Trospium (BioDeep_00000614931)

   


代谢物信息卡片


3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8$l^{5}-azaspiro[bicyclo[3.2.1]octane-8,1-pyrrolidin]-8-ylium

化学式: C25H30NO3+ (392.22255700000005)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1ccc(cc1)C(c1ccccc1)(C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)[N+]12CCCC1)O
InChI: InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1

描述信息

G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BD - Drugs for urinary frequency and incontinence
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent

同义名列表

2 个代谢物同义名

Trospium; 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8$l^{5}-azaspiro[bicyclo[3.2.1]octane-8,1-pyrrolidin]-8-ylium



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J Krhut, A Martan, R Zachoval, J Tvrdík, T Hanus. [Current state of diagnostics and treatment of overactive bladder in the Czech Republic - five years ago and today]. Ceska gynekologie. 2012 Jun; 77(3):205-10. doi: NULL. [PMID: 22779719]
  • Ernesto Callegari, Bimal Malhotra, Peter J Bungay, Rob Webster, Katherine S Fenner, Sarah Kempshall, Jennifer L LaPerle, Martin C Michel, Gary G Kay. A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder. British journal of clinical pharmacology. 2011 Aug; 72(2):235-46. doi: 10.1111/j.1365-2125.2011.03961.x. [PMID: 21392072]
  • David A Ginsberg, Michael G Oefelein, Pamela I Ellsworth. Once-daily administration of trospium chloride extended release provides 24-hr coverage of nocturnal and diurnal symptoms of overactive bladder: an integrated analysis of two phase III trials. Neurourology and urodynamics. 2011 Apr; 30(4):563-7. doi: 10.1002/nau.21018. [PMID: 21268101]
  • Birger Wenge, Joachim Geyer, Heinz Bönisch. Oxybutynin and trospium are substrates of the human organic cation transporters. Naunyn-Schmiedeberg's archives of pharmacology. 2011 Feb; 383(2):203-8. doi: 10.1007/s00210-010-0590-x. [PMID: 21212936]
  • Kishore Kumar Hotha, D Vijaya Bharathi, Sanagapati Sirish Kumar, Y Narasimha Reddy, Pankaj K Chatki, L K Ravindranath, K N Jayaveera. Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Apr; 878(13-14):981-6. doi: 10.1016/j.jchromb.2010.02.028. [PMID: 20303326]
  • Nova Silver, Bobby Sandage, LuAnn Sabounjian, Ute Schwiderski, James Shipley, Mark Harnett. Pharmacokinetics of once-daily trospium chloride 60 mg extended release and twice-daily trospium chloride 20 mg in healthy adults. Journal of clinical pharmacology. 2010 Feb; 50(2):143-50. doi: 10.1177/0091270009345498. [PMID: 19948948]
  • D R Staskin, M T Rosenberg, P K Sand, N R Zinner, R R Dmochowski. Trospium chloride once-daily extended release is effective and well tolerated for the treatment of overactive bladder syndrome: an integrated analysis of two randomised, phase III trials. International journal of clinical practice. 2009 Dec; 63(12):1715-23. doi: 10.1111/j.1742-1241.2009.02189.x. [PMID: 19930332]
  • Kelly Biastre, Thomas Burnakis. Trospium chloride treatment of overactive bladder. The Annals of pharmacotherapy. 2009 Feb; 43(2):283-95. doi: 10.1345/aph.1l160. [PMID: 19193592]
  • Lambertus P W Witte, Wilhemina M C Mulder, Jean J M C H de la Rosette, Martin C Michel. Muscarinic receptor antagonists for overactive bladder treatment: does one fit all?. Current opinion in urology. 2009 Jan; 19(1):13-9. doi: 10.1097/mou.0b013e32831a6ff3. [PMID: 19057211]
  • Jean-Jacques Wyndaele, Stefan De Wachter. Urgency in overactive bladder: translating experimental data into clinical practice. Drugs of today (Barcelona, Spain : 1998). 2008 May; 44(5):381-9. doi: 10.1358/dot.2008.44.5.1215723. [PMID: 18548139]
  • Nathan Bittner, Gregory S Merrick, Sarah Brammer, Angela Niehaus, Kent E Wallner, Wayne M Butler, Zachariah A Allen, Robert W Galbreath. Role of trospium chloride in brachytherapy-related detrusor overactivity. Urology. 2008 Mar; 71(3):460-4. doi: 10.1016/j.urology.2007.10.023. [PMID: 18342187]
  • Kristen Hesch. Agents for treatment of overactive bladder: a therapeutic class review. Proceedings (Baylor University. Medical Center). 2007 Jul; 20(3):307-14. doi: 10.1080/08998280.2007.11928310. [PMID: 17637888]
  • V V Danilov, T I Danilova. [M-cholinolytic spasmex and its role in preoperative preparation of patients with urine incontinence]. Urologiia (Moscow, Russia : 1999). 2007 Jan; ?(1):33-6. doi: NULL. [PMID: 17471995]
  • M Menarini, G Del Popolo, P Di Benedetto, J Haselmann, R H Bödeker, U Schwantes, H Madersbacher. Trospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients?. International journal of clinical pharmacology and therapeutics. 2006 Dec; 44(12):623-32. doi: 10.5414/cpp44623. [PMID: 17190372]
  • B Sandage, L Sabounjian, J Shipley, A Profy, K Lasseter, L Fox, M Harnett. Predictive power of an in vitro system to assess drug interactions of an antimuscarinic medication: a comparison of in vitro and in vivo drug-drug interaction studies of trospium chloride with digoxin. Journal of clinical pharmacology. 2006 Jul; 46(7):776-84. doi: 10.1177/0091270006289481. [PMID: 16809803]
  • E V Kul'chavenia, E V Brizhatiuk. [Tuberculosis of the urinary bladder: diagnosis and treatment]. Urologiia (Moscow, Russia : 1999). 2006 May; ?(3):61-4, 66. doi: NULL. [PMID: 16889095]
  • Jane Miller, Eileen Hoffman. The causes and consequences of overactive bladder. Journal of women's health (2002). 2006 Apr; 15(3):251-60. doi: 10.1089/jwh.2006.15.251. [PMID: 16620184]
  • Nurum Erdem, Franklin M Chu. Management of overactive bladder and urge urinary incontinence in the elderly patient. The American journal of medicine. 2006 Mar; 119(3 Suppl 1):29-36. doi: 10.1016/j.amjmed.2005.12.014. [PMID: 16483866]
  • Yongtae Kim, Naoki Yoshimura, Hitoshi Masuda, Fernando De Miguel, Michael B Chancellor. Intravesical instillation of human urine after oral administration of trospium, tolterodine and oxybutynin in a rat model of detrusor overactivity. BJU international. 2006 Feb; 97(2):400-3. doi: 10.1111/j.1464-410x.2005.05913.x. [PMID: 16430654]
  • Sharath S Hegde. Muscarinic receptors in the bladder: from basic research to therapeutics. British journal of pharmacology. 2006 Feb; 147 Suppl 2(?):S80-7. doi: 10.1038/sj.bjp.0706560. [PMID: 16465186]
  • E B Mazo, G G Krivoborodov, M E Shkol'nikov, G A Babanina, S V Kozyrev, E S Korshunov. [Trospium chloride in the treatment of idiopathic and neurogenic detrusor overactivity]. Urologiia (Moscow, Russia : 1999). 2005 Jul; ?(4):56-9. doi: NULL. [PMID: 16158750]
  • David Rp Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Therapeutics and clinical risk management. 2005 Jun; 1(2):157-67. doi: 10.2147/tcrm.1.2.157.62912. [PMID: 18360555]
  • YongTae Kim, Naoki Yoshimura, Hitoshi Masuda, Fernando de Miguel, Michael B Chancellor. Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways. Urology. 2005 Feb; 65(2):238-42. doi: 10.1016/j.urology.2004.11.021. [PMID: 15708029]
  • Eric S Rovner. Trospium chloride in the management of overactive bladder. Drugs. 2004; 64(21):2433-46. doi: 10.2165/00003495-200464210-00005. [PMID: 15482001]
  • A A Faiers, A Y Loh, D H Osmond. Resolution of rat renin substrates by isoelectric focusing. Canadian journal of biochemistry. 1977 Aug; 55(8):869-75. doi: 10.1139/o77-128. [PMID: 19143]
  • M Sano. Subcellular localizations of guanylate cyclase and 3',5'-cyclic nucleotide phosphodiesterase in sea urchin sperm. Biochimica et biophysica acta. 1976 Apr; 428(2):525-31. doi: 10.1016/0304-4165(76)90061-1. [PMID: 6049]