Cefacetrile (BioDeep_00000615025)

   


代谢物信息卡片


(6R,7R)-3-[(acetyloxy)methyl]-7-(2-cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C13H13N3O6S (339.05250380000007)
中文名称: 头孢三烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)CC#N)SC1)C(=O)O
InChI: InChI=1S/C13H13N3O6S/c1-6(17)22-4-7-5-23-12-9(15-8(18)2-3-14)11(19)16(12)10(7)13(20)21/h9,12H,2,4-5H2,1H3,(H,15,18)(H,20,21)/t9-,12-/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

3 个代谢物同义名

Cefacetrile; (6R,7R)-3-[(acetyloxy)methyl]-7-(2-cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-Cyanacetylamino-cephalosporansaeure;Cefacetrilo [inn-spanish];Cefacetrilum [inn-latin];Cephacetrile



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • E Schulz, L von Klitzing, K Sack, R Marre. Bactericidal activity and induction of cell volume alterations of cephalosporins in Escherichia coli. Chemotherapy. 1985; 31(6):425-32. doi: 10.1159/000238370. [PMID: 3908008]
  • G Bozhkova, L Angelov, M Danov. [Cefacetril in treatment of clinical bovine mastitis]. Veterinarno-meditsinski nauki. 1983; 20(1):68-75. doi: NULL. [PMID: 6868361]
  • R N Jones, H W Wilson, W J Novick. In vitro evaluation of pyridine-2-azo-p-dimethylaniline cephalosporin, a new diagnostic chromogenic reagent, and comparison with nitrocefin, cephacetrile, and other beta-lactam compounds. Journal of clinical microbiology. 1982 Apr; 15(4):677-83. doi: 10.1128/jcm.15.4.677-683.1982. [PMID: 6978350]
  • H Shibuya, J Miyawaki, T Matsuyoshi, K Anai, Y Kawano, S Onimura, S Takizawa, H Akaiwa, M Asao. [Cephacetrile. Studies on absorption excretion and diffusion into heart (author's transl)]. The Japanese journal of antibiotics. 1980 Oct; 33(10):1138-44. doi: NULL. [PMID: 7206218]
  • A J Weinstein. The cephalosporins: activity and clinical use. Drugs. 1980 Aug; 20(2):137-54. doi: 10.2165/00003495-198020020-00007. [PMID: 6995096]
  • I Matsushita, N S Paik, T Itaoka, T Kawamura, J Wada. [Antibiotic concentration during extracorporeal circulation (author's transl)]. The Japanese journal of antibiotics. 1980 Jul; 33(7):705-10. doi: NULL. [PMID: 7452909]
  • A Dominguez-Gil, J M Lanao, J M Tabernero, J L Rodriguez Commes, S de Castro. Pharmacokinetics of cephacetrile in patients undergoing haemodialysis. European journal of clinical pharmacology. 1979 Aug; 16(1):49-52. doi: 10.1007/bf00644966. [PMID: 499300]
  • V Tamassia, G Meinardi, S Grasso, I de Carneri. [Correlation between antibacterial activity of some cephalosporins and pharmacokinetic properties "in vitro" (author's transl)]. Quaderni Sclavo di diagnostica clinica e di laboratorio. 1979 Jun; 15 Suppl 1(?):785-92. doi: . [PMID: 400257]
  • C H Blanc. [Plasma and articular concentrations during administration of cephacetrile for septic arthritis]. Zeitschrift fur Unfallmedizin und Berufskrankheiten. Revue de medecine des accidents et des maladies professionelles. 1979; 72(3):118-21. doi: NULL. [PMID: 543327]
  • H Friedrich. Cephalosporins in serum and cerebrospinal fluid. Infection. 1979; 7(5):262. doi: 10.1007/bf01648940. [PMID: 511345]
  • H Friedrich, K Pelz, G Hänsel-Friedrich. Lack of penetration of cephacetril into the cerebro-spinal fluid of patients without meningitis. Infection. 1979; 7(1):41-4. doi: 10.1007/bf01640557. [PMID: 422254]
  • M Crosato, G Nigro Gomirato. [Clinical results of the use in pediatrics of a new combination of beta-lactams]. Giornale italiano di chemioterapia. 1979 Jan; 26(1-2):319-22. doi: NULL. [PMID: 400143]
  • M Watanabe. Drug-induced lysosomal changes and nephrotoxicity in rats. Acta pathologica japonica. 1978 Nov; 28(6):867-89. doi: 10.1111/j.1440-1827.1978.tb01277.x. [PMID: 735819]
  • C H Blanc, H G Meyer-Brunot, W Tosch, J L Schelling. [Serum and joint levels of cefacetrile during its administration for septic arthritis]. Schweizerische medizinische Wochenschrift. 1978 Jul; 108(26):988-94. doi: NULL. [PMID: 663591]
  • H Stuflesser, N Walker, H G Meyer-Brunot, W Theobald. Microbiological assessment of the concentration of cephacetrile in plasma and cancellous bone of femoral heads. The Journal of antimicrobial chemotherapy. 1978 Mar; 4(2):188. doi: 10.1093/jac/4.2.188. [PMID: 649541]
  • K E Andersson. On the pharmacokinetics of cephalosporin antibiotics. Scandinavian journal of infectious diseases. Supplementum. 1978; ?(13):37-46. doi: NULL. [PMID: 278145]
  • K Sack, U Kaiser, B Züllich. [Experimental studies on the renal tolerance of cefuroxime (author's transl)]. Infection. 1977; 5(2):92-4. doi: 10.1007/bf01642087. [PMID: 881267]
  • R Ratschow, J R Krone. [An investigation into the influence of human serum on the in-vitro activity of various cephalosporins (author's transl)]. Infection. 1977; 5(4):236-41. doi: 10.1007/bf01640788. [PMID: 340385]
  • A Windorfer, U Gasteiger. Studies on serum and cerebrospinal fluid levels of cephacetrile in neonates. Infection. 1977; 5(4):242-7. doi: 10.1007/bf01640789. [PMID: 598930]
  • H Aratani, M Nakatsuka. [Fundamental studies on combination of antibiotics; especially on pharmacokinetics. I. Combination of gentamicin with sulbenicillin or cephacetrile (author's transl)]. The Japanese journal of antibiotics. 1976 Dec; 29(12):1019-34. doi: . [PMID: 1051432]
  • C Tauchnitz. [The cephalosporins and their clinical value]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete. 1976 Oct; 31(20):828-34. doi: NULL. [PMID: 1051781]
  • K G Naber, P O Madsen, D Maroske, K H Bichler. Antibiotics and chemotherapeutics in renal lymph. An experimental study in dogs. Investigative urology. 1976 Jul; 14(1):23-7. doi: NULL. [PMID: 955846]
  • J M Brogard, M Dorner, C Brandt, J Lavillaureix. Cephacetrile--application of pharmacokinetic data to dosage determination. International journal of clinical pharmacology and biopharmacy. 1976 Apr; 13(3):168-76. doi: NULL. [PMID: 950258]
  • D Maroske, H Knothe, A Rox. [The liver concentration of cephradin and cephacetril and their elimination in the bile]. Infection. 1976; 4(3):159-65. doi: 10.1007/bf01638943. [PMID: 789253]
  • Y Nakai, Y Kanai, T Fugono, S Tanayama. Metabolic fate of cephacetrile after parenteral administration in rats and rabbits. The Journal of antibiotics. 1976 Jan; 29(1):81-90. doi: 10.7164/antibiotics.29.81. [PMID: 931795]
  • F Daschner. [In vitro effect of cephacetril and colistin combinations on Klebsiella pneumoniae and Proteus Strains (author's transl)]. Arzneimittel-Forschung. 1976; 26(1):87-9. doi: NULL. [PMID: 779799]
  • G Weippl. [Treatment of pneumonia in childhood (author's transl)]. Padiatrie und Padologie. 1976; 11(3):559-65. doi: NULL. [PMID: 934680]
  • R C Moellering, M N Swartz. Drug therapy: The newer cephalosporins. The New England journal of medicine. 1976 Jan; 294(1):24-8. doi: 10.1056/nejm197601012940106. [PMID: 1105179]
  • D K Luscombe, P J Nicholls. Possible interaction between cephacetrile and frusemide in rabbits and rats. The Journal of antimicrobial chemotherapy. 1975 Mar; 1(1):67-77. doi: 10.1093/jac/1.1.67. [PMID: 1176376]
  • M G Bals, E Toma. Cephacetrile, a new cephalosporin: in vitro, pharmacological and clinical evaluation. Infection. 1975; 3(3):161-4. doi: 10.1007/bf01641340. [PMID: 4377]
  • A W Mondorf. [Evidence of urinary tubular proteins in inflammatory and toxic kidney damage]. Wiener medizinische Wochenschrift. Supplement. 1975; 27(?):20-3. doi: NULL. [PMID: 5816]
  • K Naber. [Experimental and clinical studies of Celospor in kidney diseases]. Wiener medizinische Wochenschrift. Supplement. 1975; 27(?):13-20. doi: NULL. [PMID: 1064250]