Saprisartan (BioDeep_00000615019)

   


代谢物信息卡片


1-({3-bromo-2-[2-(trifluoromethane)sulfonamidophenyl]-1-benzofuran-5-yl}methyl)-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide

化学式: C25H22BrF3N4O4S (610.0497)
中文名称: 沙普立沙坦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=NC(=C(N1CC2=CC3=C(C=C2)OC(=C3Br)C4=CC=CC=C4NS(=O)(=O)C(F)(F)F)C(=O)N)C5CC5
InChI: InChI=1S/C25H22BrF3N4O4S/c1-2-19-31-21(14-8-9-14)22(24(30)34)33(19)12-13-7-10-18-16(11-13)20(26)23(37-18)15-5-3-4-6-17(15)32-38(35,36)25(27,28)29/h3-7,10-11,14,32H,2,8-9,12H2,1H3,(H2,30,34)

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

3 个代谢物同义名

3-[[3-bromo-2-[2-(trifluoromethylsulfonylamino)phenyl]-1-benzofuran-5-yl]methyl]-5-cyclopropyl-2-ethylimidazole-4-carboxamide; Saprisartan; 1-({3-bromo-2-[2-(trifluoromethane)sulfonamidophenyl]-1-benzofuran-5-yl}methyl)-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Alison J Forhead, Juanita K Jellyman, Katherine Gillham, Janelle W Ward, Dominique Blache, Abigail L Fowden. Renal growth retardation following angiotensin II type 1 (AT₁) receptor antagonism is associated with increased AT₂ receptor protein in fetal sheep. The Journal of endocrinology. 2011 Feb; 208(2):137-45. doi: 10.1677/joe-10-0360. [PMID: 21097994]
  • S T Charlton, S S Davis, L Illum. Nasal administration of an angiotensin antagonist in the rat model: effect of bioadhesive formulations on the distribution of drugs to the systemic and central nervous systems. International journal of pharmaceutics. 2007 Jun; 338(1-2):94-103. doi: 10.1016/j.ijpharm.2007.01.047. [PMID: 17337137]
  • A J Forhead, A L Fowden. Role of angiotensin II in the pressor response to cortisol in fetal sheep during late gestation. Experimental physiology. 2004 May; 89(3):323-9. doi: 10.1113/expphysiol.2004.027185. [PMID: 15123568]
  • A J Forhead, F Broughton Pipkin, A L Fowden. Effect of cortisol on blood pressure and the renin-angiotensin system in fetal sheep during late gestation. The Journal of physiology. 2000 Jul; 526 Pt 1(?):167-76. doi: 10.1111/j.1469-7793.2000.00167.x. [PMID: 10878109]
  • J Wang, G H Yi, S M Zhu, A G Gu, S Popilskis, H Zhang, D Burkhoff. The role of angiotensin II AT1 receptor in the maintenance of hemodynamics in a canine model of coronary microembolization-induced heart failure. Journal of cardiovascular pharmacology. 1999 Feb; 33(2):335-40. doi: 10.1097/00005344-199902000-00023. [PMID: 10028945]
  • I K Anderson, G M Drew. The antihypertensive profile of the angiotensin AT1 receptor antagonist, GR138950, and the influence of potential homeostatic compensatory mechanisms in renal hypertensive rats. British journal of pharmacology. 1998 Nov; 125(6):1236-46. doi: 10.1038/sj.bjp.0702187. [PMID: 9863652]
  • I K Anderson, G M Drew. Investigation of the inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antihypertensive effect of the angiotensin AT1 receptor antagonist, GR138950. British journal of pharmacology. 1997 Dec; 122(7):1385-94. doi: 10.1038/sj.bjp.0701531. [PMID: 9421286]
  • A Abdi, E J Johns. The effect of angiotensin II receptor antagonists on kidney function in two-kidney, two-clip Goldblatt hypertensive rats. European journal of pharmacology. 1997 Jul; 331(2-3):185-92. doi: 10.1016/s0014-2999(97)01038-8. [PMID: 9274978]
  • A J Forhead, F Broughton Pipkin, M F Sutherland, A L Fowden. Changes in the maternal and fetal renin-angiotensin systems in response to angiotensin II type 1 receptor blockade and angiotensin-converting enzyme inhibition in pregnant sheep during late gestation. Experimental physiology. 1997 Jul; 82(4):761-76. doi: 10.1113/expphysiol.1997.sp004063. [PMID: 9257117]
  • K L Clark, M J Robertson, G M Drew. Renal pharmacology of GR138950, a novel non-peptide angiotensin AT1 receptor antagonist. European journal of pharmacology. 1995 Jul; 280(2):195-203. doi: 10.1016/0014-2999(95)00204-x. [PMID: 7589186]
  • D B Judd, M D Dowle, D Middlemiss, D I Scopes, B C Ross, T I Jack, M Pass, E Tranquillini, J E Hobson, T A Panchal. Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a potent antihypertensive agent with high oral bioavailability. Journal of medicinal chemistry. 1994 Sep; 37(19):3108-20. doi: 10.1021/jm00045a016. [PMID: 7932534]