diphenylpyraline (BioDeep_00000615005)

   


代谢物信息卡片


Diphenylpyralamine;Diphenylpyraline Hydrochloride;Diphenylpyrilene

化学式: C19H23NO (281.1779548)
中文名称: 二苯基吡咯啉
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(CC1)CCC1OC(C2=CC=CC=C2)C3=CC=CC=C3
InChI: InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3

描述信息

R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AA - Aminoalkyl ethers
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Diphenylpyraline is a potent histamine H1?receptor antagonist. Diphenylpyraline acts as an orally active antihistamine agent?with antimuscarinic and antiallergic effects. Diphenylpyraline can be used for the research of allergic diseases, including rhinitis and hay fever, and pruritic skin disorders et.al[1].

同义名列表

3 个代谢物同义名

diphenylpyraline; Diphenylpyralamine;Diphenylpyraline Hydrochloride;Diphenylpyrilene; 4-(diphenylmethoxy)-1-methylpiperidine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Chien-Cheng Jung, Chih-Ching Chang, Yau-Sheng Tsai, Huey-Jen Su. Allergen exposure induces inflammation and affects adiponectin levels in adipose tissue. Toxicology letters. 2013 Oct; 223(1):88-95. doi: 10.1016/j.toxlet.2013.08.019. [PMID: 24012884]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Xesús Feás, Lei Ye, Patricia Regal, Cristina A Fente, Seyed V Hosseini, Alberto Cepeda. Application of dummy molecularly imprinted solid-phase extraction in the analysis of cyproheptadine in bovine urine. Journal of separation science. 2009 May; 32(10):1740-7. doi: 10.1002/jssc.200800726. [PMID: 19472275]
  • Cristina A Fente, Patricia Regal, Beatriz I Vázquez, Xexús Feás, Carlos M Franco, Alberto Cepeda. Development and validation of an LC-MS/MS confirmatory method for residue analysis of cyproheptadine in urine of food-producing animals. Journal of agricultural and food chemistry. 2009 Mar; 57(6):2595-8. doi: 10.1021/jf803395r. [PMID: 19231896]
  • Robert Weis, Johanna Faist, Ulrike di Vora, Klaus Schweiger, Barbara Brandner, Andreas J Kungl, Werner Seebacher. Antimycobacterial activity of diphenylpyraline derivatives. European journal of medicinal chemistry. 2008 Apr; 43(4):872-9. doi: 10.1016/j.ejmech.2007.06.012. [PMID: 17714832]
  • Chika Hasegawa, Takeshi Kumazawa, Xiao-Pen Lee, Masaya Fujishiro, Ayako Kuriki, Akemi Marumo, Hiroshi Seno, Keizo Sato. Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM. 2006; 20(4):537-43. doi: 10.1002/rcm.2335. [PMID: 16419026]
  • Gennady B Lapa, Gary D Byrd, Alla A Lapa, Evgeny A Budygin, Steven R Childers, Sara R Jones, Jill J Harp. The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines. Bioorganic & medicinal chemistry letters. 2005 Nov; 15(22):4915-8. doi: 10.1016/j.bmcl.2005.08.028. [PMID: 16165350]
  • A Ishii, R Kurihara, K Watanabe-Suzuki, T Kumazawa, H Seno, H Matsushima, O Suzuki, Y Katsumata. Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 2001 Jul; 758(1):117-21. doi: 10.1016/s0378-4347(01)00049-4. [PMID: 11482730]
  • T Ohno, S Kobayashi, M Hayashi, M Sakurai, I Kanazawa. Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients. Journal of the neurological sciences. 2001 Jan; 182(2):95-7. doi: 10.1016/s0022-510x(00)00441-x. [PMID: 11137513]
  • J C Grutters, L Brinkman, M M Aslander, J M van den Bosch, L Koenderman, J W Lammers. Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. The European respiratory journal. 1999 Oct; 14(4):915-22. doi: 10.1034/j.1399-3003.1999.14d31.x. [PMID: 10573242]
  • K O Ebete, J E Koundourellis. Determination of diphenylpyraline in plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1996 Mar; 677(2):319-23. doi: 10.1016/0378-4347(95)00459-9. [PMID: 8704936]