Min-Kyung Oh, Chang-Woo Yeo, Soo-Kyung Bae, Jae-Gook Shin. The disposition of three phosphodiesterase type 5 inhibitors, vardenafil, sildenafil, and udenafil, is differently influenced by the CYP3A5 genotype.
Pharmacogenetics and genomics.
2011 Dec; 21(12):820-8. doi:
10.1097/fpc.0b013e32834b79e6. [PMID: 21934637] - Chen Zhao, Suhn Hee Kim, Sung Won Lee, Ju-Hong Jeon, Kyung Ku Kang, Sung Beom Choi, Jong Kwan Park. Activity of phosphodiesterase type 5 inhibitors in patients with lower urinary tract symptoms due to benign prostatic hyperplasia.
BJU international.
2011 Jun; 107(12):1943-7. doi:
10.1111/j.1464-410x.2010.09759.x. [PMID: 21054754] - Wan-Sung Ku, Hyun-Jong Cho, In-Soo Yoon, Jeong Hoon Kim, Bong-Jin Cha, Jung Sun Kim, Kyeong-Mi Kim, Shin-Kwon Kang, Suk-Jae Chung, Chang-Koo Shim, Dae-Duk Kim. Rapid and sensitive determination of udenafil in plasma by LC-MS/MS for intranasal pharmacokinetic study in rats.
Chemical & pharmaceutical bulletin.
2011; 59(9):1083-8. doi:
10.1248/cpb.59.1083. [PMID: 21881249] - Kwang-Hee Shin, Yong-ju Chung, Bo-Hyung Kim, Tae-Eun Kim, Hwa-Sook Kim, Joo-Youn Cho, In-Jin Jang, Sang-Goo Shin, Kyung-Sang Yu. Effect of ketoconazole on the pharmacokinetics of udenafil in healthy Korean subjects.
British journal of clinical pharmacology.
2010 Mar; 69(3):307-10. doi:
10.1111/j.1365-2125.2009.03601.x. [PMID: 20233203] - H E Kang, S K Bae, M Yoo, D C Lee, Y G Kim, M G Lee. Interaction between udenafil and tamsulosin in rats: non-competitive inhibition of tamsulosin metabolism by udenafil via hepatic CYP3A1/2.
British journal of pharmacology.
2009 Mar; 156(6):1009-18. doi:
10.1111/j.1476-5381.2008.00099.x. [PMID: 19254278] - Soo Kyung Bae, Min Jeong Kang, Chang-Woo Yeo, Min-Jung Kim, Ji-Hong Shon, Kwang-Hyeon Liu, Jae-Gook Shin. Simultaneous determination of udenafil and its active metabolite, DA-8164, in human plasma and urine using ultra-performance liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2008 Sep; 22(9):939-46. doi:
10.1002/bmc.1011. [PMID: 18651603] - Bo-Hyung Kim, Hyeong-Seok Lim, Jae-Yong Chung, Jung-Ryul Kim, Kyoung Soo Lim, Dong-Ryul Sohn, Joo-Youn Cho, Kyung-Sang Yu, Sang-Goo Shin, Jae-Seung Paick, In-Jin Jang. Safety, tolerability and pharmacokinetics of udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects.
British journal of clinical pharmacology.
2008 Jun; 65(6):848-54. doi:
10.1111/j.1365-2125.2008.03107.x. [PMID: 18318773] - E Y Oh, S K Bae, J W Kwon, M You, D C Lee, M G Lee. Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats.
British journal of pharmacology.
2007 May; 151(1):24-34. doi:
10.1038/sj.bjp.0707192. [PMID: 17351661] - Jae-Young Yu, Kyung-Koo Kang, Moohi Yoo. Erectile potentials of a new phosphodiesterase type 5 inhibitor, DA-8159, in diet-induced obese rats.
Asian journal of andrology.
2006 May; 8(3):325-9. doi:
10.1111/j.1745-7262.2006.00136.x. [PMID: 16625282] - Joo H Lee, Eun J Kim, Jong W Kwon, Moohi Yoo, Myung G Lee. Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats.
Biopharmaceutics & drug disposition.
2006 Apr; 27(3):125-31. doi:
10.1002/bdd.491. [PMID: 16400709] - Seul Min Choi, Jee Eun Kim, Kyung Koo Kang. Chronic treatment of DA-8159, a new phosphodiesterase type V inhibitor, attenuates endothelial dysfunction in stroke-prone spontaneously hypertensive rat.
Life sciences.
2006 Feb; 78(11):1211-6. doi:
10.1016/j.lfs.2005.06.042. [PMID: 16214180] - Ji Young Kim, Yu Chul Kim, Myung Gull Lee, Jong Won Kwon, Moohi Yoo. Effects of water deprivation on the pharmacokinetics of DA-8159, a new erectogenic, in rats.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2006; 9(1):10-21. doi:
NULL. [PMID: 16849004] - Joo H Lee, Soo K Bae, Jong W Kwon, Won B Kim, Myung G Lee. Effects of omeprazole or cola beverage on the pharmacokinetics of oral DA-8159, a new erectogenic, in rats.
Biopharmaceutics & drug disposition.
2005 Dec; 26(9):411-6. doi:
10.1002/bdd.472. [PMID: 16163666] - Shin Jung Lee, Soo Kyung Bae, Jong Won Kwon, Moohi You, Duk Chul Lee, Myung Gull Lee. Pharmacokinetic interaction between 5-[2-propyloxy-5-(1-methyl-2-pyrollidinylethylamidosulfonyl)phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo (4,3-d) pyrimidine-7-one (DA-8159) and nitroglycerin in rats.
The Journal of pharmacy and pharmacology.
2005 Nov; 57(11):1397-405. doi:
10.1211/jpp.57.11.0004. [PMID: 16259771] - Hyun J Shim, Yu C Kim, Joo H Lee, Jong W Kwon, Won B Kim, Yoon G Kim, So H Kim, Myung G Lee. Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics.
Biopharmaceutics & drug disposition.
2005 Oct; 26(7):269-77. doi:
10.1002/bdd.455. [PMID: 15991256] - Gook Jun Ahn, Jae Young Yu, Seul Min Choi, Kyung Koo Kang, Byoung Ok Ahn, Jong Won Kwon, Sung Keun Kang, Byeong Chun Lee, Woo Suk Hwang. Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes.
International journal of andrology.
2005 Oct; 28(5):260-6. doi:
10.1111/j.1365-2605.2005.00537.x. [PMID: 16128985] - Yu C Kim, Hyun J Shim, Joo H Lee, Dong S Kim, Jong W Kwon, Won B Kim, Inchul Lee, Myung G Lee. Pharmacokinetic changes of DA-8159, a new erectogenic, and one of its metabolites, DA-8164 after intravenous and oral administration of DA-8159 to spontaneously hypertensive rats and DOCA-salt-induced hypertensive rats.
Biopharmaceutics & drug disposition.
2005 Oct; 26(7):309-20. doi:
10.1002/bdd.462. [PMID: 16035131] - Yu C Kim, Hyun J Shim, Joo H Lee, Soon H Kim, Jong W Kwon, Won B Kim, Myung G Lee. Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous DA-8159, a new erectogenic, in rats.
Biopharmaceutics & drug disposition.
2005 Sep; 26(6):233-41. doi:
10.1002/bdd.453. [PMID: 15926192] - K K Kang, J Y Yu, M Yoo, J W Kwon. The effect of DA-8159, a novel PDE5 inhibitor, on erectile function in the rat model of hypercholesterolemic erectile dysfunction.
International journal of impotence research.
2005 Sep; 17(5):409-16. doi:
10.1038/sj.ijir.3901331. [PMID: 15920460] - Hyun J Shim, Yu C Kim, Joo H Lee, Kyung J Park, Jong W Kwon, Won B Kim, Myung G Lee. Species differences in the formation of DA-8164 after intravenous and/or oral administration of DA-8159, a new erectogenic, to mice, rats, rabbits, dogs and humans.
Biopharmaceutics & drug disposition.
2005 May; 26(4):161-6. doi:
10.1002/bdd.444. [PMID: 15803515] - Hyun J Shim, Yu C Kim, Joo H Lee, Byung O Ahn, Jong W Kwon, Won B Kim, Inchul Lee, Myung G Lee. Pharmacokinetics of intravenous and oral DA-8159, a new erectogenic, in rats with protein-calorie malnutrition.
The Journal of pharmacy and pharmacology.
2004 Dec; 56(12):1543-50. doi:
10.1211/0022357044904. [PMID: 15563761] - Yu C Kim, Jong W Kwon, Won B Kim, Inchul Lee, Myung G Lee. Pharmacokinetic changes of DA-8159, a new erectogenic, after intravenous and oral administration to rats with diabetes mellitus induced by streptozotocin.
Journal of pharmaceutical sciences.
2004 Sep; 93(9):2374-87. doi:
10.1002/jps.20144. [PMID: 15295797] - Ho Kyun Cho, Kyung Koo Kang, Gook Jun Ahn, Hyun Joo Shim, Won Bae Kim. Effect of DA-8159, a selective phosphodiesterase type 5 inhibitor, on electroretinogram and retinal histology in rabbits.
Journal of Korean medical science.
2004 Aug; 19(4):586-90. doi:
10.3346/jkms.2004.19.4.586. [PMID: 15308852] - Kyung Koo Kang, Gook Jun Ahn, Hyun Joo Shim, Jong Won Kwon. DA-8159 has erectile potentials much longer than the plasma half-life in a conscious rabbit model.
Life sciences.
2004 Jul; 75(9):1075-83. doi:
10.1016/j.lfs.2004.02.017. [PMID: 15207655] - Hyun J Shim, Yu C Kim, Eun J Kim, Dong G Kim, Jong W Kwon, Won B Kim, Myung G Lee. Pharmacokinetic changes of DA-8159, a new erectogenic, after intravenous and oral administration to rats with acute renal failure induced by uranyl nitrate.
Biopharmaceutics & drug disposition.
2004 Apr; 25(3):137-42. doi:
10.1002/bdd.389. [PMID: 15083502] - Moon Koo Chung, Jong Choon Kim, Won Bae Kim, Kyung Koo Kang, Sang Seop Han. Fertility study of the new pyrazolopyrimidinone derivative DA-8159 for erectile dysfunction in rats.
Arzneimittel-Forschung.
2004; 54(3):179-86. doi:
10.1055/s-0031-1296956. [PMID: 15112865] - Hyun J Shim, Yu C Kim, Ji M Jang, Kyung J Park, Dong H Kim, Kyung K Kang, Byoung O Ahn, Jong W Kwon, Won B Kim, Myung G Lee. Subacute toxicities and toxicokinetics of DA-8159, a new phosphodiesterase type V inhibitor, after single and 4-week repeated oral administration in rats.
Biopharmaceutics & drug disposition.
2003 Dec; 24(9):409-18. doi:
10.1002/bdd.377. [PMID: 14689469] - Hyun J Shim, Yu C Kim, Kyung J Park, Dong S Kim, Jong W Kwon, Won B Kim, Myung G Lee. Pharmacokinetics of DA-8159, a new erectogenic, after intravenous and oral administration to rats: hepatic and intestinal first-pass effects.
Journal of pharmaceutical sciences.
2003 Nov; 92(11):2185-95. doi:
10.1002/jps.10482. [PMID: 14603504] - K K Kang, G J Ahn, Y S Sohn, B O Ahn, W B Kim. DA-8159, a new PDE5 inhibitor, attenuates the development of compensatory right ventricular hypertrophy in a rat model of pulmonary hypertension.
The Journal of international medical research.
2003 Nov; 31(6):517-28. doi:
10.1177/147323000303100608. [PMID: 14708417] - Joo Youn Cho, Hyeong Seok Lim, Kyung Sang Yu, Hyun Joo Shim, In Jin Jang, Sang Goo Shin. Sensitive liquid chromatography assay with ultraviolet detection for a new phosphodiesterase V inhibitor, DA-8159, in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Oct; 795(2):179-86. doi:
10.1016/s1570-0232(03)00565-8. [PMID: 14522022] - Kyung Koo Kang, Gook Jun Ahn, Yong Sung Sohn, Byoung Ok Ahn, Won Bae Kim. DA-8159, a potent cGMP phosphodiesterase inhibitor, attenuates monocrotaline-induced pulmonary hypertension in rats.
Archives of pharmacal research.
2003 Aug; 26(8):612-9. doi:
10.1007/bf02976710. [PMID: 12967196] - Hyun Joo Shim, Eun Joo Lee, Young Hee Jung, So Hee Kim, Soon Hoe Kim, Moohi Yoo, Jong Won Kwon, Won Bae Kim, Myung Gull Lee. Determination of a new phosphodiesterase V inhibitor, DA-8159, in plasma and urine by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
2002 Oct; 30(3):527-33. doi:
10.1016/s0731-7085(02)00397-7. [PMID: 12367677] - H J Shim, E J Lee, J H Kim, S H Kim, J W Kwon, W B Kim, S W Cha, M G Lee. Subacute toxicities and toxicokinetics of a new erectogenic, DA-8159, after single and 4-week repeated oral administration in dogs.
Biopharmaceutics & drug disposition.
2001 Apr; 22(3):109-17. doi:
10.1002/bdd.263. [PMID: 11745913] - H J Shim, E J Lee, S H Kim, S H Kim, M Yoo, J W Kwon, W B Kim, M G Lee. Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique.
Biopharmaceutics & drug disposition.
2000 Oct; 21(7):285-91. doi:
10.1002/bdd.238. [PMID: 11512128] - H J Shim, E J Lee, S H Kim, S H Kim, M Yoo, J W Kwon, W B Kim, H S Lee, M G Lee. Pharmacokinetics, stability, and blood partition of DA-8159, a new phosphodiesterase V inhibitor.
Research communications in molecular pathology and pharmacology.
2000; 108(3-4):275-86. doi:
NULL. [PMID: 11913718]