CS-747 (BioDeep_00000615051)

   


代谢物信息卡片


5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4H,5H,6H,7H-thieno[3,2-c]pyridin-2-yl acetate

化学式: C20H20FNO3S (373.1147862)
中文名称: 普拉格雷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4
InChI: InChI=1S/C20H20FNO3S/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21/h2-5,10,13,19H,6-9,11H2,1H3

描述信息

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent > C190801 - P2Y12 Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation[1].

同义名列表

4 个代谢物同义名

5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4H,5H,6H,7H-thieno[3,2-c]pyridin-2-yl acetate; Prasugrel; CS-747; PCR 4099



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Gjin Ndrepepa, Shqipdona Lahu, Alp Aytekin, Maria Scalamogna, John Joseph Coughlan, Senta Gewalt, Costanza Pellegrini, Katharina Mayer, Adnan Kastrati. One-Year Ischemic and Bleeding Events According to Renal Function in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Treated With Percutaneous Coronary Intervention and Third-Generation Antiplatelet Drugs. The American journal of cardiology. 2022 08; 176(?):15-23. doi: 10.1016/j.amjcard.2022.04.040. [PMID: 35606172]
  • Carol Anne Graham, Mary K Tan, Derek P Chew, Christopher P Gale, Keith A A Fox, Akshay Bagai, Mark A Henderson, Ata Ur Rehman Quraishi, Jean-Pierre Déry, Asim N Cheema, Harold Fisher, David Brieger, Sohrab R Lutchmedial, Shahar Lavi, Brian Y L Wong, Tomas Cieza, Shamir R Mehta, Neil Brass, Shaun G Goodman, Andrew T Yan. Use and outcomes of dual antiplatelet therapy for acute coronary syndrome in patients with chronic kidney disease: insights from the Canadian Observational Antiplatelet Study (COAPT). Heart and vessels. 2022 Aug; 37(8):1291-1298. doi: 10.1007/s00380-022-02029-8. [PMID: 35089380]
  • Yuichi Saito, Takeshi Nishi, Shinichi Wakabayashi, Yuji Ohno, Hideki Kitahara, Noritaka Ariyoshi, Yoshio Kobayashi. Differential Impact of Clinical and Genetic Factors on High Platelet Reactivity in Patients with Coronary Artery Disease Treated with Clopidogrel and Prasugrel. Journal of atherosclerosis and thrombosis. 2022 Jul; 29(7):1031-1039. doi: 10.5551/jat.63035. [PMID: 34234079]
  • Nishank Jain, Milind A Phadnis, Bradley C Martin, Jawahar L Mehta. Potent Antiplatelet Therapy May Reduce Death from Sepsis in Patients on Chronic Dialysis. The American journal of cardiology. 2022 01; 162(?):209-211. doi: 10.1016/j.amjcard.2021.10.001. [PMID: 34740395]
  • Chih-Chin Shih, Melissa V Chan, Nicholas S Kirkby, Ivana Vojnovic, Jane A Mitchell, Paul C Armstrong, Timothy D Warner. Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators. British journal of pharmacology. 2021 12; 178(23):4758-4771. doi: 10.1111/bph.15659. [PMID: 34383973]
  • Immaneni Sathyamurthy, M S Hiremath, Jitendra Pal Sawhney, Subhash Chandra, Hrudanand Mishra, C K Ponde, Shuvanan Ray, Suhas Hardas, Sunil Sathe, P C Rath, Bagirath R, Girish B Navasundi, Vilas Magarkar, C N Makhale, Suvro Banerjee, P R Vaidyanathan, Amal Kanti Sen, Pandey Bp, Swami Onkar C. Expert Opinion on P2Y12 Inhibitors Use in Management of Acute Coronary Syndromes: Focus on Ticagrelor. The Journal of the Association of Physicians of India. 2021 Oct; 69(10):11-12. doi: NULL. [PMID: 34781659]
  • Asmaa A Gomaa, Hanan S El-Abhar, Dalaal M Abdallah, Azza S Awad, Ayman A Soubh. Prasugrel anti-ischemic effect in rats: Modulation of hippocampal SUMO2/3-IкBα/Ubc9 and SIRT-1/miR-22 trajectories. Toxicology and applied pharmacology. 2021 09; 426(?):115635. doi: 10.1016/j.taap.2021.115635. [PMID: 34174262]
  • Thomas A Mavrakanas, Omer Kamal, David M Charytan. Prasugrel and Ticagrelor in Patients with Drug-Eluting Stents and Kidney Failure. Clinical journal of the American Society of Nephrology : CJASN. 2021 05; 16(5):757-764. doi: 10.2215/cjn.12120720. [PMID: 33811128]
  • Mohammed A Abosheasha, Afnan H El-Gowily. Superiority of cilostazol among antiplatelet FDA-approved drugs against COVID 19 Mpro and spike protein: Drug repurposing approach. Drug development research. 2021 04; 82(2):217-229. doi: 10.1002/ddr.21743. [PMID: 32984987]
  • Taiki Masuyama, Masashi Sakuma, Ryutaro Waku, Suguru Hirose, Keijiro Kitahara, Jin Naganuma, Hiroko Yazawa, Shigeru Toyoda, Shichiro Abe, Toshiaki Nakajima, Teruo Inoue. Effects of switching from clopidogrel to prasugrel at the chronic phase after coronary stenting on antiplatelet action and vascular endothelial function: Switch-Pras study. Heart and vessels. 2021 Apr; 36(4):442-451. doi: 10.1007/s00380-020-01714-w. [PMID: 33113567]
  • Masato Nakamura, Yoshihiro Morino, Tsunekazu Kakuta, Yoshiki Hata, Itaru Takamisawa, Kengo Tanabe, Hitoshi Anzai, Akihiko Takahashi, Kazushige Kadota, Hiroshi Suzuki, Tetsuzo Wakatsuki, Hideki Okayama, Jun Yamashita, Takashi Akasaka, Hiroyoshi Yokoi, Takuo Nakagami, Yoshiharu Higuchi, Junichi Yamaguchi, Takumi Kimura, Atsushi Harada, Takeshi Kuroda, Atsushi Takita, Raisuke Iijima, Yoshitaka Murakami, Shigeru Saito. Monotherapy With Prasugrel After Dual-Antiplatelet Therapy for Japanese Percutaneous Coronary Intervention Patients With High Bleeding Risk - A Prospective Cohort Study (PENDULUM mono Study). Circulation journal : official journal of the Japanese Circulation Society. 2020 12; 85(1):27-36. doi: 10.1253/circj.cj-20-0786. [PMID: 33162490]
  • Amy Sm Lam, Bryan Py Yan, Vivian Wy Lee. Trends of prescribing adherence of antiplatelet agents in Hong Kong patients with acute coronary syndrome: a 10-year retrospective observational cohort study. BMJ open. 2020 12; 10(12):e042229. doi: 10.1136/bmjopen-2020-042229. [PMID: 33273050]
  • Boris Schnorbus, Andreas Daiber, Kerstin Jurk, Silke Warnke, Jochem Koenig, Karl J Lackner, Thomas Münzel, Tommaso Gori. Effects of clopidogrel vs. prasugrel vs. ticagrelor on endothelial function, inflammatory parameters, and platelet function in patients with acute coronary syndrome undergoing coronary artery stenting: a randomized, blinded, parallel study. European heart journal. 2020 09; 41(33):3144-3152. doi: 10.1093/eurheartj/ehz917. [PMID: 31899473]
  • Federica Ilardi, Giuseppe Gargiulo, Roberta Paolillo, Marco Ferrone, Sara Cimino, Giuseppe Giugliano, Gabriele G Schiattarella, Nicola Verde, Eugenio Stabile, Cinzia Perrino, Plinio Cirillo, Enrico Coscioni, Carmine Morisco, Giovanni Esposito. Impact of chronic kidney disease on platelet aggregation in patients with acute coronary syndrome. Journal of cardiovascular medicine (Hagerstown, Md.). 2020 Sep; 21(9):660-666. doi: 10.2459/jcm.0000000000000981. [PMID: 32520854]
  • Fernando Scudiero, Guido Parodi. Dual antiplatelet therapy in patients with acute coronary syndrome during the coronavirus disease of 2019 pandemia: the right choice at the right time. Journal of cardiovascular medicine (Hagerstown, Md.). 2020 08; 21(8):535-537. doi: 10.2459/jcm.0000000000001028. [PMID: 32628420]
  • Paul C Armstrong, Plinio M Ferreira, Melissa V Chan, Martina H Lundberg Slingsby, Marilena Crescente, Chih-Chin Shih, Nicholas S Kirkby, Adrian J Hobbs, Timothy D Warner. Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy. Journal of thrombosis and haemostasis : JTH. 2020 07; 18(7):1705-1713. doi: 10.1111/jth.14826. [PMID: 32278335]
  • Paul M Haller, Stefan Stojkovic, Edita Piackova, Tijana Andric, Lukas Wisgrill, Andreas Spittler, Johann Wojta, Kurt Huber, Bernhard Jäger. The association of P2Y12 inhibitors with pro-coagulatory extracellular vesicles and microRNAs in stable coronary artery disease. Platelets. 2020 May; 31(4):497-504. doi: 10.1080/09537104.2019.1648780. [PMID: 31389740]
  • Hala M F Mohammad, Samy Makary, Hoda Atef, Mohamed El-Sherbiny, Hebatallah H Atteia, Gehan A Ibrahim, Abdelaty Shawky Mohamed, Sawsan A Zaitone. Clopidogrel or prasugrel reduces mortality and lessens cardiovascular damage from acute myocardial infarction in hypercholesterolemic male rats. Life sciences. 2020 Apr; 247(?):117429. doi: 10.1016/j.lfs.2020.117429. [PMID: 32061670]
  • Satoshi Shoji, Mitsuaki Sawano, Alexander T Sandhu, Paul A Heidenreich, Yasuyuki Shiraishi, Nobuhiro Ikemura, Koji Ueno, Masahiro Suzuki, Yohei Numasawa, Keiichi Fukuda, Shun Kohsaka. Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment. JAMA network open. 2020 04; 3(4):e202004. doi: 10.1001/jamanetworkopen.2020.2004. [PMID: 32239221]
  • William A E Parker, Christian Schulte, Temo Barwari, Fladia Phoenix, Sam M Pearson, Manuel Mayr, Peter J Grant, Robert F Storey, Ramzi A Ajjan. Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: a double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels. Cardiovascular diabetology. 2020 01; 19(1):3. doi: 10.1186/s12933-019-0981-3. [PMID: 31910903]
  • Ovidio De Filippo, Fabrizio D'Ascenzo, Sergio Raposeiras-Roubin, Emad Abu-Assi, Mattia Peyracchia, Pier Paolo Bocchino, Tim Kinnaird, Albert Ariza-Solé, Christoph Liebetrau, Sergio Manzano-Fernández, Giacomo Boccuzzi, Jose Paulo Simao Henriques, Christian Templin, Stephen B Wilton, Pierluigi Omedè, Lazar Velicki, Ioanna Xanthopoulou, Luis Correia, Enrico Cerrato, Andrea Rognoni, Ugo Fabrizio, Iván Nuñez-Gil, Mario Iannaccone, Andrea Montabone, Salma Taha, Toshiharu Fujii, Alessandro Durante, Xiantao Song, Sebastiano Gili, Giulia Magnani, Ferdinando Varbella, Tetsuma Kawaji, Pedro Flores Blanco, Alberto Garay, Giorgio Quadri, Dimitrios Alexopoulos, Berenice Caneiro Queija, Zenon Huczek, Rafael Cobas Paz, José Ramón González Juanatey, María Cespón Fernández, Shao-Ping Nie, Isabel Muñoz Pousa, Masa-Aki Kawashiri, Diego Gallo, Umberto Morbiducci, Federico Conrotto, Antonio Montefusco, Alberto Dominguez-Rodriguez, Angel López-Cuenca, Angel Cequier, Andrés Iñiguez-Romo, Tullio Usmiani, Mauro Rinaldi, Gaetano Maria De Ferrari. P2Y12 inhibitors in acute coronary syndrome patients with renal dysfunction: an analysis from the RENAMI and BleeMACS projects. European heart journal. Cardiovascular pharmacotherapy. 2020 01; 6(1):31-42. doi: 10.1093/ehjcvp/pvz048. [PMID: 31511896]
  • Nishank Jain, Suzanne L Hunt, Huizhong Cui, Milind A Phadnis, Jonathan D Mahnken, Theresa I Shireman, Junqiang Dai, Jawahar L Mehta, Rafia S Rasu. Trends for and Clinical Factors Associated with Choice of Oral P2Y12 Inhibitors for Patients on Chronic Dialysis. Cardiovascular drugs and therapy. 2019 10; 33(5):511-521. doi: 10.1007/s10557-019-06913-w. [PMID: 31729588]
  • Mitsuhiro Nishihara. Inhibitory Effect of Vonoprazan on the Metabolism of [14C]Prasugrel in Human Liver Microsomes. European journal of drug metabolism and pharmacokinetics. 2019 Oct; 44(5):713-717. doi: 10.1007/s13318-019-00554-y. [PMID: 30993551]
  • Dietmar Trenk, Laura Hille, Stefan Leggewie, Christian Stratz, Thomas G Nührenberg, Daniel Aradi, Karsten Schrör, Dirk Sibbing. Antagonizing P2Y12 Receptor Inhibitors: Current and Future Options. Thrombosis and haemostasis. 2019 10; 119(10):1606-1616. doi: 10.1055/s-0039-1693738. [PMID: 31408901]
  • Bernhard Jäger, Stefan Stojkovic, Paul M Haller, Edith Piackova, Beatrice S Kahl, Tijana Andric, Kris G Vargas, Johann Wojta, Kurt Huber. Course of platelet miRNAs after cessation of P2Y12 antagonists. European journal of clinical investigation. 2019 Aug; 49(8):e13149. doi: 10.1111/eci.13149. [PMID: 31172515]
  • Yun Wang, Michael B Nichol, Bryan Py Yan, Joanne Wu, Brian Tomlinson, Vivian Wy Lee. Descriptive analysis of real-world medication use pattern of statins and antiplatelet agents among patients with acute coronary syndrome in Hong Kong and the USA. BMJ open. 2019 07; 9(7):e024937. doi: 10.1136/bmjopen-2018-024937. [PMID: 31315855]
  • Michela Faggioni, Usman Baber, Jaya Chandrasekhar, Samantha Sartori, William Weintraub, Sunil V Rao, Birgit Vogel, Bimmer Claessen, Annapoorna Kini, Mark Effron, Zhen Ge, Stuart Keller, Craig Strauss, Clayton Snyder, Catalin Toma, Sandra Weiss, Melissa Aquino, Brian Baker, Anthony Defranco, Sameer Bansilal, Brent Muhlestein, Samir Kapadia, Stuart Pocock, Kanhaiya L Poddar, Timothy D Henry, Roxana Mehran. Use of prasugrel and clinical outcomes in African-American patients treated with percutaneous coronary intervention for acute coronary syndromes. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2019 Jul; 94(1):53-60. doi: 10.1002/ccd.28033. [PMID: 30656812]
  • Carey Kimmelstiel, Ryan Stevenson, Nga Nguyen, Layla Van Doren, Ping Zhang, James Perkins, Navin K Kapur, Andrew Weintraub, Vilma Castaneda, Athan Kuliopulos, Lidija Covic. Enhanced potency of prasugrel on protease-activated receptors following bivalirudin treatment for PCI as compared to clopidogrel. Thrombosis research. 2019 May; 177(?):59-69. doi: 10.1016/j.thromres.2019.01.017. [PMID: 30851630]
  • Sergio Raposeiras-Roubín, Emad Abu-Assi, Fabrizio D'Ascenzo, Saleta Fernández-Barbeira, Tim Kinnaird, Albert Ariza-Solé, Sergio Manzano-Fernández, Christian Templin, Lazar Velicki, Ioanna Xanthopoulou, Enrico Cerrato, Giorgio Quadri, Andrea Rognoni, Giacome Boccuzzi, Andrea Montabone, Salma Taha, Alessandro Durante, Sebastiano Gili, Giulia Magnani, Michele Autelli, Alberto Grosso, Pedro Flores Blanco, Alberto Garay, Ferdinando Varbella, Francesco Tommassini, Berenice Caneiro Queija, Rafael Cobas Paz, María Cespón Fernández, Isabel Muñoz Pousa, Diego Gallo, Umberto Morbiducci, Alberto Domínguez-Rodríguez, José Antonio Baz-Alonso, Mariano Valdés, Ángel Cequier, Fiorenzo Gaita, Dimitrios Alexopoulos, Andrés Íñiguez-Romo. Annual Incidence of Confirmed Stent Thrombosis and Clinical Predictors in Patients With ACS Treated With Ticagrelor or Prasugrel. Revista espanola de cardiologia (English ed.). 2019 Apr; 72(4):298-304. doi: 10.1016/j.rec.2018.05.021. [PMID: 29954720]
  • Gaurang Nandkishor Vaidya, Abdur Khan, Shahab Ghafghazi. Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis. Indian heart journal. 2019 Mar; 71(2):126-135. doi: 10.1016/j.ihj.2019.03.003. [PMID: 31280824]
  • Monica Verdoia, Patrizia Pergolini, Matteo Nardin, Roberta Rolla, Lucia Barbieri, Paolo Marino, Alessandro Carriero, Harry Suryapranata, Giuseppe De Luca. Prevalence and predictors of high-on treatment platelet reactivity during prasugrel treatment in patients with acute coronary syndrome undergoing stent implantation. Journal of cardiology. 2019 03; 73(3):198-203. doi: 10.1016/j.jjcc.2018.10.005. [PMID: 30522897]
  • Mikko T Holmberg, Aleksi Tornio, Maria Paile-Hyvärinen, E Katriina Tarkiainen, Mikko Neuvonen, Pertti J Neuvonen, Janne T Backman, Mikko Niemi. CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel. Clinical pharmacology and therapeutics. 2019 02; 105(2):448-457. doi: 10.1002/cpt.1177. [PMID: 29998574]
  • Magdalena Boncler, Joanna Wzorek, Nina Wolska, Dawid Polak, Cezary Watala, Marcin Rozalski. Adenosine receptor agonists deepen the inhibition of platelet aggregation by P2Y12 antagonists. Vascular pharmacology. 2019 02; 113(?):47-56. doi: 10.1016/j.vph.2018.11.005. [PMID: 30471364]
  • Maarten A H van Leeuwen, Nina W van der Hoeven, Gladys N Janssens, Henk Everaars, Alexander Nap, Jorrit S Lemkes, Guus A de Waard, Peter M van de Ven, Albert C van Rossum, Tim J F Ten Cate, Jan J Piek, Clemens von Birgelen, Javier Escaned, Marco Valgimigli, Roberto Diletti, Niels P Riksen, Nicolas M van Mieghem, Robin Nijveldt, Niels van Royen. Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment-Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel. Circulation. 2019 01; 139(5):636-646. doi: 10.1161/circulationaha.118.035931. [PMID: 30586720]
  • Tanya M Laidlaw, Katherine N Cahill, Juan Carlos Cardet, Katherine Murphy, Jing Cui, Brittney Dioneda, Parul Kothari, Benjamin A Raby, Elliot Israel, Joshua A Boyce. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. The Journal of allergy and clinical immunology. 2019 01; 143(1):316-324.e7. doi: 10.1016/j.jaci.2018.06.001. [PMID: 29890239]
  • Atsushi Kambayashi, Jennifer B Dressman. Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir. Journal of pharmaceutical sciences. 2019 Jan; 108(1):584-591. doi: 10.1016/j.xphs.2018.11.008. [PMID: 30423339]
  • Yuji Ohno, Hideki Kitahara, Kenichi Fujii, Yukinori Kohno, Noritaka Ariyoshi, Takeshi Nishi, Yoshihide Fujimoto, Yoshio Kobayashi. High residual platelet reactivity after switching from clopidogrel to low-dose prasugrel in Japanese patients with end-stage renal disease on hemodialysis. Journal of cardiology. 2019 01; 73(1):51-57. doi: 10.1016/j.jjcc.2018.07.001. [PMID: 30055865]
  • Takanari Kitazono, Yasuo Ikeda, Masakatsu Nishikawa, Satoshi Yoshiba, Kenji Abe, Akira Ogawa. Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel. Journal of thrombosis and thrombolysis. 2018 Nov; 46(4):488-495. doi: 10.1007/s11239-018-1714-2. [PMID: 30074128]
  • Niloufar Marsousi, Youssef Daali, Pierre Fontana, Jean-Luc Reny, Virginie Ancrenaz-Sirot, Alexandra Calmy, Serge Rudaz, Jules Alexandre Desmeules, Caroline Flora Samer. Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites. Clinical pharmacokinetics. 2018 10; 57(10):1347-1354. doi: 10.1007/s40262-018-0637-6. [PMID: 29453687]
  • Laurent Bonello, Marc Laine, Gilles Lemesle, Etienne Puymirat, Thibaut Dabry, Franck Thuny, Franck Paganelli, Daniel Aradi, Corinne Frere, Stéphane Burtey, Dirk Sibbing, Julien Mancini. Meta-Analysis of Potent P2Y12-ADP Receptor Antagonist Therapy Compared to Clopidogrel Therapy in Acute Coronary Syndrome Patients with Chronic Kidney Disease. Thrombosis and haemostasis. 2018 Oct; 118(10):1839-1846. doi: 10.1055/s-0038-1669426. [PMID: 30235475]
  • Dimitrios Dimitroulis, Milad Golabkesh, David Naguib, Betül Knoop, Lisa Dannenberg, Carolin Helten, Martin Pöhl, Christian Jung, Malte Kelm, Tobias Zeus, Amin Polzin. Safety and Efficacy in Prasugrel- Versus Ticagrelor-Treated Patients With ST-Elevation Myocardial Infarction. Journal of cardiovascular pharmacology. 2018 10; 72(4):186-190. doi: 10.1097/fjc.0000000000000609. [PMID: 29985284]
  • Matti K Itkonen, Aleksi Tornio, Anne M Filppula, Mikko Neuvonen, Pertti J Neuvonen, Mikko Niemi, Janne T Backman. Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans. Clinical pharmacology and therapeutics. 2018 09; 104(3):495-504. doi: 10.1002/cpt.947. [PMID: 29171020]
  • Sara Ariotti, Luis Ortega-Paz, Maarten van Leeuwen, Salvatore Brugaletta, Sergio Leonardi, K Martijn Akkerhuis, Stefano F Rimoldi, Gladys Janssens, Umberto Gianni, Jan C van den Berge, Alexios Karagiannis, Stephan Windecker, Marco Valgimigli. Effects of Ticagrelor, Prasugrel, or Clopidogrel on Endothelial Function and Other Vascular Biomarkers: A Randomized Crossover Study. JACC. Cardiovascular interventions. 2018 08; 11(16):1576-1586. doi: 10.1016/j.jcin.2018.04.022. [PMID: 29805112]
  • K Korybalska, R Rutkowski, J Luczak, N Czepulis, K Karpinski, J Witowski. The role of purinergic P2Y12 receptor blockers on the angiogenic properties of endothelial cells: an in vitro study. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2018 Aug; 69(4):. doi: 10.26402/jpp.2018.4.06. [PMID: 30415240]
  • A Bertling, A C Fender, L Schüngel, M Rumpf, K Mergemeier, G Geißler, W Sibrowski, R Kelsch, J Waltenberger, J A Jakubowski, B E Kehrel. Reversibility of platelet P2Y12 inhibition by platelet supplementation: ex vivo and in vitro comparisons of prasugrel, clopidogrel and ticagrelor. Journal of thrombosis and haemostasis : JTH. 2018 06; 16(6):1089-1098. doi: 10.1111/jth.14014. [PMID: 29582544]
  • Reza Rahmani, Laya Jiriaee, Zahra Jiriaee, Akbar Shafiee, Amir Farhang Zand Parsa. The Incidence of Myocardial Injury after Loading Doses of Clopidogrel versus Prasugrel in the Candidates for Percutaneous Coronary Intervention: A Randomized Controlled Trial. Critical pathways in cardiology. 2018 06; 17(2):69-72. doi: 10.1097/hpc.0000000000000114. [PMID: 29768313]
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