Rasagiline (BioDeep_00000615022)

   


代谢物信息卡片


(1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine

化学式: C12H13N (171.1047938)
中文名称: 雷沙吉兰
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C#CCNC1CCC2=CC=CC=C12
InChI: InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1

描述信息

N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BD - Monoamine oxidase b inhibitors
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
D020011 - Protective Agents

同义名列表

3 个代谢物同义名

Rasagiline; (1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine; RAS



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Teng Zhang, Meng-Yan Wang, Guo-Dong Wang, Qiu-Yue Lv, Yu-Qian Huang, Peng Zhang, Wen Wang, Yan Zhang, Ya-Ping Bai, Li-Qun Guo. Metformin improves nonalcoholic fatty liver disease in db/db mice by inhibiting ferroptosis. European journal of pharmacology. 2024 Mar; 966(?):176341. doi: 10.1016/j.ejphar.2024.176341. [PMID: 38244761]
  • Huandong Zhao, Ruimin Ding, Jiarui Han. Ginsenoside Rh4 Facilitates the Sensitivity of Renal Cell Carcinoma to Ferroptosis via the NRF2 Pathway. Archivos espanoles de urologia. 2024 Mar; 77(2):119-128. doi: 10.56434/j.arch.esp.urol.20247702.16. [PMID: 38583003]
  • B W Mahde, A Abbas Hussein, A S Sahib. Preparation and in vitro Evaluation of Rasagiline Mesylate Hybrid Nanoparticles. Archives of Razi Institute. 2023 06; 78(3):1023-1028. doi: 10.22092/ari.2022.360193.2563. [PMID: 38028832]
  • Zhipei Sang, Qing Song, Zhongcheng Cao, Yong Deng, Zhenghuai Tan, Li Zhang. Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry. 2021 Apr; 216(?):113310. doi: 10.1016/j.ejmech.2021.113310. [PMID: 33667847]
  • Li Liu, Yi Chen, Rui-Feng Zeng, Yun Liu, Sai-Sai Xie, Jin-Shuai Lan, Yue Ding, Yi-Ting Yang, Jun Yang, Tong Zhang. Design and synthesis of novel 3,4-dihydrocoumarins as potent and selective monoamine oxidase-B inhibitors with the neuroprotection against Parkinson's disease. Bioorganic chemistry. 2021 04; 109(?):104685. doi: 10.1016/j.bioorg.2021.104685. [PMID: 33640631]
  • Zhongcheng Cao, Qing Song, Guangjun Yu, Zhuoling Liu, Shiqing Cong, Zhenghuai Tan, Yong Deng. Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2021 04; 35(?):116074. doi: 10.1016/j.bmc.2021.116074. [PMID: 33640707]
  • Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease. European journal of medicinal chemistry. 2020 Sep; 202(?):112475. doi: 10.1016/j.ejmech.2020.112475. [PMID: 32652406]
  • Meng Wang, Wenjia Zhou, Quanying Zhang, Shunlin Zong, Chengzhe Lv. Pharmacokinetics, Pharmacodynamics, and Safety of a Single Escalating Dose and Repeated Doses of Rasagiline Transdermal Patch in Healthy Chinese Subjects. Clinical pharmacology in drug development. 2020 07; 9(5):602-609. doi: 10.1002/cpdd.761. [PMID: 31823527]
  • Zhipei Sang, Keren Wang, Ping Bai, Anguo Wu, Jian Shi, Wenmin Liu, Gaofeng Zhu, Yiling Wang, Yu Lan, Zude Chen, Yiyang Zhao, Zhanpin Qiao, Changning Wang, Zhenghuai Tan. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2020 May; 194(?):112265. doi: 10.1016/j.ejmech.2020.112265. [PMID: 32240904]
  • Li Luo, Qing Song, Yan Li, Zhongcheng Cao, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorganic & medicinal chemistry. 2020 04; 28(8):115400. doi: 10.1016/j.bmc.2020.115400. [PMID: 32146060]
  • Ziyi Yang, Qing Song, Zhongcheng Cao, Guangjun Yu, Zhuoling Liu, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. Bioorganic & medicinal chemistry. 2020 04; 28(7):115374. doi: 10.1016/j.bmc.2020.115374. [PMID: 32089390]
  • De-Qi Jiang, Hua-Kun Wang, Yan Wang, Ming-Xing Li, Li-Lin Jiang, Yong Wang. Rasagiline combined with levodopa therapy versus levodopa monotherapy for patients with Parkinson's disease: a systematic review. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2020 Jan; 41(1):101-109. doi: 10.1007/s10072-019-04050-8. [PMID: 31446579]
  • Zhipei Sang, Keren Wang, Pengfei Zhang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2019 Oct; 180(?):238-252. doi: 10.1016/j.ejmech.2019.07.021. [PMID: 31310916]
  • N Kanwar, R Bhandari, A Kuhad, V R Sinha. Polycaprolactone-based neurotherapeutic delivery of rasagiline targeting behavioral and biochemical deficits in Parkinson's disease. Drug delivery and translational research. 2019 10; 9(5):891-905. doi: 10.1007/s13346-019-00625-2. [PMID: 30877626]
  • Zhipei Sang, Keren Wang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2019 Sep; 178(?):726-739. doi: 10.1016/j.ejmech.2019.06.026. [PMID: 31229875]
  • Anna Elgart, Laura Rabinovich-Guilatt, Eli Eyal, Aviva Gross, Ofer Spiegelstein. Pharmacokinetics and safety of single and multiple doses of rasagiline in healthy Japanese and caucasian subjects. Basic & clinical pharmacology & toxicology. 2019 Mar; 124(3):273-284. doi: 10.1111/bcpt.13131. [PMID: 30218626]
  • Sameh Ahmed, Nehad A Abdallah. Dansyl azide as a selective fluorescence tagging probe for click chemistry reactions and its application to monitor rasagiline in pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 165(?):357-365. doi: 10.1016/j.jpba.2018.12.026. [PMID: 30580084]
  • Jeffrey M Statland, Dan Moore, Yunxia Wang, Maureen Walsh, Tahseen Mozaffar, Lauren Elman, Sharon P Nations, Hiroshi Mitsumoto, J Americo Fernandes, David Saperstein, Ghazala Hayat, Laura Herbelin, Chafic Karam, Jonathan Katz, Heather M Wilkins, Abdulbaki Agbas, Russell H Swerdlow, Regina M Santella, Mazen M Dimachkie, Richard J Barohn. Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial. Muscle & nerve. 2019 02; 59(2):201-207. doi: 10.1002/mus.26335. [PMID: 30192007]
  • Ying Jiang, Xuemei Zhang, Hongjie Mu, Hongchen Hua, Dongyu Duan, Xiuju Yan, Yiyun Wang, Qingqing Meng, Xiaoyan Lu, Aiping Wang, Wanhui Liu, Youxin Li, Kaoxiang Sun. Preparation and evaluation of injectable Rasagiline mesylate dual-controlled drug delivery system for the treatment of Parkinson's disease. Drug delivery. 2018 Nov; 25(1):143-152. doi: 10.1080/10717544.2017.1419514. [PMID: 29275639]
  • Shiyang Zhou, Guangying Chen, Gangliang Huang. Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase. Bioorganic & medicinal chemistry. 2018 09; 26(17):4863-4870. doi: 10.1016/j.bmc.2018.08.024. [PMID: 30143367]
  • Liulin Wang, Kabir H Biswas, Bo Kyeong Yoon, Lisa M Kawakami, Soohyun Park, Jay T Groves, Lin Li, Wei Huang, Nam-Joon Cho. Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers. Langmuir : the ACS journal of surfaces and colloids. 2018 09; 34(36):10764-10773. doi: 10.1021/acs.langmuir.8b01348. [PMID: 30049212]
  • Rui Xu, Ganyuan Xiao, Yan Li, Hongyan Liu, Qing Song, Xiaoyu Zhang, Ziyi Yang, Yunxiaozhu Zheng, Zhenghuai Tan, Yong Deng. Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry. 2018 05; 26(8):1885-1895. doi: 10.1016/j.bmc.2018.02.037. [PMID: 29500132]
  • Zhongcheng Cao, Jie Yang, Rui Xu, Qin Song, Xiaoyu Zhang, Hongyan Liu, Xiaoming Qiang, Yan Li, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. Bioorganic & medicinal chemistry. 2018 03; 26(5):1102-1115. doi: 10.1016/j.bmc.2018.01.030. [PMID: 29409707]
  • Wenjia Zhou, Chengzhe Lv, Quanying Zhang, Shunlin Zong, Meng Wang. Pharmacokinetics, Pharmacodynamics, and Safety of Rasagiline Transdermal Patch: A Preliminary Study in Healthy Chinese Subjects. Clinical drug investigation. 2018 Feb; 38(2):125-133. doi: 10.1007/s40261-017-0588-y. [PMID: 29159774]
  • Jin-Shuai Lan, Yun Liu, Jian-Wei Hou, Jing Yang, Xin-Yu Zhang, Yuan Zhao, Sai-Sai Xie, Yue Ding, Tong Zhang. Design, synthesis and evaluation of resveratrol-indazole hybrids as novel monoamine oxidases inhibitors with amyloid-β aggregation inhibition. Bioorganic chemistry. 2018 02; 76(?):130-139. doi: 10.1016/j.bioorg.2017.11.009. [PMID: 29172101]
  • Thomas Müller, Peter Riederer, Edna Grünblatt. Determination of Monoamine Oxidase A and B Activity in Long-Term Treated Patients With Parkinson Disease. Clinical neuropharmacology. 2017 Sep; 40(5):208-211. doi: 10.1097/wnf.0000000000000233. [PMID: 28682929]
  • Thomas Müller, Peter Riederer, Edna Grünblatt. Simultaneous determination of MAO-A and -B activity following first time intake of an irreversible MAO-B inhibitor in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2017 06; 124(6):745-748. doi: 10.1007/s00702-017-1705-z. [PMID: 28299453]
  • Xia Yang, Xiaoming Qiang, Yan Li, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease. Bioorganic chemistry. 2017 04; 71(?):305-314. doi: 10.1016/j.bioorg.2017.02.016. [PMID: 28267984]
  • Li Luo, Yan Li, Xiaoming Qiang, Zhongcheng Cao, Rui Xu, Xia Yang, Ganyuan Xiao, Qing Song, Zhenghuai Tan, Yong Deng. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry. 2017 03; 25(6):1997-2009. doi: 10.1016/j.bmc.2017.02.027. [PMID: 28237559]
  • Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):718-722. doi: 10.1016/j.bmcl.2017.01.050. [PMID: 28131710]
  • Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng. Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2017 Jan; 126(?):762-775. doi: 10.1016/j.ejmech.2016.12.009. [PMID: 27951485]
  • M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology. 2016 Aug; 233(15-16):2955-71. doi: 10.1007/s00213-016-4342-6. [PMID: 27259485]
  • Ting Wang, Leting Yang, Jing Hua, Huiru Xie, Xuehua Jiang, Ling Wang. Simultaneous bioanalysis of rasagiline and its major metabolites in human plasma by LC-MS/MS: Application to a clinical pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2016 Jun; 125(?):280-5. doi: 10.1016/j.jpba.2016.04.003. [PMID: 27060436]
  • Yan Li, Xiaoming Qiang, Li Luo, Yuxing Li, Ganyuan Xiao, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2016 05; 24(10):2342-51. doi: 10.1016/j.bmc.2016.04.012. [PMID: 27079124]
  • Xia Chen, Qian Zhao, Ji Jiang, Jian Liu, Pei Hu. Pharmacokinetics of Rasagiline in Healthy Adult Chinese Volunteers with Various Genotypes: A Single-Center, Open-Label, Multiple-Dose Study. Clinical drug investigation. 2016 May; 36(5):369-76. doi: 10.1007/s40261-016-0380-4. [PMID: 26951202]
  • Ravindrababu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Siddhartha Nuthakki, Sivaprasad Pendyala, Naveenbabu Kilaru. Pharmacokinetic interaction study between flavanones (hesperetin, naringenin) and rasagiline mesylate in wistar rats. Drug development and industrial pharmacy. 2016; 42(7):1110-7. doi: 10.3109/03639045.2015.1115868. [PMID: 26530401]
  • Juthathip Suphanklang, Wichai Santimaleeworagun, Ouppatham Supasyndh. Combination of Escitalopram and Rasagiline Induced Serotonin Syndrome: A Case Report and Review Literature. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2015 Dec; 98(12):1254-7. doi: NULL. [PMID: 27004312]
  • Jasmin Bartl, Thomas Müller, Edna Grünblatt, Manfred Gerlach, Peter Riederer. Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity. Journal of neural transmission (Vienna, Austria : 1996). 2014 Apr; 121(4):379-83. doi: 10.1007/s00702-013-1120-z. [PMID: 24272680]
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