3-Propylxanthine (BioDeep_00000614988)
代谢物信息卡片
3-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
化学式: C8H10N4O2 (194.080372)
中文名称: 3-丙基黄嘌呤
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCN1C2=C(C(=O)NC1=O)NC=N2
InChI: InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
Enprofylline acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease[1][2][3].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:126237
- KEGGdrug: D04006
- PubChem: 1676
- Metlin: METLIN85437
- DrugBank: DB00824
- ChEMBL: CHEMBL279898
- CAS: 41078-02-8
- medchemexpress: HY-14117
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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INOH(0)
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COVID-19 Disease Map(0)
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文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Masayuki Nadai, Miki Kato, Hideo Yoshizumi, Masao Kimura, Shunsuke Kurono, Fumie Abe, Hiroko Saito, Takaaki Hasegawa. Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
Life sciences.
2007 Sep; 81(15):1175-82. doi:
10.1016/j.lfs.2007.07.032. [PMID: 17897683] - Lazaros C Foukas, Nathalie Daniele, Chariklia Ktori, Karen E Anderson, Jorgen Jensen, Peter R Shepherd. Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
The Journal of biological chemistry.
2002 Oct; 277(40):37124-30. doi:
10.1074/jbc.m202101200. [PMID: 12145276] - Soon-Ai Kim, Melissa A Marshall, Neli Melman, Hak Sung Kim, Christa E Müller, Joel Linden, Kenneth A Jacobson. Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.
Journal of medicinal chemistry.
2002 May; 45(11):2131-8. doi:
10.1021/jm0104318. [PMID: 12014951] - V B Bhat, K M Madyastha. Antioxidant and radical scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline.
Biochemical and biophysical research communications.
2001 Nov; 288(5):1212-7. doi:
10.1006/bbrc.2001.5922. [PMID: 11700041] - J W Fisher, J Brookins. Adenosine A(2A) and A(2B) receptor activation of erythropoietin production.
American journal of physiology. Renal physiology.
2001 Nov; 281(5):F826-32. doi:
10.1152/ajprenal.2001.281.5.f826. [PMID: 11592940] - J Linden, T Thai, H Figler, X Jin, A S Robeva. Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
Molecular pharmacology.
1999 Oct; 56(4):705-13. doi:
NULL. [PMID: 10496952] - A De Sarro, S Grasso, M Zappala, F Nava, G De Sarro. Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats.
Naunyn-Schmiedeberg's archives of pharmacology.
1997 Jul; 356(1):48-55. doi:
10.1007/pl00005027. [PMID: 9228189] - M Nadai, T Hasegawa, L Wang, S Haghgoo, T Okasaka, T Nabeshima, N Kato. Alterations in renal uptake kinetics of the xanthine derivative enprofylline in endotoxaemic mice.
The Journal of pharmacy and pharmacology.
1996 Jul; 48(7):744-8. doi:
10.1111/j.2042-7158.1996.tb03963.x. [PMID: 8866341] - I Feoktistov, I Biaggioni. Role of adenosine in asthma.
Drug development research.
1996; 39(?):333-6. doi:
10.1002/(sici)1098-2299(199611/12)39:3/4<333::aid-ddr14>3.0.co;2-2. [PMID: 11542498] - M Nadai, T Hasegawa, L Wang, S Haghgoo, T Nabeshima, N Kato. Time-dependent changes in the pharmacokinetics and renal excretion of xanthine derivative enprofylline induced by bacterial endotoxin in rats.
Biological & pharmaceutical bulletin.
1995 Aug; 18(8):1089-93. doi:
10.1248/bpb.18.1089. [PMID: 8535402] - K R Chapman, K Ljungholm, A Kallen. Long-term xanthine therapy of asthma. Enprofylline and theophylline compared. International Enprofylline Study Group.
Chest.
1994 Nov; 106(5):1407-13. doi:
10.1378/chest.106.5.1407. [PMID: 7956392] - M Nadai, T Hasegawa, L Wang, O Tagaya, T Nabeshima. Alterations in the pharmacokinetics and protein binding of enprofylline in Eisai hyperbilirubinemic rats.
Drug metabolism and disposition: the biological fate of chemicals.
1994 Jul; 22(4):561-5. doi:
NULL. [PMID: 7956730] - I Muraoka, T Hasegawa, M Nadai, L Wang, O Tagaya, T Nabeshima. Influence of age on the disposition and renal handling of enprofylline in rats.
The Journal of pharmacy and pharmacology.
1994 Mar; 46(3):230-4. doi:
10.1111/j.2042-7158.1994.tb03785.x. [PMID: 8027934] - C Svensson, U Alkner, U Pipkorn, C G Persson. Histamine-induced airway mucosal exudation of bulk plasma and plasma-derived mediators is not inhibited by intravenous bronchodilators.
European journal of clinical pharmacology.
1994; 46(1):59-65. doi:
10.1007/bf00195917. [PMID: 8005188] - J D Orón, J Cortijo, M Perpiñá, E J Morcillo. Effects of alkylxanthines on contractility of diaphragm fibres isolated from normal and sensitized guinea-pigs.
The Journal of pharmacy and pharmacology.
1993 Dec; 45(12):1060-6. doi:
10.1111/j.2042-7158.1993.tb07181.x. [PMID: 7908975] - M Nadai, T Hasegawa, K Kato, L Wang, T Nabeshima, N Kato. The disposition and renal handling of enprofylline in endotoxemic rats by bacterial lipopolysaccharide (LPS).
Drug metabolism and disposition: the biological fate of chemicals.
1993 Jul; 21(4):611-6. doi:
NULL. [PMID: 8104119] - L Wang, T Hasegawa, M Nadai, T Nabeshima. The effects of N-benzoyl-beta-alanine, a new nephroprotective drug, on the distribution and renal excretion of enprofylline in rats.
The Journal of pharmacy and pharmacology.
1993 Jul; 45(7):622-6. doi:
10.1111/j.2042-7158.1993.tb05665.x. [PMID: 8105057] - I Muraoka, T Hasegawa, M Nadai, K Kato, T Nabeshima. Pharmacokinetics and renal handling of enprofylline in pregnant rats.
Drug metabolism and disposition: the biological fate of chemicals.
1992 Sep; 20(5):653-7. doi:
NULL. [PMID: 1358568] - I Erjefält, C G Persson. Increased sensitivity to toluene diisocyanate (TDI) in airways previously exposed to low doses of TDI.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1992 Sep; 22(9):854-62. doi:
10.1111/j.1365-2222.1992.tb02831.x. [PMID: 1330235] - Y Tsunekawa, T Hasegawa, M Nadai, K Takagi, T Nabeshima. Interspecies differences and scaling for the pharmacokinetics of xanthine derivatives.
The Journal of pharmacy and pharmacology.
1992 Jul; 44(7):594-9. doi:
10.1111/j.2042-7158.1992.tb05471.x. [PMID: 1357141] - M Nadai, T Hasegawa, I Muraoka, K Takagi, T Nabeshima. Dose-dependent pharmacokinetics of enprofylline and its renal handling in rats.
Journal of pharmaceutical sciences.
1991 Jul; 80(7):648-52. doi:
10.1002/jps.2600800707. [PMID: 1941561] - I Erjefält, C G Persson. Pharmacologic control of plasma exudation into tracheobronchial airways.
The American review of respiratory disease.
1991 May; 143(5 Pt 1):1008-14. doi:
10.1164/ajrccm/143.5_pt_1.1008. [PMID: 1902634] - T Hasegawa, M Nadai, T Kuzuya, I Muraoka, R Apichartpichean, K Takagi, K Miyamoto. The possible mechanism of interaction between xanthines and quinolone.
The Journal of pharmacy and pharmacology.
1990 Nov; 42(11):767-72. doi:
10.1111/j.2042-7158.1990.tb07018.x. [PMID: 1982300] - P Youngchaiyud, S Charoenratanakul, A Nana, E Wong, L Laxmyr, P Bamberg. Intravenous enprofylline in the treatment of patients with acute asthma.
The Journal of international medical research.
1990 Nov; 18(6):473-82. doi:
10.1177/030006059001800605. [PMID: 2292329] - J W Daly, I Hide, P K Bridson. Imidazodiazepinediones: a new class of adenosine receptor antagonists.
Journal of medicinal chemistry.
1990 Oct; 33(10):2818-21. doi:
10.1021/jm00172a022. [PMID: 2213834] - S R O'Donnell, I Erjefält, C G Persson. Early and late tracheobronchial plasma exudation by platelet-activating factor administered to the airway mucosal surface in guinea pigs: effects of WEB 2086 and enprofylline.
The Journal of pharmacology and experimental therapeutics.
1990 Jul; 254(1):65-70. doi:
NULL. [PMID: 2366192] - B Tiplady, D Fagan, M Lamont, M Brockway, D B Scott. A comparison of the CNS effects of enprofylline and theophylline in healthy subjects assessed by performance testing and subjective measures.
British journal of clinical pharmacology.
1990 Jul; 30(1):55-61. doi:
10.1111/j.1365-2125.1990.tb03743.x. [PMID: 1975198] - L E Brackett, M T Shamim, J W Daly. Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants.
Biochemical pharmacology.
1990 Jun; 39(12):1897-904. doi:
10.1016/0006-2952(90)90607-m. [PMID: 2353933] - J D Arnold, R J Courtenay-Evans, R Whitfield, J F O'Reilly, G R Petrie, A J Higgins, C G Swift. Comparative assessment of enprofylline and theophylline for chronic obstructive airways disease in the elderly.
Respiratory medicine.
1990 May; 84(3):211-5. doi:
10.1016/s0954-6111(08)80037-6. [PMID: 2218006] - K R Chapman, S Boucher, R H Hyland, A Day, H Kreisman, R Rivington, R V Hodder, E L York, R T Abboud, S Peters. A comparison of enprofylline and theophylline in the maintenance therapy of chronic reversible obstructive airway disease.
The Journal of allergy and clinical immunology.
1990 Feb; 85(2):514-21. doi:
10.1016/0091-6749(90)90164-y. [PMID: 2406328] - J S Vilsvik, C G Persson, T Amundsen, E Brenna, T Naustdal, U Syvertsen, L Storstein, A G Källén, G Eriksson, S Holte. Comparison between theophylline and an adenosine non-blocking xanthine in acute asthma.
The European respiratory journal.
1990 Jan; 3(1):27-32. doi:
. [PMID: 2311727] - G H Koëter, J Kraan, M Boorsma, J H Jonkman, T W van der Mark. Effect of theophylline and enprofylline on bronchial hyperresponsiveness.
Thorax.
1989 Dec; 44(12):1022-6. doi:
10.1136/thx.44.12.1022. [PMID: 2694418] - H T Heidemann, S Müller, L Mertins, G Stepan, K Hoffmann, E E Ohnhaus. Effect of aminophylline on cisplatin nephrotoxicity in the rat.
British journal of pharmacology.
1989 Jun; 97(2):313-8. doi:
10.1111/j.1476-5381.1989.tb11956.x. [PMID: 2758217] - P Smits, J Schouten, T Thien. Cardiovascular effects of two xanthines and the relation to adenosine antagonism.
Clinical pharmacology and therapeutics.
1989 Jun; 45(6):593-9. doi:
10.1038/clpt.1989.79. [PMID: 2659234] - L C Laursen, O Borgå, L Krohn, B Weeke. Distribution of enprofylline and theophylline between plasma and cerebrospinal fluid.
Therapeutic drug monitoring.
1989; 11(2):162-4. doi:
10.1097/00007691-198903000-00007. [PMID: 2718221] - K Arnman, B Willén, L Borgström, T B Conradson. Intravenous infusion of enprofylline with an exponentially decreasing drug concentration in acute asthma.
Therapeutic drug monitoring.
1989; 11(3):249-52. doi:
10.1097/00007691-198905000-00006. [PMID: 2728082] - H Clarke, M J Cushley, C G Persson, S T Holgate. The protective effects of intravenous theophylline and enprofylline against histamine- and adenosine 5'-monophosphate-provoked bronchoconstriction: implications for the mechanisms of action of xanthine derivatives in asthma.
Pulmonary pharmacology.
1989; 2(3):147-54. doi:
10.1016/0952-0600(89)90039-2. [PMID: 2562472] - B J Chapman, C McDonald, S Capewell, M H Frame, G K Crompton. Enprofylline in chronic asthma.
British journal of diseases of the chest.
1988 Oct; 82(4):354-9. doi:
10.1016/0007-0971(88)90088-5. [PMID: 3076790] - J Y Hsieh, T J Thornton, W F Bayne. High-performance liquid chromatographic determination of enprofylline in human plasma.
Journal of chromatography.
1988 Aug; 430(1):175-9. doi:
10.1016/s0378-4347(00)83149-7. [PMID: 3215954] - W T Watson, K J Simons, F E Simons. Pharmacokinetics of enprofylline administered intravenously and as a sustained-release tablet at steady state in children with asthma.
The Journal of pediatrics.
1988 Apr; 112(4):658-62. doi:
10.1016/s0022-3476(88)80193-8. [PMID: 3351694] - L C Laursen, O Borgå, K Ljungholm, B Weeke. Transfer of enprofylline into breast milk.
Therapeutic drug monitoring.
1988; 10(2):150-2. doi:
10.1097/00007691-198802000-00005. [PMID: 3381231] - J Kraan, L Borgström, G H Koëter, M Laseur, J H Jonkman, O E de Noord. Creation of four consecutive instantaneous steady-state plasma concentration plateaus of theophylline and enprofylline by repeated infusions with exponentially decreasing delivery rates.
European journal of clinical pharmacology.
1988; 35(6):657-61. doi:
10.1007/bf00637603. [PMID: 3234473] - J Kraan, J H Jonkman, G H Koëter, C H Gips, P E de Jong, T W van der Mark, I Ekman, R A de Zeeuw. The pharmacokinetics of theophylline and enprofylline in patients with liver cirrhosis and in patients with chronic renal disease.
European journal of clinical pharmacology.
1988; 35(4):357-62. doi:
10.1007/bf00561364. [PMID: 3197743] - J B Gouyon, M Arnaud, J P Guignard. Renal effects of low-dose aminophylline and enprofylline in newborn rabbits.
Life sciences.
1988; 42(13):1271-8. doi:
10.1016/0024-3205(88)90220-2. [PMID: 3352455] - D L Maxwell, R W Fuller, T B Conradson, C M Dixon, V Aber, J M Hughes, P J Barnes. Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man.
Acta physiologica Scandinavica.
1987 Nov; 131(3):459-65. doi:
10.1111/j.1748-1716.1987.tb08262.x. [PMID: 3425350] - M S Yates, C J Bowmer, R Kellett, M G Collis. Effect of 8-phenyltheophylline, enprofylline and hydrochlorothiazide on glycerol-induced acute renal failure in the rat.
The Journal of pharmacy and pharmacology.
1987 Oct; 39(10):803-8. doi:
10.1111/j.2042-7158.1987.tb05122.x. [PMID: 2891817] - D S Sitar, F Y Aoki, D J Hoban, K G Hidinger, P R Montgomery, P A Mitenko. Enprofylline disposition in the presence and absence of amoxycillin or erythromycin.
British journal of clinical pharmacology.
1987 Jul; 24(1):57-61. doi:
10.1111/j.1365-2125.1987.tb03136.x. [PMID: 3620286] - O Paulsen, O Borgå, K E Andersson. Effects of ampicillin on the elimination of enprofylline in man.
Pharmacology & toxicology.
1987 May; 60(5):380-4. doi:
10.1111/j.1600-0773.1987.tb01531.x. [PMID: 3615348] - C Hultqvist, O Borgå. Enprofylline pharmacokinetics in children with asthma.
European journal of clinical pharmacology.
1987; 32(5):533-5. doi:
10.1007/bf00637683. [PMID: 3622600] - J B Rasmussen, E Lunell. Additive bronchodilator effects of terbutaline and enprofylline in asthma.
European journal of clinical pharmacology.
1987; 32(1):23-6. doi:
10.1007/bf00609953. [PMID: 3582466] - E Lunell, O Borgå. Pharmacokinetics of enprofylline in healthy elderly subjects.
European journal of clinical pharmacology.
1987; 32(1):67-70. doi:
10.1007/bf00609959. [PMID: 3582470] - M G Collis, G S Baxter, J R Keddie. The adenosine receptor antagonist, 8-phenyltheophylline, causes diuresis and saliuresis in the rat.
The Journal of pharmacy and pharmacology.
1986 Nov; 38(11):850-2. doi:
10.1111/j.2042-7158.1986.tb04510.x. [PMID: 2879020] - C G Persson. Development of safer xanthine drugs for treatment of obstructive airways disease.
The Journal of allergy and clinical immunology.
1986 Oct; 78(4 Pt 2):817-24. doi:
10.1016/0091-6749(86)90067-9. [PMID: 3534062] - C G Persson, K E Andersson, G Kjellin. Effects of enprofylline and theophylline may show the role of adenosine.
Life sciences.
1986 Mar; 38(12):1057-72. doi:
10.1016/0024-3205(86)90241-9. [PMID: 3007902] - T B Conradson. Bronchodilating plasma concentrations of enprofylline and theophylline have minor cardiovascular effects in man.
Acta pharmacologica et toxicologica.
1986 Mar; 58(3):204-8. doi:
10.1111/j.1600-0773.1986.tb00095.x. [PMID: 3716813] - P Gresele, J Arnout, H Deckmyn, J Vermylen. Mechanism of the antiplatelet action of dipyridamole in whole blood: modulation of adenosine concentration and activity.
Thrombosis and haemostasis.
1986 Feb; 55(1):12-8. doi:
. [PMID: 3704998] - T Haahtela, K Venho, G Eriksson. Comparison of enprofylline and theophylline for intravenous treatment of acute asthma.
Allergy.
1986 Feb; 41(2):160-2. doi:
10.1111/j.1398-9995.1986.tb00293.x. [PMID: 3518528] - L C Laursen, G Eriksson, B Weeke. Enprofylline and theophylline slow-eroding tablets in the treatment of asthma: a comparison.
Respiration; international review of thoracic diseases.
1986; 50(1):57-61. doi:
10.1159/000194907. [PMID: 3523664] - O Borgå, R Larsson, E Lunell. Effects of probenecid on enprofylline kinetics in man.
European journal of clinical pharmacology.
1986; 30(2):221-3. doi:
10.1007/bf00614308. [PMID: 3709650] - T B Kluge, M Oellerich, G Schumann, G W Sybrecht. Enprofylline: pharmacokinetics and comparison with theophylline of acute effects on bronchial reactivity in normal subjects.
European journal of clinical pharmacology.
1986; 30(1):21-5. doi:
10.1007/bf00614190. [PMID: 3709629] - R Pauwels, D Van Renterghem, M Van der Straeten, N Johannesson, C G Persson. The effect of theophylline and enprofylline on allergen-induced bronchoconstriction.
The Journal of allergy and clinical immunology.
1985 Oct; 76(4):583-90. doi:
10.1016/0091-6749(85)90779-1. [PMID: 4056246] - L C Laursen, N Johannesson, B Weeke. Effects of enprofylline and theophylline on exercise-induced asthma.
Allergy.
1985 Oct; 40(7):506-9. doi:
10.1111/j.1398-9995.1985.tb00258.x. [PMID: 3907395] - N Johannesson, K E Andersson, B Joelsson, C G Persson. Relaxation of lower esophageal sphincter and stimulation of gastric secretion and diuresis by antiasthmatic xanthines. Role of adenosine antagonism.
The American review of respiratory disease.
1985 Jan; 131(1):26-30. doi:
10.1164/arrd.1985.131.1.26. [PMID: 3966710] - G Thomas, J C Duarte. Inhibitory actions of enprofylline and aminophylline on extravasation of plasma proteins induced by various agents in the rat skin.
Agents and actions.
1984 Dec; 15(5-6):584-7. doi:
10.1007/bf01966778. [PMID: 6532181] - L C Laursen, N Johannesson, B Weeke. Continuous treatment of asthmatic patients with enprofylline and theophylline.
European journal of respiratory diseases.
1984 Oct; 65(7):504-8. doi:
NULL. [PMID: 6386511] - L C Laursen, N Johannesson, I Søndergaard, B Weeke. Maximally effective plasma concentrations of enprofylline and theophylline during constant infusion.
British journal of clinical pharmacology.
1984 Oct; 18(4):591-5. doi:
10.1111/j.1365-2125.1984.tb02509.x. [PMID: 6487499] - E Lunell, O Borgå, R Larsson. Pharmacokinetics of enprofylline in patients with impaired renal function after a single intravenous dose.
European journal of clinical pharmacology.
1984; 26(1):87-93. doi:
10.1007/bf00546714. [PMID: 6714295] - E Lunell, K E Andersson, O Borgå, P O Fagerström, N Johannesson, G Kjellin, C G Persson, K Sjölund. Absorption of enprofylline from the gastrointestinal tract in healthy subjects.
European journal of clinical pharmacology.
1984; 27(3):329-33. doi:
10.1007/bf00542170. [PMID: 6510461] - K E Andersson, N Johannesson, B Karlberg, C G Persson. Increase in plasma free fatty acids and natriuresis by xanthines may reflect adenosine antagonism.
European journal of clinical pharmacology.
1984; 26(1):33-8. doi:
10.1007/bf00546705. [PMID: 6370703] - L C Laursen, N Johannesson, I Søndergaard, B Weeke. Comparison of oral enprofylline and theophylline in asthmatic patients.
European journal of clinical pharmacology.
1984; 26(6):707-9. doi:
10.1007/bf00541929. [PMID: 6489410] - E Lunell, K E Andersson, C G Persson, N Svedmyr. Intravenous enprofylline in asthma patients.
European journal of respiratory diseases.
1984 Jan; 65(1):28-34. doi:
NULL. [PMID: 6705855] - P G Baer, E L Armstrong, L M Cagen. Dissociation of effects of xanthine analogs on renal prostaglandins and renal excretory function in the awake rat.
The Journal of pharmacology and experimental therapeutics.
1983 Dec; 227(3):600-4. doi:
NULL. [PMID: 6581288] - O Borgå, K E Andersson, L E Edholm, P O Fagerström, E Lunell, C G Persson. Enprofylline kinetics in healthy subjects after single doses.
Clinical pharmacology and therapeutics.
1983 Dec; 34(6):799-804. doi:
10.1038/clpt.1983.252. [PMID: 6641096] - E Lunell, K E Andersson, C G Persson. Tolerance and some circulatory effects of intravenous and oral enprofylline in healthy volunteers.
Acta pharmacologica et toxicologica.
1983 Sep; 53(3):205-11. doi:
10.1111/j.1600-0773.1983.tb01126.x. [PMID: 6637510] - E Lunell, N Svedmyr, K E Andersson, C G Persson. A novel bronchodilator xanthine apparently without adenosine receptor antagonism and tremorogenic effect.
European journal of respiratory diseases.
1983 Jul; 64(5):333-9. doi:
NULL. [PMID: 6309542] - K Tegnér, O Borgå, I Svensson. Protein binding of enprofylline.
European journal of clinical pharmacology.
1983; 25(5):703-8. doi:
10.1007/bf00542362. [PMID: 6420163] - L C Laursen, N Johannesson, P O Fagerström, B Weeke. Intravenous administration of enprofylline to asthmatic patients.
European journal of clinical pharmacology.
1983; 24(3):323-7. doi:
10.1007/bf00610048. [PMID: 6345176] - L C Laursen, N Johannesson, A Dirksen, R Djurup, E P Munch, E Taudorf, B Weeke. Enprofylline--effects of a new bronchodilating xanthine derivative in asthmatic patients.
Allergy.
1983 Jan; 38(1):75-9. doi:
10.1111/j.1398-9995.1983.tb00859.x. [PMID: 6340552] - C G Persson, I Erjefält, L E Edholm, J A Karlsson, C J Lamm. Tracheal relaxant and cardiostimulant actions of xanthines can be differentiated from diuretic and CNS-stimulant effects. Role of adenosine antagonism?.
Life sciences.
1982 Dec; 31(24):2673-81. doi:
10.1016/0024-3205(82)90711-1. [PMID: 6130456] - E Lunell, N Svedmyr, K E Andersson, C G Persson. Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease.
European journal of clinical pharmacology.
1982; 22(5):395-402. doi:
10.1007/bf00542541. [PMID: 6288396]