Esopiclone (BioDeep_00000614948)

   


代谢物信息卡片


(5S)-6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate

化学式: C17H17ClN6O3 (388.1050602)
中文名称: 右佐匹克隆
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl
InChI: InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/t16-/m0/s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CF - Benzodiazepine related drugs
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic

同义名列表

3 个代谢物同义名

(5S)-6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; Eszopiclone; Esopiclone



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wang Yichen, W U Shiyi, Wang Zhengyan, Chang Wenling, Xie Zhihao, Tang Xing, Zhao Songmei, Zhou Jing, Chen Zehong, Wang Chao, Yang Chunxia. Efficacy of Zhumian Tang formula granules combined with eszopiclone for the treatment of poor sleep quality: a multi-center, randomized controlled, superiority trial. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):163-171. doi: 10.19852/j.cnki.jtcm.2024.01.002. [PMID: 38213251]
  • Ruo-Yang Li, De-Liang Zhu, Ke-Yu Chen. Efficacy and safety of eszopiclone combined with drug therapy in the treatment of insomnia after stroke: A network meta-analysis and systematic review. PloS one. 2024; 19(2):e0297064. doi: 10.1371/journal.pone.0297064. [PMID: 38315683]
  • Ruichen Liu, Dongke Liu, Jin Zhang, Hengchang Zang, Yanhui Gao. Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat. Journal of pharmaceutical and biomedical analysis. 2020 Sep; 188(?):113363. doi: 10.1016/j.jpba.2020.113363. [PMID: 32502953]
  • Xijun Zheng, Yingchun He, Fang Yin, Hongxia Liu, Yunfei Li, Qingshan Zheng, Lujin Li. Pharmacological interventions for the treatment of insomnia: quantitative comparison of drug efficacy. Sleep medicine. 2020 08; 72(?):41-49. doi: 10.1016/j.sleep.2020.03.022. [PMID: 32544795]
  • Shivpoojan Kori, Ankush Parmar, Jony Goyal, Shweta Sharma. Cloud point extraction coupled with microwave-assisted back-extraction (CPE-MABE) for determination of Eszopiclone (Z-drug) using UV-Visible, HPLC and mass spectroscopic (MS) techniques: Spiked and in vivo analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Feb; 1074-1075(?):129-138. doi: 10.1016/j.jchromb.2018.01.005. [PMID: 29396378]
  • ". Drugs for Insomnia. The Medical letter on drugs and therapeutics. 2015 Jul; 57(1472):95-8. doi: ". [PMID: 26147892]
  • F Wu, X L Zhao, M J Wei, S M Wang, H Zhou, S J Guo, P Zhang. Pharmacokinetics and safety of eszopiclone in healthy Chinese volunteers. Arzneimittel-Forschung. 2012 Dec; 62(12):561-5. doi: 10.1055/s-0032-1327570. [PMID: 23038043]
  • Kishore Kumar Hotha, D Vijaya Bharathi, B Jagadeesh, L K Ravindranath, K N Jaya Veera, V Venkateswarulu. A rapid LC-MS/MS method for quantitation of eszopiclone in human plasma: application to a human pharmacokinetic study. Biomedical chromatography : BMC. 2012 Feb; 26(2):225-31. doi: 10.1002/bmc.1651. [PMID: 21618564]
  • Robert N Pechnick, Liliana M Lacayo, Charlene M Manalo, Yasmin Bholat, Inna Spivak. Eszopiclone stimulates the hypothalamo-pituitary-adrenal axis in the rat. European journal of pharmacology. 2011 Jul; 661(1-3):22-6. doi: 10.1016/j.ejphar.2011.04.016. [PMID: 21540024]
  • Min Meng, Lisa Rohde, Vladimír Cápka, Spencer J Carter, Patrick K Bennett. Fast chiral chromatographic method development and validation for the quantitation of eszopiclone in human plasma using LC/MS/MS. Journal of pharmaceutical and biomedical analysis. 2010 Dec; 53(4):973-82. doi: 10.1016/j.jpba.2010.05.006. [PMID: 20650591]
  • Richard L Doty, Jonathan Treem, Isabelle Tourbier, Natasha Mirza. A double-blind study of the influences of eszopiclone on dysgeusia and taste function. Pharmacology, biochemistry, and behavior. 2009 Dec; 94(2):312-8. doi: 10.1016/j.pbb.2009.09.011. [PMID: 19772869]