Frovatriptan (BioDeep_00000614999)
Metabolite Card
Formula: C14H17N3O (243.1372)
Chinese Names:
Spectrum Hits:
Top Source () 0%
Molecular Structure
SMILES: CNC1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)N
InChI: InChI=1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1
Description
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations > N02CC - Selective serotonin (5ht1) agonists
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
Synonyms
Cross Reference
7 cross reference id
- ChEBI: CHEBI:134991
- KEGGdrug: D07997
- PubChem: 77992
- Metlin: METLIN85456
- DrugBank: DB00998
- ChEMBL: CHEMBL1279
- CAS: 158747-02-5
Classification Terms
Related Pathways
Reactome(0)
BioCyc(0)
PlantCyc(0)
Biological Process
0 related biological process reactions.
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| Sub-cellular location | Genes |
|---|
Literature Reference
- Lidia Savi, Selene Mogavero, Colin Gerard Egan. Efficacy and pharmacokinetic activity of frovatriptan compared to rizatriptan in patients with moderate-to-severe migraine.
Drug design, development and therapy.
2014; 8(?):983-92. doi:
10.2147/dddt.s61295. [PMID: 25092964] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Fernando Rodrigues de Sá Alves, Eliezer J Barreiro, Carlos Alberto Manssour Fraga. From nature to drug discovery: the indole scaffold as a 'privileged structure'.
Mini reviews in medicinal chemistry.
2009 Jun; 9(7):782-93. doi:
10.2174/138955709788452649. [PMID: 19519503] - Massimiliano Sorbello, Massimiliano Veroux, Melania Cutuli, Gianluigi Morello, Annalaura Paratore, Mirko Tindaro Sidoti, Jessica Giuseppina Maugeri, Massimiliano Gagliano, Giuseppe Giuffrida, Daniela Corona, Pierfrancesco Veroux. Anaesthesiologic protocol for kidney transplantation in two patients with Fabry Disease: a case series.
Cases journal.
2008 Nov; 1(1):321. doi:
10.1186/1757-1626-1-321. [PMID: 19014714] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Färkkilä Markus, Kallela Mikko. Frovatriptan review.
Expert opinion on pharmacotherapy.
2007 Dec; 8(17):3029-33. doi:
10.1517/14656566.8.17.3029. [PMID: 18001261] - Yvonne D'Arcy. New pain management options: drugs.
Nursing.
2007 Jan; 37(1):18-9. doi:
10.1097/00152193-200701000-00013. [PMID: 17198138] - Yvonne D'Arcy. Latest pain relief a combination of new and old.
The Nurse practitioner.
2007 Jan; 32(1):11-2. doi:
10.1097/00006205-200701000-00003. [PMID: 17198336] - Miguel J A Láinez. Rizatriptan in the treatment of migraine.
Neuropsychiatric disease and treatment.
2006 Sep; 2(3):247-59. doi:
10.2147/nedt.2006.2.3.247. [PMID: 19412472] - Ann Moons. Regulatory and functional interactions of plant growth regulators and plant glutathione S-transferases (GSTs).
Vitamins and hormones.
2005; 72(?):155-202. doi:
10.1016/s0083-6729(05)72005-7. [PMID: 16492471] - Arthur H Elkind, Andrew Wade, Gary Ishkanian. Pharmacokinetics of frovatriptan in adolescent migraineurs.
Journal of clinical pharmacology.
2004 Oct; 44(10):1158-65. doi:
10.1177/0091270004268046. [PMID: 15342617] - Jerome Goldstein. Frovatriptan: a review.
Expert opinion on pharmacotherapy.
2003 Jan; 4(1):83-93. doi:
10.1517/14656566.4.1.83. [PMID: 12517245] - ". New medications show promise for migraine sufferers.
Dentistry today.
2002 Oct; 21(10):70. doi:
". [PMID: 12382492] - P Buchan, A Wade, C Ward, S D Oliver, A J Stewart, S Freestone. Frovatriptan: a review of drug-drug interactions.
Headache.
2002 Apr; 42 Suppl 2(?):S63-73. doi:
10.1046/j.1526-4610.42.s2.4.x. [PMID: 12028322] - P Buchan, C Keywood, A Wade, C Ward. Clinical pharmacokinetics of frovatriptan.
Headache.
2002 Apr; 42 Suppl 2(?):S54-62. doi:
10.1046/j.1526-4610.42.s2.3.x. [PMID: 12028321] - S S Jhee, T Shiovitz, A W Crawford, N R Cutler. Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review.
Clinical pharmacokinetics.
2001; 40(3):189-205. doi:
10.2165/00003088-200140030-00004. [PMID: 11327198] - D Deleu, Y Hanssens. Current and emerging second-generation triptans in acute migraine therapy: a comparative review.
Journal of clinical pharmacology.
2000 Jul; 40(7):687-700. doi:
10.1177/00912700022009431. [PMID: 10883409]
