Halazepam (BioDeep_00000614985)

   


代谢物信息卡片


7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

化学式: C17H12ClF3N2O (352.0590208)
中文名称: 哈拉西泮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3)CC(F)(F)F
InChI: InChI=1S/C17H12ClF3N2O/c18-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)22-9-15(24)23(14)10-17(19,20)21/h1-8H,9-10H2

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

4 个代谢物同义名

halazepam civ (200 mg) (as); Halazepam; 7-chloro-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one; Halazepamum [INN-Latin]



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Boni Elewski, Amir Tavakkol. Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. Therapeutics and clinical risk management. 2005 Dec; 1(4):299-306. doi: . [PMID: 18360572]
  • Maria Elisa Capella-Peiró, Devasish Bose, Adrià Martinavarro-Domínguez, Mayte Gil-Agustí, Josep Esteve-Romero. Direct injection micellar liquid chromatographic determination of benzodiazepines in serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Nov; 780(2):241-9. doi: 10.1016/s1570-0232(02)00523-8. [PMID: 12401349]
  • D Song, S Zhang, K Kohlhof. Determination of chlordiazepoxide in mouse plasma by gas chromatography-negative-ion chemical ionization mass spectrometry. Journal of chromatography. B, Biomedical applications. 1994 Oct; 660(1):95-101. doi: 10.1016/0378-4347(94)00282-7. [PMID: 7858728]
  • J W Sloan, W R Martin, E Wala, K M Dickey. Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog. Drug and alcohol dependence. 1991 Oct; 28(3):249-64. doi: 10.1016/0376-8716(91)90058-7. [PMID: 1684320]
  • E P Wala, J W Sloan, W R Martin, T Pruitt. Pharmacokinetics and metabolism of halazepam in naive and dependent dogs. Pharmacology, biochemistry, and behavior. 1991 Mar; 38(3):561-7. doi: 10.1016/0091-3057(91)90014-s. [PMID: 1676848]
  • S K Gupta, E H Ellinwood. Liquid chromatographic assay and pharmacokinetics of halazepam and its metabolite in humans. Journal of pharmaceutical sciences. 1990 Sep; 79(9):822-5. doi: 10.1002/jps.2600790916. [PMID: 1980307]
  • M Chung, J M Hilbert, R P Gural, E Radwanski, S Symchowicz, N Zampaglione. Multiple-dose halazepam kinetics. Clinical pharmacology and therapeutics. 1984 Jun; 35(6):838-42. doi: 10.1038/clpt.1984.122. [PMID: 6145534]
  • D J Greenblatt, A Locniskar, R I Shader. Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography. Psychopharmacology. 1983; 80(2):178-80. doi: 10.1007/bf00427965. [PMID: 6410448]