Cinacalcet (BioDeep_00000615000)
代谢物信息卡片
[(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoromethyl)phenyl]propyl})amine
化学式: C22H22F3N (357.1704)
中文名称: 西那卡塞
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
InChI: InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D057966 - Calcimimetic Agents
H - Systemic hormonal preparations, excl. sex hormones and insulins > H05 - Calcium homeostasis > H05B - Anti-parathyroid agents
C78275 - Agent Affecting Blood or Body Fluid > C2136 - Malignancy-Associated Hypercalcemia Inhibitor
D000077264 - Calcium-Regulating Hormones and Agents
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:48390
- KEGGdrug: D03504
- PubChem: 156419
- Metlin: METLIN85457
- DrugBank: DB01012
- ChEMBL: CHEMBL1201284
- MeSH: Cinacalcet
- CAS: 1025064-29-2
- CAS: 226256-56-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Feng He, Cheng-Guo Wu, Yang Gao, Sabrina N Rahman, Magda Zaoralová, Makaía M Papasergi-Scott, Ting-Jia Gu, Michael J Robertson, Alpay B Seven, Lingjun Li, Jesper M Mathiesen, Georgios Skiniotis. Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor.
Nature.
2024 Feb; 626(8001):1141-1148. doi:
10.1038/s41586-024-07055-2. [PMID: 38326620] - Pía Villarroel Heise, Leopoldo Ardiles Arnaiz, Mariana Cifuentes Köster, Francisca Peña D'Ardaillon, Eduardo Lorca Herrera, Marcela Reyes Jedlicki. [Use of cinacalcet in secondary hyperparathyroidism: assessment of nutritional, lipid and inflammatory status in chronic kidney disease].
Nutricion hospitalaria.
2023 Dec; 40(6):1236-1245. doi:
10.20960/nh.04501. [PMID: 37522433] - Tianqi Zhang, Meimei Yang, Chi Ma, Xinya Wei, Zhuobo Zhang. BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
The European journal of neuroscience.
2023 May; ?(?):. doi:
10.1111/ejn.16035. [PMID: 37161649] - Ewa Bulska, Andrzej Gawor, Anna Konopka, Grzegorz Wryk, Bożena Czarkowska-Pączek, Zdzisław Gajewski, Leszek Pączek. Label-Free Mass Spectrometry-Based Quantitative Proteomics to Evaluate the Effects of the Calcium-Sensing Receptor Agonist Cinacalcet on Protein Expression in Rat Brains and Livers.
Medical science monitor : international medical journal of experimental and clinical research.
2022 Aug; 28(?):e937338. doi:
10.12659/msm.937338. [PMID: 35941808] - Pieter Evenepoel, Hanne Skou Jørgensen. Parathyroidectomy Versus Calcimimetic: The Lower the PTH the Better?.
The Journal of clinical endocrinology and metabolism.
2022 Jul; 107(8):e3532-e3533. doi:
10.1210/clinem/dgac211. [PMID: 35427422] - Aarti Mathur, JiYoon B Ahn, Whitney Sutton, Martha A Zeiger, Dorry L Segev, Mara McAdams-DeMarco. Increasing rates of parathyroidectomy to treat secondary hyperparathyroidism in dialysis patients with Medicare coverage.
Surgery.
2022 Jul; 172(1):118-126. doi:
10.1016/j.surg.2022.02.005. [PMID: 35314072] - Carlo Massimetti, Anteo Di Napoli, Sandro Feriozzi. [Long-term efficacy and safety of treatment with cinacalcet in hypercalcemic persistent secondary hyperparathyroidism in renal transplant].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2022 Jun; 39(3):. doi:
. [PMID: 35819043] - Hirotaka Komaba, Takayuki Hamano, Naohiko Fujii, Kensuke Moriwaki, Atsushi Wada, Ikuto Masakane, Kosaku Nitta, Masafumi Fukagawa. Parathyroidectomy vs Cinacalcet Among Patients Undergoing Hemodialysis.
The Journal of clinical endocrinology and metabolism.
2022 Jun; 107(7):2016-2025. doi:
10.1210/clinem/dgac142. [PMID: 35277957] - Olivia Lenoir, Pierre-Louis Tharaux. Should we consider calcimimetics as a therapeutic option for nephrotic syndrome?.
Kidney international.
2022 06; 101(6):1110-1112. doi:
10.1016/j.kint.2022.04.008. [PMID: 35597590] - Anne K Mühlig, Johanna Steingröver, Hannah S Heidelbach, Madelaine Wingerath, Wiebke Sachs, Irm Hermans-Borgmeyer, Catherine Meyer-Schwesinger, Hoon Young Choi, Beom Jin Lim, Christian Patry, Georg Friedrich Hoffmann, Nicole Endlich, Katharina Bracke, Mariella Weiß, Andreas H Guse, Moritz Lassé, Markus M Rinschen, Fabian Braun, Tobias B Huber, Victor G Puelles, Claus Peter Schmitt, Jun Oh. The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice.
Kidney international.
2022 06; 101(6):1186-1199. doi:
10.1016/j.kint.2022.01.036. [PMID: 35271934] - Manju Chandran, John P Bilezikian, Joel Lau, Reshma Rajeev, Samantha Peiling Yang, Miny Samuel, Rajeev Parameswaran. The efficacy and safety of cinacalcet in primary hyperparathyroidism: a systematic review and meta-analysis of randomized controlled trials and cohort studies.
Reviews in endocrine & metabolic disorders.
2022 06; 23(3):485-501. doi:
10.1007/s11154-021-09694-6. [PMID: 35041148] - Tracy Maree Josephs, Frankie Zhang, Le Vi Dinh, Andrew N Keller, Arthur D Conigrave, Ben Capuano, Karen Joan Gregory, Katie Leach. Personalised medicines for familial hypercalcemia and hyperparathyroidism.
Journal of molecular endocrinology.
2022 05; 69(1):243-257. doi:
10.1530/jme-21-0263. [PMID: 35318962] - Hironori Nakamura, Masanori Tokumoto, Mariko Anayama, Shigekazu Kurihara, Yasushi Makino, Katsuhiko Tamura, Masaki Nagasawa. A case of a hemodialysis patient with secondary hyperparathyroidism who was resistant to etelcalcetide treatment but not to cinacalcet hydrochloride.
CEN case reports.
2022 05; 11(2):254-258. doi:
10.1007/s13730-021-00664-0. [PMID: 34787825] - Laura Wade, Anita Aindow, Lorraine Isherwood, M Zulf Mughal, Renuka Ramakrishnan. Successful use of cinacalcet monotherapy in the management of siblings with homozygous calcium-sensing receptor mutation.
Journal of pediatric endocrinology & metabolism : JPEM.
2022 Apr; 35(4):549-556. doi:
10.1515/jpem-2021-0632. [PMID: 35073615] - Eliana Gonçalves-Alves, Marta Garcia, Carlos J Rodríguez-Hernández, Soledad Gómez-González, Rupert C Ecker, Mariona Suñol, Oscar Muñoz-Aznar, Angel M Carcaboso, Jaume Mora, Cinzia Lavarino, Silvia Mateo-Lozano. AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia.
International journal of molecular sciences.
2022 Apr; 23(8):. doi:
10.3390/ijms23084323. [PMID: 35457141] - Luis Alvarado, Nishtha Sharma, Roxann Lerma, Alok Dwivedi, Adeel Ahmad, Aimee Hechanova, Fernanda Payan-Schober, Azikiwe Nwosu, Eyas Alkhalili. Parathyroidectomy Versus Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Hemodialysis Patients.
World journal of surgery.
2022 Apr; 46(4):813-819. doi:
10.1007/s00268-022-06439-7. [PMID: 35022799] - J Wang, G-G Chen, L-L Ren. Cinacalcet hydrochloride-nanoemulsion: preparation, characterization, enhanced bioavailability and pharmacodynamics.
European review for medical and pharmacological sciences.
2022 04; 26(8):3010-3024. doi:
10.26355/eurrev_202204_28632. [PMID: 35503601] - Mengjing Wang, Donghai Wen, Weichen Zhang, Weisheng Chen, Ye Tao, Chunyan Fan, Bihong Huang, Jing Chen, Hongying Wang, Minmin Zhang. Effects of Cinacalcet and Parathyroidectomy on Blood Pressure in Maintenance Hemodialysis Patients with Secondary Hyperparathyroidism.
Iranian journal of kidney diseases.
2022 03; 16(2):135-146. doi:
NULL. [PMID: 35489082] - Hui-Wen Chiu, Yi-Chou Hou, Chien-Lin Lu, Kuo-Cheng Lu, Wen-Chih Liu, Jia-Fwu Shyu, Jia-Feng Chang, Cai-Mei Zheng. Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2022 02; 37(2):215-225. doi:
10.1002/jbmr.4459. [PMID: 34633122] - Narjes Ramezanipour, Sayyed Hamid Zarkesh Esfahani, Richard Eastell, John Newell-Price, Graham Trevitt, Richard J Ross, Ian R Wilkinson. Development of a Hypoparathyroid Male Rodent Model for Testing Delayed-Clearance PTH Molecules.
Endocrinology.
2022 02; 163(2):. doi:
10.1210/endocr/bqab239. [PMID: 34940833] - Daniela Cavaco, Pedro Amaro, Joana Simões-Pereira, Maria Conceição Pereira. X-linked hypophosphataemic rickets: Report of a novel PHEX mutation and cinacalcet as adjuvant therapy in the mineral metabolism control.
Modern rheumatology case reports.
2022 Jan; 6(1):145-149. doi:
10.1093/mrcr/rxab031. [PMID: 34561702] - M Miedziaszczyk, I Idasiak-Piechocka, O W Wiśniewski, K Lacka. A systematic review of the pharmacotherapy of secondary hyperparathyroidism (SHPT) in grades 3-5 Chronic Kidney Disease (CKD).
European review for medical and pharmacological sciences.
2022 Jan; 26(1):232-239. doi:
10.26355/eurrev_202201_27773. [PMID: 35049000] - Fatma Özgüç Çömlek, Selma Demir, Hakan Gürkan, Mustafa İnan, Atakan Sezer, Emine Dilek, Filiz Kökenli. The efficiency of cinacalcet treatment in delaying parathyroidectomy in a case with neonatal severe hyperparathyroidism caused by homozygous mutation in the CASR gene.
Pediatric endocrinology, diabetes, and metabolism.
2022; 28(2):168-174. doi:
10.5114/pedm.2022.115070. [PMID: 35399047] - William G Goodman, Donald T Ward, Kevin J Martin, Debra Drayer, Carol Moore, Jiahong Xu, James Lai, Yun Chon, Edward F Nemeth. Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia.
Journal of the American Society of Nephrology : JASN.
2022 01; 33(1):201-212. doi:
10.1681/asn.2021060825. [PMID: 34732508] - Claude Bachmeyer, Nicolas Belaube, Valeria Loi, Dominique Wendum, Mathieu Gauthé, Jean Philippe Haymann. Hypercalcemia and Acute Renal Failure Indicating Peritoneal Sarcoidosis.
The American journal of medicine.
2021 12; 134(12):e571-e572. doi:
10.1016/j.amjmed.2021.06.023. [PMID: 34297974] - Aarti Mathur, Whitney Sutton, JiYoon B Ahn, Jason D Prescott, Martha A Zeiger, Dorry L Segev, Mara McAdams-DeMarco. Association Between Treatment of Secondary Hyperparathyroidism and Posttransplant Outcomes.
Transplantation.
2021 12; 105(12):e366-e374. doi:
10.1097/tp.0000000000003653. [PMID: 33534525] - Junpei Sanada, Shinji Kamei, Masashi Shimoda, Fuminori Tatsumi, Tomohiko Kimura, Atsushi Obata, Kenji Kohara, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune, Hideaki Kaneto. Amelioration of hypercalcemia by cinacalcet treatment in a subject with relapsing acquired hypocalciuric hypercalcemia: A case report.
Medicine.
2021 Oct; 100(42):e27579. doi:
10.1097/md.0000000000027579. [PMID: 34678905] - Jaruwan Ngamkam, Somratai Vadcharavivad, Nutthada Areepium, Titinun Auamnoy, Kullaya Takkavatakarn, Pisut Katavetin, Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong. The impact of CASR A990G polymorphism in response to cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism.
Scientific reports.
2021 09; 11(1):18006. doi:
10.1038/s41598-021-97587-8. [PMID: 34504264] - Samuel Frey, Thomas Goronflot, Clarisse Kerleau, Pierre-Antoine Gourraud, Cécile Caillard, Maryvonne Hourmant, Éric Mirallié, Lucile Figueres. Parathyroidectomy or cinacalcet: Do we still not know the best option for graft function in kidney-transplanted patients? A meta-analysis.
Surgery.
2021 09; 170(3):727-735. doi:
10.1016/j.surg.2021.02.048. [PMID: 33810851] - J G Timmons, R Manners, M Bailey, C McDougall. Cognitive impairment reversed by cinacalcet administration in primary hyperparathyroidism.
Hormones (Athens, Greece).
2021 Sep; 20(3):587-589. doi:
10.1007/s42000-021-00292-4. [PMID: 33881757] - Scott C Fligor, Chun Li, Ryoko Hamaguchi, Jeffrey William, Benjamin C James. Decreasing Surgical Management of Secondary Hyperparathyroidism in the United States.
The Journal of surgical research.
2021 08; 264(?):444-453. doi:
10.1016/j.jss.2021.03.013. [PMID: 33848844] - Midori Minezaki, Yuichi Takashi, Kentaro Ochi, Ryo Mitsuoka, Yuka Yamao, Tadachika Kudo, Daiji Kawanami, Kunihisa Kobayashi, Ichiro Abe. Reduction in parathyroid adenomas by cinacalcet therapy in patients with primary hyperparathyroidism.
Journal of bone and mineral metabolism.
2021 Jul; 39(4):583-588. doi:
10.1007/s00774-020-01190-2. [PMID: 33409573] - Rania A Elrashidy, Samah E Ibrahim. Cinacalcet as a surrogate therapy for diabetic cardiomyopathy in rats through AMPK-mediated promotion of mitochondrial and autophagic function.
Toxicology and applied pharmacology.
2021 06; 421(?):115533. doi:
10.1016/j.taap.2021.115533. [PMID: 33848515] - Fadil M Hannan, Mark Stevenson, Asha L Bayliss, Victoria J Stokes, Michelle Stewart, Kreepa G Kooblall, Caroline M Gorvin, Gemma Codner, Lydia Teboul, Sara Wells, Rajesh V Thakker. Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.
Human molecular genetics.
2021 05; 30(10):880-892. doi:
10.1093/hmg/ddab076. [PMID: 33729479] - Shinya Nakatani, Kozo Nishide, Senji Okuno, Eiji Ishimura, Daijiro Kabata, Fumiyuki Morioka, Yuri Machiba, Hideki Uedono, Akihiro Tsuda, Shigeichi Shoji, Masaaki Inaba, Katsuhito Mori, Tomoyuki Yamakawa, Masanori Emoto. Cinacalcet may suppress kidney enlargement in hemodialysis patients with autosomal dominant polycystic kidney disease.
Scientific reports.
2021 05; 11(1):10014. doi:
10.1038/s41598-021-89480-1. [PMID: 33976330] - Eman M Alfadhli. Management of Primary Hyperparathyroidism With Severe Hypercalcemia During the COVID-19 Pandemic.
Clinical therapeutics.
2021 04; 43(4):711-719. doi:
10.1016/j.clinthera.2021.02.003. [PMID: 33752899] - Helen Eddington, Rajkumar Chinnadurai, Helen Alderson, Sara T Ibrahim, Constantina Chrysochou, Darren Green, Ibi Erekosima, Alastair Hutchison, Abdalla Bubtana, Janet Hegarty, Philip A Kalra. A randomised controlled trial to examine the effects of cinacalcet on bone and cardiovascular parameters in haemodialysis patients with advanced secondary hyperparathyroidism.
BMC nephrology.
2021 03; 22(1):106. doi:
10.1186/s12882-021-02312-2. [PMID: 33757437] - M T Mogl, T Skachko, E M Dobrindt, P Reinke, C Bures, J Pratschke, N Rayes. Surgery for Renal Hyperparathyroidism in the Era of Cinacalcet: A Single-Center Experience.
Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society.
2021 Mar; 110(1):66-72. doi:
10.1177/1457496919897004. [PMID: 31906794] - Zhuolin Zhang, Lele Cai, Hong Wu, Xinglu Xu, Wenqing Fang, Xuan He, Xiao Wang, Xin Li. Paricalcitol versus Calcitriol + Cinacalcet for the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease in China: A Cost-Effectiveness Analysis.
Frontiers in public health.
2021; 9(?):712027. doi:
10.3389/fpubh.2021.712027. [PMID: 34368073] - Catherine McManus, Aaron Oh, James A Lee, Chin Hur, Jennifer H Kuo. Timing of parathyroidectomy for tertiary hyperparathyroidism with end-stage renal disease: A cost-effectiveness analysis.
Surgery.
2021 01; 169(1):94-101. doi:
10.1016/j.surg.2020.06.012. [PMID: 32732069] - Sungdam Han, Minkook Son, Byungjin Choi, ChulHyoung Park, Dong Ho Shin, Jong Hwan Jung, Min-Jeong Lee, Gyu-Tae Shin, Heungsoo Kim, Rae Woong Park, Inwhee Park. Characterization of Medication Trends for Chronic Kidney Disease: Mineral and Bone Disorder Treatment Using Electronic Health Record-Based Common Data Model.
BioMed research international.
2021; 2021(?):5504873. doi:
10.1155/2021/5504873. [PMID: 34853790] - Kuo-Chin Hung, Jia-Feng Chang, Yung-Ho Hsu, Chih-Yu Hsieh, Mai-Szu Wu, Mei-Yi Wu, I-Jen Chiu, Ren-Si Syu, Ting-Ming Wang, Chang-Chin Wu, Lie-Yee Hung, Cai-Mei Zheng, Kuo-Cheng Lu. Therapeutic Effect of Calcimimetics on Osteoclast-Osteoblast Crosslink in Chronic Kidney Disease and Mineral Bone Disease.
International journal of molecular sciences.
2020 Nov; 21(22):. doi:
10.3390/ijms21228712. [PMID: 33218086] - Cynthia Basu, Xiaoye Ma, May Mo, Hong Amy Xia, Richard Brundage, Mahmoud Al-Kofahi, Bradley P Carlin. Pharmacokinetic/pharmacodynamic data extrapolation models for improved pediatric efficacy and toxicity estimation, with application to secondary hyperparathyroidism.
Pharmaceutical statistics.
2020 11; 19(6):882-896. doi:
10.1002/pst.2043. [PMID: 32648333] - Michael T Sheehan, Robert A Wermers, Aminah Jatoi, Charles L Loprinzi, Adedayo A Onitilo. Oral cinacalcet responsiveness in non-parathyroid hormone mediated hypercalcemia of malignancy.
Medical hypotheses.
2020 Oct; 143(?):110149. doi:
10.1016/j.mehy.2020.110149. [PMID: 32763659] - Suetonia C Palmer, Dimitris Mavridis, David W Johnson, Marcello Tonelli, Marinella Ruospo, Giovanni F M Strippoli. Comparative Effectiveness of Calcimimetic Agents for Secondary Hyperparathyroidism in Adults: A Systematic Review and Network Meta-analysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 09; 76(3):321-330. doi:
10.1053/j.ajkd.2020.02.439. [PMID: 32475604] - Bradley A Warady, Eric Ng, Laura Bloss, May Mo, Franz Schaefer, Justine Bacchetta. Cinacalcet studies in pediatric subjects with secondary hyperparathyroidism receiving dialysis.
Pediatric nephrology (Berlin, Germany).
2020 09; 35(9):1679-1697. doi:
10.1007/s00467-020-04516-4. [PMID: 32367309] - Naoto Hamano, Yuichi Endo, Takehisa Kawata, Masafumi Fukagawa. Development of evocalcet for unmet needs among calcimimetic agents.
Expert review of endocrinology & metabolism.
2020 09; 15(5):299-310. doi:
10.1080/17446651.2020.1780911. [PMID: 32552012] - James B Wetmore. Calcimimetics: A Promise Unfulfilled.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 09; 76(3):308-310. doi:
10.1053/j.ajkd.2020.03.018. [PMID: 32624256] - Julie Bernardor, Claus Peter Schmitt, Jun Oh, Anne-Laure Sellier-Leclerc, Anja Büscher, Luca Dello Strologo, Gurkan Genc, Ulrike John, Marcus Weitz, Matthias Zirngibl, Kai Krupka, Burkhard Tönshoff, Justine Bacchetta. The use of cinacalcet after pediatric renal transplantation: an international CERTAIN Registry analysis.
Pediatric nephrology (Berlin, Germany).
2020 09; 35(9):1707-1718. doi:
10.1007/s00467-020-04558-8. [PMID: 32367310] - Masamitsu Morishita, Yukio Maruyama, Masatsugu Nakao, Nanae Matsuo, Yudo Tanno, Ichiro Ohkido, Masato Ikeda, Takashi Yokoo. Factors affecting the relationship between ionized and corrected calcium levels in peritoneal dialysis patients: a retrospective cross-sectional study.
BMC nephrology.
2020 08; 21(1):370. doi:
10.1186/s12882-020-02033-y. [PMID: 32847525] - Hanne Skou Jørgensen, Etienne Cavalier, Pieter Evenepoel. Clinical evidence of direct bone effects of cinacalcet.
Kidney international.
2020 08; 98(2):514-515. doi:
10.1016/j.kint.2020.04.013. [PMID: 32709295] - Pablo Moreno, Ana Coloma, José V Torregrosa, Nuria Montero, José Francos, Sergi Codina, Anna Manonelles, Oriol Bestard, Arantxa García-Barrasa, Edoardo Melilli, Josep M Cruzado. Long-term results of a randomized study comparing parathyroidectomy with cinacalcet for treating tertiary hyperparathyroidism.
Clinical transplantation.
2020 08; 34(8):e13988. doi:
10.1111/ctr.13988. [PMID: 32438479] - Yiting Sun, Binyao Tian, Zitong Sheng, Pengzhi Wan, Tianhua Xu, Li Yao. Efficacy and safety of cinacalcet compared with other treatments for secondary hyperparathyroidism in patients with chronic kidney disease or end-stage renal disease: a meta-analysis.
BMC nephrology.
2020 07; 21(1):316. doi:
10.1186/s12882-019-1639-9. [PMID: 32736534] - Gabriel Giollo Rivelli, Marcelo Lopes de Lima, Marilda Mazzali. Therapy for persistent hypercalcemic hyperparathyroidism post-renal transplant: cinacalcet versus parathyroidectomy.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2020 Jul; 42(3):315-322. doi:
10.1590/2175-8239-jbn-2019-0207. [PMID: 32720971] - Carlo Massimetti, Antonio Bellasi, Sandro Feriozzi. [Cholecalciferol supplementation improves secondary hyperparathyroidism control in hemodialysis patients].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2020 Jun; 37(3):. doi:
. [PMID: 32530156] - Gabriel Giollo Rivelli, Marcelo Lopes de Lima, Marilda Mazzali. Safety and Efficacy of a 3-Year Therapy With Cinacalcet in Persistent Hyperparathyroidism After Renal Transplant.
Transplantation proceedings.
2020 Jun; 52(5):1284-1286. doi:
10.1016/j.transproceed.2020.02.024. [PMID: 32204903] - Rafif A Al-Ahmad, Areej A Sheerah, Khalid A Alhasan, Jameela A Kari. Cinacalcet use in pediatric chronic kidney disease. A survey study.
Saudi medical journal.
2020 May; 41(5):479-484. doi:
10.15537/smj.2020.5.25072. [PMID: 32373914] - Atsuko Uehara, Tomo Suzuki, Yutaro Yamamoto, Masataka Hasegawa, Kenichiro Koitabashi, Masahiko Yazawa, Junki Koike, Yugo Shibagaki. A Functional Parathyroid Cyst from the Hemorrhagic Degeneration of a Parathyroid Adenoma.
Internal medicine (Tokyo, Japan).
2020 Feb; 59(3):389-394. doi:
10.2169/internalmedicine.3319-19. [PMID: 31588082] - Mark D Danese, Deborah Lubeck, Vasily Belozeroff, Tzu-Chieh Lin, Pooja Desai, Michelle Gleeson, Kevin Martin, Michel Chonchol. Real World Use and Effects of Calcimimetics in Treating Mineral and Bone Disorder in Hemodialysis Patients.
American journal of nephrology.
2020; 51(10):815-822. doi:
10.1159/000510360. [PMID: 32966995] - Tadashi Imafuku, Motoko Tanaka, Koki Tokunaga, Shigeyuki Miyamura, Hiromasa Kato, Shoma Tanaka, Takehiro Nakano, Kenshiro Hirata, Daisuke Kadowaki, Hitoshi Maeda, Kazutaka Matsushita, Masaki Otagiri, Hirotaka Komaba, Masafumi Fukagawa, Hiroshi Watanabe, Toru Maruyama. Effect of Cinacalcet on the Redox Status of Albumin in Secondary Hyperparathyroidism Patients Receiving Hemodialysis.
Biological & pharmaceutical bulletin.
2020; 43(10):1583-1590. doi:
10.1248/bpb.b20-00472. [PMID: 32999168] - Justine Bacchetta, Claus Peter Schmitt, Gema Ariceta, Sevcan A Bakkaloglu, Jaap Groothoff, Mandy Wan, Marc Vervloet, Rukshana Shroff, Dieter Haffner. Cinacalcet use in paediatric dialysis: a position statement from the European Society for Paediatric Nephrology and the Chronic Kidney Disease-Mineral and Bone Disorders Working Group of the ERA-EDTA.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2020 01; 35(1):47-64. doi:
10.1093/ndt/gfz159. [PMID: 31641778] - Sergei Chavez-Abiega, Iris Mos, Patricia P Centeno, Taha Elajnaf, Wolfgang Schlattl, Donald T Ward, Joachim Goedhart, Enikö Kallay. Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR).
Advances in experimental medicine and biology.
2020; 1131(?):1031-1063. doi:
10.1007/978-3-030-12457-1_41. [PMID: 31646544] - Sinem Gulcan-Kersin, Tarik Kirkgoz, Mehmet Eltan, Turkay Rzayev, Pinar Ata, Hulya Bilgen, Eren Ozek, Abdullah Bereket, Serap Turan. Cinacalcet as a First-Line Treatment in Neonatal Severe Hyperparathyroidism Secondary to Calcium Sensing Receptor (CaSR) Mutation.
Hormone research in paediatrics.
2020; 93(5):313-321. doi:
10.1159/000510623. [PMID: 33147586] - Son Nguyen, Elvira O Gosmanova, Aidar R Gosmanov. Cinacalcet-Associated Resolution of Primary Hyperparathyroidism in a Patient With Normal Kidney Function.
Journal of investigative medicine high impact case reports.
2020 Jan; 8(?):2324709620936836. doi:
10.1177/2324709620936836. [PMID: 32583691] - Catherine Joseph, Shweta Shah, Jessica Geer, Marisa Juarez-Calderon, Poyyapakkam R Srivaths, Sarah J Swartz. Cinacalcet for secondary hyperparathyroidism in end-stage renal disease patients below age 5 years
.
Clinical nephrology.
2019 Dec; 92(6):279-286. doi:
10.5414/cn109871. [PMID: 31587754] - Vincent M Brandenburg, Alexander Schuh, Rafael Kramann. Valvular Calcification in Chronic Kidney Disease.
Advances in chronic kidney disease.
2019 11; 26(6):464-471. doi:
10.1053/j.ackd.2019.10.004. [PMID: 31831124] - Jun Xu, Yan Yang, Liang Ma, Ping Fu, Hongying Peng. Cinacalcet plus vitamin D versus vitamin D alone for the treatment of secondary hyperparathyroidism in patients undergoing dialysis: a meta-analysis of randomized controlled trials.
International urology and nephrology.
2019 Nov; 51(11):2027-2036. doi:
10.1007/s11255-019-02271-6. [PMID: 31531805] - Elijah Kakani, Mohamed Elyamny, Taha Ayach, Amr El-Husseini. Pathogenesis and management of vascular calcification in CKD and dialysis patients.
Seminars in dialysis.
2019 11; 32(6):553-561. doi:
10.1111/sdi.12840. [PMID: 31464003] - Sharon M Moe, Jin Long, Tae-Hwi Linus Schwantes-An, Brian S Decker, Leah Wetherill, Howard J Edenberg, Xiaoling Xuei, Matteo Vatta, Tatiana M Foroud, Glenn M Chertow. Angiotensin-related genetic determinants of cardiovascular disease in patients undergoing hemodialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2019 11; 34(11):1924-1931. doi:
10.1093/ndt/gfy191. [PMID: 29982608] - Paweena Susantitaphong, Somratai Vadcharavivad, Teerada Susomboon, Wanchana Singhan, Netsiri Dumrongpisutikul, Ketsuda Jakchairoongruang, Somchai Eiam-Ong, Kearkiat Praditpornsilpa. The effectiveness of cinacalcet: a randomized, open label study in chronic hemodialysis patients with severe secondary hyperparathyroidism.
Renal failure.
2019 Nov; 41(1):326-333. doi:
10.1080/0886022x.2018.1562356. [PMID: 31014177] - Won Woong Kim, Yumie Rhee, Beom Seok Kim, Kwangsoon Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung. Clinical outcomes of parathyroidectomy versus cinacalcet in the clinical management of secondary hyperparathyroidism.
Endocrine journal.
2019 Oct; 66(10):881-889. doi:
10.1507/endocrj.ej19-0036. [PMID: 31189770] - Sean DeLacey, Ziyue Liu, Andrea Broyles, Sarah A El-Azab, Cristian F Guandique, Benjamin C James, Erik A Imel. Hyperparathyroidism and parathyroidectomy in X-linked hypophosphatemia patients.
Bone.
2019 10; 127(?):386-392. doi:
10.1016/j.bone.2019.06.025. [PMID: 31276850] - Lin-Ling Li, Cai-Li Chen, Ning-Fang Cai, Jin-Ling Yi, Chao Zheng, Yan Feng, Wen-Gang Xiong, Xi Luo, Wei-Hua Li, Ze-Neng Cheng. An improved LC-MS/MS method for determination of cinacalcet in human plasma and its application to the evaluation of food intake effect on the pharmacokinetics of cinacalcet in healthy volunteers.
Biomedical chromatography : BMC.
2019 Oct; 33(10):e4631. doi:
10.1002/bmc.4631. [PMID: 31254484] - Katsunori Manaka, Junichiro Sato, Yuka Kinoshita, Nobuaki Ito, Megumi Fujita, Taroh Iiri, Masaomi Nangaku, Noriko Makita. Effectiveness and safety of cinacalcet for primary hyperparathyroidism: a single center experience.
Endocrine journal.
2019 Aug; 66(8):683-689. doi:
10.1507/endocrj.ej19-0034. [PMID: 31092749] - Jacqueline Deen, Helmut Schaider. The use of cinacalcet for the treatment of calciphylaxis in patients with chronic kidney disease: A comprehensive review.
The Australasian journal of dermatology.
2019 Aug; 60(3):e186-e194. doi:
10.1111/ajd.12992. [PMID: 30666627] - Shane A Wiebe, Allein Plain, Wanling Pan, Debbie O'Neill, Branko Braam, R Todd Alexander. NHE8 attenuates Ca2+ influx into NRK cells and the proximal tubule epithelium.
American journal of physiology. Renal physiology.
2019 08; 317(2):F240-F253. doi:
10.1152/ajprenal.00329.2018. [PMID: 31042050] - Sérgio Gardano Elias Bucharles, Fellype Carvalho Barreto, Miguel Carlos Riella. The impact of cinacalcet in the mineral metabolism markers of patients on dialysis with severe secondary hyperparathyroidism.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2019 Jul; 41(3):336-344. doi:
10.1590/2175-8239-jbn-2018-0219. [PMID: 31419274] - Cai-Mei Zheng, Yung-Ho Hsu, Chia-Chao Wu, Chien-Lin Lu, Wen-Chih Liu, Jing-Quan Zheng, Yuh-Feng Lin, Hui-Wen Chiu, Tian-Jong Chang, Jia-Fwu Shyu, Kuo-Cheng Lu. Osteoclast-Released Wnt-10b Underlies Cinacalcet Related Bone Improvement in Chronic Kidney Disease.
International journal of molecular sciences.
2019 Jun; 20(11):. doi:
10.3390/ijms20112800. [PMID: 31181716] - Hyung Ah Jo, Kum Hyun Han, Yoon Kyoung So, Heungman Jun, Sang Youb Han. Effect of Cinacalcet in Kidney Transplant Patients With Hyperparathyroidism.
Transplantation proceedings.
2019 Jun; 51(5):1397-1401. doi:
10.1016/j.transproceed.2019.01.141. [PMID: 31155177] - Wenjuan Shi, Xiuyan Tan, Zhongdong Li, Minmin Zhang, Bihong Huang, Fang Lu, Jing Jia, Jing Chen, Mingkang Zhong. Pharmacokinetics and pharmacodynamics of cinacalcet in patients with renal failure receiving hemodialysis and hemodiafiltration therapy
.
International journal of clinical pharmacology and therapeutics.
2019 Jun; 57(6):284-289. doi:
10.5414/cp203260. [PMID: 30935461] - Douglas S Fuller, David Hallett, Paul J Dluzniewski, Bruno Fouqueray, Michel Jadoul, Hal Morgenstern, Friedrich K Port, Francesca Tentori, Ronald L Pisoni. Predictors of cinacalcet discontinuation and reinitiation in hemodialysis patients: results from 7 European countries.
BMC nephrology.
2019 05; 20(1):169. doi:
10.1186/s12882-019-1355-5. [PMID: 31088377] - Min Wu, Ye Feng, Guo-Xin Ye, Yu-Chen Han, Si-Si Wang, Hai-Feng Ni, Feng-Mei Wang, Min Gao, Lin-Li Lv, Bi-Cheng Liu. Calcium-sensing receptor activation attenuates collagen expression in renal proximal tubular epithelial cells.
American journal of physiology. Renal physiology.
2019 05; 316(5):F1006-F1015. doi:
10.1152/ajprenal.00413.2018. [PMID: 30838870] - Sandro Mazzaferro, Marzia Pasquali. Direct bone effects of calcimimetics in chronic kidney disease?.
Kidney international.
2019 05; 95(5):1012-1014. doi:
10.1016/j.kint.2019.01.045. [PMID: 31010472] - Justin J Lee, Xiong Liu, Debbie O'Neill, Megan R Beggs, Petra Weissgerber, Veit Flockerzi, Xing-Zhen Chen, Henrik Dimke, R Todd Alexander. Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption.
JCI insight.
2019 04; 5(?):. doi:
10.1172/jci.insight.128013. [PMID: 31013259] - Thomas E Forman, Anna-Kaisa Niemi, Priya Prahalad, Run Zhang Shi, Laura M Nally. Cinacalcet therapy in an infant with an R185Q calcium-sensing receptor mutation causing hyperparathyroidism: a case report and review of the literature.
Journal of pediatric endocrinology & metabolism : JPEM.
2019 Mar; 32(3):305-310. doi:
10.1515/jpem-2018-0307. [PMID: 30730839] - Bradley A Warady, Janet N Iles, Gema Ariceta, Bastian Dehmel, Guillermo Hidalgo, Xun Jiang, Benjamin Laskin, Shahnaz Shahinfar, Johan Vande Walle, Franz Schaefer. A randomized, double-blind, placebo-controlled study to assess the efficacy and safety of cinacalcet in pediatric patients with chronic kidney disease and secondary hyperparathyroidism receiving dialysis.
Pediatric nephrology (Berlin, Germany).
2019 03; 34(3):475-486. doi:
10.1007/s00467-018-4116-y. [PMID: 30506144] - Jason R Stubbs, Margaret R Stedman, Sai Liu, Jin Long, Yoko Franchetti, Raymond E West, Alexander J Prokopienko, Jonathan D Mahnken, Glenn M Chertow, Thomas D Nolin. Trimethylamine N-Oxide and Cardiovascular Outcomes in Patients with ESKD Receiving Maintenance Hemodialysis.
Clinical journal of the American Society of Nephrology : CJASN.
2019 02; 14(2):261-267. doi:
10.2215/cjn.06190518. [PMID: 30665924] - Douglas S Fuller, Shan Xing, Vasily Belozeroff, Alon Yehoshua, Hal Morgenstern, Bruce M Robinson, Robert J Rubin, Nisha Bhatt, Ronald L Pisoni. Variability in Cinacalcet Prescription across US Hemodialysis Facilities.
Clinical journal of the American Society of Nephrology : CJASN.
2019 02; 14(2):241-249. doi:
10.2215/cjn.09550818. [PMID: 30665922] - Ramya Bhargava, Philip A Kalra, Mark Hann, Paul Brenchley, Helen Hurst, Alastair J Hutchison. A randomized controlled trial of different serum phosphate ranges in subjects on hemodialysis.
BMC nephrology.
2019 02; 20(1):37. doi:
10.1186/s12882-019-1216-2. [PMID: 30717691] - R R Dulfer, E Y Koh, W Y van der Plas, A F Engelsman, E J M Nieveen van Dijkum, R A Pol, L Vogt, M H de Borst, S Kruijff, A Schepers, N M Appelman-Dijkstra, J I Rotmans, D A Hesselink, C H J van Eijck, E J Hoorn, T M van Ginhoven. Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis.
Langenbeck's archives of surgery.
2019 Feb; 404(1):71-79. doi:
10.1007/s00423-019-01755-4. [PMID: 30729318] - Schelto Kruijff, Willemijn Y van der Plas, Roderick R Dulfer, Menno R Vriens, Tessa M van Ginhoven, Anton F Engelsman, Leigh W Delbridge. Changing landscape of the treatment of hyperparathyroidism related to end-stage renal disease-can we turn the clock backward?.
Surgery.
2019 02; 165(2):289-290. doi:
10.1016/j.surg.2018.07.043. [PMID: 30266441] - Xiaoqing Xu, Guoguang Chen, Yaning Li, Jingjing Wang, Jun Yin, Lili Ren. Enhanced dissolution and oral bioavailbility of cinacalcet hydrochlorde nanocrystals with no food effect.
Nanotechnology.
2019 Feb; 30(5):055102. doi:
10.1088/1361-6528/aaef46. [PMID: 30511665] - Tae-Hwi Schwantes-An, Sai Liu, Margaret Stedman, Brian S Decker, Leah Wetherill, Howard J Edenberg, Matteo Vatta, Tatiana M Foroud, Glenn M Chertow, Sharon M Moe. Fibroblast Growth Factor 23 Genotype and Cardiovascular Disease in Patients Undergoing Hemodialysis.
American journal of nephrology.
2019; 49(2):125-132. doi:
10.1159/000496060. [PMID: 30669147] - Shin Tokunaga, Yuichi Endo, Takehisa Kawata. [Pharmacological and clinical profiles of a novel calcimimetic, evocalcet (ORKEDIA®)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2019; 154(1):35-43. doi:
10.1254/fpj.154.35. [PMID: 31308348] - Brendan M Finnerty, Tyler W Chan, Gregory Jones, Tarek Khader, Maureen Moore, Katherine D Gray, Toni Beninato, Anthony C Watkins, Rasa Zarnegar, Thomas J Fahey. Parathyroidectomy versus Cinacalcet in the Management of Tertiary Hyperparathyroidism: Surgery Improves Renal Transplant Allograft Survival.
Surgery.
2019 01; 165(1):129-134. doi:
10.1016/j.surg.2018.04.090. [PMID: 30415867] - Irene Ruderman, Stephen G Holt, Geoffrey S Kirkland, Sophie Maslen, Carmel M Hawley, Veronica Oliver, Rathika Krishnasamy, Nicholas A Gray, Girish S Talaulikar, Craig L Nelson, Yogeshwar Rajaram, Hilton Gock, Eric Au, Grahame J Elder, Rahul Mainra, Nigel D Toussaint. Outcomes of cinacalcet withdrawal in Australian dialysis patients.
Internal medicine journal.
2019 Jan; 49(1):48-54. doi:
10.1111/imj.14036. [PMID: 29992701] - Gudrun Schappacher-Tilp, Doris H Fuertinger, Peter Kotanko. A Multi-Compartment Model Capturing the Pharmacokinetics of the Calcimimetic Cinacalcet.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 53(2):429-438. doi:
10.33594/000000148. [PMID: 31424183] - Winnie Y Sohn, Anthony A Portale, Isidro B Salusky, Hao Zhang, Lucy L Yan, Bella Ertik, Shahnaz Shahinfar, Edward Lee, Bastian Dehmel, Bradley A Warady. An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis.
Pediatric nephrology (Berlin, Germany).
2019 01; 34(1):145-154. doi:
10.1007/s00467-018-4054-8. [PMID: 30141180] - Willemijn Y van der Plas, Anton F Engelsman, Marille Umakanthan, Amanda Mather, Stan B Sidhu, Leigh W Delbridge, Carol Pollock, David Waugh, Mark S Sywak, Schelto Kruijff. Treatment strategy of end stage renal disease-related hyperparathyroidism before, during, and after the era of calcimimetics.
Surgery.
2019 01; 165(1):135-141. doi:
10.1016/j.surg.2018.04.092. [PMID: 30413324]
