Bepotastine (BioDeep_00000615042)

   


代谢物信息卡片


4-{4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid

化学式: C21H25ClN2O3 (388.1554)
中文名称: 贝他斯汀, 贝托斯汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O
InChI: InChI=1S/C21H25ClN2O3/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26)/t21-/m0/s1

描述信息

C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Bepotastine is a selective and orally active second-generation histamine H1 receptor antagonist, can suppress the expression of nerve growth factor (NGF). Bepotastine has the potential for allergic rhinitis, allergic conjunctivitis and urticaria/pruritus research[1][2][3][4].

同义名列表

4 个代谢物同义名

(S)-Bepotastine; Bepotastine; 4-{4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid; Bepotastine besilate;Betotastine besilate;TAU-284DS



数据库引用编号

9 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Ismael Carrillo-Martin, Alexei Gonzalez-Estrada, Ves Dimov. Bepotastine besilate for the treatment of perennial allergic rhinitis. Expert opinion on pharmacotherapy. 2018 Oct; 19(15):1727-1730. doi: 10.1080/14656566.2018.1519020. [PMID: 30208284]
  • Kayoko Kanamitsu, Yoshitane Nozaki, Yoko Nagaya, Yuichi Sugiyama, Hiroyuki Kusuhara. Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data. Drug metabolism and pharmacokinetics. 2017 Apr; 32(2):135-144. doi: 10.1016/j.dmpk.2016.11.007. [PMID: 28190755]
  • Yun Kyoung Choi, Yoon Hee Chung, Yun Sung Nam, Da Young Kang, Hohyun Kim, Seo Eun Lee, Hak Rim Kim, Yong Seong Lee, Ji Hoon Jeong. UPLC-MS/MS method for determination of bepotastine in human plasma. Journal of chromatographic science. 2014 Sep; 52(8):886-93. doi: 10.1093/chromsci/bmt135. [PMID: 24023058]
  • Jianzhong Shentu, Huili Zhou, Xingjiang Hu, Guolan Wu, Lihua Wu, Meixiang Zhu, You Zhai, Yunliang Zheng, Jian Liu. Comparative fasting bioavailability of 2 bepotastine formulations in healthy male Chinese volunteers: an open-label, randomized, single-dose, 2-way crossover study. Clinical therapeutics. 2014 Apr; 36(4):579-85. doi: 10.1016/j.clinthera.2014.02.020. [PMID: 24656153]
  • Dongying Zhang, Manabu Tashiro, Katsuhiko Shibuya, Nobuyuki Okamura, Yoshihito Funaki, Takeo Yoshikawa, Masato Kato, Kazuhiko Yanai. Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. Journal of clinical psychopharmacology. 2010 Dec; 30(6):694-701. doi: 10.1097/jcp.0b013e3181fa8526. [PMID: 21105284]
  • Jon I Williams, James A Gow, Sharon M Klier, Shannon L McCue, Anne Marie F Salapatek, Timothy R McNamara. Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Current medical research and opinion. 2010 Oct; 26(10):2329-38. doi: 10.1185/03007995.2010.486753. [PMID: 20735291]
  • Naoko Inomata, Satoko Tatewaki, Zenro Ikezawa. Multiple H1-antihistamine-induced urticaria. The Journal of dermatology. 2009 Apr; 36(4):224-7. doi: 10.1111/j.1346-8138.2009.00627.x. [PMID: 19348661]
  • Manabu Tashiro, Xudong Duan, Motohisa Kato, Masayasu Miyake, Shoichi Watanuki, Yoichi Ishikawa, Yoshihito Funaki, Ren Iwata, Masatoshi Itoh, Kazuhiko Yanai. Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin. British journal of clinical pharmacology. 2008 Jun; 65(6):811-21. doi: 10.1111/j.1365-2125.2008.03143.x. [PMID: 18410464]
  • Hideaki Tanizaki, Naotomo Kambe, Yuumi Nakamura, Akane Tanaka, Hiroshi Matsuda, Yoshiki Miyachi. Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. International archives of allergy and immunology. 2008; 145(4):277-82. doi: 10.1159/000110886. [PMID: 18004068]
  • Rikiya Ohashi, Yukari Kamikozawa, Mika Sugiura, Hajime Fukuda, Hikaru Yabuuchi, Ikumi Tamai. Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate. Drug metabolism and disposition: the biological fate of chemicals. 2006 May; 34(5):793-9. doi: 10.1124/dmd.105.007559. [PMID: 16455807]
  • M Kato, A Nishida, Y Aga, J Kita, Y Kudo, H Narita, T Endo. Pharmacokinetic and pharmacodynamic evaluation of central effect of the novel antiallergic agent betotastine besilate. Arzneimittel-Forschung. 1997 Oct; 47(10):1116-24. doi: . [PMID: 9368705]