Levosimedan (BioDeep_00000614992)
代谢物信息卡片
1-cyano-N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl]phenyl}methanecarbohydrazonoyl cyanide
化学式: C14H12N6O (280.1072542)
中文名称: 左西孟旦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC(=O)NN=C1C2=CC=C(C=C2)NN=C(C#N)C#N
InChI: InChI=1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)/t9-/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058987 - Phosphodiesterase 3 Inhibitors
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D020011 - Protective Agents > D002316 - Cardiotonic Agents
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:50567
- PubChem: 3033825
- Metlin: METLIN85443
- DrugBank: DB00922
- ChEMBL: CHEMBL2051955
- MeSH: Simendan
- CAS: 141505-33-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- F Xu, Y Bian, G Q Zhang, L Y Gao, Y F Liu, T X Liu, G Li, R X Song, L J Su, Y J Zhou, J Y Cui, X L Yan, F M Guo, H Y Zhang, Q H Li, M Zhao, L K Ma, B A You, G Wang, L Kong, J L Ma, X F Zhou, Z L Chang, Z Y Tang, D Y Yu, K Cheng, L Xue, X Li, J J Pang, J L Wang, H T Zhang, X Z Yu, Y G Chen. [Safety and efficacy of the early administration of levosimendan in patients with acute non-ST-segment elevation myocardial infarction and elevated NT-proBNP levels: An Early Management Strategy of Acute Heart Failure (EMS-AHF)].
Zhonghua nei ke za zhi.
2023 Apr; 62(4):374-383. doi:
10.3760/cma.j.cn112138-20220420-00284. [PMID: 37032132] - Md Sayeed Akhtar, Md Quamrul Hassan, Obaid Afzal, Abdulmalik S A Altamimi, Mohd Zaheen Hassan, Arun Kumar, Asif Ansari Shaik Mohammad, Fauzia Tabassum. Comparative efficacy of levosimendan, ramipril, and sacubitril/valsartan in isoproterenol induced experimental heart failure: a hemodynamic and molecular approach.
Current molecular pharmacology.
2022 Sep; ?(?):. doi:
10.2174/1874467215666220919104526. [PMID: 36121084] - Matthias Lapere, Filip Rega, Steffen Rex. Levosimendan in paediatric cardiac anaesthesiology: A systematic review and meta-analysis.
European journal of anaesthesiology.
2022 Aug; 39(8):646-655. doi:
10.1097/eja.0000000000001711. [PMID: 35792892] - Xueyan Cui, Zhongsu Wang, Xue Dong, Zijie Cheng, Le Zhang, Yan Mu, Xin Huang, Yan Li, Yinglong Hong, Yi Han. Comparative Effectiveness and Safety of Milrinone and Levosimendan as Initial Inotrope Therapy in Patients With Acute Heart Failure With Renal Dysfunction.
Journal of cardiovascular pharmacology.
2022 06; 79(6):781-790. doi:
10.1097/fjc.0000000000001255. [PMID: 35507915] - Ze-Shi Li, Kuo Wang, Tuo Pan, Yan-Hua Sun, Chang Liu, Yong-Qing Cheng, He Zhang, Hai-Tao Zhang, Dong-Jin Wang, Zu-Jun Chen. The evaluation of levosimendan in patients with acute myocardial infarction related ventricular septal rupture undergoing cardiac surgery: a prospective observational cohort study with propensity score analysis.
BMC anesthesiology.
2022 05; 22(1):135. doi:
10.1186/s12871-022-01663-z. [PMID: 35501683] - Pei-Hsun Sung, Han-Tan Chai, Chih-Chao Yang, John Y Chiang, Chih-Hung Chen, Yi-Ling Chen, Hon-Kan Yip. Combined levosimendan and Sacubitril/Valsartan markedly protected the heart and kidney against cardiorenal syndrome in rat.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112745. doi:
10.1016/j.biopha.2022.112745. [PMID: 35202913] - Miaomiao Li, Yue Zhang, Qianli Wan, Yiou Li, Tianzhen Qu, Fang Yuan. Use of levosimendan combined with Shenfu injection to treat acute heart failure patients with hypotension: a prospective randomized controlled single-blind study.
BMC cardiovascular disorders.
2022 03; 22(1):130. doi:
10.1186/s12872-022-02572-2. [PMID: 35350988] - Maryam Baeeri, Mahban Rahimifard, Maryam Armandeh, Behnaz Bameri, Madiha Khalid, Hamed Haghi-Aminjan, Ramtin Farhadi, Mohammad Abdollahi. The Effect of Levosimendan on Phosphine-Induced Nephrotoxicity: Biochemical and Histopathological Assessment.
Drug research.
2022 Feb; 72(2):109-118. doi:
10.1055/a-1661-5439. [PMID: 34788887] - Henrik Fox, Jan F Gummert, Philipp Sommer, Cornelius Knabbe, Christian Sohns. Synergistic effects of levosimendan and convalescence plasma as bailout strategy in acute cardiogenic shock in COVID-19: A case report.
Cardiology journal.
2022 ; 29(1):157-159. doi:
10.5603/cj.a2021.0119. [PMID: 34622432] - Shen Xiangli, Li Lan, Zu Libiya, Ma Jun, Jiang Shubin. Effect of levosimendan combined with recombinant human brain natriuretic peptide on diuretic resistance.
The Libyan journal of medicine.
2021 Dec; 16(1):1973762. doi:
10.1080/19932820.2021.1973762. [PMID: 34493175] - Patrick M Honore, Sebastien Redant, Sofie Moorthamers, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani, Willem Boer, David De Bels. What should clinicians know about the renal effect and the mechanism of action of levosimendan?.
Expert opinion on drug safety.
2021 Dec; 20(12):1459-1461. doi:
10.1080/14740338.2021.1986483. [PMID: 34612116] - Irmak Durur-Subasi, Duygu Kose, Muhammed Yayla, Busra Sirin, Adem Karaman, Ilknur Calik, Fatih Alper. Does the cardiovascular drug levosimendan prevent iodinated contrast medium nephrotoxicity with glycerol aggravation in rats?.
European radiology experimental.
2021 11; 5(1):49. doi:
10.1186/s41747-021-00249-7. [PMID: 34786647] - Yu-Xiang Long, Di-Yu Cui, Xue Kuang, Yue Hu, Shuang Hu, Chun-Ping Wang, Zeng-Zhang Liu. Effect of levosimendan on renal function in background of left ventricular dysfunction: a meta-analysis of randomized trials.
Expert opinion on drug safety.
2021 Nov; 20(11):1411-1420. doi:
10.1080/14740338.2021.1951700. [PMID: 34214005] - Yun-Tai Yao, Li-Xian He, Yuan-Yuan Zhao. The effect of levosimendan on postoperative bleeding and blood transfusion in cardiac surgical patients: a PRISMA-compliant systematic review and meta-analysis.
Perfusion.
2021 Oct; 36(7):694-703. doi:
10.1177/0267659120963909. [PMID: 33070760] - Tianyuan Jia, Shiwei Wang, Chengzhun Luo, Zida Wang, Guoxiang Liu, Zhaoming Shang, Xiaoye Lu, Qian Yang, Changqing Zhu. Levosimendan Ameliorates Post-resuscitation Acute Intestinal Microcirculation Dysfunction Partly Independent of its Effects on Systemic Circulation: A Pilot Study on Cardiac Arrest in a Rat Model.
Shock (Augusta, Ga.).
2021 10; 56(4):639-646. doi:
10.1097/shk.0000000000001771. [PMID: 33710108] - Roua Hassoun, Heidi Budde, Hans Georg Mannherz, Mária Lódi, Setsuko Fujita-Becker, Kai Thorsten Laser, Anna Gärtner, Karin Klingel, Desirée Möhner, Robert Stehle, Innas Sultana, Thomas Schaaf, Mario Majchrzak, Verena Krause, Christian Herrmann, Marc M Nowaczyk, Andreas Mügge, Gabriele Pfitzer, Rasmus R Schröder, Nazha Hamdani, Hendrik Milting, Kornelia Jaquet, Diana Cimiotti. De Novo Missense Mutations in TNNC1 and TNNI3 Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targeting Agents.
International journal of molecular sciences.
2021 Sep; 22(17):. doi:
10.3390/ijms22179625. [PMID: 34502534] - Elin M Thorlacius, Maria Vistnes, Tiina Ojala, Juho Keski-Nisula, Mattias Molin, Birgitta S Romlin, Mats Synnergren, Sven-Erik Ricksten, Håkan Wåhlander, Albert Castellheim. Levosimendan Versus Milrinone and Release of Myocardial Biomarkers After Pediatric Cardiac Surgery: Post Hoc Analysis of Clinical Trial Data.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2021 07; 22(7):e402-e409. doi:
10.1097/pcc.0000000000002712. [PMID: 33739957] - Serkan Suakıtıcı, Bülent Barış Güven, Alpaslan Tanoglu, Sezai Özkan. A combination of levosimendan and N-Acetylcysteine shows significant favorable efficacy on experimental liver ischemia/reperfusion injury.
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.
2021 Jul; 27(4):381-388. doi:
10.14744/tjtes.2020.81782. [PMID: 34213003] - Maria Tholén, Sven-Erik Ricksten, Lukas Lannemyr. Effects of levosimendan on renal blood flow and glomerular filtration in patients with acute kidney injury after cardiac surgery: a double blind, randomized placebo-controlled study.
Critical care (London, England).
2021 06; 25(1):207. doi:
10.1186/s13054-021-03628-z. [PMID: 34118980] - Helene A Häberle. [Levosimendan - a 20-Year Experience].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.
2021 Jun; 56(6):414-426. doi:
10.1055/a-1214-4485. [PMID: 34187074] - Basil John, Mariya Babu, Sandramol Shaji, Suja Abraham, Jabir Abdullakutty. Clinical outcomes of levosimendan versus dobutamine in patients with acute decompensated heart failure with reduced ejection fraction and impaired renal function.
Indian heart journal.
2021 May; 73(3):372-375. doi:
10.1016/j.ihj.2021.02.010. [PMID: 34154760] - Matthias Heringlake, Julian Alvarez, Dominique Bettex, Stefaan Bouchez, Sonja Fruhwald, Massimo Girardis, Elena Grossini, Fabio Guarracino, Antoine Herpain, Wolfgang Toller, Luigi Tritapepe, Piero Pollesello. An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety.
Expert review of cardiovascular therapy.
2021 Apr; 19(4):325-335. doi:
10.1080/14779072.2021.1905520. [PMID: 33739204] - Oliver K Jawitz, Amanda S Stebbins, Vignesh Raman, Brooke Alhanti, Sean van Diepen, Matthias Heringlake, Stephen Fremes, Richard Whitlock, Steven R Meyer, Rajendra H Mehta, Mark Stafford-Smith, Shaun G Goodman, John H Alexander, Renato D Lopes. Association between levosimendan, postoperative AKI, and mortality in cardiac surgery: Insights from the LEVO-CTS trial.
American heart journal.
2021 01; 231(?):18-24. doi:
10.1016/j.ahj.2020.10.066. [PMID: 33127531] - Antonio Piperata, Tomaso Bottio, Gino Gerosa. COVID-19 infection in left ventricular assist device patients.
Journal of cardiac surgery.
2020 Nov; 35(11):3231-3234. doi:
10.1111/jocs.14969. [PMID: 32827186] - Mingming Fu, Zhiqian Wang, Yan Liu. Effects of Xinkeshu combined with levosimendan on perioperative heart failure in oldest-old patients with hip fractures.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2020 10; 40(5):870-874. doi:
10.19852/j.cnki.jtcm.20200807.001. [PMID: 33000589] - Carolyn Weber, Matthias Esser, Kaveh Eghbalzadeh, Anton Sabashnikov, Ilija Djordjevic, Johanna Maier, Julia Merkle, Yeong-Hoon Choi, Navid Madershahian, Oliver Liakopoulos, Antje Christin Deppe, Thorsten C W Wahlers. Levosimendan Reduces Mortality and Low Cardiac Output Syndrome in Cardiac Surgery.
The Thoracic and cardiovascular surgeon.
2020 08; 68(5):401-409. doi:
10.1055/s-0039-3400496. [PMID: 31770777] - Alberto Zangrillo, Vladimir V Lomivorotov, Antonio Pisano, Maria Grazia Calabrò, Alessandro Belletti, Luca Brazzi, Evgeny V Grigoryev, Fabio Guarracino, Fabrizio Monaco, Eugenio Garofalo, Martina Crivellari, Valery V Likhvantsev, Evgeny V Fominskiy, Gianluca Paternoster, Andrey Yavorovskiy, Vadim V Pasyuga, Alessandro Oriani, Rosalba Lembo, Alessandro Bianchi, A Mara Scandroglio, Marat N Abubakirov, Nora Di Tomasso, Giovanni Landoni. Long-term outcome of perioperative low cardiac output syndrome in cardiac surgery: 1-year results of a multicenter randomized trial.
Journal of critical care.
2020 08; 58(?):89-95. doi:
10.1016/j.jcrc.2020.04.005. [PMID: 32402931] - Aly M Abdelrahman, Suhail Al Salam, Yousuf Al Suleimani, Mohamed Ashique, Priyadarsini Manoj, Badreldin H Ali. Effect of levosimendan, an inodilator, on streptozotocin-induced diabetic nephropathy in rats.
European journal of pharmacology.
2020 Apr; 873(?):172960. doi:
10.1016/j.ejphar.2020.172960. [PMID: 32001219] - Sen-Bo Yan, Xiao-Yan Wang, Guo-Kai Shang, Zhi-Hao Wang, Qi-Ming Deng, Jia-Wen Song, Wen-Wen Sai, Ming Song, Ming Zhong, Wei Zhang. Impact of Perioperative Levosimendan Administration on Risk of Bleeding After Cardiac Surgery: A Meta-analysis of Randomized Controlled Trials.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2020 Apr; 20(2):149-160. doi:
10.1007/s40256-019-00372-2. [PMID: 31523760] - Martin Fredholm, Kirsten Jörgensen, Erik Houltz, Sven-Erik Ricksten. Levosimendan or milrinone for right ventricular inotropic treatment?-A secondary analysis of a randomized trial.
Acta anaesthesiologica Scandinavica.
2020 02; 64(2):193-201. doi:
10.1111/aas.13486. [PMID: 31556095] - Xianyong Liao, Lin Qian, Song Zhang, Xiang Chen, Jing Lei. Network Meta-Analysis of the Safety of Drug Therapy for Cardiogenic Shock.
Journal of healthcare engineering.
2020; 2020(?):8862256. doi:
10.1155/2020/8862256. [PMID: 32802302] - Anbiao Wang, Chaomei Cui, Yiou Fan, Jie Zi, Jie Zhang, Guanglai Wang, Fang Wang, Jun Wang, Qi Tan. Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: a prospective randomized controlled trial.
Critical care (London, England).
2019 12; 23(1):428. doi:
10.1186/s13054-019-2704-2. [PMID: 31888711] - Jose Luis Guerrero Orriach, I Navarro Arce, P Hernandez Rodriguez, A Raigón Ponferrada, A Malo Manso, M Ramirez Aliaga, A Ramirez Fernandez, J J Escalona Belmonte, I Bellido Estevez, A Gomez Luque, R Barrera Serrano, C S Toledo Medina, M Rubio Navarro, J Cruz Mañas. Preservation of renal function in cardiac surgery patients with low cardiac output syndrome: levosimendan vs beta agonists.
BMC anesthesiology.
2019 11; 19(1):212. doi:
10.1186/s12871-019-0888-2. [PMID: 31735161] - Elin M Thorlacius, Pertti K Suominen, Håkan Wåhlander, Juho Keski-Nisula, Maria Vistnes, Sven-Erik Ricksten, Mats Synnergren, Birgitta S Romlin, Albert Castellheim. The Effect of Levosimendan Versus Milrinone on the Occurrence Rate of Acute Kidney Injury Following Congenital Heart Surgery in Infants: A Randomized Clinical Trial.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2019 10; 20(10):947-956. doi:
10.1097/pcc.0000000000002017. [PMID: 31274775] - David B Antcliffe, Shalini Santhakumaran, Robert M L Orme, Josie K Ward, Farah Al-Beidh, Kieran O'Dea, Gavin D Perkins, Mervyn Singer, Daniel F McAuley, Alexina J Mason, Mary Cross, Deborah Ashby, Anthony C Gordon. Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial.
Intensive care medicine.
2019 10; 45(10):1392-1400. doi:
10.1007/s00134-019-05731-w. [PMID: 31428804] - Peta M A Alexander, Ayse Akcan-Arikan, Lara S Shekerdemian. Another Outcome Lost to the Benefits of Levosimendan?.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2019 10; 20(10):992-994. doi:
10.1097/pcc.0000000000002019. [PMID: 31580276] - Junchen Zhu, Yu Zhang, Lvlin Chen, Yan He, Xiaoming Qing. Levosimendan in patients with low cardiac output syndrome undergoing cardiac surgery: A systematic review and meta-analysis.
Anaesthesia, critical care & pain medicine.
2019 06; 38(3):243-249. doi:
10.1016/j.accpm.2018.08.005. [PMID: 30342103] - Fang Feng, Yu Chen, Min Li, Jiao-Jiao Yuan, Xue-Ni Chang, Chen-Ming Dong. Levosimendan does not reduce the mortality of critically ill adult patients with sepsis and septic shock: a meta-analysis.
Chinese medical journal.
2019 May; 132(10):1212-1217. doi:
10.1097/cm9.0000000000000197. [PMID: 31140992] - J Li, X-Y Wang, Z-Y Yang, Y Li, F Yang, P Yuan, J Yang. The efficacy of simendan in the treatment of acute heart failure and its impact on NT-proBNP.
European review for medical and pharmacological sciences.
2019 May; 23(9):4027-4032. doi:
10.26355/eurrev_201905_17833. [PMID: 31115032] - Jian Pan, Yun-Mei Yang, Jian-Yong Zhu, Yuan-Qiang Lu. Multiorgan Drug Action of Levosimendan in Critical Illnesses.
BioMed research international.
2019; 2019(?):9731467. doi:
10.1155/2019/9731467. [PMID: 31641670] - Azadeh Aminzadeh, Saeed Mehrzadi. Cardioprotective effect of levosimendan against homocysteine-induced mitochondrial stress and apoptotic cell death in H9C2.
Biochemical and biophysical research communications.
2018 12; 507(1-4):395-399. doi:
10.1016/j.bbrc.2018.11.049. [PMID: 30446219] - S Bouchez, F Fedele, G Giannakoulas, F Gustafsson, V-P Harjola, K Karason, M Kivikko, D von Lewinski, F Oliva, Z Papp, J Parissis, Piero Pollesello, G Pölzl, C Tschöpe. Levosimendan in Acute and Advanced Heart Failure: an Expert Perspective on Posology and Therapeutic Application.
Cardiovascular drugs and therapy.
2018 12; 32(6):617-624. doi:
10.1007/s10557-018-6838-2. [PMID: 30402660] - Hongfei Chen, Fangfang Xia, Zhousheng Jin, Kejian Shi, Yun Xia, Le Liu, Thomas J Papadimos, Xuzhong Xu, Limei Chen. Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart.
BMC anesthesiology.
2018 11; 18(1):174. doi:
10.1186/s12871-018-0627-0. [PMID: 30458723] - Alberto Zangrillo, Gabriele Alvaro, Alessandro Belletti, Antonio Pisano, Luca Brazzi, Maria G Calabrò, Fabio Guarracino, Tiziana Bove, Evgeny V Grigoryev, Fabrizio Monaco, Vladimir A Boboshko, Valery V Likhvantsev, Anna M Scandroglio, Gianluca Paternoster, Rosalba Lembo, Samuele Frassoni, Marco Comis, Vadim V Pasyuga, Paolo Navalesi, Vladimir V Lomivorotov. Effect of Levosimendan on Renal Outcome in Cardiac Surgery Patients With Chronic Kidney Disease and Perioperative Cardiovascular Dysfunction: A Substudy of a Multicenter Randomized Trial.
Journal of cardiothoracic and vascular anesthesia.
2018 10; 32(5):2152-2159. doi:
10.1053/j.jvca.2018.02.039. [PMID: 29580796] - Prashanth Nandhabalan, Nicholas Ioannou, Christopher Meadows, Duncan Wyncoll. Refractory septic shock: our pragmatic approach.
Critical care (London, England).
2018 Sep; 22(1):215. doi:
10.1186/s13054-018-2144-4. [PMID: 30231909] - Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, Yasuhide Watanabe, Naoyuki Matsuda, Naoki Yoshimura, Yuichi Hattori. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 09; 391(9):1021-1032. doi:
10.1007/s00210-018-1527-z. [PMID: 29922941] - Lukas Lannemyr, Sven-Erik Ricksten, Bengt Rundqvist, Bert Andersson, Sven-Erik Bartfay, Charlotta Ljungman, Pia Dahlberg, Niklas Bergh, Clara Hjalmarsson, Thomas Gilljam, Entela Bollano, Kristjan Karason. Differential Effects of Levosimendan and Dobutamine on Glomerular Filtration Rate in Patients With Heart Failure and Renal Impairment:A Randomized Double-Blind Controlled Trial.
Journal of the American Heart Association.
2018 08; 7(16):e008455. doi:
10.1161/jaha.117.008455. [PMID: 30369310] - Hua Qiang, Xiu Luo, Jian-Hua Huo, Zhi-Quan Wang. Perioperative Use of Levosimendan Improves Clinical Outcomes in Patients After Cardiac Surgery: A Systematic Review and Meta-Analysis.
Journal of cardiovascular pharmacology.
2018 07; 72(1):11-18. doi:
10.1097/fjc.0000000000000584. [PMID: 29672418] - Josep Comín-Colet, Nicolás Manito, Javier Segovia-Cubero, Juan Delgado, José Manuel García Pinilla, Luis Almenar, María G Crespo-Leiro, Alessandro Sionis, Teresa Blasco, Domingo Pascual-Figal, Francisco Gonzalez-Vilchez, José Luis Lambert-Rodríguez, María Grau, Jordi Bruguera. Efficacy and safety of intermittent intravenous outpatient administration of levosimendan in patients with advanced heart failure: the LION-HEART multicentre randomised trial.
European journal of heart failure.
2018 07; 20(7):1128-1136. doi:
10.1002/ejhf.1145. [PMID: 29405611] - C X Xu, L Li, S J Gong, Y H Yu, J Yan. [The effects of levosimendan on the cardiac function and prognosis in elderly patients with septic shock and myocardial contractility impairment].
Zhonghua nei ke za zhi.
2018 Jun; 57(6):423-428. doi:
10.3760/cma.j.issn.0578-1426.2018.06.006. [PMID: 29925127] - Ayman Elbadawi, Islam Y Elgendy, Marwan Saad, Michael Megaly, Amgad Mentias, Ahmed S Abuzaid, Hend I Shahin, Vinay Goswamy, Hesham Abowali, Barry London. Meta-Analysis of Trials on Prophylactic Use of Levosimendan in Patients Undergoing Cardiac Surgery.
The Annals of thoracic surgery.
2018 05; 105(5):1403-1410. doi:
10.1016/j.athoracsur.2017.11.027. [PMID: 29573810] - Pushkar Mahendra Desai, Manjula S Sarkar, Sanjeeta R Umbarkar. Prophylactic preoperative levosimendan for off-pump coronary artery bypass grafting in patients with left ventricular dysfunction: Single-centered randomized prospective study.
Annals of cardiac anaesthesia.
2018 Apr; 21(2):123-128. doi:
10.4103/aca.aca_178_17. [PMID: 29652271] - Wei Chang, Jian-Feng Xie, Jing-Yuan Xu, Yi Yang. Effect of levosimendan on mortality in severe sepsis and septic shock: a meta-analysis of randomised trials.
BMJ open.
2018 03; 8(3):e019338. doi:
10.1136/bmjopen-2017-019338. [PMID: 29602841] - Xi Chen, Tianlun Huang, Xuan Cao, Gaosi Xu. Comparative Efficacy of Drugs for Preventing Acute Kidney Injury after Cardiac Surgery: A Network Meta-Analysis.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2018 Feb; 18(1):49-58. doi:
10.1007/s40256-017-0245-0. [PMID: 28819767] - Alessandro Putzu, Sara Clivio, Alessandro Belletti, Tiziano Cassina. Perioperative levosimendan in cardiac surgery: A systematic review with meta-analysis and trial sequential analysis.
International journal of cardiology.
2018 Jan; 251(?):22-31. doi:
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Critical care (London, England).
2017 Oct; 21(1):252. doi:
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Journal of cardiovascular medicine (Hagerstown, Md.).
2017 10; 18(10):771-773. doi:
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BMC anesthesiology.
2017 Sep; 17(1):128. doi:
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Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.
2017 Sep; 36(9):619-625. doi:
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Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.
2017 Sep; 23(5):368-376. doi:
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Journal of the Chinese Medical Association : JCMA.
2017 Jul; 80(7):432-441. doi:
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Journal of clinical monitoring and computing.
2017 Feb; 31(1):227-230. doi:
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American journal of cardiovascular drugs : drugs, devices, and other interventions.
2017 Feb; 17(1):17-25. doi:
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Brazilian journal of anesthesiology (Elsevier).
2017 Jan; 67(1):89-91. doi:
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American journal of physiology. Heart and circulatory physiology.
2017 Jan; 312(1):H46-H59. doi:
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Journal of cardiothoracic surgery.
2016 Dec; 11(1):162. doi:
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The heart surgery forum.
2016 Oct; 19(5):E230-E236. doi:
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Current opinion in anaesthesiology.
2016 Aug; 29(4):454-61. doi:
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American heart journal.
2016 Jul; 177(?):66-73. doi:
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Minerva cardioangiologica.
2016 Apr; 64(2):101-13. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2016 Mar; 67(3):408-16. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
2015 Aug; 21(?):2439-45. doi:
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Anatolian journal of cardiology.
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Journal of cardiac surgery.
2015 Jul; 30(7):547-54. doi:
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Scientific reports.
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The Journal of surgical research.
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Current vascular pharmacology.
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Bratislavske lekarske listy.
2015; 116(1):47-50. doi:
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PloS one.
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PloS one.
2015; 10(4):e0124742. doi:
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Critical care (London, England).
2014 Nov; 18(6):652. doi:
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Journal of cardiothoracic surgery.
2014 Nov; 9(?):167. doi:
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European journal of pharmacology.
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Clinical transplantation.
2014 Oct; 28(10):1105-11. doi:
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Journal of cardiothoracic and vascular anesthesia.
2014 Jun; 28(3):586-94. doi:
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Critical care medicine.
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Medizinische Klinik, Intensivmedizin und Notfallmedizin.
2014 May; 109(4):267-70. doi:
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Journal of cardiovascular medicine (Hagerstown, Md.).
2014 Apr; 15(4):322-30. doi:
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European journal of heart failure.
2014 Mar; 16(3):281-8. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
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Toxicology and industrial health.
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Journal of cardiovascular pharmacology.
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Bratislavske lekarske listy.
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Cardiovascular drugs and therapy.
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Journal of investigative surgery : the official journal of the Academy of Surgical Research.
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Toxicological sciences : an official journal of the Society of Toxicology.
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Critical care (London, England).
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